Kti B.ing Revisi.docx

PHARMACEUTICAL EXCIPIENT

1. Definition of pharmaceutical excipients. Pharmaceutical excipients are a component of pharmaceutical products other than inert, active ingredients added at the time of formulation for particular purpose. 2. Purposed server by excipients. Pharmaceutical excipients are substances intended to enhance utulity, steadiness, durability, and as dyestuffs, maybe added both to official preparations and to unoffocial preparations. 3. Type of pharmaceutical excipients a. Filler Filler tipically also fill out the size of a table o capsule, making it practical to pruduce and convenientfor the consumer to use. b. Solvent and cosolvents Use to dissolve another subtance in preparation of a solution, maybe aqueous or oleaginous. Cosolvents are definied as water miscible organic solvents that ore used in liquid drug formulations. c. Antifungal and antibacterial preservatives Use in liquid and semisolid preparations to prevent growth of fungi microorganism. Example : butyl paraben d. Suspending agent Suspending agent used to reduce sedimentation rate of particles in a vehicle in which they are not soluble. Example: tragacanth, agar e. Flavoring agent Flavoring agent used to increase patient acceptance. Example: rose oil, orange oil, etc. f. Suppository base Vehicle of suppositories. Example: cocoa butter 4. Example of preparation formulation a. Formula for oral suspension (hadiwibowo, 2108)

Fuction Active ingredient Suspending agent Co-solvent Antimicrobial preservative vehicle

Formula 1 Material’s Name Magnesium hydroxide Aluminium hydroxide CMC sodium Propylene glycol Nipagin Aquades

Dosage 200mg/5mL 200mg/5mL 1% 10% 0.2% Ad 60mL

5. Conclusion The importance of ensuring proper excipients for use in a formulation is sometines overlooked. In fact, the existence and function of these excipients also greatly determine the failure of a pharmaceutical preparation formulation.

ANGGOTA KELOMPOK : 1. IKA LELY ANDREINA 2. FITRIA ANGGRAINI W.S 3. SUFANGGI SURYA P 4. MURIFATUL