Preparation 1 - Powders.docx

Powders - Mixture of finely divided solids or chemicals - Dry form - External – topical - Internal - Bulk – multiple dosage - Divided – single dose Production Method Comminution Method - Reduces the particle size Extemporaneous Preparations 1. Trituration - Comminute - Smaller particles 2. Pulverization by Intervention - The use of volatile substance - Volatile substance will not be present in the final product - Hard to comminute 3. Levigation - Mineral oil (most common) - Commonly used in the preparation of ointments - Use of suitable non-solvent Blending/Mixing Extemporaneous 1. Spatulation - Eutectic – lowering of the melting point/liquefaction 2. Trituration 3. Sifting - Bulk 4. Tumbling 5. Geometric Dilution - For potent substances - To assure uniform distribution

Packaging Materials Paper Type 1. Vegetable Parchment - Thin, semi-opaque - Moisture resistant 2. White Bond Paper - Opaque - Not moisture resistant 3. Glassine - Glazed - Transparent - Water-resistant 4. Wax Paper - Transparent - Water-proof PREPARATION #1 – DIVIDED POWDERS INGREDIENTS Levothyroxine Na *Eltroxin 50 mcg

MATERIALS Pill Tile Stainless steel spatula Glassine paper White Bond Paper Scissors Glue Mortar/Pestle

Synonym/s: Chartula/Chartulae Pptab – papelitos Description of the Final Product: Divided Use/s: Thyroid Hormone; Hypothyroidism