Zofran (ondansetron)

NURS 1566 Clinical Form 3: Clinical Medications Worksheets (You will need to make additional copies of these forms) Generic Name ondansetron Peak 15-30 min

Trade Name Classification Dose Route Time/frequency Zofran antiemetics 4-8 mg IVP Q 6 hrs PRN Onset Duration Normal dosage range 4 mg before induction of anesthesia or postoperatively rapid 4-8 hrs

Why is your patient getting this medication Nausea

For IV meds, compatibility with IV drips and/or solutions Administer undiluted immediately before induction of anesthesia or postoperatively if nausea and vomiting occur shortly after surgery, Dilute doses for prevention of nausea and vomiting associated with chemotherapy in 50 ml of D5W, 0.9% NaCl, D5/0.9% NaCl, D5/0.45% NaCl. Solution is clear and colorless. Stable for 7 days at room temperature following dilution.

Mechanism of action and indications (Why med ordered) Blocks the effects of serotonin at 5-HT3-receptor sites (selective antagonist) located in vagal nerve terminals and the chemoreceptor trigger zone in the CNS.

Nursing Implications (what to focus on) Contraindications/warnings/interactions Hypersensitivity, L i v e r i m p a i r m e n t ( d a i l y d o s e n o t t o e x c e e d

Interactions with other patient drugs, OTC or herbal medicines (ask patient specifically) None known for this patient

Nursing Process- Assessment (Pre-administration assessment) Assess patient for nausea, vomiting, abdominal distention, and bowel sounds prior to and following administration. Assess patient for extrapyramidal effects (involuntary movements, facial grimacing, rigidity, shuffling walk, trembling of hands) periodically during therapy.

Lab value alterations caused by medicine May cause transient ↑ in serum bilirubin, AST, and ALT levels. Be sure to teach the patient the following about this medication Instruct patient to take ondansetron as directed, Advise patient to notify health care professional immediately if involuntary movement of eyes, face, or limbs occurs.

Assessment Why would you hold or not give this med? No nausea or vomiting.

Evaluation Check after giving Prevention of nausea.