Kerangka Konsep.docx

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1.5 KERANGKA KONSEPTUAL

Peradangan sinovial menyebabkan keterbatasan diseluruh gerak aktif dan pasif (Davey Patrick, 2006)

Rheumatoid arthritis

Pemilihan obat belum sesuai dapat mengakibatkan kegagalan terapi karena adanya Drug Related Problem (DRP) (Cipolle et al 2007)

Prevalensi penyakit sendi/rematik/encok berdasarkan diagnosis 11,9% dan berdasarkan diagnosis atau gejala 24,7% dimana penyakit Rheumatoid Arthritis termasuk didalamnya (Riskesdas, 2013).

Efeksamping memiliki pengaruh pada outcome jangka panjang, sehingga pemilihan terapi harus dipertimbangkan ( Dipiro T Joseph, 2008) Tanda Dan Gejala

Lelah (malaise)

Nyeri sendi

Keterbatasan aktifitas

Stiffness dipagi hari > 30 menit

Poliartritis simetris pada sendi perifer

Terapi

Non Farmakologi

Farmakologi

Adjuvant

Analgesik/ antiinflamasi

DMARD

NSAID

Pain Assesment

Kesesuaian Indikasi

Efektifitas Obat

Keterbatasan Aktivitas

DRP

Efek samping obat

Potential Aberrant Drug-Related Behavior

Lainnya

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