Zofran Ivp

Generic Name Trade Name Zofran ondansetron Peak

Onset

15-30 min

rapid

NURS 2516 Clinical Medications Worksheets Classification Dose Route Time/frequency antiemetics 4 mg IVP Q 6 hr. PRN Normal dose range: 4 mg before induction of anesthesia or post-op Duration For IV meds, compatibility with IV drips and /or solutions 4 hr-8 hr

Administer undiluted immediately before induction of anesthesia or postoperatively if nausea and vomiting occur shortly after surgery Rate: give over at least 30 sec and preferably over 2-5min

Mechanism of action and indications (Why med ordered)

Nursing Implications (what to focus on) Contraindications/warnings/interactions

Prevention of postoperative nausea and vomiting

Hypersensitivity

Blocks the effects of serotonin at 5-HT3-receptor sites (selective antagonist) located in vagal nerve terminals and the chemoreceptor trigger zone in the CNS

Common side effects Headache, constipation, diarrhea

Interactions with other patient drugs, OTC or herbal medicines (ask patient specifically)

Lab value alterations caused by medicine

May be affected by drugs altering the activity of liver enzymes

May cause transient ↑ in serum bilirubin, AST, and ALT levels

Be sure to teach the patient the following about this medication Advise patient to notify health care professional immediately if involuntary movement of eyes, face, or limbs occurs

Nursing Process- Assessment (Pre-administration assessment) Assess patient for nausea, vomiting, abdominal distention, and bowel sounds prior to and following administration

Assessment Why would you hold or not give this med? Assess patient for extrapyramidal effects (involuntary movements, facial grimacing, rigidity, shuffling walk, trembling of hands)

Evaluation Check after giving Prevention of post-op nausea and vomiting