Mekanisme Kerja Oral Kontasepsi.docx

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MEKANISME KERJA ORAN KONTASEPSI Etinilestradiol dan progestogen terabsorbsi di usus halus, serta mengalami first pass effect dengan asam glukoronat lalu dimetabolisme hati oleh enzim sitokrom P450 3A4, kemudian glukronat diekskresikan oleh empedu dan dipecah oleh bakteri usus kemudian diserap kembali sebagai obat aktif pada usus halus. Setelah terabsorbsi dan menghasilkan efek, lalu etinilestradiol diekskresi melalui urin.

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