Focis Program May 2005

Photograph by Peter Vanderwarker

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

• Plenary Session • Thematic Symposia • Oral Abstract Sessions

• Satellite Programs • Exhibit Hall • Poster Hall • Thematic Symposia • Oral Abstract Session

• Industry Tutorials • Oral Abstract Session • Speaker Ready Room

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Westin Copley Place ......................................................................... inside cover Supporting Organizations ................................................................................ 2 Mission Statement & Strategic Plan .................................................................... 3 Member Societies ........................................................................................... 5 FOCIS Centers of Excellence ............................................................................ 6 Steering Committee ......................................................................................... 7 FOCIS Committees and Executive Office Staff ..................................................... 8 Faculty ........................................................................................................ 11 General Information ...................................................................................... 16 CME Information .......................................................................................... 16 Program-At-a-Glance .................................................................................... 18 Satellite Symposia ........................................................................................ 19 Industry Tutorials ........................................................................................... 34 Business Meetings ........................................................................................ 38

TABLE OF CONTENTS

Table of Contents

Program Schedule ........................................................................................ 39 Exhibitor Information ..................................................................................... 58 Travel Award Recipients ................................................................................. 66 Abstracts in Order of Presentation ................................................................... 67 CME Self-Reporter ...................................................................................... 133

FOCIS

555 East Wells Street Suite 1100 Milwaukee, WI 53202 Phone (414) 918-3192 Fax (414) 276-3349 [email protected] www.focisnet.org

Future Meetings FOCIS 2006 June 1-5, 2006 San Francisco Marriott

FOCIS 2007 June 7-11, 2007 Sheraton San Diego Hotel & Marina 1

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Supporting Organizations

FOCIS gratefully acknowledges the continued support of its funders. This support allows FOCIS to continue to fulfill its mission to foster interdisciplinary approaches to both understand and treat immune-based diseases, and ultimately, to improve human health through immunology.

Thank you to the 2005 Industr y Liaison Council... Industry

Thank you to the FOCIS 2005 Major Supporters...

National Institutes of Health

Thank you to the FOCIS 2005 Contributing Supporters...

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Mission Statement Federation of Clinical Immunology Societies, Inc. (FOCIS) has been created to engender crossfertilization among the many specialty societies that are included in the broad field of clinical immunology. A major role of the Federation is to organize an annual meeting involving clinician scientists from many different constituent societies, which share an interest in clinical immunology. An additional principal purpose of the Federation is to educate the community, physicians, trainees, and patients in the broad discipline of clinical immunology as well as to promote an understanding of the field of clinical immunology.

FOCIS Annual Meeting The FOCIS Annual Meeting provides a scientific forum to foster the cross-disciplinary approach required to understand and treat immune-based diseases. The evolution of clinical immunology is a reflection of the shared pathophysiology of many diseases including: autoimmune diseases, cancer, allergy/asthma, infectious diseases, immune deficiency, and transplant rejection. While clinicians necessarily remain linked to diseases associated with their own specialty, the immunological sciences underlying recent advances in diagnosing and treating these diverse diseases are multi-disciplinary and cut across traditional clinical boundaries. The ultimate goal of the FOCIS Annual Meeting is to create a better understanding of the shared pathophysiological underpinnings of clinical immunology and the new therapeutic approaches suggested by these novel relationships, including the increasingly widespread use of biologics in therapy. In addition to highlighting the best science in the field, the FOCIS Annual Meeting is an incubator for developing scientists and practitioners alike to meet with one another and representatives of the relevant biotech and pharmaceutical industries whose combined support is invaluable to the success of the field of clinical immunology. 3

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005-2008 Strategic Plan Core Purpose: To improve human health through immunology.

Mission: To foster interdisciplinary approaches to both understand and treat immune-based diseases.

Core V alues: Values: Interdisciplinar y: Interdisciplinary: Believing in the importance of interdisciplinary approaches in education, research, and patient care; translating new knowledge from basic science into multiple clinical disciplines. Leadership: Embracing active and committed leadership to ensure a successful future. Collaboration: Strengthening relationships by proactively reaching out to related groups. Training and Education: Supporting basic and clinical scientists to perform the best research, to create new tools and provide new insights.

Goals I.

Education of Clinical TTrainees rainees and Investigators Create educational programs that maintain, develop and increase the knowledge, understanding, skills and professional performance of trainees and investigators in the broad field of clinical immunology.

II.

Education of Basic Scientists Enable basic scientists to understand the pathogenesis of immunological disease and the principles of clinical research.

III. FOCIS Centers of Excellence (FCE) Establish a variety of diverse of FCE that are fully functional as interdisciplinary “umbrella” programs that bring a unique approach to research and patient care. IV IV.. Annual Meeting Establish the FOCIS Annual Meeting as the premier venue for clinical immunology in the world. V. Endowment Establish an ample endowment to support the FOCIS infrastructure, Annual Meeting, educational, and research initiatives. VI. Committee Structure Develop and appoint membership to committees designed to support FOCIS mission.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Member Societies American Academy of Allergy, Asthma, and Immunology (AAAAI) American College of Rheumatology (ACR) American Society for Blood and Marrow Transplantation (ASBMT) American Society for Histocompatibility and Immunogenetics (ASHI) American Society of Transplantation (AST) American Uveitis Society (AUS) America’s Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Association of Medical Laboratory Immunologists (AMLI) Clinical Immunology Society (CIS) Crohn’s and Colitis Foundation of America (CCFA) Immunology of Diabetes Society (IDS) International Complement Society (ICS) International Cytokine Society (ICS) International Society for Interferon and Cytokine Research (ISICR) International Society for Neuroimmunology (ISNI) International Society for the Biological Therapy of Cancer (ISBTC) Society for Investigative Dermatology (SID) Society for Mucosal Immunology (SMI)

Affiliate Societies Australasian Society of Clinical Immunology and Allergy (ASCIA) Clinical Immunology Chapter of the Sociedad Mexicana de Inmunologia Commonwealth of Independent States Society of Allergology and Clinical Immunology Israel Association of Allergy and Clinical Immunology The Italian Society of Allergology and Clinical Immunology Pan American Group for Immunodeficiency Section of Clinical Immunology and Allergy of the Royal Society of Medicine The International Society for NeuroImmunoModulation World Allergy Organization (WAO)

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

FOCIS Centers of Excellence Albert Einstein College of Medicine Director: Chaim Putterman

Medical School Director: Alice B. Gottlieb

University of Southern California Director: Chaim Oscar Jacob

Baylor College of Medicine Director: David P. Huston

University of Alabama Birmingham Director: Robert P. Kimberly

Stanford University Medical Center Director: C. Garrison Fathman

University of California Los Angeles Director: Bevra Hahn

Yale University Director: Jordan S. Pober

Brigham & W omen’ Women’ omen’ss Hospital Director: Paul Anderson Children’ Children’ss Hospital Boston Director: Raif S. Geha Cincinnati Children’ Children’ss Hospital Director: Alexandra H. Filipovich Cleveland Clinic Foundation Director: Brian Mandell Columbia University Director: Betty Diamond Dartmouth Medical School Director: Lloyd H. Kasper Duke University Medical School Director: E. William St. Clair Emor y Clinic Emory Director: Jorg Josef Goronzy FOCIS Center of Seattle Director: Keith B. Elkon Hospital for Special Surger y Surgery Director: Mary K. Crow Mayo Clinic Director: Hirohito Kita McGill University Director: Emil Skamene Robarts Research Institute &W ester n University Wester estern Director: Joaquin Madrenas Rober ood Johnson Robertt W Wood

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University of California San Diego Director: Arthur Kavanaugh

Washington University Director: Wayne M. Yokoyama

International FCE

University of Chicago Director: Stephen Hanauer

Ghent University Hospital Director: Eric Veys

University of Colorado Health Sciences Center Director: George S. Eisenbarth

Giannina Gaslini Institute Director: Lorenzo Moretta

University of Florida Director: John F. Valentine University of Iowa Director: Elizabeth H. Field University of Miami Director: Jay Skyler University of North Carolina Director: Dhavalkumar D. Patel University of Pennsylvania Medical School Director: Arnold I. Levinson University of Pittsburgh Director: Scott Plevy

Institute of Immunology of Central enezuela University Medical School, V Venezuela Director: Nicolas E. Bianco Institute of Immunology Czech Republic (pending) Director: Jirina Bartunkova Oxford Radcliffe Hospitals Director: Helen M. Chapel, MD Rostov-on-Don State Medical University Director: Lyudmila P. Siziakina, MD Shiraz University of Medical Sciences Director: Sara Kashef

University Hospital of Freiburg University of Rochester Medical Center Director: Hans-Hartmut Peter Director: Christopher H. Ritchlin Universite Libre de Bruxells University of California Hopital Erasme San Francisco Director: Michael Goldman Director: Jeffrey A. Bluestone

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Steering Committee Grant J. Anhalt Johns Hopkins University School of Medicine Society for Investigative Dermatology (SID)

T. Mohanakumar Washington University-School of Medicine International Cytokine Society (ICS)

Jack PP.. Antel Montreal Neurology Hospital & Institute International Society for Neuroimmunology (ISNI) & America’s Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS)

William J. Murphy University of North Virginia Medical School American Society for Blood and Marrow Transplantation (ASBMT)

Richard S. Blumberg Brigham & Women’s Hospital Crohn’s and Colitis Foundation of America (CCFA) Jeffrey A. Bluestone University of California-San Francisco TrialNet Mar y K. Crow Mary Hospital for Special Surgery American College of Rheumatology (ACR) Charlotte Cunningham-Rundles The Mount Sinai Medical Center Clinical Immunology Society (CIS) Mohamed R. Daha Leiden University Medical Center International Complement Society (ICS) Lynn K. Gordon Jules Stein Eye Institute-UCLA American Uveitis Society (AUS)

Maurice R.G. O’Gorman The Children’s Memorial Hospital Association of Medical Laboratory Immunologists (AMLI) Charles G. Orosz Ohio State University American Society for Histocompatibility and Immunogenetics (ASHI) Lanny J. Rosenwasser National Jewish Medical Research Center American Academy of Allergy, Asthma and Immunology (AAAAI) Daniel Rotrosen National Institute of Allergy and Infectious Diseases Federal Liaison Kendall A. Smith Cornell University Medical College International Society for Interferon and Cytokine Research (ISICR)

Warren Strober Vijay Kuchroo Society for Mucosal Immunology Harvard Medical School International Society for Neuroimmunology (ISNI) Matthias G. V on Herrath Von La Jolla Institute Allergy & Immunology Peter E. Lipsky Immunology of Diabetes Society (IDS) Federal Liaison Adriana Zeevi Michael TT.. Lotze University of Pittsburgh Medical Center University of Pittsburgh American Society of Transplantation (AST) International Society for the Biological Therapy of Cancer (ISBTC)

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

FOCIS Executive Committee Chair

Secretar y/T reasurer Secretary/T y/Treasurer

C. Garrison Fathman Stanford University

Jonathan Braun UCLA Medical Center

Vice-Chair David A. Hafler Harvard Medical School

FOCIS Committee Chairs FOCIS Centers of Excellence Chair David PP.. Huston Baylor College of Medicine

Education Committee Paul J. Utz, Chair Stanford University School of Medicine Abul K. Abbas, Vice-Chair University of California-San Francisco

International Committee Stefan Meuer Meuer,, Chair University of Heidelberg

Research Committee Dhaval Patel, Chair University of North Carolina Bill St. Clair ice-Chair Clair,, V Vice-Chair Duke University Medical Center

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Development Committee Lanny J. Rosenwasser Rosenwasser,, Chair National Jewish Medical Research Center Emil Skamene, Vice-Chair McGill University Health Centre

Accreditation Committee George S. Eisenbarth, Chair University of Colorado Health Science Center

Communication Advisors Lynn K. Gordon Jules Stein Eye Institute-UCLA Andrew Saxon UCLA School of Medicine

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 Program Committee Chairs

Members

Richard S. Blumberg Brigham & Women’s Hospital

Abul K. Abbas University of California-San Francisco

Vijay Kuchroo Harvard Medical School

Jeffrey A. Bluestone University of California-San Francisco

Megan Sykes Massachusetts General Hospital

Mar y K. Crow Mary Hospital for Special Surgery Thomas A. Fleisher National Institutes of Health Lynn K. Gordon Jules Stein Eye Institute-UCLA Norma Sue Kenyon, PhD University of Miami Gerald TT.. Nepom Virginia Mason Research Center Benaroya Research Institute John D. Rioux Whitehead Institute Lanny J. Rosenwasser National Jewish Medical Research Center Warren Strober National Institutes of Allergy and Infectious Diseases/National Institutes of Health Paul J. Utz Stanford University Matthias G. V on Herrath Von La Jolla Institute Allergy & Immunology Adriana Zeevi University of Pittsburgh Medical Center

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 Program Committee Abstract Review Committee Abul K. Abbas University of California-San Francisco

Cathr yn Nagler -Anderson Cathryn Nagler-Anderson Massachusetts General Hospital

Deborah Anderson Brigham and Women’s Hospital

Maurice R.G. O’Gorman The Children’s Memorial Hospital

Jack PP.. Antel Montreal Neurology Hospital & Institute

Trevor Owens McGill University

Ken Beaman Rosalind Franklin University Medical Center

Jerome Ritz Harvard Medical School

Jeffrey A. Bluestone University of California-San Francisco

Kendall A. Smith Cornell University Medical College

Richard S. Blumberg Brigham & Women’s Hospital

Terr y Strom erry Beth Israel Deaconess Medical Center

Jonathan Braun UCLA Medical Center

Megan Sykes Massachusetts General Hospital

Rachel Caspi National Institutes of Health

Dale Umetsu Stanford University School of Medicine

Mar y K. Crow Mary Hospital for Special Surgery

Paul J. Utz Stanford University School of Medicine

Charlotte Cunningham-Rundles The Mount Sinai Medical Center

Matthias G. V on Herrath Von La Jolla Institute Allergy & Immunology

Mohamed R. Daha Leiden University Medical Center Raif S. Geha Children’s Hospital Boston

Gail L. Bast Executive Director

Lynn K. Gordon Jules Stein Eye Institute-UCLA

Megan M. Kelley Meetings Manager

David PP.. Huston Baylor College of Medicine

Sarah J. Krause Program Manager

Vijay Kuchroo Harvard Medical School

Jennifer D. W arpool Warpool Program Coordinator

Thomas S. Kupper Brigham and Women’s Hospital Michael TT.. Lotze University of Pittsburgh T. Mohanakumar Washington University-School of Medicine 10

FOCIS Executive Office Staff

555 East Wells Street, Suite 1100 Milwaukee, WI 53202 Phone (414) 918-3192 Fax (414) 276-3349 [email protected] www.focisnet.org

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 Faculty Abul Abbas, MD Buckner,, MD Jane Buckner Department of Pathology, University of California—San Francisco Assistant Member, Benaroya Research Institute; Clinical Assistant Professor, University of Washington, Department of Medicine Salvatore Albani, MD PhD Professor of Medicine and Pediatrics, University of California Michael Carroll, PhD San Diego Professor of Pediatrics (Pathology), Harvard Medical School Disclosure: Scientific Founder, Androclus Therapeutics Rober ter Robertt Car Carter ter,, MD Jack Antel, MD Professor of Medicine, Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama BirMcGill University, Montreal mingham K. Frank Austen, MD Disclosure: Paid consultant for Genentech. AstraZeneca Professor of Respiratory and Inflammatory Diseases, Harvard Medical School; Director, Inflammation & Allergic Dis- Andrew C. Chan, MD PhD eases Research Section, Brigham and Women’s Hospital Vice President, Research Immunology, Genentech, South San Francisco, CA Jean Francois Bach, MD DSc Professory of Immunology, Rne Descartes Paris V University; Head, Disclosure: Employee of Genentech Laboratory Immunology

Lieping Chen, MD PhD Johns Hopkins University School of Medicine

Tim Behrens, MD Professor of Medicine, University of Minnesota Medical School Chris Contag, PhD Assistant Professor, Departments of Pediatrics, Radiology and Nina Bhardwaj, MD PhD Professor of Medicine, Director, Tumor Vaccine Program, NYU Microbiology and Immunology Cathleen Cooper Cooper,, MD Scientific Review Administrator, Transplantation, Tolerance, and Christine A. Biron, PhD Esther Elizabeth Britzenhoff Professor of Medical Science; Chair- Tumor Immunology Study Section and Referral; Officer, Division person, Department of Molecular Microbiology & Immunology; of Receipt and Referral, Center for Scientific Review Brown University Michael Croft, PhD La Jolla Institute for Allergy and Immunology, Division of MoJeffrey Bluestone, PhD A.W. and Mary Clausen Distinguished Professor of Medicine, lecular Immunology Cancer Institute

Pathology, Microbiology & Immunology; Director, Diabetes Center Mar y K. Crow Mary Crow,, MD Disclosure: Potential financial gain from topics discussed, IP and Hospital for Special Surgery Co-Founder of XCYTE Therapies. Chella S. David, PhD Richard S. Blumberg, MD Mayo Clinic College of Medicine Associate Professor of Medicine, Brigham and Women’s Hospital Glen Dranoff, MD Jonathan Braun, MD PhD Associate Professor of Medicine, Dana-Farber Cancer Institute, Department of Pathology and Lab Medicine, David Geffen Harvard Medical School School of Medicine at UCLA Disclosure: Equity in Santarus Corporation (San Diego, CA) and Prometheus Corporation (San Deigo, CA) 11

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 Faculty Juha Kere, MD PhD Professor, Karolinska Institute, Stockholm, Sweden Disclosure: Member of Board of Directors of Geneos Ltd, a company holding patent applications on the use of GPRA, an asthma candidate gene that is the subject of this speaker’s presentaAlexander Flugel, MD Laboratory for Cellular and Molecular Neuroimmunology, Max- tion. Speaker is one of the inventors of these patent applications and a minority shareholder of Geneos Ltd. Planck Institute for Neurobiology, Martinried/Munich David Fiorentino, MD PhD Assistant Professor; Director, Cutaneous Autoimmunity Clinic, Stanford University School of Medicine, Department of Dermatology

y, MD Khoury Samia Khour Stephen J. Galli, MD Co-Director, Partners MS Center; Associate Professor of NeurolProfessor of Pathology and of Microbiology and Immunology, ogy, Harvard Medical School Stanford University School of Medicine Hirohita Kita, MD Raif Geha, MD J. Gambles Professor of Pediatrics, Harvard Medical School; Professor of Medicine, Mayo Clinic College of Medicine Lars Klareskog, MD PhD Rheumatology Unit, Department of Medicine, Karolinska InstiRonald N. Germain, MD PhD Deputy Chief, Laboratory of Immunology; Chief, Lymphocyte tute, Stockholm Disclosure: Served as an expert consultant to several pharmaceuBiology Section, Laboratory of Immunology, National Institute of tical companies, with no financial interest in these companies Allergy and Infectious Diseases, National Institutes of Health Dwight Kono, MD Joan Goverman, PhD Associate Professor, The Scripps Research Institute, Department Department of Immunology, University of Washington, Seattle of Immunology David A. Hafler Hafler,, MD Art Krieg, MD Jack, Sadie and David Breakstone Professor of Neurology, DeChief Scientific Officer, Coley Pharmaceutical Group partment of Neurology, Brigham and Women’s Hospital, Disclosure: Founder and stockholder of Coley Pharmaceutical Harvard Medical School Group Chief, Division of Immunology, Children’s Hospital Boston

Mar tin Hemler Martin Hemler,, PhD Matthew Krummel, PhD Professor, Department of Pathology, Harvard Medical School, Assistant Professor, Department of Pathology, UCSF and Department of Cancer, Immunology, and AIDS, Dana Vijay K. Kuchroo, PhD DVM Farber Cancer Institute Professor of Neurology, Brigham and Women’s Hospital, Harvard Steve Jacobson, PhD Medical School Chief, Viral Section, National Institutes of Health Eric Lander Lander,, PhD Dan Kastner Kastner,, MD PhD Director, Broad Institute of MIT and Harvard Medical School Chief, Genetics and Genomics Branch, National Institute of ArAntonio Lanzavecchia, MD thritis and Muscoloskeletal and Skin Diseases Institute for Research in Biomedicine

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 Faculty David Lee, MD PhD Lorenzo Moretta, MD Division of Rheumatology, Immunology, and Allergy, Brigham Full Professor of General Pathology and Pathophysiology, Uniand Women’s Hospital, Harvard Medical School versity of Genova; Scientific Director, Giannina Gaslini Institute, Genova, Italy Andrew Lichtman, MD PhD y Nabel, MD PhD Associate Professor of Pathology, Brigham and Women’s Hospi- Gar Gary tal and Harvard Medical School Director of Vaccine Research Center, National Institutes of Health Peter Lipsky Lipsky,, MD Robert Negrin, MD Chief, Autoimmunity Branch, National Institute of Arthritis and Professor of Medicine, Stanford University School of Medicine Musculoskeletal and Skin Diseases, National Institutes of Health Lindsay B. Nicholson, MD PhD Youn-Jun Liu, MD PhD Clinical Sciences, Pathology and Microbiology, University of Bristol Professor and Chairman, Department of Immunology; Director, Hans Ochs, MD Center for Cancer Immunology Research, M.D. Anderson Can- Professor of Pediatrics; University of Washington, School of cer Center Medicine; Department of Pediatrics Roy Lobb, PhD Advisor, Abingworth Ventures Disclosure: Consultant to Biogen IDEC on VLA-4 Michael TT.. Lotze, MD University Pittsburgh Molecular Medicine Institute

John O’Shea, MD Molecular Immunology and Inflammation Branch, National Institutes of Health Disclosure: CRADA with Pfizer

Drew Pardoll, MD PhD Andrew Luster Seraph Professor; Co-Director, Cancer Immunology & HematoLuster,, MD PhD Chief, Division of Rheumatology, Allergy and Immunology, Mas- poiesis Program sachusetts General Hospital Virginia Pascual, MD Ann Marshak-Rothstein, PhD Associate Investigator, Baylor Institute for Immunology Research Professor of Microbiology, Boston University School of Medicine Dhaval Patel, MD PhD Diane Mathis, PhD Director, Thurston Arthritis Center; Chief, Rheumatology, Allergy Head, Section on Immunology and Immunogenetics; Joslin Dia- and Immunology; Professor of Medicine betes Center/ Professor of Medicine; Harvard Medical School University of North Carolina at Chapel Hill Stephan Meuer Karl Peggs Chairman, Department of Immunology, University of Heidelberg Senior Lecturer, Royal Free and University College, London Medical School; Visiting Investigator, MSKCC, NY Stephen D. Miller Miller,, PhD Cong. John E. Porter Professor of Biomedical Sciences, Depart- J. Theodore Phillips, MD PhD ment of Microbiology-Immunology, Northwestern University Medi- Clinical Associate Professor, Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas cal School, Chicago Shiv Pillai, MBBS PhD Branch Moody Moody,, MD Department of Medicine, Brigham and Women’s Hospital, Associate Professor of Medicine, Massachusetts General Hospital and Harvard Medical School Harvard Medical School 13

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 Faculty Jeffrey V V.. Ravetch, MD PhD Federica Sallusto Theresa and Eugene Lane Professor; Head, Laboratory of Mo- Institute for Research in Biomedicine lecular Genetics and Immunology, The Rockefeller University Jane Salmon, MD Paul Ridker Ridker,, MD Professor of Medicine, Weill Medical College, Cornell UniverBrigham and Women’s Hospital sity, Attending Physician and Senior Scientist, Hospital for Special Surgery John D. Rioux, PhD Director, Inflammatory Disease Research, Broad Institute of MIT and Harvard; Assistant Professor of Medicine, Harvard Medical School, Brigham and Womens Hospital; Associate Professor Medicine, University of Montreal, Montreal Heart Instutite

Mohamed Sayegh, MD Brigham and Women’s Hospital Kathy Siminovitch, MD FRCP Professor, Department of Medicine, University of Toronto, Mount Sinai Hospital/University Health Network

Jerome Ritz, MD Professor of Medicine, Dana-Farber Cancer Institute, Harvard Arlene H. Sharpe, MD PhD Medical School Harvard Medical School William Robinson, MD PhD Grace Shen Division of Immunology and Rheumatology, Stanford University Director, Ocular Immunology Program, Division of Extramural School of Medicine, GRECC, Palo Alto VA Health Care System Research, National Eye Institute Kenneth Rock, MD Kendall A. Smith, MD Professor and Chair, Department of Pathology, UMass Medical Cornell University Medical College School Jean-Paul Soulillou, PhD Derr y Roopenian, PhD Derry Nantes University Senior Staff Scientist, The Jackson Laboratory Disclosure: Member of Scientific Board of TcLAND Alexander Rudensky Rudensky,, PhD Professor and Investigator, HHMI/University of Washington

Larr y Steinman, MD Larry Stanford University School of Medicine

David Sachs, MD Ralph Steinman, MD Director, Transplantation Biology Research Center, Massachu- Rockefeller University setts General Hospital; Professor of Surgery (Immunology), Megan Sykes, MD Harvard Medical School Massachusetts General Hospital, Harvard Medical School Steve Sacks, MD PhD Cox TTerhorst, erhorst, PhD Head of the Department of Nephrology & Transplantation, Guy’s Chief, Division of Immunology, Beth Israel Deaconess Medical Kings’ & St. Thomas School of Medicine, Kings College London Center; Professor of Medicine, Harvard Medical School Shimon Sakaguchi, MD PhD Professor, Institute for Frontier Medical Sciences, Kyoto University

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 Faculty Angus Thomson, PhD DSc FRCPath Professor of Surgery and Immunology, University of Pittsburgh, Director of Transplant Immunology, Starzl Transplant Institute Disclosure: Member, Scientific Advisory Board, Therakos

Sander J. van Deventer Deventer,, MD Laboratory of Experimental Internal Medicine Edward W akeland, PhD Wakeland, Director, Center for Immunology, University of Texas Medical Center

John TTodd, odd, PhD Professor of Medical Genetics, Cambridge Institute for Medical Hanspeter W aldner Waldner aldner,, PhD Research; Director, JDRF/WT Diabetes and Inflammation Labo- Brigham and Women’s Hospital and Harvard Medical School ratory Howard W einer Weiner einer,, MD urley Shannon J. TTurley urley,, PhD Robert L. Kroc Professor of Neurology, Harvard Medical School Assistant Professor, Department of Cancer, Immunology and David S. Wilkes, MD AIDS, Dana Farber Cancer Institute; Assistant Professor, DepartCalvin H. English Professor of Medicine, Microbiology and Imment of Pathology, Harvard Medical School munology; Director, Center for Immunobiology Dale TT.. Umetsu, MD PhD David W ofsy Wofsy ofsy,, MD The Prince Turki al Saud Professor of Pediatrics, Childrens HosProfessor of Medicine and Microbiology/Immunology, Univerpital Boston, Harvard Medical School sity of California, San Francisco Paul J. Utz, MD Disclosure: Consultant for Genentech, Aspreva, Bristol-Myers Stanford University Squibb, Serono Inder V er ma, MSc PhD Ver erma, John B. W ong, MD FFACD ACD Wong, Salk Institute for Biological Sciences Professor of Medicine; Chief, Division of Clinical Decision MakMatthias von Herrath, MD Associate Professor with Tenure, Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Deigo, CA

ing, Tufts-New England Medical Center, Tufts University School of Medicine Disclosure: Grants NIH National Library of Medicine; ScheringPloegh, Honoraria for speaking, Schering-Ploegh, Centocor Kathr yn W ood, PhD Kathryn Wood, Professor of Immunology, University of Oxford Anette Ziegler Ziegler,, MD Professor of Internal Medicine, Ludwig-Maximilians University, Munich; Senior Physician, Internal Medicine, Schwabing Hospital; Director, Immunology and Diabetes Department, Diabetes Research Institute

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

General Information Dates: The meeting begins Thursday, May 12 and adjourns Monday, May 16, 2005. Venue: Westin Copley Place

• •

10 Huntington Avenue Boston, Massachusetts 02116 www.westin.com

Registration Information Name badges will be mailed to pre-registrants prior to the meeting. Final programs and registration bags will be distributed at the registration desk, located at the Westin Copley Place. Registration will be open during the following hours: 3 rd Floor- Essex Foyer: Thursday, May 12

8:00 am-8:00 pm

4 Floor- America Foyer: Friday, May 13 Saturday, May 14 Sunday, May 15

7:00 am-5:00 pm 7:00 am-5:00 pm 7:00 am-5:00 pm

th

CME Information Target Audience: The target audience for this meeting is a multi-disciplinary group of individuals with an interest in clinical immunology: • Researchers • Clinical investigators • Clinicians • Postdoctoral fellows • Pre-doctoral students • Graduate students Learning Objectives: At the completion of the meeting, participants should be able to: • Discuss the current research and/or clinical topics relevant to the session topics. • Demonstrate a gained level of insight into the methods being used by researchers and practitioners. • Describe a personal exposure to several stimulating areas of inquiry with faculty and presenters. Accreditation Statement: The Clinical Immunology Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Credit Designation: The Clinical Immunology Society (CIS) designates this educational activity on an hour-for-hour basis in Category 1 credit toward the Physicians Recognition Award of the American Medical Association. Each physician should only claim those hours of credit he/she actually spends in the educational activity. 16

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program At-a-Glance Thursday

Friday

7:00 a.m.

Saturday

Sunday

Industry Tutorials

Industry Tutorials

7:30 a.m

Monday

Poster Session 1 (7:30-8:30 am)

8:00 a.m. 8:30 a.m.

Planary Session

Planary Session

Planary Session

Break

Break

Break

Plenary Session (8:30-10:00 am)

9:00 a.m. 9:30 a.m. 10:00 a.m. 10:30 a.m

Concurrent Thematic Symposia

11:00 a.m. 11:30 a.m. 12:00 p.m. 12:30 p.m. 1:00 p.m.

Member Society Satellite Programs

Concurrent Thematic Symposia (10:30 am - 12:30 pm)

Lunch, Industry Tutorials

1:30 p.m.

Lunch, Industry Tutorials

Lunch

Industry Symposia (1:30 - 3:00 pm)

2:00 p.m. 2:30 p.m. 3:00 p.m.

Break

Break

3:30 p.m.

Concurrent Oral Abstract Sessions

4:00 p.m.

Concurrent Oral Abstract Sessions (3:30 - 5:30 pm)

4:30 p.m. 5:00 p.m. 5:30 p.m.

Poster Session 2

6:30 p.m. 7:00 p.m.

8:00 p.m. 8:30 p.m. 9:00 p.m

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Poster Session 2 Poster Session 2 (5:30-7:30 pm)

6:00 p.m.

7:30 p.m.

Break

Welcome Reception (7:00 - 9:00 pm)

Break

NIH Grants Information Session (12:30 - 2:00 pm)

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia Thursday Thursday,, May 12, 2005 American Academy of Allergy Allergy,, Asthma and Immunology Eosinophil Biology in Health and Disease 1:15-4:30 pm Moderator: Lanny J. Rosenwasser, MD FAAAAI Co-Moderator: Peter F. Weller, MD FAAAAI

Essex North-East, 3rd Floor

1:15-1:20pm

Introduction Lanny J. Rosenwasser, MD FAAAAI and Peter F. Weller, MD FAAAAI

1:20-2:00 pm

Hypereosinophilic Syndromes Peter F. Weller, MD FAAAAI

2:00-2:40 pm

Eosinophils in Asthma Criag Gerard, MD PhD

2:40-3:10 pm

Break

3:10-3:50 pm

Eosinophil Biology in Animal Models James J. Lee, PhD

3:50-4:30 pm

GI in Eosinophilia: Basic and Clinical Mechanisms Marc Rothenberg, MD PhD FAAAAI

American College of Rheumatology Rheumatoid Arthritis Scientific Forum: A Forum to Identify Opportunities for Advances in Rheumatoid Arthritis Research 8:00 am-5:00 pm Essex Nor th-Center North-Center th-Center,, 3rd Floor 8:00-8:30 am

Welcome Introduction and Overview of RA Scientific Forum Goals Opportunities and Challenges in RA Research Speakers: Michael Brenner, MD Harvard Medical School, Boston, MA David Fox, MD University of Michigan, Ann Arbor, MI

Session I Epidemiology and Genetics: Defining Environmental and Inherited Risk Factors for RA 8:30-8:50 am

Epidemiology of RA: What Questions Can We Answer in the Next Decade? Alan J. Silman, MD University of Manchester, Manchester England

8:50-9:10 am

Strategies to Define Links Between Environmental Triggers and Autoimmunity in RA Lars Klareskog, MD Karolinska Hospital, Stockholm Sweden 19

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia American College of Rheumatology (Session 1 continued...) 9:10-9:30 am

Genetics of RA: MHC and Non-MHC Loci Peter Gregerson, MD Biology I Human Genetics, North Shore Univ. Hospital

9:30-9:50 am

Genetic Determinants of Lymphocyte Function in RA Shimon Sakaguchi, MD Kyoto University, Institute for Frontier Medical Sciences

9:50-10:20 am

Panel Discussion, Question and Answer Peter Gregerson, MD Lars Klareskog, MD Shimon Sakaguchi, MD Alan Silman, MD

10:20-10:40 am

Break

Session II Synovium, Cartilage and Bone in RA: Identifying Molecular Control Points of Disease Progression and Novel Therapeutic TTargets argets 10:40-11:00 am

Synovial Fibroblasts: Instigators or Targets? Gary Firestein, MD University of California – San Diego

11:00-11:20 am

Development of the Synovial Lining and its Role in Inflammatory Arthritis Michael Brenner, MD

11:20-11:40 am

Synovial Angiogenesis – How Can it Be Reversed? Alisa Koch, MD University of Michgan, Ann Arbor, MI

11:40 am-12:00 pm Events at the Interface of Pannus with Cartilage and Bone Steffen Gay, MD Center of Experimental Rheumatology, Zurich, Switzerland

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12:00-12:20 pm

The Response of Cartilage and Bone to Synovitis: How Can Repair of Damaged Joints be Promoted? Steven Goldring, MD Beth Israel Deconess Medical Center, Boston, MA

12:20-1:00 pm

Panel Discussions, Question and Answer William Arend, MD, University of Colorado, Denver, CO Gary Firestein, MD Steffen Gay, MD Steven Goldring, MD Alisa Koch, MD

1:00-2:00 pm

Lunch on your own

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia American College of Rheumatology (continued...) Session III Redefining the Contributions of Innate and Adaptive Immune Mechanisms to RA 2:00-2:20 pm

Understanding Lymphocyte Function in RA Cornelia Weyand, MD Emory University, Atlanta, GA

2:20-2:40 pm

Autoantibodies and the Joint – Unique Immune and Inflammatory Mechanisms Diane Mathis, MD Harvard Medical School, Boston, MA

2:40-3:00 pm

Cytokine Networks in RA Synovium Iain McInnes, MD, University of Glasgow, Glasgow, United Kingdom

3:00-3:20 pm

Reversing the Roles of Innate and Adaptive Immune Components in RA David Fox, MD

3:20-3:40 pm

Panel Discussion, Question and Answer Cornelia Weyand, MD Diane Mathis, MD Peter Lipsky, MD, National Institute of Arthritis Musculoskeletal and Skin Diseases Michael Holers, MD, University of Colorado, Denver, CO

3:40-4:00 pm

Break

Session IV Achieving and Measuring Remission and Cure of RA 4:00-4:20 pm

Developing Better Approaches to Measuring the Clinical Activity of RA and the Utility of Novel Therapeutics David Felson, MD Boston University School of Medicine, Boston, MA

4:20-4:40 pm

Measuring and Mitigating the Total Impact of RA: Medical, Economic and Social Aspects Edward Yelin, MD University of Texas, Houston, TX

4:40-5:00 pm

Defining Better Targets and Better Strategies for Treating RA William Arend, MD

5:00-5:25 pm

Panel Discussion, Question and Answer David Felson, MD Edward Yelin, MD William Arend, MD James O’Dell, MD, University of Nebraska, Omaha, NE William St. Clair, MD, Duke University Medical Center, Durham, NC

5:25-5:30 pm

Concluding Remarks and Adjournment Michael Brenner, MD David Fox, MD

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia American Uveitis Society Bench to Bedside: TTranslational ranslational approaches to ocular Inflammation An American Uveitis Society Sponsored Meeting Organizers: Reza Dana, LLynn ynn Gordon, Rober Robertt Nussenblatt for the AUS

Webster/Courier ebster/Courier,, 7th Floor

Despite significant research efforts and advances in diagnostic and therapeutic capabilities, ocular inflammatory diseases remain a significant cause of ocular morbidity and legal blindness. The purpose of this symposium is to explore some of the major concepts in pathogenesis of ocular inflammatory disease and discuss new approaches to understanding immune regulation as it relates to the eye. The format is a combined short presentation followed by open discussion. Specific aspects of the ocular microenvironment will be considered throughout the symposium. This symposium is presented in three parts. First, an overview of the current models of ocular inflammatory diseases will be presented followed by an active discussion regarding the strengths and weaknesses of these models. Second, aspects of innate and adoptive immunity will be considered as they relate to ocular inflammatory diseases. Finally, concepts relating to immune regulation or modulation, including soluble and cellular mediators will be discussed. The goal of this meeting is to maximize discussion. The presentations by our speakers will set the stage for an active discussion which will be stimulated by questions which will be posed to the audience. The discussions will have three goals: understanding the current state of the art, identification of important future directions, and development of strategic goals in investigation of ocular inflammatory disease.

22

1:00-1:05 pm

Welcome

1:05- 2:00 pm

Animal Models- Anterior and Posterior Robert Hendricks and Rachel Caspi

2:00-2:20 pm

Break

2:20-3:20 pm

Innate and Adaptive Immunity Ralph Levinson and Howard Weiner

3:20-3:40 pm

Break

3:40-4:40 pm

Immunoregulation Andrew Tayler and Arlene Sharpe

4:40-5:00 pm

Wrap Up

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia Clinical Immunology Society Emerging Lab TTechnologies echnologies 9:00 am-12:30 pm CME A vailable Available Registration fee: $15.00 On-Site Registration Available

Essex Nor th-W est, 3rd Floor North-W th-West, Program Organizers Jonathan Braun, MD PhD Matthias G. Von Herrath, MD William Robinson, MD PhD

9:00 am

Introduction and Overview Jonathan Braun, UCLA

9:05 am

Multibead Array Analysis of HLAs and KIRs in Transplantation Elaine Reed, UCLA

Proteomic Analysis of Signal TTransduction ransduction Pathways: 9:25 am Reverse Phase Protein Array Analysis of Phospho-proteins Steven Chan, Stanford University Imaging TTechnologies: echnologies: 9:45 am PET: Anti-Tumor T Cell Marking Jonathan Braun, UCLA Glycomics: 10:05 am

Mass Spectrometry Identification of Immunostimmulatory Oligosaccharides Rudolf Grimm, Agilent Technologies

Human Proteome Arrays: 10:25 am Human Proteome Array Analysis of Autoimmune Disease and Cancer Paul Predki, Invitrogen 10:45 am

Break

Technologies to Characterize the Specificity of Immune Responses: 11:00 am Antigen Microarray Analysis of Antibody Responses in Infection and Autoimmunity William Robinson, Stanford University 11:20 am

Peptide:MHC Microarray for Profiling T Cell Specificity and Function Daniel Chen, Stanford University

11:40 am

Flow Cytometry Analysis of Antigen-Specific T Cell Responses Amit Bar-Or, Montreal Neurologic Institute

The Road Ahead: 12:00 pm Roundtable Discussion: Translating Diagnostic Technologies Into the Clinic: Promise and Pitfalls Vicki Seyfert, Immune Tolerance Network Thomas Fleisher, NIH Bruce Sands, Massachusetts General Hospital 23

2005 ANNUAL MEETING FINAL PROGRAM

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May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia Clinical Immunology Society Primar y Immunodeficiency Diseases Consor tium Conference Primary Consortium 8:00 am-5:00 pm (Reception to follow) CME A vailable Available Registration Fee $25.00 On-Site Registration Available

Staffordshire, 3rd Floor

Program Organizers Charlotte Cunningham-Rundles, MD PhD Kathleen E. Sullivan, MD PhD Helen Chapel, MD Jordan Orange, MD PhD

This intensive one-day conference will provide an opportunity to capitalize on the diagnosis and treatment of primary immunodeficiency diseases in a setting that encourages interactive participation amongst presenters and attendees that will facilitate the exchange of information. The target audience for this conference is a multi-disciplinary group of individuals with an interest in clinical immunology focusing on Primary Immune Deficiency. Themes of the day will include: • Antibody Deficiency Diseases: Cases/ Diagnosis/ Molecular Defects in B Cell Differentiation/ Isotype Switch, Somatic Hypermutation, etc. • Combined Immune Defects: Cases/ Diagnosis/ Molecular Defects/ Signaling Pathways/ Treatment Strategies • Pathways in Innate Immunity: Natural Killer Cells • Monocyte Neutrophil Disorders: Analysis/ Treatment • Cytokine and Signaling Defects: Common Themes, Infections, Toll Receptors and Signaling • Laboratory Evaluation of Primary Immunodeficiency • Immune Reconstitution: Gene Therapy Strategies/ Stem Cell/ Bone Marrow/ Measures of Term Reconstitution • Use of Standard and Novel Therapies: Cytokines, Immune Modulation, Monoclonal Antibodies Both research and case-based presentations will be made. The sessions will start with a keynote presenter, giving details of the latest research work in their respective fields. Following this, a second block will include the research presentations given by new investigators, fitting into the themes just introduced. These sessions will be laboratory based but in each case, elucidating facets of the Primary Immune Deficiencies. Laboratory Investigations will include data handling and genetics.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia Federation of Clinical Immunology Societies Basic Immunology for Clinicians: Update 2005 8:00am-5:00 pm Conference Center at Har vard Medical School, Rotunda Harvard

Sponsored by Abbott Laboratories (www.abbott.com) This one-day course will review fundamental principles of adaptive immunity and immunological tolerance, with an emphasis on recent advances. Topics to be discussed include: antigen processing and presentation (including dendritic cell biology); T lymphocyte activation and homeostasis (including costimulation and apoptosis); innate immunity (including Toll receptors and the biology of NK cells); cytokines and helper T Cell subsets; and self-tolerance and its breakdown. Ample time will be scheduled for discussions and interactive exchanges with the faculty. Outlines of lectures and illustrations will be provided in a course syllabus and on CD-ROM for each student. Faculty Abul K. Abbas, MD University of California - San Francisco San Francisco, CA Hidde L. Ploegh, PhD Harvard Medical School Boston, MA Schedule Lecture 1: Innate Immunity Lecture 2: Antigen Presentation Lecture 3: Activation and Regulation of T Lymphocytes Lecture 4: Effector Mechanisms of Cell-Mediated Immunity Lecture 5: Lymphocyte Development Lecture 6: Tolerance and Autoimmunity

Shuttles will run from the Westin Copley Place to the Conference Center from 7:00 - 8:00 am, returning at 5:00 pm. 26

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia Federation of Clinical Immunology Societies FOCIS Centers of Excellence TTrainee rainee Satellite Symposium 8:00 am- 5:00 pm Essex Center & Essex South, 3rd Floor 7:00 -8:00 am

Continental Breakfast

8:00-8:15 am

Welcome David P. Huston, MD, Baylor College of Medicine

8:15-9:00 am

The Expanding Scope of Clinical Immunology - Cardiovascular Disease Keynote Speaker: Cornelia Weyand, MD, PhD, Emory University

9:05-10:20 am

Trainee Abstract Minisymposium

9:05-9:20 am

Antibodies to Citrulline-Modified Proteins Enhance Tissue Injury in Inflammatory Arthritis Kristine Kuhn, University of Colorado

9:20-9:35 am

B-Cell and Dendritic Cell Perturbations in the Fingerprinting of SLE Meghavi Kosboth, MD, University of Florida

9:35-9:50 am

Presence of Interferon-a in Systemic Lupus Erythematosus Plasma is Highly Correlated with Expression of Interferon Target Genes in SLE PBMC Jing Hua, MD PhD, Hospital for Special Surgery

9:50-10:05 am

Plasma Cell Differentiation of CD27- and CD27+ Human B Cells Jennifer Huggins, MD, University of Rochester

10:05-10:20 am

Characterization of an Immunodeficient Patient with TLR7, 8, 9 Defects Douglas McDonald, MD PhD, Children’s Hospital Boston

10:20-10:35 am

Break

10:35-11:35 am

Plenary Session

10:35-11:05 am

FMF and Beyond: Misadventures in the Genomics of Inflammation Dan Kastner, MD PhD, NIH/NIAMS

11:05-11:35 am

New Insights into the Mechanism of Disease and Targets for Treatment of the Antiphospholipid Syndrome Jane Salmon, MD, Hospital for Special Surgery

11:35 am-1:15 pm

Lunch & Poster Presentations with Authors Present

1:30-2:30 pm 1:30-2:00 pm

Plenary Session Genetic Control of Autoimmunity by Aire Mark Anderson, MD PhD, University of California – San Francisco

2:00-2:30 pm

Mast Cells and Inflammatory Arthritis David Lee, MD PhD, Brigham & Women’s Hospital

2:35-3:50 pm

Trainee Abstract Minisymposium

2:35-2:50 pm

Targeting of Antigen-Specific T Cells With Macromolecular Conjugates Tarek Fahmy, PhD, Yale University 27

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia Federation of Clinical Immunology Societies (continued...)

28

2:50-3:05 pm

High-Throughput Analysis of Autoantibodies Recognizing Myelin Antigens in Acute Disseminated Encephalomyelitis. Kevin O’Connor, PhD, Brigham & Women’s Hospital

3:05-3:20 pm

De Novo Generation of Antigen-Specific CD4+CD25+ Regulatory T Cells from Human CD4+CD25- Cells Mindi Walker, PhD, Benaroya Research Institute

3:20-3:35 pm

Differential Expression of Phosphorylated NF-kB/RelA in Normal and Psoriatic Epidermis and Downregulation of NF-kB in Response to Treat ment with Etanercept. Paul Lizzul, MD, PhD, Robert Wood Johnson

3:35-3:50 pm

Binding of the Green Tea Polyphenol, Epigallocatechin Gallate, to the CD4 Receptor on Human CD4+ T Cells Resulting in Inhibition of HIV-1gp120-Binding Christina Nance, PhD, Baylor College of Medicine

3:50-4:00 pm

Break

4:00-4:30 pm

Closing Plenary: The Intersection of Science and Architecture Peter Vanderwarker

4:30-4:40 pm

Closing Remarks David Huston

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia International Complement Society Complement in Health and Disease 8:00 am-12:00 pm

Webster/Courier ebster/Courier,, 7th Floor

Chairs: John Lambris and Moh Daha Organized by: International Complement Society

Sponsored by Biovista (www.biovista.com) 8:00-8:30 am

Novel Elisa-Based Methods for the Diagnostic Assessment of Complement Mohamed R. Daha Leiden University Medical Center Leiden, The Netherlands

8:30-9:00 am

Cleaning the Bloodstream: A Complement-Erythrocyte Dependent Process Anne Nicholson – Weller Harvard Medical School and Beth Israel Deaconess Medical Center Boston, USA

9:00-9:30 am

Protective Role of Innate Immunity in Autoimmune Disease Marat Alimzhanov CBR Institute for Biomedical Research and Dept. of Pediatrics, Harvard Medical School Boston, USA

9:30-10:00 am

Gastrointestinal and/or Myocardial Schemia/Reperfusion Models in Mice Gregory L. Stahl Brigham and Womens Hospital and Harvard Medical School Boston, USA

10:00-10:30 am

Coffee Break

10:30-11:00 am

Signaling of Human T Cells Through CD46 John Atkinson Washington University School of Medicine St. Louis, USA

11:00-11:30 am

From Atoms to Systems: a Multidisciplinary Approach to Study Complement Functions John Lambris University of Pennsylvania Philadelphia, USA

11:30 am-12:00 pmExtended Discussion

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia International Society for Neuroimmunology - Immunology of Diabetes Society Early Clinical TTrials rials in Multiple Sclerosis and TType ype 1 Diabetes: A Look Down the Pipeline 8:00am-5:00 pm St. George, 3rd Floor 9:00-11:45 am Speakers: 9:00 – 9:15 am

Antigen Specific Inter ventions and TT-/or -/or B-Cell TTargeted argeted Approaches Interventions Chairs: Amit Bar-Or and George Eisenbarth Introduction: Questions that Mice Pose to the Clinician Matthias von Herrath

9:15 – 9:35 am

Antigen Specific DNA Vaccine and Altered Peptide Ligands in MS and T1D Hideki Garren

9:35 – 9:55 am

Anti-CD25 Therapy/Daclizumab and Deletion of Aggressive T Cell with ECDI Stephen Miller

9:55 – 10:35 am

Autoantibodies in MS and Anti-CD20/B Cell Targeted Therapy Kevin O’Connor Amit Bar-Or

10:35 – 10:45 am

Break

10:45 – 11:00 am

The European Anti-CD3 Results Lucienne Chatenoud

11:00 – 11:15 am

Statins in the Treatment of Autoimmunity Scott Zamvil

11:15 – 11:45

Two selected abstract presentations from FOCIS submissions

11:45 am– 1:00 pm Lunch (provided) 1:00 – 4:30 pm

Speakers: 1:00 – 1:20 pm

30

Systemic Immune Modulators, Combination Therapies and Failed Thera pies in TType ype 1 Diabetes and MS Chairs: Kevan Herold and Jerr y Palmer Jerry Introduction: Clinical Caveats When Using Systemic Immune Modulation David Harlan

1:20 – 1:40 pm

CTLA-4-Ig/Costimulatory Blockade Samia Khoury

1:40 – 2:00 pm

Islet Regeneration Therapy – Novel Avenues Jacob Petersen

2:00 – 2:20 pm

Anti-VLA-4/Adhesion Molecules/Trafficking Benoit Lapointe

2:20 – 2:40 pm

The Trial Net Experience Jerry Nepom

2:40 – 3:00 pm

Break

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia International Society for Neuroimmunology - Immunology of Diabetes Society (continued...) 3:00 – 3:30 pm

Combination Therapies in MS and T1D Peter Calabresi Kevan Herold

3:30 – 3:50 pm

Lessons from Negative Trials – MS Jack Antel

3:50 – 4:10 pm

Lessons from Negative Trials – Type 1 Diabetes George Eisenbarth

4:10 – 5:00 pm

Panel Discussion: Future Avenues and Strategies George Eisenbarth, Jack Antel, David Harlan, David Hafler, Carla Greenbaum, Jerry Nepom, Vicki Seyfert, Jerry Palmer, Dick Insel

Idea, Goals and Synopsis: The idea for this symposium was jointly conceived by the International Neuroimmunology and Diabetes Societies. This event is organized in a similar fashion as last year’s joint-symposium, which was focused on more basic aspects of pathogenesis and was successful and well-received. The focus this year is on agents already introduced into early phase studies in patients, especially those, where human immune-monitoring and mechanistic data are available. The morning session is focused on antigen specific therapies and interventions that directly target T- and B-cells. In the afternoon, the aspects of systemic immune modulation and possible combinatorial therapies will be discussed. We will close with two talks highlighting past failures, which directly lead into a panel discussion that will suggest and debate future avenues and optimal strategies. We believe that this topic is highly relevant for refining future immune based interventions in multiple sclerosis (MS) and type 1 diabetes (T1D) and several other autoimmune disorders. Identifying parallels as well as differences between MS and T1D will allow us to better to fully realize the potential of novel treatments. The symposium, which already features international experts, will also serve as a forum for the most outstanding abstracts to be chosen from work submitted to ICI/FOCIS 2004. In summary, bridging the knowledge and experience across two disciplines is timely and a good strategy to further our understanding into autoimmune disease mechanisms and prospective therapeutics. Sharing data during the early phase trials in both diseases will allow us to identify parallels and differences and help to optimally design future interventions. Furthermore, lessons learned from one disease might be helpful for the other and vice versa. Clinicians, basic scientists, pharmaceutical industry and, ultimately, patients, will all profit from this satellite meeting.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Satellite Symposia International Society for Neuroimm unology Neuroimmunology Immune-Mediated Disease in Non-Human Primates: Critical Models for Preclinical Studies PRIMOCID (non human PRimate MOdels of Chronic Imm une Disorders) Immune 2:00-5:00 pm Essex Nor th-W est, 3rd Floor North-W th-West,

Organized by the Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands An EU-Sponsored Research Infrastructure Chairpersons: Dr. Sandra Amor and Dr. Margreet Jonker Invited Speakers: Dr. Sandra Amor Dr. Marc de Beats Prof. Stuart Knechtle Dr. Mark de Boer Prof. Avi Ben-Nun Dr. Thomas Hanke Dr. Margreet Jonker

Preclinical Models of Multiple Sclerosis in Non-Human Primates Myastenia Gravis Model in Rhesus Monkeys Non-Human Primate Models of Transplantation Costimulation Blockade: The Benefits of Non-Human Primate Models A New Model of Optic Neuritis in Rhesus Monkeys Pre-Clinical Therapy Evaluation for Arthritis Summing Up

This symposium will highlight the non-human primate models of immune disorders as essential steps toward the clinical development of new therapies and drugs. The BPRC offers the opportunity to the EU research community to use the institutes animals and scientific expertise for studies requiring non-human primates, an activity which sponsored by the EU as Research Infrastructure. Contact Inf ormation: Information: Dr Dr.. Sandra Amor or Dr Dr.. Margreet Jonker Biomedical Primate Research Centre PO Box 3306 2280GH Rijswijk Netherlands +31152842699 [email protected] [email protected]

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Industr y TTutorials utorials Industry Friday 3 Friday,, May 1 13 Cytometric Bead Array Cytokine and Gene Expression Profiling of Host Immune Responses to Emerging Infectious D iseases Diseases David Kelvin, PhD 12:30-1:30 pm Lunch served

Adams Room, 7th Floor

Presented by BD Biosciences Severe acute respiratory syndrome (SARS) is a notable example of a recently-emerging infectious disease. The highly variable pathogenesis of SARS may be the result of unabated proinflammatory host responses against the SARS coronavirus (CoV). To model host gene expression during SARS CoV infection, we collected longitudinal samples from mild and critical care SARS patients from the onset of symptoms through convalescence or, in some cases, death. Using Cytometric Bead Array (CBA) system (BD Bioscience) and high-density cDNA microarray analysis of peripheral blood RNA, we uncovered multiple gene pathways whose expression patterns associated with different disease courses of SARS. For example, persistent increased expression of the chemokine CXCL10 in the periphery and lungs was linked to uncontrolled immune responses against the SARS CoV. Moreover, signatures of other interferon-associated genes identified deviated adaptive immune responses in patients who were at risk for poor outcome in SARS. In this regard, CBA and gene expression analysis may represent a powerful prognostic tool in differentiating patients on the basis of their host immune responses and immune-mediated injury due to serious infections. Clinical Genomics - IT Strategies to Enable TTranslational ranslational Research 12:30-1:30 pm Flying Cloud Room, 7th Floor

Presented by IBM The healthcare and pharmaceutical industries have been buzzing with the promise of personalized medicine since the inception of the human genome project. As this decade unfolds, continued advances in science, technology and information technology will accelerate the translation of research discoveries into clinical practice. In order to achieve this goal of information based medicine, an advanced information infrastructure will be required across the healthcare continuum. This presentation will explore the factors and technologies enabling the move towards information based medicine. Specifically, it will explore the emerging area of Clinical Genomics, where the integration of phenotypic and genotypic data will present a host of opportunities for identifying and validating novel disease markers, enabling more focused clinical research and ultimately transforming the delivery of healthcare.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Industr y TTutorials utorials Industry Saturday Saturday,, May 14 Advances in Immune Monitoring and Epitope Discover y: A SARS Case Study Discovery: Kur tis Bray Kurtis Bray,, Ph.D., Director Director,, Research and Development, Beckman Coulter Coulter,, Inc. 7:00-8:00 am Breakfast Served

Webster Room, 7th Floor

Presented by Beckman Coulter

Objective: SARS is a severe infectious disease caused by a virus identified through gene sequencing and serological analysis as a new strain of human Coronavirus. SARS coronovirus (SARS-CoV) causes severe acute respiratory symptoms in patients and results in a high mortality rate. Antigenic peptides recognized by SARS virus specific CTL’s are useful tools for studying the CTL responses during infection enabling researchers to better monitor disease and develop T-Cell mediated vaccines. In order to identify potential immunogenic epitopes from the SARS N protein, we used Beckman Coulter’s iTopia™ Epitope Discovery System to analyze the protein across 8 MHC Class I alleles. This technology identifies and ranks candidate epitopes across 8 class I alleles based on true experimental binding, affinity and off rate determinations in an in vitro 96-well format Results: Identification of SARS candidate epitopes were as follows: 6 epitopes for HLA*A0101, 30 epitopes for HLA*A0201, 18 epitopes for HLA*A0301, 28 epitopes for HLA*A1101, 37 epitopes for HLA*A2402, 18 epitopes for HLA*B0702, 7 epitopes for HLA*B0801 and 27 epitopes for HLA*B1501. Based on iTopia rankings of candidate epitopes, SARS iTAg™ MHC Tetramers for two of the candidate epitopes of the A1101 allele were manufactured and used to stain cryopreserved PBMC’s from an A1101+ convalescent SARS patient. Both tetramers showed strong staining, confirming the biologic activity of these two epitopes. Conclusion: Using the iTopia Epitope Discovery System, the SARS N protein (422 amino acids) was screened and potential immunogenic epitopes were identified based on true experimental binding, affinity and off rate determinations. SARS results demonstrate the capacity of the iTopia system to screen large number of MHC Class I restricted peptides and prioritize the epitopes with greatest potential for producing an immune response. Biologic activity of two of the identified epitopes was confirmed by in vitro staining with MHC tetramers of cells from a convalescent SARS patient.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Industr y TTutorials utorials Industry A Method for Analyzing Gene Expression Using RNA Isolated From Whole Blood 12:30-1:30 pm Adams Room, 7th Floor Lunch Served

Presented by Agilent Technologies With the recent advances of diagnostic tools such as microarray analysis and quantitative amplification technologies, including real-time reverse transcriptase – polymerase chain reaction (RTPCR), there is an increasing need for rapid and inexpensive methods to purify high quality RNA. Agilent Technologies has developed a “whole solution” platform for the analysis of differential gene expression experiments, and RNA isolation is often the critical first step for these applications. In many research and clinical assays whole blood is the desired source of cellular RNA. However, isolation of RNA from blood is frequently compromised by instability of the mRNA profile and the presence of interfering compounds such as hemoglobin and heparin. We have developed a method for isolating high- purity, intact cellular RNA from whole blood by combining our Total RNA Isolation Mini Kit with PreAnalytiX PAXgeneâ blood collection tubes. PAXgene tubes enable the collection and stabilization of whole blood samples. Agilent’s RNA isolation technology ensures purification of total cellular RNA that is essentially free of interfering components, including genomic DNA, and does not require the use of toxic chemicals such as phenol or chloroform. In preliminary experiments using the RNA as input in Agilent’s Low RNA Input Fluorescent Linear Amplification Kit, ample yield of high specific activity cRNA was synthesized. The labeled cRNAs were further utilized in hybridizations to Agilent Human 1A Oligo Microarrays. Multiplex Serum Cytokine Analysis for Immunogenicity and Immune Competence Meeta Patnaik, MD, Vice President, Pathway Diagnostics 12:30-1:30 pm Lunch Served

W ebster Room, 7th Floor Webster

Presented by Beckman Coulter

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Industr y TTutorials utorials Industry Fine Mapping Solutions to the MHC and Beyond Sarah Shaw-Murray Shaw-Murray,, PhD 12:30-1:30 pm

Flying Cloud Room, 7th Floor Presented by Illumina

For almost 20 years, researchers have been using genome-wide linkage analysis to search for genes conferring susceptibility to inflammatory diseases. The results of these linkage studies have been difficult to replicate. One exception is linkage of most inflammatory disorders to the MHC region. Unfortunately, the MHC region is also one of the most difficult regions to fine map in order to determine the associated gene and the underlying etiologic variant conferring susceptibility to disease. Illumina has developed two high density SNP genotyping products that overcome these challenges. The Illumina MHC panel consists of two multiplexes, each with ~1,200 SNPs that are designed for use with Illumina’s GoldenGate® assay and can be used either independently or in conjunction with one another. The first multiplex is “exon-centric” and contains SNPs within 10 kb of coding sequences of genes in the MHC region spanning from ret finger protein (RFP) to motilin (MLN). The second multiplex consists of SNPs evenly spaced across the region with an emphasis on tag SNPs. For genome-wide fine mapping studies, Illumina’s new InfiniumTM assay provides a whole genome genotyping solution that enables investigators to more precisely identify inflammatory disease susceptibility genes.

Sunday Sunday,, May 15 Monitoring V accine Response: Standardization of Functional Cell Assays Vaccine Enrique Rabellino, MD, Medical Officer Officer,, Beckman Coulter Coulter,, Inc. 7:00-8:00 am Breakfast Served

W ebster Room, 7th Floor Webster

Presented by Beckman Coulter

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Business Meetings Clinical Immunology Society Council Meeting Wednesday, May 11 4:00 -11:00 pm Flying Cloud Room FOCIS Centers of Excellence Directors Meeting Friday, May 13 5:30-7:00 pm Adams Room FOCIS Inter national Advisor y Committee Meeting International Advisory Friday, May 13 11:30 am-12:30 pm Adams Room FOCIS 2006 Organizing Committee Meeting Saturday, May 14 5:30-7:30 pm Ambassador Suite Clinical Immunology Society Annual Business Meeting Saturday, May 14 6:30-7:45 pm Turner’s Fisheries FOCIS Steering Committee Meeting Monday, May 16 1:00-3:00 pm Webster/Courier Lunch served @ 12:30

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Friday Friday,, May 13, 2005 7:00 am-5:00 pm

Registration Open

7:30-8:30 am

Poster Session 1

8:30-10:00 am

Plenar y Session Plenary Regulation of T Cell Differentiation Chair: Vijay K. Kuchroo, DVM PhD

St. George, 3rd Floor America Ballroom, 4th Floor

Signals for T and B Cell Activation Antonio Lanzavecchia, MD Antigen Specific Control of the Immune System by Dendritic Cells Ralph Steinman, MD 10:00-10:30 am

Break

10:30 am-12:30 pm

Concurrent Thematic Symposia I. Regulator y T Cells in TTransplant ransplant & Autoimmunity Regulatory Chair: Shimon Sakaguchi, MD PhD

America North, 4th Floor

Preventing Rejection with Alloantigen Reactive Regulatory T Cells Kathryn Wood Generation of Regultory T Cells: Induction and Isolation of Antigen Specific TR Jane Buckner, MD Naturally Arising CD25+CD4+ Regulatory T Cells in Immunologic Tolerance Shimon Sakaguchi, MD PhD Foxp3 as a Dedicated Genetic Mechanism of Dominant Tolerance Alexander Rudensky, PhD (OR-01) Distinct Regulatory Functions are Defined by HLA-DR Expression on Human CD4+CD25 T Reg Cells C.M. Baecher-Allan II. FCR and Complement Chair: Michael Carroll, PhD

America Center Center,, 4th Floor

Blockade of Locally Acting Complement in Renal Transplantation Steve Sacks The Antiphospholipid Syndrome Revisited: A Disorder Initiated by Inflammation Jane Salmon, MD FC Receptor Function in Immunity and Tolerance Jeffrey V. Ravetch, MD PhD Functions of the Novel MHC Class I Like Fc Receptor, FcRn Derry Roopenian, PhD

39

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Friday Friday,, May 13, 2005 (continued) III. Dendritic Cells (T ransplant) (Transplant) Chair: Mar y K. Crow Mary Crow,, MD

America South, 4th Floor

Dendritic Cells as Modulators of Transplant Outcome Angus Thomson, PhD DSc FRCPath Dendritic Cells and the Modulation of Immunity Nina Bhardwaj, MD PhD GM-CSF Based Cancer Vaccines Glen Dranoff, MD Dendritic Cells and Immunity Youn-Jun Liu, MD PhD (OR-02) CNS Dendritic Cells Drive Naïve T Cell Proliferation and Epitope Spreading in Relapsing Experimental Autoimmune Encephalomyelitis S.D. Miller IV IV.. Antibodies in Disease Pathogensis and Therapy Chair: Paul J. Utz, MD

Staffordshire, 3rd Floor

Role of Autoimmunity in the Pathogenesis of Lung Allograft Rejection David S. Wilkes, MD Overcoming Natural Antibodies in Xenotransplantation David Sachs, MD B Cell Immunity After Allogeneic Stem Cell Transplantation Jerome Ritz, MD Natural History of Islet Autoimmunity in Type 1 Diabetes Anette Ziegler, MD (OR-03) A New Spontaneous Mouse Model for Human Devic’s Disease E. Bettelli 12:30-1:30 pm

40

Lunch y TTutorials utorials presented by BD Biosciences and IBM (see page 34) Industr Industry Poster Session 1 (continued)

7 th Floor St. George, 3rd Floor

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Friday Friday,, May 13, 2005 (continued) 1:30-3:00 pm

Industr y Symposium Presented by Biogen IDEC America Ballroom, 4th Floor Industry This session is programmed by FOCIS and supported by an unrestricted educational grant from Biogen IDEC. Selective Adhesion Molecule Inhibition in Autoimmune Disease Moderator: Roy Lobb, PhD How Does VLA-4 Work? Mechanistic Insights—Past, Present, and Future Martin Hemler, PhD Clinical Results of Selective VLA-4 Blockade with Natalizumab in Relapsing Multiple Sclerosis J. Theodore Phillips, MD PhD Speaker TBA

3:00-3:30 pm

Break

3:30-5:30 pm

Concurrent Oral Abstract Sessions I. Antibodies and B Cells Chair: Shiv Pillai, MBBS PhD

America North, 4th Floor

(OR-04) Elucidating the Mechanism of Anti-MOG Antibody –Mediated Demyelination. C. B. Marta (OR-05) Synovial Intracellular Citrullinated Proteins Colocalizing with Peptidyl Arginine Deiminase are Pathophysiologically Relevant Antigenic Determinants of Rheumatoid Arthritis-Specific Humoral Autoim munity. L. De Rycke (OR-06) Antibodies to Citrulline-Modified Proteins Enhance Tissue Injury in Inflammatory Arthritis. K. A. Kuhn (OR-07) T to B Epitope Spreading is Responsible for the Diversification of Autoantibody Responses Within the Small Nuclear Ribnucleoprotein Complex. U. S. Deshmukh (OR-08) In Sjogren’s Syndrome Serum Autoantibodies Recognize Tear Lipocalin and Alpha-Fodrin. Riccardo Navone (OR-09) Microarray Profiling of Anti-Lipid Antibodies in MS. J. L. Kanter (OR-10) High-Throughput Analysis of Autoantibodies Recognizing Myelin Antigens in Acute Dissemi nated Encephalomyelitis. K. C. O’Connor (OR-11) Role of CD38 in Human B Cells: Evidence of a Functional and Physical Association with CD 19. S. Deaglio

41

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Friday Friday,, May 13, 2005 (continued) II. Innate Immune System Regulating Disease Chair: Hanspeter W aldner Waldner aldner,, PhD

America Center Center,, 4th Floor

(OR-12) Toll-Like Receptor 2 Regulates Cellular Responses to Axonal Degeneration in the Central Ner vous System. A. A. Babcock (OR-13) Linking Innate Immunity to Autoimmunity Through the Role of TLRs and the MyD-88 Signaling Pathway. P. P. Ho (OR-14) Transcription Factor T-Bet Regulates Inflammatory Arthritis Through Linking the Innate and Adaptive Immunity. J. Wang (OR-15) Three Different TLR9 CpG Stimulants Exhibit Diverse Effects in Murine Graft-Versus Host Disease (GVHD). R. A. Puliaev (OR-16) HSP60 Inhibits Th1-Mediated Hepatitis Model Via Innate Regulation of Th1/Th2 Transcription Factors and Cytokines. Alexandra Zanin-Zhorov (OR-17) Toll Receptor Ligands Potently and Broadly Enhance the Immune Response of Immunodepressed Cutaneous T-Cell Lymphoma Patients. M. Wysocka (OR-18) Beta-Adrenergic and Toll-Like Receptor 2 Signalling in Epidermal Keratinocytes Drive the Skin Immune Response to a Soluble Protein. Georges J.M. Maestroni III. T Regs and Regulation of Immune Response Chair: Joan Goverman, PhD

America South, 4th Floor

Oral Anti-CD3 Suppresses Autoimmunity by Inducing TGF-b Dependent LAP+ Regulatory T Cells Howard Weiner, MD (OR-19) Regulatory Function Is Deficient in CD4+CD25+ T Cells from Patients with Systemic Lupus Erythematosus. M. I. Vargas-Rojas (OR-20) IL-2 Mediates Expansion but Not Maintenances of TGF Induced T Regs in Inflammation: A Novel Role of IL-10. M. C. Fantini (OR-21) Identification of Important Functional Domains of FOXP3 by Analysis of Mutations Present in Patients with IPEX Syndrome. T. R. Torgerson (OR-22) GRAIL Expression Is Associated with the Biological Activity of CD25+ T Regulatory Cells. D. A. MacKenzie 42

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Friday Friday,, May 13, 2005 (continued) IV IV.. New Pathways of Immune Regulation Chair: Marie W ahren, MD PhD Wahren,

Staffordshire, 3rd Floor

(OR-27) Requirement for the Adipocyte Fatty Acid Binding Protein aP2 in Allergic Airway Inflammation. B. Shum (OR-28) Transcriptional Regulation of Autoimmune Diseases by Tumor Suppressor p53. Xiaochun Wan (OR-29) The Sjögren’s Syndrome Associated Autoantigen Ro52 Is a RING-Dependent E3 Ligase That Suppresses Cellular Proliferation. A. Espinosa (OR-30) Graft-Versus-Leukemia Target Antigens in Chronic Myelogenous Leukemia (CML) are Expressed on Myeloid Progenitor Cells. J. Wu (OR-31) BAFF-but Not LT-Dependent B Cell Expansion Contributes to the Suppression of Lethal Intestinal Inflamation. Yasuyo Shimomura (OR-32) Increased Constitutive Activation of NF-B in Patients with Multiple Sclerosis. J. Yan (OR-33) Control of Macrophage Activation Via Myeloid CD200R Signaling During Experimental Autoimmune Uveoretinitis. J. Calderm (OR-34) Role of Fgl2 Prothrombinase/Fibroleukin in Experimental and Human Allograft Rejection. Qin Ning

43

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Friday Friday,, May 13, 2005 (continued) V. NK and NK T Cells Chair: TBA

Webster/Courier ebster/Courier,, 7th Floor

(OR-35) Glycolipid Mediated Activation of iNKT Cells is Sufficient to Induce Airway Hyperreactivity Independent of Conventional CD4 T Cells. E. H. Meyer (OR-36) The Involvement of CD1-Restricted NKT Cells in the Pathogenesis of Collagen-Induced and Antibody-Induced Arthritis. S. Kaieda (OR-37) Effects of Natural Killer (NK) Cells on Allogeneic Bone Marrow Transplantation. Swati Bhattacharyya (OR-38) - NK-Mediated Protection in CFA-Injected NOD Mice ig I.F. Lee (OR-39) Microsomal Triglyceride Transfer Protein Regulation of CD1d-Mediated Glycolipid Antigen Presentation. S. K. Dougan (OR-40) Exogenous IL-2 Promotes IL-5 Production by Human CD4+ NKT Cell Clones: The Role of IL-2 in the Immune Regulation. K. Sakuishi (OR-41) - Specificity of NK T Cells Against GD3 Ganglioside. Dianna Y. Wu (OR-42) CD4+ Invariant T Cell Receptor+ NKT Cells and the Development of Bronchial Asthma in Humans. Omid Akbari 5:30-7:30 pm

Poster Session 2 (W ine and Cheese Ser ved) (Wine Served)

7:00-9:00 pm

Welcome Reception Open to all delegates

44

St. George, 3rd Floor Essex Ballroom, 3rd Floor

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Saturday Saturday,, May 14, 2005 7:00 am-5:00 pm

Registration Open

7:00 am-8:00 am

Industr y TTutorials utorials presented by Beckman Coulter (see page 35) Industry

7:30-8:30 am

Poster Session 1

St. George, Essex, 3rd Floor

8:30-10:00 am

Plenar y Session Plenary Genetics & Gene Therapy Chair: Megan Sykes, MD

America Ballroom, 4th Floor

7th Floor

Edward Wakeland, PhD Gene Therapy: Medicine of the 21st Century Inder Verma 10:00-10:30 am

Break

10:30 am-12:30 pm

Concurrent Thematic Symposia I. Genetics of Immune-Mediated Diseases & TTransplantation ransplantation Chair: Jack PP.. Antel, MD

America North, 4th Floor

Towards a Taxonomy of Type 1 Diabetes John Todd Inflammatory Bowel Disease-A Genetics Success Story Kathy Siminovitch, MD FRCP GPRA, A Susceptibility Gene for Allergy and Asthma Juha Kere, MD PhD The SLAM Family of Cell Surface Receptors Controls Immune Responses to Viruses and Bacteria Cox Terhorst, PhD (OR- 43) TIM-1 Induces T Cell Activation and Inhibits the Development of Peripheral Tolerance. S. E. Umetsu II. TLR, NK, Innate Immunity Chair: Stephan Meuer Meuer,, MD

America Center Center,, 4th Floor

Checkpoints in Human NK Cell Activation and Function Lorenzo Moretta, MD Endogenous TLR Ligands and Systemic Autoimmune Disease Ann Marshak-Rothstein, PhD Danger Signals and the Initiation of Immune Responses Kenneth Rock, MD Active Control of CDI Antigen Processing in Human Dendritic Cells Branch Moody, MD (OR-44) In Vivo Homeostatic Proliferation of Naive CD4+ T-Cells Restrains the TCR Repertoire in Healthy Human Adults. S. Kohler 45

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Saturday Saturday,, May 14, 2005 (continued) III. Immunodysregulation and Immunoreconstitution Chair: Matthias vonHerrath, MD

America South, 4th Floor

Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX): A Model of Foiled Peripheral Self-Tolerance Hans Ochs, MD Innate Autoimmunity Michael Carroll, MD Immune Deficiency Due to Defects in Isotype Switching Raif Geha, MD Alemtuzumab in Allogeneic Transplantation: Between Scylla and Charybdis Karl Peggs, MD (OR-45) Intragraft Foxp3 Expression is Associated with Rejection and is Suppressed by CsA. K. G. Haanstra

46

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Saturday Saturday,, May 14, 2005 (continued) IV IV.. Disease Regulation: Role of Antigens, Cytokines, Chemokines Chair: Andrew Luster Luster,, MD PhD

Staffordshire, 3rd Floor

Fevers, Genes, and Pathways: The Systemic Autoinflammatory Diseases Dan Kastner, MD PhD Chemokines and Lipid Chemoattractants in Disease Andrew Luster, MD PhD Cytokine Signal: Basic and Applied John O’Shea, MD Cytokines in Viral Infections Christine A. Biron, PhD (OR-46) Insulin with Native B:9-23 Sequence is an Essential Autoantigen in the NOD Mouse. M. Nakayama 12:30-1:30 pm

1:30-3:00 pm

Lunch utorials presented by Industr y TTutorials Industry Agilent TTechnologies, echnologies, Beckman Coulter Coulter,, Illumina (see page 36) Poster Session 1 (continued)

7th Floor St. George, Essex, 3rd Floor

Industr y Symposium Presented by Centocor Industry This session is programmed by FOCIS and supported by an unrestricted educational grant from Centocor. Immune-Mediated Inflammator y Disorders: Elucidating Patter ns in Immune Disease Concomitancy Inflammatory Patterns and Connectivity America Ballroom, 4th Flooor Moderator: John B. W ong, MD Wong, Patterns of Immune Disease: Exploring the Biologic Underpinnings Abul Abbas, MD The Gastroenterology Perspective Sander J. van Deventer, MD The Clinical Immunology Perspective Speaker TBA Current Implications and Future Direction David F. Fiorentino, MD, PhD Closing

3:00-3:30 pm

Break

3:30-5:30 pm

Oral Abstract Sessions I. Genetics and Genomics Chair: John Rioux, PhD

America North, 4th Floor

(OR-47) Differential Transcript Profiling Identifies Candidate Genes in the New Zealand Model of Systemic Lupus Erythematosus, Including the B-Cell Transcription Factor, Bach2. R. J. Rigby

47

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Saturday Saturday,, May 14, 2005 (continued) (OR-48) Impact of the Lupus Susceptibility Locus, Sle1 on B Cell Tolerance. K. Raman (OR-49) Insulin-VNTR Modulate Functional Phenotypes of T-Cell Responses to Proinsulin in HLA-DRB1*04 Positive Subjects with and without Type 1 Diabetes. I.Durinovic-Bello (OR-50) A Toll Receptor Pathway Polymorphism Affects Susceptibility to Inflammatory Bowel Disease. P. L. De Jager (OR-51) Finally Found: Human BAFF-R Deficiency Causes Hypogammaglobulinemia. K. Warnatz (OR-52) Polymorphisms in CTLA4 and CD28 Are Associated with SLE. D. S. Cunninghame Graham (OR-53) Building an Admixture Map for Disease Gene Discovery in African Americans. A.Waliszewska II. Immunodiagnosis Chair: TBA

America Center Center,, 4th Floor

(OR-54) Detection of Allergen-Antibody Complexes on Murine B Cells Using Flow Cytometry. P. A. Wachholz (OR-55) Novel Candidate Markers for Multiple Sclerosis Using Phage cDNA Display. V.Somers (OR-56) Phenotypic and Functionnal Ex Vivo Profiling of Human CMV Specific CD8+ T-Cell Responses After Allo-HSCT. V.Bajzik (OR-57) A Compliant Solution for Monitoring Proteins Using a Lab-on-a-Chip Instrument. P. Barthmaier (OR-58) Correlation of Clinical Outcome with Immunophenotype in Islet Transplant Recipients. N. S. Kenyon (OR-59) Autoimmunity in Children with Atypical Type 1 and Type 2 Diabetes. L. K. Gilliam (OR-60) Development of a Clinical Assay Evaluating Toll-Like Receptor Function. R. P. Deering (OR-122) Identification of Disease Profiles for Rheumatoid Arthritis Using Antibody and Antigen Arrays. D. Hirschberg

48

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Saturday Saturday,, May 14, 2005 (continued) III. TTolerance olerance Chair: Stephen D. Miller Miller,, PhD

America South, 4th Floor

(OR-61) Tolerance to Inhaled Proteins Does Not Develop in the Presence of Proteinase-Activated Recep tor-2 (PAR-2) Activation. C. Ebeling (OR-62) Nasal Vaccination with a Proteosome-Based Adjuvant and Glatiramer Acetate Clears Alzheimer’s Amyloid in an Antibody-Independent Fashion. Dan Frenkel (OR-63) Collaboration between Central Tolerance and Peripheral Regulation to Control Autoimmunity. Z. Chen (OR-64) Mechanisms of Retinal Immune Privilege. C. H. Lau (OR-65) - Treatment with a Donor-Specific Transfusion and Anti-CD154 mAb Induces Non-Responsive ness in a Population of T Cells That Recognize Alloantigen Via Indirect Antigen Presentation. N. E. Phillips (OR-66) Successful Induction of Mixed Chimerism and Tolerance with Non-Myeloablative Conditioning in Mice Presensitized with Fully Mismatched Skin Grafts. P. D. Bardwell IV IV.. Dendritic Cells and Regulation of Disease Chair: Shannon TTurley urley urley,, PhD

Staffordshire, 3rd Floor

(OR-67) Dendritic Cell Response to Necrosis is Defective in Atopy. H. Kandil (OR- 68) CD150 (SLAM) Modulates TLR and CD40 Pathways in Monocyte-Derived Dendritic Cells. B. Rethi (OR-69) Activation of Human NK Cells by Plasmacytoid DC and Its Modulation by CD4+ T Cells and CD25hi T Regulatory Cells. C. Romagnani (OR-70) Hepatitis C Virus Core Protein Induced, Monocyte-Mediated Mechanisms of Reduced IFN and Plasmacytoid Dendritic Cells Loss in Patients with Chronic HCV Infection. A.Dolganiuc (OR-71) Delayed IL-10 Induced Human Tolerogenic DC Inhibit Naive T Cell Proliferation by Mechanisms Other Than Their Exaggerated PD-L1/2 Induction. F. Li (OR-72) Induction of Heme Oxygenase-1 (HO-1) Inhibits Dendritic Cell Differentiation and Adaptive Immunity. J. J. Listopad (OR-73) Donor-Specific Allograft Tolerance by Administration of Recipient-Derived Immature Dendritic Cells and Suboptimal Immunosuppression. 49 G. Beriou

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Saturday Saturday,, May 14, 2005 (continued) (OR-74) - Impact of Plasmacytoid Dendritic Cell (PDC) Recovery on Outcome after Allogeneic Stem Cell Transplantation (allo-SCT). M. Mohty V. Immunodeficiency Chair: Dale Umetsu, MD PhD

Webster/Courier ebster/Courier,, 7th Floor

(OR-75) Functional Interaction of Common Gamma Chain and Growth Hormone Receptor Signaling Apparatus. M. Adriani (OR-76) Novel Humoral Immunodeficiency in Humans Associated with Deleterious Homozygous Muta tion in CD19. D. Castano (OR-77) Mutations in TACI Are Associated with Immunodeficient Phenotypes in Humans. U. Salzer (OR-78) Expansion of Maternally Derived Monoclonal T Cells with a CD3 + CD8 + TCR Phenotype in Two Children with Severe Combined Immunodeficiency. E. Hodges (OR-79) Semi-Nested Degenerate rtPCR Allows Rapid Identification of TCR-beta Rearrangement on the Single Cell Level. Dun Zhou 5:30-7:30 pm

Poster Session 2 (W ine and Cheese Ser ved) (Wine Served)

St. George, Essex, 3rd Floor

Sunday Sunday,, May 15, 2005 7:00am-5:00 pm

Registration Open

7:00-8:00 am

utorials presented by Beckman Coulter (see page_) Industr y TTutorials Industry

8:30-10:00 am

Plenar y Session Plenary Tracking Pathogenic & Therapeutic Immune Responses Chair: Richard Blumberg, MD

7 th Floor America Ballroom, 4th Floor

Imaging Inflammation in Type-1 Diabetes Diane Mathis, PhD Imaging Cell Fates and Function Noninvasively Chris Contag 10:30 am-12:30 pm

Concurrent Thematic Symposia I. In Vivo Imaging Chair: Jeffrey Bluestone, PhD Multicellular Synapse Dynamics In Vivo Matthew Krummel, PhD

50

Trafficking of Immune Populations with Biolumenescence Robert Negrin, MD

America North, 4th Floor

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Sunday Sunday,, May 15, 2005 (continued) II. Costimulation and TTolerance olerance Chair: TBA High Resolution Dynamic Visualization of Immune Cell Function In Vivo in Health and Disease Ronald N. Germain, MD PhD Live Imagine of Autoaggressive T Cells Attacking the CNS Alexander Flugel, MD (OR-80) Expanded T Cells from Human Type 1 Diabetic Pancreatic Draining Lymph Nodes React with Insulin A Chain 1-15. S. C. Kent The Roles of the New Negative T-Cell Costimulatory Pathways in Regulating Autoimmunity Samia Khoury, MD CD137 and HVEM in the Control of Transplantation Tolerance Lieping Chen, MD PhD OX40: OX4OL in T Cell Immunity and Disease Michael Croft, PhD Novel T Cell Costimulatory Pathways in Transplantation Mohamed H. Sayegh, MD (OR-81) Anti-CD28 Antibodies-Induced Transplant Tolerance Involving TCR- Class II- CD80/86+ Regula tory Cells and Tryptophan Degradation. F. Haspot III. Mast Cell, Eosinophils, Allergic Reactions Chair: Stephen J. Galli, MD

America South, 4th Floor

Mast Cells as Effector and Potential Immunoregulatory Cells in Acquired Immune Responses Stephen J. Galli, MD Mast Cells and Inflammatory Arthritis David Lee, MD PhD Homing/Recruitment and Function of Peripheral Tissue Mast Cell K. Frank Austen, MD Role of Eosinophils in Innate Immunity and Allergic Inflammation Hirohita Kita, MD IV IV.. Living with the Bugs: Good or Bad Chair: Kendall A. Smith, MD

Staffordshire, 3rd Floor

Immunopathology in HTLV-I Associated Neurologic Disease Steve Jacobson, PhD How Viruses Enhance or Abrogate Type 1 Diabetes Matthias von Herrath, MD Infection and Immunity in Atheroclerosis Andrew Lichtman, MD PhD

51

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Sunday Sunday,, May 15, 2005 (continued) How Did Infections Protect Us from Allergic and Autoimmune Diseases? Jean Francois Bach (OR-82) - Immature Myeloid Dendritic Cells Induce Intestinal Granulomas under Certain Environmental Conditions. K. Sugimoto 12:30-1:30 pm 1:30-3:00 pm

Lunch Poster Session 1 (continued)

St. George, Essex, 3rd Floor

Industr y Symposia Presented by Genentech America Ballroom, 4th Floor Industry This session is programmed by FOCIS and supported by an unrestricted educational grant from Genentech. Linking B Cells and Autoimmune Diseases Moderator: Dhaval Patel, MD PhD Pathways of B Cell Activation Robert Carter, MD B Cells and Autoimmunity Peter E. Lipsky, MD Therapeutic Targeting of B Cells Dhaval Patel, MD PhD

3:00-3:30 pm

Break

3:30-5:30 pm

Oral Abstract Sessions I.New Animal Models: Defining Antigens Recognition by Animal Models Chair: Chella David, PhD

America North, 4th Floor

(OR-83) HLA-A11/KboDbo Transgenic Mice are Susceptible to PLP41-60 Induced Experimental Autoim mune Encephalomyelitis (EAE). A.K. Mangalam (OR-84) Fibrinogen-Induced Arthritis in Mice as a Novel Model for Rheumatoid Arthritis. P. P. Ho (OR-85) Murine Model of Mixed Connective Tissue Disease in HLA-DR4 Transgenic Mice Induced with U1-70kD Small Nuclear Ribonucleoprotein Autoantigen. R. W. Hoffman (OR-86) Proteoglycan-Induced Arthritis: A New and Unique TCR Transgenic Arthritis Model. S. E. Berlo (OR-87) BDC 12-4.1 (Anti-Insulin B:9-23) T Cell Receptor Transgenic Mice Are Lymphopenic but Entrain Early Insulitis and Can Cause Early Diabetes Modified by Insulin 2 Gene Expression. J. M. Jasinski (OR-88) Implication for the Pathogenesis and Immunoregulation in a Murine Model of Sarcoidosis. B.Wei

52

(OR-89) A New Model of Endogeneous AML Following Irradiation and Allogeneic Bone Marrow Transplantation. B.Van Wijmeersch

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Sunday Sunday,, May 15, 2005 (continued) II.

Costimulation Chair: Arlene Sharpe, MD PhD

America Center Center,, 4th Floor

(OR-90) Monoclonal Antibody Targeting of TIRC7 Results in Significant Therapeutic Effects on T and B Cell Response in Collagen-Induced Arthritis in Mice. N. Utku (OR-91) Transgenic Expression of Program Death Ligand 1 Protects Islets from Autoimmune Diabetes in Nonobese Diabetic Mice. Huey-Kang Sytwu (OR-92) PD-L1/PD-L2 Expression Protects Against the Development of Autoimmune Diabetes. Mary E. Keir (OR-93) ICOS Engagement of CD4 T-Cells Following Pulmonary Influenza Infection: Evidence for Nega tive Regulation of T-Cell Effector Function. M. E. Dahl (OR-94) Tim-4 Is the Ligand for Tim-1, and the Tim-1/Tim-4 Interaction Regulates T Cell Expansion. J. Hartt Meyers (OR-95) Evidence for Early Anergy Followed by Rapid Peripheral Deletion of Donor-Specific CD8 T Cells after Non-Myeloablative BMT with Anti-CD154: In Search of a Tolerogenic Donor Cell. T. Fehr (OR-96) TIM-3 Mediated Enhancement of Anti-Tumor Immune Responses. Brian K. Helmich III. Immunotherapy Chair: TBA

America South, 4th Floor

(OR-97) Apoptosis Induction as a Therapeutic Intervention To Eliminate Encephalitogenic T Cells; Antisense XIAP (AEG35169) in Murine Models of EAE. S. P. Zehntner (OR-98) Blockade of TNF Preferentially Inhibits Proliferation of Anti - CD3, Recall - Antigen Responsive and Autoreactive Human VLA-1+CD45RO+CD4+ T Cells. S. Ben-Horin (OR-99) An Immunization Strategy for Generation of T Cell Receptor Mimics. Vaughan P. Wittman (OR-100) Differential Expression of Phosphorylated NF-kB/RelA in Normal and Psoriatic Epidermis and Downregulation of NF-kB in Response to Treatment with Etanercept. P. F. Lizzul (OR-101) Anti-IL-2R Therapy: An Alternative Strategy for Regulating CD40L Expression. J. Shen (OR-102) Prophylactic Administration of Abatacept (CTLA4-Ig; BMS-188667) Prevents Disease Induc tion and Bone Destruction in a Rat Model of Collagen-Induced Arthritis. B.Kliwinski 53

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Sunday Sunday,, May 15, 2005 (continued) (OR-103) Abatacept (CTLA4Ig) Modulates Human T-Cell Proliferation and Cytokine Production but Does Not Affect TNF Production by Monocytes. P. M. Davis (OR-104) Essential Role of IL-10 in Restricting Immunity during a Chronic Viral Infection. Mette Ejrnaes IV IV.. Trafficking and Adhesion Chair: TBA

Staffordshire, 3rd Floor

(OR-105) Effects of Natalizumab (anti-VLA-4 Antibody) on Immune Cell Adhesion and Migration in Patients with MS. Masaaki Niino (OR-106) Molecular Imaging of Adhesion Molecules in Experimental Autoimmune Encephalomyelitis (EAE). R. A. Linker (OR-107) Immunotherpy of Relapsing Experimental Autoimmune Encephalomyelitis (EAE) by Neutral ization of CD4+ T Cell Chemoattractant Cytokine IL-16. D. S. Skundric (OR-108) High Resolution Dynamic Visualization of Immune Cell Function In Vivo in Health and Disease. R. N. Germain (OR-109) Migration Matters: Regulatory T Cell Compartmentalization Determines Suppressive Activity In Vivo. K. Siegmund (OR-110) The Anti-Inflammatory Action of Methotrexate is Not Mediated by Lymphocyte Apoptosis, but by the Suppression of Activation and Adhesion Molecules. A.Johnston (OR-111) Conditional Deletion of Alpha (v) Integrins Causes Inflammatory Bowel Disease. A.Lacy-Hulbert V. Cytokine Mediated Immunoregulation Chair: Lindsay B. Nicholson, MD PhD

Webster/Courier ebster/Courier,, 7th Floor

(OR-112) Phenotype of Cytokine Expressing Cells in Peanut Allergen-Primed Mice. P. A. Wachholz (OR-113) Foxp3+ Regulatory T Cells Can Be Induced from CD4+CD25- TGF Transgenic Cells and Are Able To Condition Dendritic Cells To Suppress Naïve T Cells. Y. Carrier (OR-114) Atorvastatin Prevents the Th1 Differentiation of Myelin-Reactive T Cells During EAE by Interfer ing with the Prenylation of Ras and the Activation of ERK. S. E. Dunn

54

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Program Schedule Sunday Sunday,, May 15, 2005 (continued) (OR-115) Regulation of T Cell Differentiation by IL-4R-Chain Single Nucleotide Polymorphisms. A. Skapenko (OR-116) Diverging Roles for the IL-12 Family in T Cell Immunity: IL-12 and IL-27-EBI3 Have Similar Contributions to Pathogen Responses While IL-23 Is Unique to Certain Autoimmune Pathways. Jacqueline M. Benson (OR-117) IL-4 Can Be a Key Positive Regulator of Inflammatory Arthritis. Koichiro Ohmura (OR-118) IL-12/23-Deficient Genotype Reveals Two Distinct Pathways Leading to Arthritis in Mice. H. Hess (OR-119) Systemic Onset Juvenile Idiopathic Arthritis is an IL-1 Mediated Disease. F. Allantaz 5:30-7:30 pm

Poster Session 2

St. George, Essex, 3rd Floor

Monday Monday,, May 16, 2005 8:30-10:00 am

Distinguished Lecture: Genetics and Genomics Chair: David A. Hafler Hafler,, MD

America Ballroom, 4th Floor

HIV Vaccines Epitope Diversity and T Cell Memory Gary Nabel, MD PhD Genomic Information: Implications for Medicine Eric Lander, PhD 10:00- 10:30 am

Break

10:30 am-12:30 pm

Concurrent Thematic Symposia I. Therapeutic V accines Vaccines Introduction Chair: Lucienne Chatenoud, MD PhD

America North, 4th Floor

Enhancing Tumor Vaccination Through In Vivo Plasmacytoid Dendritic Cell Activation Via TLR9 Art Krieg, MD Breaking Tumor-Induced Tolerance with Therapeutic Intent Drew Pardoll, MD PhD The Quest for Antigen Specific Therapy for Autoimmune Disease Larry Steinman, MD Modulation of Adaptive Immunity in Rheumatoid Arthritis Salvatore Albani, MD PhD

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Program Schedule Monday Monday,, May 16, 2005 (continued) II. Development of Immune-Based Therapeutics Chair: Michael Lotze, MD

America Center Center,, 4th Floor

B Cell Immunotherapy Andrew C. Chan, MD PhD On the Horizon: Better Therapies for Systemic Lupus Erthematosus David Wofsy, MD Monoclonar Antibody and Cellular Therapy in Type 1 Diabetes Jeffrey Bluestone, PhD Molecular Pathogensis of RA and Mode of Action of TNF-Blocking and Other Target Therapies Lars Klareskog, MD PhD (OR-120) - A High Affinity, Soluble T Cell Receptor for Targeting Tumours Expressing NY-ESO and HLAA2. R. Ashfield. III. Roles of Interferons in Defense & Disease Chair: Tim Behrens, MD

America South, 4th Floor

Role of Interferon-alpha in Systemic Lupus Erythematosus Virginia Pascual, MD The Interferon Pathway and Human Lupus Tim Behrens, MD The Role of Interferons in Systemic Autoimmunity Dwight Kono, MD Control of T-Cell Immunity by Dendritic Cells Frederica Sallusto IV IV.. Immunodiagnostic Disease Predictors Chair: Jonathan Braun, MD PhD

Staffordshire, 3rd Floor

Proteomic Analysis Reveals Molecular Subtypes of Rheumatoid Arthritis William Robinson Molecular and Microbial Disease Markers in Inflammatory Bowel Disease Jonathan Braun, MD PhD

Paul Ridker, MD Can We Detect Tolerance Following Allograft Transplantation? Jean-Paul Soulillou (OR-121) GAD65- and Proinsulin-Specific CD4+ T-Cells Detected by MHC Class II Tetramers in the Peripheral Blood of Type 1 Diabetic Patients and Prediabetic Subjects. V. Oling 56

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Program Schedule Monday Monday,, May 16, 2005 (continued) 12:30-2:00 pm

NIH Grants Information Session

America North, 4th Floor

This session will inform applicants about the NIH peer review and program funding processes. The session is directed at all academic investigators. The topics will include the receipt and referral process, the review process, as well as the funding mechanisms and NIH program initiatives available to clini cian-scientists.

Dr. Cathleen Cooper Scientific Review Administrator, Transplantation, Tolerance, and Tumor Immunology Study Section and Referral; Officer, Division of Receipt and Referral, Center for Scientific Review Dr. Grace Shen Director, Ocular Immunology Program, Division of Extramural Research, National Eye Institute

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Exhibit Hall - Essex Ballroom, 3

rd

Booth # Company 1-2 Agilent Technologies 3-4 DakoCytomation 5-6 DynalBiotech ASA 7-8 Whatman/Schleicher & Schuell 9 National Institute of Allergy and Infectious Diseases 10 Journal of Experimental Medicine 11-12 Centocor, Inc. 13 Immune Tolerance Network 14 Elsevier 15 American Autoimmune Related Diseases Association 16-18 Grifols International SA 19-23 Beckman Coulter, Inc. 24 BD Biosciences 25 Autoimmun Diagnostika GMBH/Cell Technology, Inc. 26 Biacore, Inc. 27 Cellular Technology, Ltd. CTL 58

28 29 30 31 32 33 34 35 36 37 38 39 40 41 42

Floor

EFORE (USA), Inc. ALPCO Diagnostics BioLegend, Inc. Jackson ImmunoResearch Laboratories, Inc. KRONUS, Inc. LINCO Research, Inc. Luminex Corporation Miltenyi Biotec, Inc. ProImmune, Inc. Bristol-Myers Squibb SeraCare Life Sciences THERAKOS Upstate Blackwell Publishing IgG America

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Exhibit Hall Exhibit Hall Hours Friday, May 13 Saturday, May 14 Sunday, May 15

Opening Reception 7:00-9:00 pm 7:00 am-7:30 pm 7:00 am-7:30 pm

Exhibit Hall hours are designed to correspond with Poster Sessions also being held in the Essex Ballroom. Poster viewing hours are 7:30-8:30 am, 12:30-1:30 pm, and 5:30-7:30 pm. However, the Exhibit Hall and poster areas will be accessible from 7:30 am to 7:30 pm.

13th International Congress of Immunology

ALPCO Diagnostics

Sociedade Brasileira de Imunologia Apuiar 44 Sao Paulo Brasil

PO Box 451 Windham, NH 03087 Booth Number: 29 ALPCO Diagnostics offers a comprehensive range of over 600 high-quality immunoassay kits to both the research and clinical laboratory communities. ALPCO is featuring kits in the areas of Allergy Research, Autoimmunity, Rheumatology, Thyroid Function, and Hepatology. Please visit us to receive our full product catalog, Immunoassay Kits Beyond the Ordinary.

The 13 International Congress of Immunology, sponsored by the International Union of Immunological Societies (IUIS), the Brazilian Society of Immunology (SBI) and the Latin American Society of Immunology (ALAI) will be held in Rio de Janeiro, August 12th-17 th, 2007. The Scientific Program will be outstanding; there will be a full social program to allow delegates to AutoImmun Diagnostika GMBH/Cell T echnology Technology echnology,, experience the charm of Rio de Janeiro, one of the most beauti- Inc.\Cell T echnology Technology echnology,, Inc. ful cities in the world, nicknamed “Cidade Maravilhosa” (Won- 8980 Old Annapolis Road derful City). Suite L Columbia, MD 21045 American Autoimmune Related Booth Number: 25 th

Diseases Association 22100 Gratiot Ave. E. Detroit, MI 48021 Booth Number: 15

Agilent TTechnologies echnologies 2850 Centerville Road Wilmington, DE 19808 Booth Number: 1-2

Cell Technology, Inc. (www.celltechnologyinc.com) is the North American Distributor of Image Analyzers (for EliSpot / Viral Plaque/ IFA assay) and test kits manufactured by AutoImmun Diagnostika, Strassberg, Germany (www.aid-diagnostika.com). Additionally, Cell Technology Inc. provides storage and distribution services for biological materials.

BD Biosciences

2350 Qume Drive San Jose, CA 95131 Agilent Technologies is a leading supplier of life science techBooth Number: 24 nologies, providing solutions for gene expression, proteomics and informatics that optimize sensitivity and workflow productiv- BD Biosciences, a business segment of BD (Becton, Dickinson ity. Key products include: whole genome and custom microarrays, and Company), has four business units: Clontech, Discovery scanners; HPLC, LC/MS/MS and HPLC-Chip/MS; ion trap and Labware, Immunocytometry Systems, and Pharmingen. As one TOF mass spectrometers; lab-on-a-chip products; reagents; and of the largest companies supporting the life sciences, BD Biosciences provides integrated, high value products and services data analysis software. for genomics, proteomics, drug discovery and development, and cell analysis. 59

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Exhibit Hall Beckman Coulter

Blackwell Publishing

7330 Carroll Road San Diego, CA 92121 Booth Number: 19-23

Booth Number: 41

From Epitope Discovery to Patient Monitoring. Your Immune Monitoring Partner: Beckman Coulter. Come see the latest solutions from Beckman Coulter that help you innovate, simplify and automate your immune monitoring processes. From our revolutionary iTopia Epitope Discovery System and iTAg MHC Tetramers to the IC 100 cellular imaging system, Quanta and FC 500 Series flow cytometry systems, as well as the A2 MicroArray System, Beckman Coulter delivers complete Immune Monitoring solutions. Learn more by visiting our booth.

Biacore, Inc. 200 Centennial Ave, Suite 100 Piscataway, NJ 08854 Booth Number: 26

Blackwell Publishing is one of the world’s leading medical publishers, representing the very best in academic research, professional development and student learning. Our Immunology portfolio contains some of the leading journals in the field, including Immunological Reviews, the official journals of the British Society for Immunology: Clinical and Experimental Immunology and Immunology , and the Scandinavian Journal of Immunology . Visit us at booth# 41, or browse our website at: www.blackwellimmunology.com

Bristol-Myers Squibb 345 Park Ave New York, NY 10154 Booth Number: 37

Bristol-Myers Squibb welcomes you to Boston! We invite you to visit our exhibit and learn more about T-Cell Co-Stimulation. BristolBiacore supplies analytical systems that improve productivity of Myers Squibb is a pharmaceutical and related health care prodresearch and development in the life science and pharmaceuti- ucts company whose mission is to extend and enhance human cal markets. Unique data on protein interactions give insights life. into protein functionality, the role of proteins in normal and diseased states, and the influence of potential drug candidates. Cellular T echnology Technology echnology,, Ltd.-CTL The company also provides ready-to-use solutions to determine 10515 Carnegie Ave. food quality and safety. For more information, visit Cleveland, OH 44106 www.biacore.com Booth Number: 27

BioLegend, Inc.

From academic roots, CTL has grown to become the world leader in ELISPOT development and automated image analysis. We provide scientifically validated ELISPOT products for all needs and budgets including the ImmunoSport Analyzer line, ImmunoSpot Software with dual color, scanning, and analysis At BioLegend, we are committed to providing world-class qualservices, and contracted research. Seeing is believing! Visit our ity research reagents and outstanding value. BioLegend feabooth and witness how CTL’s products can be an asset to your tures antibodies/conjugates against human, mouse, and rat laboratory. www.immunospot.com covering the areas of cell immunophenotyping, cytokines and chemokines, adhesion, phosphorylation, cancer research, cellcycle analysis, and apoptosis. BioLegend reagents’ applications include flow cytometry, ELISA, ELISPOT, immunoprecipitation, Western blotting, immunofluorescence microscopy, immunohistochemistry, and in vitro/in vivo functional assays. BioLegend offers a wide range of custom conjugation services to meet our customers’ specific needs.

8395 Camino Sante Fe, Suite E San Diego, CA 92121 Booth Number: 30

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Exhibit Hall Centocor Centocor,, Inc.

Dynal Biotech ASA

200 Great Valley Parkway Malvern, PA 19355 Booth Number: 11-12

Ullernchausjeen 52 N-0379 OS6 Norway Centocor, a wholly owned subsidiary of Johnson & Johnson, Booth Number: 5-6 creates, acquires and markets biomedicines that benefit patients Dynal Biotech is the leading supplier of basic and clinical reand the healthcare community. Centocor is dedicated to re- search grade magnetic beads for human and mouse cell sepasearching and developing treatments for a wide range of im- ration and expansion. By coupling your own antibodies, you mune mediated inflammatory disorders (I.M.I.D.) to help physi- can also isolate or deplete cells from a variety of samples. cians deliver innovative treatments to improve health and re- Dynabeads bridge the gap from basic research methods, through store quality of life. research & validation to routine applied ex-vivo immunotherapy. Clinical-grade Dynabeads are versatile tools in clinical research Clinical Immunology Society to separate viable cell populations. Come and see us at our 555 E. Wells Street booth. Suite 1100 EFORE (USA), Inc. Milwaukee, WI 53202 6029 W. Campus Circle Drive Booth Number: Foyer Irving, TX 75063 The Clinical Immunology Society (CIS) is the key inter-disciplinBooth Number: 28 ary organization for the field of clinical immunology with the mission to support and advance the community of immunologic scholars and physicians in education, research, and patient care. Established in 1986, CIS is devoted to fostering developments in the science and practice of clinical immunology. CIS is an international professional organization which includes 700 clinicians, investigators, and trainees. CIS has various programming objectives and is known worldwide for Educational Residential Seasonal Schools.

DakoCytomation 4850 Innovation Drive Fort Collins, CO 80525 Booth Number: 3-4 DakoCytomation A/S, headquartered in Copenhagen, Denmark, is a leading cancer diagnostics company with a focus on personalized medicine. DakoCytomation offers systems solutions for clinical laboratories and life science researchers, providing tests and instruments so that physicians can link diagnostic results to specific therapies and optimize patient care. The privately held company has significant R&D and manufacturing activities in Denmark, UK and USA, with operations in 20 countries, distributors in 50+ countries and more than 1,300 employees. www.dakocytomation.com

EFORE (USA), Inc. is the distributor for Bio-Sys Bioreader and Biocount(r) in the United States and Canada. Bioreader’s are used for counting Elispot and Colony Forming Units (CFU) as well as Plaque Assays. [email protected] Elispot: * Diagnosis of genetic defects * Allergic diseases * Autoimmune diseases * Transplantation * Cancer research * Acute inflammation, acute infectious diseases and septic shock

Elsevier 655 Avenue of the Americas New York, NY 10010 Booth Number: 14 Elsevier publishes journals, books and reference works across immunology. Come to the booth to: Claim conference discounts on key book titles such as Measuring Immunity or the new edition of Mucosal Immunology; Discover the benefits to authors of publishing in our prestigious journals, such as Clinical Immunology; Human Immunology or Cytokine and pick up a free sample of Trends in Immunology or Current Opinion in Immunology.

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Exhibit Hall Grifols International SA

Jackson ImmunoResearch Laboratories, Inc.

Department of Inflammation 200 Cambridge Park Drive Cambridge, MA 02140 Booth Number: 16-18

872 West Baltimore Pike PO Box 9 West Grove, PA 19390 Booth Number: 31

Grifols has been working for health since 1940 creating innovative products and services based on the values of ethics and responsibility. The Bioscience Division develops quality plasmaderived therapies with outstanding records of safety and efficacy. Grifols’ plasma derivative production uses the most advanced technology by a highly-qualified team— and all of this with complete traceability of the entire process. Grifols plasma derivatives are accompanied by PediGri: a commitment of completely transparent information to health professionals.

Affinity-purified secondary antibodies (many absorbed against other species for multiple labeling) (see also our new anti-mouse IgG subclass specific antibodies), anti-digoxin, anti-biotin, antiFITC, streptavidin, and purified immunoglobulins are conjugated with fluorophores (including Cy2, Cy3, and Cy5), enzymes, Biotin-SP , colloidal gold, phycoerythrin, and allophycocyanin. Monovalen Fab fragments are available for blocking endogenous Ig and for lableing two antibodies from the same host.

IgG America 34 Flint Street Marblehead, MA 01445 Booth Number: 42 IgG America is a national specialty pharmacy that provides immune globulin (IgG) services. IgG America provides immune globulin, supplies, pump/pole, pharmacy clinical monitoring, and all nursing services required to administer IgG in the home and or alternate site settings. Please visit us at www.iggamerica.com or call toll-free 877-674-9700.

Immune TTolerance olerance Network Suite 300 4800 Montgomery Lane Bethesda, MD 20814 Booth Number: 13 The Immune Tolerance Network (ITN) aims to accelerate the development of immune tolerance therapies in kidney, liver and islet transplantation, autoimmune diseases and allergy & asthma. The ITN solicits proposals for clinical trials and associated tolerance assay studies from academic and industry-based researchers in a year-round, open call for proposals. The ITN is jointly sponsored by the NIAID, NIDDK and JDRF. More information may be found at www.immunetolerance.org

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Journal of Experimental Medicine 1114 First Ave New York, NY 10021 Booth Number: 10 The Journal of Experimental Medicine provides broad coverage in all research areas encompassing the host’s response to disease. The topics covered include: hematopoiesis; infectious disease; inflammation; microbial pathogenesis; oncology; stem cells; vaccines; vascular biology; and virology. With a high impact factor of 15.302 (2003 ISI® Journal Citation Reports®), the JEM is a leading life sciences journal in two ISI categories: Immunology and Research & Experimental Medicine. The JEM now has a free open archive of full-text, searchable PDF versions of all articles dating back to 1896, a new design, and new features including In This Issue overview and commentaries/news.

KRONUS, Inc. 12554 W. Bridger St. Suite 108 Boise, ID 83713 Booth Number: 32 KRONUS will be showcasing a variety of immunoassay test kits for use by clinical and research laboratories to aid in the differential diagnosis and management of various autoimmune diseases in the areas of Type 1 Diabetes, Celiac Disease, Addison’s Disease, thyroid autoimmunity (including Grave’s Disease) and Myasthenia Gravis/Lambert-Eaton Myasthenic Syndrome. Please visit our exhibit to learn more about the complete line of KRONUS products!

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Exhibit Hall LINCO Research, Inc. 14 Research Park Drive Saint Charles, MO 63304 Booth Number: 33

National Institute of Allergy and Infectious Diseases/National Institutes of Health

4900 Seminary Road Suite 1100 LINCO Research is a recognized leader in the development Alexandria, VA 22311 and commercialization of multiplexed immunoassays for the Booth Number: 9 Luminex xMAP platform. LINCOplex multi-analyte panels are With nationwide responsibility for improving the health and well available for cytokines/chemokines, as well as biomarkers for being of all Americans, the Department of Health and Human the study of metabolic diseases (diabetes, obesity, cardiac dis- Services, (DHHS), oversees the biomedical research programs ease). Several specialty panels are also available for analytes of the National Institutes of Health, (NIH), and those of NIH’s related to bone, sepsis/apoptosis and skin. LINCO is also a research Institutes. NIAID is the second largest of 27 Institutes well known provider of traditional RIA and ELISA kits for diabe- and Centers of the world-renowned National Institutes of Health, tes and obesity. DHHS, the U.S. Government’s premier biomedical research in-

Luminex Corporation

stitution. The 317-acre NIH campus is located in Bethesda, Maryland.

12212 Technology Blvd. Austin, TX 78727 Booth Number: 34

ProImmune, Inc.

Miltenyi Biotec, Inc.

jor unmet need, such as cancer, infectious diseases, autoimmunity, and in transplantation.

Oxford BioBusiness Center Luminex Corporation develops, manufactures and markets pro- Littlemore Park prietary biological testing technologies, with applications through- Littlemore, Oxford OX4 4SS out the life-sciences industry. This industry depends on a broad Booth Number: 36 range of tests, known as “bioassays,” to discover new drugs, ProImmune is a leading provider of products and services for identify new genes or simply monitor blood cholesterol levels. monitoring the state of the immune system, including recombiThe experts at Luminex have developed an innovative approach nant Pro5TM MHC Pentamers, custom peptide libraries and to bioassays, known as xMAP technology. This groundbreaking antibodies. Pro5TM MHC Pentamers can be used to evaluate T technology, enables companies and laboratories to perform bio- cell immunity in disease and in response to therapy, enabling assays more quickly and cost-effectively than with other systems, investigators to accelerate their research and the discovery and without sacrificing accuracy. development of new biopharmaceutical drugs in areas of ma-

251 Auburn Ravine Road Suite 208 Auburn, CA 95603 Booth Number: 35

SeraCare Life Sciences

1935 Avenida Deloro Suite F Miltenyi Biotec, manufacturer of MACS Separation Technology, Oceanside, CA 92056 supplies equipment and reagents for the immunomagnetic isola- Booth Number: 38 tion of specific cell types, organelles, and molecules from hetero- SeraCare offers a broad range of biological based materials geneous samples. The CliniMACS system, approved in the Euro- and services, including clinical specimens used for target idenpean Union since December of 1997, is indicated for the purifi- tification, culture and media components, blood-derived base cation of stem cells for the use in bone marrow transplantation. matrices, positive and negative control sera, and various purified proteins. Products featured will include our extensive bank of specimens obtained from apparent ADR cases, with potential use in toxicogenomic and protein identification, and viable, well-characterized cryopreserved human PBMC’s. 63

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Exhibit Hall THERAKOS

Whatman/Schleicher & Schuell BioScience, Inc.

437 Creamery Way Exton, PA 19341 Booth Number: 39

PO Box 2012 10 Optical Avenue Keene, NH 03431 Booth Number: 7-8

THERAKOS, Inc., an immune cell therapy company, is a worldwide leader in extracorporeal disease management. THERAKOS Photopheresis, including the UVAR ® XTS ™ System and UVADEX ® Methoxsalen Sterile Solution, IS approved for the palliative treatment of skin manifestations in Cutaneous T-Cell Lymphoma, and is currently being studied in other immune mediated diseases.

Upstate 706 Forest Street Charlottesville, VA 22903 Booth Number: 40 Upstate is a leading provider of cell signaling products and services for research and drug discovery. Products include antibodies, enzymes, siRNA and assay kits for signaling pathway analysis, as well as a complete offering of cytokine, chemokine and growth factor multiplex kits for the Luminex System.

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Whatman/Schleicher & Schuell BioScience will feature the company’s full line of protein array products and services, including the new S&S Two-Color Labeling and Fluorescent Detection Kit. FAST Quant protein array kits and software for multiplex cytokine quantification, FAST Slides and protein arraying kits, and a complete menu of protein arraying, processing and scanning services.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

FOCIS 2005 TTravel ravel A ward Recipients Award Biogen IDEC

Bristol-Myers Squibb

Daniel Bandari Halima El-Mouslimany Steve Brass Ritika Jaini Anjali Shah Olaf Stuve Greg Wu

Robert Axtell Alicia Babcock Estelle Bettelli Tarek Fahmy Lisa Gilliam Peggy Ho Jing Hua Jennifer Huggins Meghavi Kosboth Kristi Kuhn Paul Lizzul Douglas McDonald Maki Nakayama Christina Nance Mindi Walker Kefei Yu

Boehringer Ingelheim Phillip Bardwell S. Ben-Horin Gilles Benichou Swati Bhattacharyya Claudia Calder V. Cotta-de-Almei P. Davis Cory Ebeling Alexander Espinosa Massimo Claudio Fantini Thomas Fehr Dan Frenkel R. Gorczyski Brian Helmich S. Kaieda C. Kliwinski Chun Lau I-Fang Lee D. MacKenzie Everett Meyer Qin Ning N. Phillips J. Shen Yasuyo Shimomura B. Shum Phillipe Stock Troy Torgerson M. Vargas-Rojas Xiaochun Wan Vaughan Wittman Dianna Wu Jun Yan Simone Zehntner

Dana Foundation Rebecca Ashfield Clare Baecher-Allen K. Haanstra Fabienne Haspot Sally Kent Siegfried Kohler Stephen Miller Vivetka Oling Ken Sugimoto Dale Umetsu

FOCIS Marsilio Adriani Florence Allantaz Jacqueline Benson Gaelle Beriou Yijun Carrier D. Castano Miguel de La Fuente Scott DeGregorio F. Dolganiuc S. Dunn Anna Eriksson Ronald Germain

Anjelica Gonzalez Xiaonan Han Henry Hess Ali Jabbari Andrew Johnston H. Kandil Sonja Kierstein Brent Koehn Subramaniam Krishnan Adam Lacy-Hulbert F. Li Julie Lin Ralf Linker J. Listopad Peng Liu Dalam Ly Emma Masteller Laurie Minns Mohamad Mohty Koichiro Ohmura Georgios Papachristou B. Rethi Khaja Rheman Chiara Romagnani Pedro Ruiz Michael Shakarijan Nicole Sherry Alla Skapenko Dusanka Skundric Jason Song Peter Sziglieti Henrik Toft-Hansen Yue Wang Bo Wei Kristy Wolniak

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

FOCIS 2005 TTravel ravel A ward Recipients Award Juvenile Diabetes Research Foundation Damien Bresson Christopher Moore Yu Feng Peng Govinda Rajagopalan

National Institutes of Health V. Bajzik Peter Barthmaier S. Berlo D. Cunningham-Graham Silvia Deaglio Raquel Deering Phillip DeJager Leen DeRycke Umesh Deshmukh Ivana Durinovic-Bello R. Hoffman Jean Jasinski Jennifer Kanter Norma Sue Kenyon Georges Maestroni Cecilia Marta Riccardo Navone Roman Puliaev K. Raman Robert Rigby Veerle Anne-Marie Somers W. Walchholz J. Wang Klau Warnatz Maria Wysocka Alexandra Zanin-Zhorov

National Multiple Sclerosis Society Alexandra Degenhart Susan Gauthier Adil Javed Salvatore Napoli

Immune TTolerance olerance Network Omid Akbari Martin Dahl Stephanie Dougan J. Harrt Meyers Mary Keir Masaaki Niino Huey-Kang Sytwu Nalan Utku Bart Van Wijmeersch C. Wu

Novartis Elena Yarmola Linda Wu

Teva Elizabeth Hodges Ashutosh Mangalam Kevin O’Connor Daniel Li K. Sakuishi U. Salzer Alicja Waliszewska Dun Zhou

FOCIS 2005 Par ticipation A ward Recipients Participation Award Jeffrey Modell Foundation Clara Bueno Eva Carmona Audrey Chen

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Abstracts in Order of Presentation Poster Session 1 Friday Friday,, May 13, 2005 7:30 am - 1:30 pm Allergy/Asthma F1.01 - Prevalence of Aeroallergens in Allergic Rhinitis. Mohammad Amin Kashef,1 Sara Kashef,2 Fardin Eghtedari.3 1 Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran.

F1.05 - Increased Experession in CD30+ and CD57+ Molecules on CD4+ T Cells in Atopic Asthmatic Children: A Preliminar y Repor t. liminary Report. N. E. Martinez-Jimenez,1 E. Rojas-Ramos,1 Y. B. Garfias,2 E. G. Zenteno,2 R. L. Lascurain.2 1Clinical Immunology and Allergy, ISSSTE, Mexico, Mexico City, Mexico; 2Biochemistry, INER, SSA, Mexico, Mexico City, Mexico.

F1.06 - CCR3 Expressed on CD4+ T Cells Correlations with IL-4 Production in Allergic Rhinitis Patients. Preliminar y RePreliminary port. E. Rojas-Ramos,1 M. N. Martinez-Jimenez,1 E. G. Zenteno,2 Y. B. Garfias,2 R. L. Lascurain.2 1Clinical Immunology and Allergy, F1.02 - Modulation of Immunological Functions of Mast Cells ISSSTE, Mexico, Mexico City, Mexico; 2Biochemistry, INER,SSA, by Heat Shock. Mexico, Mexico City, Mexico. E. Mortaz, F. A. Redegeld, M. W. Heijden, F. P. Nijkamp, H. R. Wong, F. Engels. 1Dept. Pharmacology & Pathophysiology, F1.07 - Mugwort-Pollen Allergy Represents an Ideal CandiUtrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, date for Peptide Immunotherapy Immunotherapy.. Netherlands; 2Dept. Pharmacology & Pathophysiology, Institute B. Jahn-Schmid,1 G. F. Fischer,2 B. Bohle,1 F. Ferreira,3 C. Ebner.1 for Pharmaceutical Sciences (UIPS), Utrecht, Netherlands; 3Dept. 1Dept. of Pathophysiology, Medical University of Vienna, Vienna, Pharmacology & Pathophysiology, Institute for Pharmaceutical Austria; 2Dept. of Blood Serology, Medical University of Vienna, Sciences (UIPS), Utrecht, Netherlands; 4Dept. Pharmacology & Vienna, Austria; 3Department of Immunology and Allergology, Pathophysiology, Institute for Pharmaceutical Sciences (UIPS), University of Salzburg, Salzburg, Austria. Utrecht, Netherlands; 5Critical Care, Division of Critical Care Medicine, Children’s Hospital Medical Center and Children’s F1.08 - Characterization of Human Cord Blood-Derived In Hospital, Cincinnati, OH, USA; 6Dept. Pharmacology & Pathophysiology, Institute for Pharmaceutical Sciences (UIPS), Utrecht, Vitro Generated Mast Cells: Hemopoietic Antigens, Chemokine Receptors, Activation Markers, TTetraspanins. etraspanins. Netherlands. 1 I. Mirkina, T. Schweighoffer. RD-ADV, Novartis Institutes for ™F1.03 - Naive CD4+ T Cell Activation by Antigen-Present- Biomedical Research, Vienna, Austria. ing Air way Eosinophils. Airway H. Wang,1 P. F. Weller.1 1Division of Allergy and Inflammation, ™F1.09 - IL-4Ra Single Nucleotide Polymorphisms in Allery Aspergillosis. Bronchopulmonary Beth Israel Deaconess Medical Center, Harvard Medical School, gic Bronchopulmonar 1 Alan P. Knutsen, Barbara Kariuki,1 Manoj R. Warrier.2 1AlBoston, MA, USA. lergy/Immunology, Saint Louis University, St. Louis, MO, USA; 2 F1.04 - TTransfor ransfor ming Growth Factor Beta-1 May Up Regulate Allergy/Immunology, Cincinnati Children’s Hospital, Cincinnati, ransforming Interferon Gamma Production by Peripheral Blood Mono- OH, USA. nuclear Cells from Asthmatics and Normal Controls. J. Joseph,1 S. Benedict,1 M. Joseph,2 B. Al-Ramadi.3 1Internal Medicine, Faculty of Medicine & Health Sciences, Al Ain, Abudhabi, United Arab Emirates; 2Pediatrics, Al Ain Hospital, Al Ain, Abudhabi, United Arab Emirates; 3Microbiology & Immunology, FAculty of Medicine & Health Sciences, Al Ain, Abudhabi, United Arab Emirates. 67 ™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F1.10 - House Dust Mite Allergen (Der p1 and Blo t5) Levels in Asthmatics’ Home in Hong Kong. Baoqing Sun, Adrian Wu, Nanshan Zhong. 1Dept of Medicine, Guangzhou Institute of Respiratory Deseases, Guangzhou, GuangDong, China; 2Dept of Medicine, The University of HongKong, HongKong, Hong Kong; 3Dept of Medicine, Guangzhou Institute of Respiratory Deseases, Guangzhou, GuangDong, China.

F1.15 - Exposure to Monomeric Human Myeloma IgE in the Absence of Known Specific Antigen Can Enhance Chemokine Production in In Vitro-Derived Human Mast Cells. Adrian M. Piliponsky,1 Kentaro Matsuda,1 Motoyasu Iikura,1 Toshiaki Kawakami,2 Evelyn Wang,1 Mindy Tsai,1 Stephen J. Galli.1,3 1Pathology, Stanford University School of Medicine, Stanford, CA, USA; 2Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA; 3Microbiology and Immunology, Stanford University School of Medicine, F1.11 - House Dust Mite Allergen Der f Increase Bronchial Stanford, CA, USA. Epithelial Cell Cytokine Expression. Baoqing Sun, Nanshan Zhong. 1Dept of Medicine, Guangzhou F1.16 - Comparison of the Efficacy of Intranasal Phototherapy Institute of Respiratory Diseases, Guangzhou, GuangDong, and Fexofenadine Hydrochloride for the TTreatment reatment of SeaChina; 2Dept of Medicine, Guangzhou Institute of Respiratory sonal Allergic Rhinitis. Diseases, Guangzhou, GuangDong, China. A. Koreck, Zs Csoma, M. Boros-Gyevi, L. Kemeny. 1Department of Dermatology and Allergology, University of Szeged, Szeged, F1.12 - D. pteronyssinus Extract-T reated Confluent A549 Cells Hungary.. Extract-Treated (cA549) Secrete Mediators That Stimulate Human Pulmonar y F1.17 - Inhibition of the Peptidyl-prolyl Isomerase (PPIase) Pulmonary Fibroblasts TTo o Increase Secretion of V ascular Endothelial Pin1 Induces Caspase-3-Mediated Apoptosis of Human PeVascular Growth Factor (VEGF). ripheral Blood Eosinophils. A. Capetandes,1 M. Frieri.1 1Dept of Pathology, Division of Z. J. Shen,1 S. J. Esnault,1 J. S. Malter.1 1Pathology and LaboraAllergy Immunology, Nassau University Medical Center, East tory Medicine, Waisman Center for Developmental Disabilities, Meadow, NY, USA. University of Wisconsin, Madison, WI, USA. F1.13 - Skin Reactivity for Aeroallergens and Peripheral Eosinophilia in Children with Otitis Media with Effusion. Fardin Eghtedari,1 Hossein Mohammadi-Nik,1 Sara Kashef,1 Mohammad Hadi Imanieh,1 Farhad Handjani,1 Eskandar Kamali-Sarvestani,1 Marzieh Orouj.1 1Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran.

™F1.18 - Natural CD25+CD4+ Regulator y Cells Inhibit ProRegulatory liferation of CD25-CD4+ Cells from Naive or Immunized BALB/ c Mice When Stimulated by Dendritic Cells Pulsed with Fel d 1 or Major Fel d 1 T Cell Epitopes. F. R. Hentges,1 C. A. Leonard,1 C. P. Le Pogam.1 1Laboratory of Immunogenetics and Allergology, CRP-Sante, Luxembourg, Luxembourg.

F1.14 - Recurrent Angioedema by Blastocystis Hominis Suc™F1.19 - Omalizumab Improves Asthma Outcomes Irrespeccessfully TTreated reated with Paromomycin. TRA) Use. (LTRA) tive of Leukotriene Receptor Antagonist (L D. Micheloud,1 J. Jensen,1 E. Fernandez-Cruz,1 J. Carbone.1 M. Massanari,1 Y. Deniz,2 R. Maykut,1 C. Reisner,3 G. Geba.1 1 Clinical Immunology Unit, University Hospital Gregorio Maranon, 1 US Clinical Development and Medical Affairs, Novartis PharMadrid, Spain. maceuticals Corporation, East Hanover, NJ, USA; 2Clinical Development, Genentech, South San Francisco, CA, USA; 3Clinical Development, Novartis Pharmaceuticals, East Hanover, NJ, USA.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F1.20 - Administration of Chitin Down-Regulate Serum IgE Levels and Lung Eosinophilia in Ova-Albumin Allergic Mouse. C.-L. Kao,1 C.-R. Shen,1,2 C.-J. Lin,1 J.-K. Chen,3 M.-L. Kuo,2 C.-L. Liu.4 1Graduate Institute of Medical Biotechnology, Chang Gung University, Kweishan, Taoyuan, Taiwan; 2Graduate Institute of Basic Medical Sciences, Chang Gung University, Kweishan, Taoyuan, Taiwan; 3Department of Environment and Biotechnology, Refine and Manufacture Research Center, Chinese Petroleum Company, Chiayi, Chiayi, Taiwan; 4Graduate Institute of Engineering and Department of Biochemical Engineering, MingChi University of Technology, Taishan, Taipei, Taiwan. F1.21 - Allergic /T /Toxic oxic Manifestations Associated with Ingestion of Stir-Fried/ Cooked Mushrooms. M. Ishaq, I. M. Sameera, M. Taj. 1Allergy/Pulmonology, AlJunaid Hospital, Nowshera, Pakistan.

™F1.22 - Effects of TTacrolimus acrolimus Upon TT-L -L ymphocyte, NK Cell, -Lymphocyte, and Eosinophil Activation. C. N. Huynh,1 E. S. Lee,1 Q. N. Chung,1 M. A. Gibson,1 R. L. Roberts.1 1Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. F1.23 - Hemopoietic Cells Accumulate in Murine Lungs in Response to Ectopic Grafts of Lung Tissue from Allergic and from IL-5 TTransgenic ransgenic Donors. M. I. Gaspar-Elsas, E. S. Maximiano, T. Q. Souza-Pinto, D. Joseph, B. B. Vargaftig, P. Xavier Elsas. 1Pediatrics, Instituto Fernandes Figueira - FIOCRUZ, Rio de Janeiro, RJ, Brazil; 2Immunology, Inst. Microbiol. Prof. Paulo de Goes - UFRJ, Rio de Janeiro, RJ, Brazil; 3Pharmacology, Instituto de Ciencias Biomedicas - USP, Sao Paulo, SP, Brazil; 4Unite Pharmacol. Cellulaire - U485 INSERM, Institut Pasteur Paris, Paris, Ile-deFrance, France.

F1.25 - Anaphylaxis to Intravenous and Oral Cyclosporin in a Child and Successful Desensitization. Sara Kashef,1 Mojhgan Kiani,2 Habib Nourani-Khojasteh,3 Mani Ramzi.3 1Allergy Research Center, Pediatric Immunology & Allergy, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Pediatric Immunology & Allergy, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Department of Hematology & Oncology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran. F1.26 - Skin Reactivity to Aeroallergens Is Not Related to the Nasal Polyp Tissue Eosinophil Inflammation. Fardin Eghtedari,1 Seyed Reza Cheraghzadeh,2 Sara Kashef,3 Ahmad Monabati,4 Elham Shoraka.5 1Allergy Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Allergy Research Center, Pediatric Immunology & Allergy, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 5Department of Obstetrics & Gynecology, Shahid Beheshti Hospital, Shiraz, Fars, Islamic Republic of Iran.

™F1.27 - Superior Safety of Polymerized Allergen VVaccines: accines: Zero Systemic Reactions during 55,000 Injections of Polymerized Ragweed and Grass V accines in 500 Allergy Patients. Vaccines S. Kagen, J. Zondlo, R. Muthiah, M. Kagen. 1Allergy - Immunology, Kagen Allergy Clinic, Appleton, WI, USA.

F1.28 - TTrans rans Fatty Acid and Atopic Eczema/Der matitis SynEczema/Dermatitis drome: The Relationship with a Free Radical cis-trans Isomermatitis. ization of Membrane Lipids TTrans rans LIPIDS in Atopic Der Dermatitis. L. Chini,1 F. Angelini,1 C. Chatgilialoglu,2 S. Dellonte,2 V. ™F1.24 - Intracellular Stores of Interleukin-4 (IL-4) Receptor a Moschese,1 S. Corrente,1 R. Iannini,1 M. Chianca,1 P. Rossi,1 C. L. A. Spencer,1 R. C.N. Melo,1,2 S. A.C. Perez,1 A. M. Dvorak,3 Ferreri.2 1Pediatrics, Policlinico Tor Vergata, University of Rome P. F. Weller.1 1Department of Medicine, Beth Israel Deaconess Tor Vergata, Rome, Italy; 2ISOF, Consiglio Nazionale delle Medical Center, Boston, MA, USA; 2Department of Biology, Fed- Ricerche, Bologna, Italy. eral University of Juiz de Fora, Juiz de Fora, MG, Brazil; 3Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

69

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F1.29 - Proinflammator y Cytokines and Nitric Oxide in ExProinflammatory haled Breth Condensate in Monitoring of Exacerbation Asthma in Children. Boleslaw Kalicki,1 Anna Jung,1 Wanda Stankiewicz,2 Marek Dabrowski,2 Janusz Zuber.1 1Paediatric, Military Medical Institute, Warsaw, Poland; 2Immunology, Institute of Hygiene and Epidemiology, Warsaw, Poland.

F1.35 - Interleukin-4 and Its Alter natively Spliced V ariant Alternatively Variant δ2) in Healthy Donors and Patients with Atopic Asthma. (IL-4δ2) (IL-4 A. A. Babakhin,1 E. I. Bateneva,1 S. M. Andreev,1 M. R. Khaitov,1 D. Y. Trofimov,1 L. P. Alekseev,1 L. M. DuBuske.2 1National Research Center, Institute of Immunology, Moscow, Russian Federation; 2Immunology Research Institute of New England, Gardner, MA, USA.

F1.36 - B Epitope Assay of hIL-4 δ2, an Alternative Splicing hIL-4δ2, Variant of hIL-4. S. M. Andreev,1 I. V. Dubinkin,1 A. O. Petrukhina,1 A. M. Vasiliev,2 I. V. Kosarev,2 N. V. Tokhtamysheva,2 G. Y. Puchkova,2 A. A. Babakhin,1 L. M. DuBuske.3 1NRC Institute of Immunology, Moscow, Russian Federation; 2Institute of Immunological Engineering, Lyubuchany, Moscow Region, Russian Federation; 3ImF1.31 - Cow’ Cow’ss Milk Allergy in Infantile Colic. Mohammad Hadi Imanieh,1 Hosein Moravej,1 Sara Kashef,1 munology Research Institute of New England, Gardner, MA, Farhad Handjani, 1 Eskandar Kamali-Sarvestani, 1 Fardin USA. Eghtedari,1 Marzieh Orouj.1 1Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of F1.37 - LPS Differentially Modulates Th2 Cell Responses to Antigen during Acute and Relapse Allergic Asthma in Mice. Iran. M. Zerbs,1 R. Bankoti,1 G. Dekan,2 G. Stingl,1 M. M. Epstein.1 F1.32 - 5-Lipoxygenase Locolization to Cytosolic Lipid Bod- 1Dermatology, Medical University of Vienna, Vienna, Austria; 2 Clinical Pathology, Medical University of Vienna, Vienna, Ausies in Rat Basophil Leukemia Cells. tria. 1 1 1 1 2 Z. Jin, D. Wan, H. B. Wang, I. Ghiran, R. J. Soberman, P. F. Weller.1 1Division of Allergy and Inflammation, Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, F1.38 - Differential Th2 Immune Responses in C57BL/6 and USA; 2Massachusetts General Hospital, Harverd Medical School, BALB/c Mice in a Novel Model of Milk-Induced Allergic Boston, MA, USA. Asthma. M. Zerbs,1 G. Dekan,2 G. Stingl,1 M. M. Epstein.1 1DermatolF1.33 - Approaches to Immunogenicity of Human Protein ogy, Medical University of Vienna, Vienna, Austria; 2Clinical Pathology, Medical University of Vienna, Vienna, Austria. Products. H. S. Ko.1 1Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food F1.39 - Response of Older Patients with Asthma to and Drug Administration, Rockville, MD, USA. Omalizumab: A Pooled Analysis across 5 Clinical TTrials. rials. R. J. Maykut,1 Y. Deniz,2 M. Massanari,1 C. Reisner,3 F. Kianifard,1 F1.34 - Plasma Concentration of Soluble IL-4 Receptor in G. P. Geba.1 1&2Clinical Development, Genentech, Inc., South Asthma Patients during Specific Bronchial Challenge with San Francisco, CA, USA; 3CRD, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA. Dermatophagoides Pteronyssinus(Dp) Allergen. F1.30 - Combined Skin Prick, Immediate Patch and SpecificIgE TTesting esting in the Diagnosis of Peanut Allergy in Children. B. K. Wainstein,1 A. Yee,1 M. Ziegler,1 D. Jelley,1 J. B. Ziegler.1 1 Immunology and Infectious Diseases, Sydney Children’s Hospital, Sydney, New South Wales, Australia.

K. Kowal,1 A. Pampuch,1 L. M. DuBuske,2 A. BodzentaLukaszyk.1 1Department of Allergology and Internal Medicine, University Medical School of Bialystok, Bialystok, Poland; 2Immunology Research Institute of New England, Gardner, MA, USA.

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F1.40 - Development of a CD154-Dependent Model of IL-13 Producing B Cells. O. Hajoui,1 J. Guay,1 S. Al-Tamemi,1,2 B. D. Mazer.1,2 1Meakins Christie Laboratories, McGill University, Montreal, QC, Canada; 2 Division of Allergy and Immunology, Montreal Children’s Hospital, Montreal, QC, Canada.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F1.41 - Daclizumab Does Not Alter the Function of Healthy Human CD4+CD25+ Regulator y T Cell In V itro. Regulatory Vitro. T. Sornasse,1 Y. Zhang,1 W. Hong,1 D. Polakoff,1 V. V. Vexler.1 1 Research, Translational Medicine, Protein Design Labs, Inc., Fremont, CA, USA.

F1.48 - Vitamin E Supplementation Augments the Levels of Endogenous Antioxidants and Improves Lung Function in Asthmatic Patients. Ahmed Nadeem, Sunil K. Chhabra, Hanumanthrao G. Raj. 1 Department of Biochemistry, Vallabhbhai Patel Chest Institute,University of Delhi, Delhi, India; 2Department of CardioF1.42 - Respirator y Exposure to OV A Induce Functional Ef- respiratory Physiology, Vallabhbhai Patel Chest Institute,University Respiratory OVA of Delhi, Delhi, India. fector CD4 T Cells. B. Chiu,1 V. R. Stolberg,2 S. W. Chensue.1,2 1Pathologh, UniverBone Marrow or Stem Cell TTransplantation ransplantation sity of Michigan Medical School, Ann Arbor, MI, USA; 2Pathology and Laboratory Medicine, VA Ann Arbor Healthcare SysF1.49 - Recover y of CD4 and CD8 LLymphocyte ymphocyte Subsets and Recovery tem, Ann Arbor, MI, USA. Their Impact on Acute Graft-vs. Host Disease (GVHD) after F1.43 - A-317491 Inhibits the Activation of Guinea-Pig Pul- Reduced Intensity Conditioning (RIC) Allogeneic Stem Cell er minals by α,β− methylene- Transplantation (allo-SCT). monar yV agal Sensor y Ner ve TTer α,β−methylenemonary Vagal Sensory Nerve erminals M. Mohty,1 D. Blaise,1 C. Faucher,1 D. Olive,1 B. Gaugler.1 ATP TP.. 1 A. Pelleg,1 B. J. Undem.2 1&2Asthma Center, Johns Hopkins Immunologie des Tumeurs, Insitut Paoli-Calmettes, Marseille, France. University, Baltimore, MD, USA. F1.50 - Cross-Presentation of Minor Histocompatibility Antigens Requires Dendritic Cells and Immunoproteasomes. F1.45 - Sodium Sulfite Activates Mast Cells and Basophils T. M. Hill,1 L. Van Kaer,1 J. W. Yewdell,2 D. C. Roopenian,3 S. Joyce.1 1Microbiology and Immunology, Vanderbilt University through Induction of Oxidative Stress. 2 C. R. Collaco,1 D. J. Hochman,1 R. M. Goldblum,1 E. G. Brooks.1 School of Medicine, Nashville, TN, USA; Laboratory of Viral Diseases, 1 Pediatrics, The University of Texas Medical Branch, Galveston, Diseases, National Institute of Allergy and Infectious 3 National Institutes of Health, Bethesda, MD, USA; The Jackson TX, USA. Laboratory, Bar Harbor, ME, USA. F1.44 – Abstract Withdrawn

F1.46 - Structural Basis for Epitopes Sharing between Group 1 Allergens of Cedar Pollen. T. Midoro-Horiuti,1 C. H. Schein,2 V. Mathura,2 W. Braun,2 E. W. Czerwinski, 2 A. Togawa, 1 Y. Kondo, 1 T. Oka, 3 M. Watanabe,4 R. M. Goldblum.1 1Pediatrics, University of Texas Medical Branch, Galveston, TX, USA; 2Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX, USA; 3Oka Pharmacy, Tamano, Okayama, Japan; 4Tokyo Research Laboratories, Kowa Co., Ltd., Noguchi, Tokyo, Japan.

F1.51 - Permanent Mixed Chimerism in Mice by Short, Low Toxicity reatment Allows Myoblast Allograft oxicity,, Radiation Free TTreatment Tolerance across Fully MHC-Mismatched Barriers. L. Stephan,1 J. P. Tremblay.2 1Human Genetic, CRCHUL, Quebec, QC, Canada; 2Human Genetic, CRCHUL, Quebec, QC, Canada.

F1.52 - Neonatal CD4+ CD25+ T Cells – Age Restricted Deolerance. velopment of Immune TTolerance. R. Reibke,1 B. Arnold,2 G. J. Hammerling.2 1Dept. of Internal F1.47 - Food Allergy Related Hospitalizations New Y ork State Medicine III, University of Munich, Klinikum Grosshadern, York Munich, Germany; 2Molecular Immunology, German Cancer Hospitals from 1994-2003. L. R. Forbes,1 R. Y. Lin.2 1Pediatrics, St. Vincent’s Medical Cen- Research Center, Heidelberg, Germany. ter Manhattan, New York, NY, USA; 2Medicine, St. Vincent’s Medical Center Manhattan, New York, NY, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

71

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F1.53 - In Vivo Neutralization of Both Interferon Gamma (IFNg) and Interleukin-2 (IL-2) Accelerates Anti-Host Cytotoxic T Lymphocyte (CTL) Development and Acute Graft-V ersus-Host Graft-Versus-Host Disease (GVHD) in the Parent-Into-F1 Model. I. A. Puliaeva,1 R. A. Puliaev,1 F. D. Finkelman,2 C. S. Via.1 1 Pathology, Uniformed Services University of Health Sciences, Bethesda, MD, USA; 2Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

F1.59 - Distinct Effects of Early and Delayed CTLA4-Blockade after Murine miHC-Disparate Allogeneic Bone Marrow TTransransplantation: Graft-V ersus-Host Disease V ersus Auto-Immunity Graft-Versus-Host Versus Auto-Immunity.. S. Fevery,1 P. Vandenberghe,2 B. Sprangers,1 O. Rutgeerts,1 C. Lenaerts,1 J. Goebels,1 C. Segers,1 W. Landuyt,3 L. Boon,6 A. Kasran,4 C. De Wolf-Peeters,5 M. Waer,1 A. D. Billiau.1 1Lab. Experimental Transplantation, University of Leuven, Leuven, Belgium; 2Center of Human Genetics; 3Lab. Experimental Radiotherapy; 4Lab. Experimental Immunology; 5Dep. Pathology, Uni6 F1.54 - Role of Apoptotic Cells in the Induction of Regulator y versity of Leuven, Leuven, Belgium; Bioceros NV, Amsterdam, Regulatory Netherlands. T Cells. 1 1 1 1 Kim A. Campbell, Amy Krutsick, Janine Huber, David Peritt. ransplantation in a Patient 1 Research & Clinical Development, Therakos, Inc., Exton, PA, F1.60 - Successful Bone Marrow TTransplantation with WHIM Syndrome. USA. Y. Kamachi,1 Y. Nakamura,1 A. Hama,1 K. Kudo,1 A. Yoshimi,1 1 2 1 1 Pediatrics, Nagoya F1.55 - Distribution of CD4+25+ Cells in Fetal Sheep Early in N. Watanabe, I. Tsuge, S. Kojima. University Graduate School of Medicine, Nagoya, Aichi, JaGestation. pan; 2Pediatrics, Fujita Health University, Toyoake, Aichi, Japan. Alireza Torabi,1 John S. Pixley,2 Jessica Chase, Esmail D. Zanjani.1 1Department of Animal Biotechnology and Department of Medicine, University of Nevada, Reno, Reno, NV, USA; F1.61 - Characterization and Depletion of Human PBMNC 2 VA Medical Center, University of Nevada, Reno, Reno, NV, Reactive with Murine Stimulator Cells. L. D. Fast,1 G. DiLeone,1 M. Chuck.1 1Department of Medicine, USA. Rhode Island Hospital/Brown University, Providence, RI, USA. F1.56 - Clinical Relevance of Recipient Leukocyte Infusion (RLI) Therapy Therapy.. T. I. Saito,1 M. Sykes.1 1TBRC/BMT Section, Massachusetts General Hospital, Boston, MA, USA. F1.57 - Anti-Mouse Thymocyte Globulin Administration Prevents Acute Graft-versus-Host Disease in a Murine Model. M. C. Ruzek,1 J. S. Waire,1 A. Vitsky,2 J. Williams,3 S. M. Richards,1 R. D. Garman.1 1Immunology and Clinical Laboratory Sciences, Genzyme Corporation, Framingham, MA, USA; 2 Pathology, Genzyme Corporation, Framingham, MA, USA; 3Immune Mediated Diseases, Genzyme Corporation, Framingham, MA, USA. F1.58 - IFN-Gamma Promotes LLymphohematopoietic ymphohematopoietic GVH Reactions while Attenuating GVHD in Murine Allogeneic Hematopoietic Cell TTransplantation ransplantation Models. Hui Wang,1 Shumei Wang,1 Megan Sykes,1 Yong-Guang Yang.1 1Bone Marrow Transplantation Section, Transplantation Biology Research Center, Boston, MA, USA.

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Poster Session 2 Friday Friday,, May 13, 2005 3:30 pm - 7:30 pm Reproductive Immunology F2.01 - Cytokines in the Placenta of Pakistani Newborns with and without Intrauterine Growth Retardation. M. Hahn-Zoric,1 S. Amu,1,2 A. Malik,2 R. Asraf,3 S. Zaman,4 I. Kjellmer,5 H. Hagberg,6 L. Padyukov,1 L. A. Hanson.1 1Department of Clinical Immunology, Gothenburg University/Sahlgrenska University Hospital, Gothenburg, Sweden; 2Department of Obstetrics and Gynecology, King Edward Medical College, Lahore, Pakistan; 3Department of Social and Preventive Pediatrics, King Edward Medical College, Lahore, Pakistan; 4Department of Social and Preventive Pediatrics, Fatima Jinnah Medical College/Sir Ganga Ran Hospital, Lahore, Pakistan; 5Perinatal Center, Department of Pediatrics, Gothenburg University, Gothenburg, Sweden; 6Department of Obstetrics and Gynecology, Gothenburg University, Gothenburg, Sweden.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F2.02 - Setup of IgG MAR Methods and Determination of the Prevalence of Antisperm Antibodies in Semen of Immunoinfertile. Abdolreza Esmaeilzadeh, Mehri Ghasemi, Sudabeh Esmaeilzadeh. 1Immunology, Zanjan Medicall Collage, Zanjan, Zanjan, Islamic Republic of Iran; 2Zanjan University of Medical Scienc, Zanjan, Zanjan, Islamic Republic of Iran; 3Azad University of Bonab, Bonab, Azerbaijan e Shargi, Islamic Republic of Iran.

F2.06 - Prolonged Preterm Rupture of Fetal Membranes (PPROM), Is Associated with an Increased Maternal Anti-Fetal TT-Cell -Cell Responsiveness. A. Steinborn,1 C. Seidl,2 E. Schmitt,3 Y. Stein,1 A. Klee,4 M. Gonser,4 E. Seifried,2 C. Sohn.5 1Depart. Obstet. Gynecol., University of Frankfurt, Frankfurt/Main, Germany; 2Institute of Transfusion Medicine and Immunohaematology, Blood Transfusion Center of German Red Cross, Frankfurt/Main, Germany; 3 Institute of Immunology, University of Mainz, Mainz, Germany; 4 Depart. Obstet. Gynecol., Dr. Horst-Schmidt Hospital, F2.03 - Sildenafil Does Not Influence Natural Killer Cell Ac- Wiesbaden, Germany; 5Depart. Obstet. Gynecol., University tivity in W omen with a Histor y of Recurrent Spontaneous of Heidelberg, Heidelberg, Germany. History Women Abortion. AT3 Knock Down Reduces the Invasion of ChorioSTA M. Jerzak,1 M. Kniotek,2 N. Stachowicz,3 A. Gorski,2 W. F2.07 - ST 1 1 Baranowski. Department of Gynecology, Military Institute of carcinoma Cells. 1 2 1 Medicine, Warsaw, Poland; 2Department of Clinical Immunol- Tobias G. Poehlmann, Anja Meissner, Tobias Wengenmayer, 2 1 1 ogy, Transplantation Institute, University School of Medicine, Karlheinz Friedrich, Ekkehard Schleussner, Udo R. Markert. 2 1 3 Warsaw, Poland; 1st Department of Gynecology, University Obstetrics, Friedrich Schiller University, Jena, Germany; Biochemistry, Friedrich Schiller University, Jena, Germany. Medical School, Lublin, Poland. F2.04 - IgE Is Distributed on Macrophages Both in Human and Murine TTer er m Placentae. erm J. Wang,1 X. Cui.2 1Department of Immunology and Cell Biology, School of Animal Health Science, Hebei Agricultural University, Baoding, Hebei, China; 2Department of Medicine, Hospital Affiliated to Xuanhua Iron and Steel Company Ltd, Xuanhua, Hebei, China.

F2.08 - Evaluation of Four Different Methods of Sperm Surface Antigens Extraction Using Biotinilated Sperm Due to Finding a Better Method for ELISA TTechnique. echnique. Asghar Talebian, Mohammad Reza Sadeghi. 1Reproductive Endocrinology, Avesina Research Center, Tehran, Tehran, Islamic Republic of Iran; 2Reproductive Endocrinology, Avesina Research Center, Tehran, Tehran, Islamic Republic of Iran.

F2.05 - Complement Activation as a Mediator of Recurrent Immunologically-T riggered Miscarriages. Immunologically-Triggered G. Girardi,1 E. Chan,1 P. Redecha,1 J. M. Thurman,2 V. M. Holers,2 J. Salmon.1 1Department of Medicine, Hospital for Special Surgery-Weill Medical College, Cornell University, New York, NY, USA; 2Departments of Medicine and Immunology, University of Colorado HSC, Denver, CO, USA.

F2.09 - The Changes of T LLymphocyte ymphocyte CD Markers in Patients Exposed to Mustard Gas. Minoo K. Adib,1 Fariborz Mokarian,2 Mohammad R. Azizy.1 1 Immunology, Medical School.Isfahan University of Medical Sciences, Isfahan, Isfahan, Islamic Republic of Iran; 2Oncology, Omid Hospital.Isfahan University of Medical Sciences, Isfahan, Isfahan, Islamic Republic of Iran; 3Immunology, Medical School.Isfahan University of Medical Sciences, Isfahan, Isfahan, Islamic Republic of Iran. F2.10 - Binding of Phage Displaying Multimeric CD147 on U937 Cell Conducts Apoptotic Signal. Nutjeera Intasai,1 Watchara Kasinrerk,1 Sabine Mai,2 Chatchai Tayapiwatana.1 1Clinical Immunology, Fac of Associated Medical Sciences, Chiang Mai, Thailand; 2The Genomic Centre for Cancer Research & Diagnosis, Manitoba Institute of Cell Biology, Manitoba, Winnipeg, Canada.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

73

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F2.11 - Sensitivity of Soil Bacteria towards Cadmium Metal and Its Effect on Moung Bean Plant. Rafia Azmat, Aliya Hayat, Tanveer Khanum. 1Chemistry, Jinnah University for Women, Karachi, Sindh, Pakistan; 2Microbiology, Jinnah University for Women, Karachi, Sindh, Pakistan; 3Microbiology, Jinnah University for Women, Karachi, Sindh, Pakistan.

F2.17 - Cigarette Smoke Extract Impairs CD40 Ligand-Induced Maturation of Human Dendritic Cells. T. W. Barnes,1 P. R. Kroening,1 H. Kita,2 R. Vassallo.1 1Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA; 2Division of Allergic Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA.

F2.12 - Surgical TTrauma rauma and the Mannan-Binding Lectin (MBL) Pathway of Innate Immunity Immunity.. H. Ytting,1 I. J. Christensen,1 S. Thiel,2 J. C. Jensenius,2 H. J. Nielsen.1 1Dept. of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark; 2Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark.

F2.18 - Isolation of Lactobacilli, Bacillus and Psuedomonas from Y ogur o Deter mine Their Bacteriocin Activity Determine Yogur ogurtt and TTo Against V arious Clinical Isolates. Various Tanveer Khanum, Nadia Noor, Nasra Jalil, Sadaf Hedayat. 1 Microbiology, Jinnah University for Women, Karachi, Sindh, Pakistan; 2Microbiology, Jinnah University for Women, Karachi, Sindh, Pakistan.

y of Hemaimmune Reaction Road Map. F2.13 - The Theor Theory uAnti-TuF2.19 - Dendritic Cells Overexpressing FasL Induce Anti-T Guo Feng. 1Department of Blood Transfusion, Chang Hai Hos- moral TT-Cell -Cell Response In V ivo. Vivo. pital Second Military Medical University, Shanghai, China. Sofia Buonocore, Najate Ouled Haddou, Fabrice Moore, Marianne Laporte, Frederic Paulart, Francoise Flemal, Kris F2.14 - A Novel CD70+ APC Imprints a Unique Pattern of NK Thielemans, Michel Goldman, Veronique Flamand. 1LaboraReceptors on Gut Mucosal CD8 T Cells. tory of Experimental Immunology, Institut d’Immunologie A. Laouar,1 V. Haridas,1 R. A.W. van Lier,2 H. Yagita,3 N. Medicale (IMI), Brussels, Belgium; 2Dermatology Department, Manjunath.1 1Dept. of Pediatrics, Harvard Medical School, Erasme Hospital, Brussels, Belgium; 3Laboraory of Physiology, CBR Institute for Biomedical Research, Boston, MA, USA; 2Dept. Vrije Universiteit Brussel, Brussels, Belgium. of Pediatrics, Harvard Medical School, CBR Institute for Biomedical Research, Boston, MA, USA; 3Dept. of Laboratory Immunol- ™F2.20 - CD8aa + TT-Cells -Cells Represent a Long-Lived Memor y Memory ogy, Academic Medical Center, Amsterdam, Amsterdam, Neth- T-Cell Subset in Patients with Melanoma Undergoing Epitopeerlands; 4Dept. of Medicine, Juntendo University, Tokyo, Tokyo, Based TTumor umor V accination. Vaccination. Japan; 5Dept. of Pediatrics, Harvard Medical School, CBR InstiI. Magalhaes,1 N. K. Vudattu,1 K. Freitag,1 J. Karbach,2 A. tute for Biomedical Research, Boston, MA, USA. Kumar,3 Z. Zhu,3 K. Kuus-Reichel,3 M. Juelch,4 C. Castelli,5 E. Jaeger,2 M. Maeurer.1 1Dept. of Medical Microbiology, UniverF2.15 - CAUSAL Protein Signaling Networks Derived from sity of Mainz, Mainz, Germany; 2Dept. of Hematology/OncolMultiparameter Single-Cell Data. ogy, Krankenhaus Nordwest, Frankfurt, Germany; 3Immunomics 1 2 3 2 O. D. Perez, K. Sachs, D. Pe’er, D. Lauffenburger, G. P. Operation, Beckman Coulter Inc., San Diego, CA, USA; 4Thymed Nolan.1 1Department of Microbiology and Immunology, Stanford GmbH, Mainz, Germany; 5Dept. of Immunotherapy of Human University School of Medicine, Stanford, CA, USA; 2Biological Tumors, Istituto Tumori, Milano, Italy; 6Microbiology and Tumor Engineering Division, Massachusetts Institute of Technology, Cam- Biology Center, Karolinska Institute, Solna, Sweden. bridge, MA, USA; 3Department of Genetics, Harvard Medical School, Boston, MA, USA.

™F2.16 - Don’t Judge a Cell by Its Surface Only: Combination with Functional Assays. D. T. Montag,1 M. T. Lotze.1,2,3 1Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; 2Surgery, University of Pittsburgh, Pittsburgh, PA, USA; 3Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA, USA. 74

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F2.21 - Human Adipocyte and Its Participation in Innate Immunity Immunity.. Laurence Hoareau,1 Marie-Paule Gonthier,1 Regis Roche,1 Franck Festy,1 Christian Lefebvre D Hellencourt,1 Maya Cesari,1 JeanPierre Riviere,2 Marie-Amedee Dijoux,2 Sandrine Bes-Houtmann.1 1 University of Reunion, LBGM, Saint Denis, Reunion, France; 2 Laboratoire d’anapathologie, CHD Felix Guyon, Saint Denis, Reunion, France.

F2.26 - The Role of Mannose-Binding Lectin in Natural IgM Mediated Ischemia/Reper fusion Injur y. Ischemia/Reperfusion Injury M. Zhang,1 K. Takahashi,4 E. M. Alicot,6 T. Vorup-Jensen,1 B. Kessler,2 J. Christian Jensenius,5 R.A. B. Ezekowitz,4 F. D. Moore,3 M. C. Carroll.1 1CBR Institute of Biomedical Research, Harvard Medical School, Boston, MA, USA; 2Dept. of Pathology, Harvard Medical School, Boston, MA, USA; 3Surgery, Brigham and Women’s Hospital, Boston, MA, USA; 4Dept. of Pediatrics, Massachusetts General Hospital, Boston, MA, USA; 5Dept. of MediF2.22 - HDL-Reverse Cholesterol TTranspor ranspor rans- cal Microbiology and Immunology, University of Aarhus, Aarhus ransportt and Signal TTransC, Denmark; 6DecImmune Therapeutics, Boston, MA, USA. duction in TT-Cells. -Cells. T. Fulop,1 A. Larbi,1 A. Khalil,1 N. Douziech,1 C. Fortin,1 G. ve Nerve Dupuis.2 1Research Center on Aging, Universite de Sherbrooke, F2.27 - Effect of Plaferon LB on the Damaged Peripheral Ner Sherbrooke, QC, Canada; 2Deapartment of Biochemistry, Regeneration. Universite de Sherbrooke, Sherbrooke, QC, Canada. T. Chikovani,1,2 M. Kvezereli,2 G. Burkadze,1 T. Giorgadze,2 V. Bakhutashvili.2 1Microbilogy, Virology & Immunology, Tbilisi State F2.23 - The Effect of TTreatment reatment Recurrent Herpes Simplex with Medical University, Tbilisi, Georgia; 2Biomedicine, Institute of Medical Biotechnology, Tbilisi, Georgia. Larifan. 1 1 2 Evita Niedrite, Ingmars Mikazans, Guna Feldmane, Arija Volrate.2 1Dept. of Dermatovenereology, Riga Stradin’s Univer- F2.28 - Activation of the Lectin Pathway of Complement in Nephropathy.. sity, Riga, Latvia; 2Institute of Microbiology and Virology, Riga, IgA Nephropathy M. R. Daha,1 M. P. Rastaldi,2 M. A. Seelen,1 J. W. Eijgenraam,1 Latvia. B. D. Oortwijn,1 D. J. Van Gijlswijk - Janssen,1 M. C. Faber F2.24 - Multidimensional Liquid Phase Separations of Intact Krol,1 N. Calvaresi,2 M. Matsushita,3 T. Fujita,4 C. Van Kooten,1 1 1 Proteins as an Alternative to 2D Gel Electrophoresis for A. Roos. Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands; 2Renal Immunopathology CenProteomics. ter, Milan, Italy; 3Institute of Glycothechnology and Department A. Apffel,1 A. Adler,1 T. Sana,1 J. Garcia,1 R. Kincaid,1 S. of Applied Biochemistry, Tokai University, Hiratsuka, Japan; 4DeUdiavar.1 1Molecular Technologies Laboratory, Agilent Laborapartment of Biochemistry, Fukushima Medical University, tories, Palo Alto, CA, USA. Fukushima, Japan. F2.25 - Screening of Immunostimulator y Oligosaccharides Immunostimulatory by Using a New HPLC-Chip/MS TTechnology echnology echnology.. R. Grimm,1 H. Yin,1 M. Ninonuevo,2 K. Killeen,1 C. Lebrilla.2 1 Integrated Biology Solutions, Agilent Technologies, Palo Alto, CA, USA; 2Department of Biomedicine, UC Davis, Davis, CA, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

F2.29 - Characterisation of Antibody Titres in an Intravenous Immunoglobulin Concentrate (Flebogamma®). M. Lopez,1 J. I. Jorquera.1 1R&D Area, Instituto Grifols, S.A., Parets del Valles, Barcelona, Spain. F2.30 - FLEBOGAMMA® Intravenous Immunoglobulin; Evaluation of Neutralizing Antibodies to V accinia V irus. Vaccinia Virus. H. Biescas,1 R. Gajardo,1 A. Vandermeeren,2 M. Esteban,2 J. I. Jorquera.1 1Research and Development Area, Instituto Grifols, Barcelona, Spain; 2Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma, Madrid, Spain.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F2.31 - Compatibility Study of TTwo wo Intravenous Immunoglobulin Preparations with Plastic Containers. M. Lopez,1 M. Costa,1 J. I. Jorquera.1 1R&D Area, Instituto Grifols, S.A., Parets del Valles, Barcelona, Spain.

F2.37 - Use of C1 Inhibitor Concentrate for TTreatment reatment of Angioedema Attacks in Patients with C1 Inhibitor Deficiency Deficiency.. Sur vey of 1102 Infusions in 503 Patients. Survey A. Zanichelli,1 L. C. Zingale,1 B. Cicardi,1 L. Maggioni,1 E. Pappalardo,1 M. Cicardi.1 1Internal Medicine, University of F2.32 - Peripheral Blood LLymphocyte ymphocyte Immunological Profile Milan, Hospital S. Giuseppe, Milan, Milan, Italy. of Patients with Autoimmune Hepatitis in Different Stages of F2.38 - Immunonutritional Assessment of Special Plasma’ Plasma’ss Immunosuppressive Therapy Therapy.. 1 K. Gutkowski, M. Hartleb, A. Pluta, D. Gutkowska. Physio- Donors. therapy Institute, Rzeszow’s University, Rzeszow, Poland; Osmel Gaspar Guerra Segura, Nerys Noa Rdguez. 1Immunol2 Gastroenetology Department, Medical University of Silesia, ogy Lab, Teach.and Gen. Hosp. Dr. A.Neto, Guantanamo, Katowice, Poland; 3Physiotherapy Institute, Rzeszow’s Univer- Guantanamo, Cuba; 2Quality Control, Provincial Blood Bank, sity, Rzeszow, Poland; 4Epidemiology Department, Center for Guantanamo, Guantanamo, Cuba. Disease Control and Prevention, Rzeszow, Poland. F2.39 - Presentation of the Human Hepatitis B Surface AntiF2.33 - Identifying Common “Innate Signature” from Gene gen – Loop by the Cpn10 Scaffold Induces a Specific AntiExpression Profile in Innate vs. Adaptive LLymphocytes. ymphocytes. body Response in Mice by Genetic Immunization. T. Yamagata,1 C. Benoist,1 D. Mathis.1 1Section on Immunology S. Neckermann,1 J. Lohrmann,2 W. Zimmermann.1 1Tumor Imand Immunogenetics, Joslin Diabetes Center, Boston, MA, USA. munology Laboratory, Department of Urology, University Clinic Grosshadern, Ludwig-Maximilians-University, Munich, Germany; F2.34 - Different O-glycosylated Structures Are Expressed in 2GENOVAC GmbH, Freiburg, Germany. T Cell Activation. Marisela Linares,1 Ma.Carmen Jimenez-Martinez,1 Blanca F2.40 - Angioedema without Urticaria in 929 Italian Patients: Ortiz,2 Edgar Zenteno,2 Ricardo Lascurain.3 1Research Unit, Proposal for a Diagnostic and Therapeutic Approach. Institute of Ophthalmology, Fundacion Conde de Valenciana, L. C. Zingale,1 L. Beltrami,2 A. Zanichelli,1 M. Cicardi.1 1Dpt of Mexico, D.F., Mexico, D.F., Mexico; 2Biochemistry, Instituto Internal Medicine, University of Milan, Milan, Italy; 2Dpt of CarNacional Enfermedades Respiratorias, Mexico, D.F., Mexico, diology, University of Milan, Milan, Italy. D.F., Mexico; 3Biochemistry, Universidad Nacional Autonoma de Mexico, Mexico, D.F., Mexico, D.F. F2.41 - Dynamic Control of T Cell Homing by Gut and Pe-

F2.35 - Shor t-T er m Ator vastatin TTreatment reatment Enhances Specific Short-T t-Ter erm Atorvastatin Antibody Production Following TTetanus etanus TToxoid oxoid V accination Vaccination in Healthy V olunteers. Volunteers. P. Y. Lee,1 P. O. Scumpia,1 J. A. Byars,1 K. M. Kelly,1 H. Zhuang,1 D. Theriaque,1 J. Shuster,1 P. W. Stacpoole,1 M. S. Segal,1 W. H. Reeves,1 M. L. Brantly.1 1General Clinical Research Center, University of Florida, Gainesville, FL, USA.

ripheral Dendritic Cells. J. R. Mora,1 G. Cheng,1 D. Picarella,2 M. Briskin,2 N. Buchanan,2 U. H. von Andrian.1 1CBRI, Harvard Medical School, Boston, MA, USA; 2Millennium Pharmaceuticals, Cambridge, MA, USA.

F2.42 - Isoation and Characterization of W ater Isolates for Water Bacteriocinogenic Activity Activity.. Hina Waheed, Nazish Aziz, Tanveer Khanum, Kishwar Jabeen, Saba Ali Imama, Hina Rahat, Aliya Hayat. 1Microbiology, Jinnah F2.36 - An Immunology Syllabus to Student’ Student’ss Medicine. University for Women, Karachi, Sindh, Pakistan; 2Microbiology, 1 Osmel Gaspar Guerra Segura. Immunology Lab, Teach. and Same, Karachi, Sindh, Pakistan; 3Microbiology, Same, Karachi, Gen. Hosp. Dr. A. Neto, Guantanamo, Guantanamo, Cuba. Sindh, Pakistan; 4Microbiology, Same, Karachi, Sindh, Pakistan; 5 Microbiology, Same, Karachi, Sindh, Pakistan.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F2.43 - Inhibition of Pericardic Adhesions by the Amoebian Anti-Inflammator y Pentapeptide (MLIF). Preliminar y Results. Anti-Inflammatory Preliminary J. A. Gimenez-Scherer,1 C. Riera-Kinkel,2 R. Silva-Garcia,1 M. G. Rico Rosillo,1 J. Garcia,3 E. Foyo,3 E. Tena,3 R. Arguero,2 R. R. Kretschmer. 1 1Unidad de Investigacion Medica en Inmunologia, H. Pediatria, Centro Medico Nacional Siglo XXI, IMSS, Mexico, DF, Mexico; 2Hospital de Cardiologia, Centro Medico Nacional Siglo XXI, IMSS, Mexico, DF, Mexico; 3Bioterio, Centro Medico Nacional Siglo XXI, IMSS, Mexico, DF, Mexico.

F2.49 - Protective Effect of Thalidomide in Rats with Granuloma in the Cerebral Amygdala and Pentylenetetrazole-Induced Epilepsy Epilepsy.. L. Aguirre-Cruz,1 M. Martinez-Moreno,1 G. Palencia,1 N. Mendez-Mar,1 J. Manjarrez,2 R. Alvarado,2 E. Flores,3 M. Pacheco,3 P. Salgado,3 L. Rodriguez-Fragoso,4 J. Sotelo.1 1 Neuroimmunology Department, National Institute of Neurology and Neurosurgery (INNN), Mexico City, Mexico; 2Reticular Formation Physiology Laboratory, INNN, Mexico City, Mexico; 3 Magnetic Resonance Unity, INNN, Mexico City, Mexico; 4PharF2.44 - Attenuation of the GAA-Specific Immune Response in macy Faculty, Autonomous University of Morelos, Cuernavaca, 6 neo/6neo GAA Knockout Mice, a Model of Pompe Disease. Morelos, Mexico. K. J. Munroe,1 S. M. Richards,1 R. D. Garman,1 A. M. Joseph.1 1 ™F2.50 - Self-Limitation of Th1-Mediated Inflammation by &, Framingham, MA, USA. Ig!õ F2.45 - The Effect of Electro Active Dental Metal Fillings Re- M. Feuerer, K. Eulenburg, A. Hamann, J. Huehn. 1Exp. Rheuplacement on LLymphocyte ymphocyte Activity in Patients with Oral Dis- matology, Charite Universitaetsmedizin Berlin, Berlin, Germany. comfort. J. Prochazkova,1 S. Podzimek,1 M. Miksovsky,1 J. Bartova,1 K. Hana.2 1Clinical Department, The Institute of Dental Research, 1st Medical Faculty and GUH, Charles University, Prague, Czech Republic; 2Research Department, The Institute of Biomedical Engineering, Czech Technical University, Prague, Czech Republic.

™F2.51 - Origin and Generation of Distinct CD4+ Regulator y T Cell Subsets. tory C. Siewert,1 K. Siegmund,1 M. Feuerer,1 L. Klein,2 A. Hamann,1 1 J. Huehn. 1 Experimental Rheumatology, Charite Universitaetsmedizin Berlin, Berlin, Germany; 2IMP/IMBA, Vienna, Austria.

F2.46 - A Review of the Allergic /T oxic Adverse Reactions to /Toxic Anti-T uberculous Drugs(A TD), A 10 Y ears Therapeutic Sur vey Drugs(ATD), Years Survey vey.. F2.52 - Correlation between Histamine and Mast Cells and Anti-Tuberculous 1 M. Ishaq, Taj M. , I. M. Sameera. Allergy/Pulmonology, Al- Presence of IgE. Junaid Hospital, Nowshera, Pakistan. Mandana Sattari,1 Shidehmehr Mofakham,1 Saeed Khalili.1 1 Immunology, Shaheed Beheshti University, Medical School, ™F2.47 - Defective Intrathymic T Cell Development and Early Tehran, Islamic Republic of Iran. Onset of IBD in Mice Devoid of W ASP and N-W ASP WASP N-WASP ASP.. V. Cotta-de-Almeida,1,3 D. Onaldi,1 M. Maillard,1,4 F. W. Alt,2 S. B. Snapper.1 1Dept of Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; 2Dept of Genetics, Children’s Hospital/Harvard Medical School, Boston, MA, USA; 3Dept of Cell Biology, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil; 4Lausanne University Hospital, Lausanne, Switzerland.

F2.53 - Neutrophil Chemotaxis and Dental Caries. Mandana Sattari,1 Saeed Khalili,1 Maryam Basirat.1 1Immunology, Shaheed Beheshti University Medical Science, Tehran, Islamic Republic of Iran.

F2.54 - Correlation between Neuropeptides Concentration and Different Parts of Human Gingiva and the Effects of Neuropeptides on Neutrophil Death. F2.48 - FFAS AS Induced Apoptosis – A Model System for BiF ARTM Mandana Sattari,1 Saeed Khalili.1 1Immunology Dept, Shaeed BiFAR Implementation. Beheshti University of Medical Science, Tehren, Islamic Republic H. Kalinski, A. Chajut, A. Khan, R. Skaliter. 1Research and of Iran. Development, Quark Biotech, Inc., Fremont, CA, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

77

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

F2.55 - Human MyD88s Is the Result of MyD88 Splicing like That Reported in the Mouse. A. Dominguez,1 J. L. Ventura,2 A. Zentella,2 R. Kretschmer,1 J. R. Velazquez.1 1Investigation in Medical Immunology, Instituto Mexicano del Seguro Social CMNSXXI, Mexico City, DF, Mexico; 2 Biochemestry, Instituto Nacional de Nutricion Salvador Zubiran, Mexico City, DF, Mexico.

Poster Session 1 Saturday,, May 14, 2005 Saturday 7:30 am - 1:30 pm Autoimmune Neurologic Diseases

™Sa1.01 - Receptor-Modified T Cells as Novel Therapeutic

Approach for Multiple Sclerosis. I. Moisini, T. L. Geiger. 1Pathology, St. Jude Children’s Research F2.56 - Relationship of School Attendance with Quality of Hospital, Memphis, TN, USA; 2Pathology, University of TennesLife, Physical Function, Disease Activity and Damage in Pe- see Health Science Center, Memphis, TN, USA. diatric Systemic Lupus Er ythematosus. Erythematosus. L. N. Moorthy,1 M. G. Peterson,2 M. J. Harrison,2 K. B. Onel,3 Sa1.02 - The Role of Leukemia Inhibitor y Factor (LIF) in ExInhibitory M. J. Baratelli,1 D. R. Mohan,1 Thomas Lehman.2 1Robert Wood perimental Autoimmune Encephalomyelitis (EAE). Johnson University, New Brunswick, NJ; 2Hospital for Special R. A. Linker,1 A. Wieczarkowiecz,1 S. Weikard,2 N. Kruse,1 C. Surgery, New York, NY; 3La Rabida Children’s Hospital, ChiKleinschnitz,2 B. Holtmann,3 M. Sendtner,3 R. Gold.1 1Insitute cago, IL. for Multiple Sclerosis Research, University of Goettingen and Gemeinnuetzige Hertie-Stiftung, Goettingen, Germany; 2Dept. F2.57 - Improvement of Antimycobacterial Therapy Due to IL- of Neurology, Clinical Research Group for Multiple Sclerosis, 10 Activity Blockage Is Strain Dependent. University of Wurzburg, Wuerzburg, Germany; 3Institute for 1,2 1 1,3 S. Roque, C. Nóbrega, R. Appelberg, M. Correia-Neves. Neurobiology, University of Wurzburg, Wuerzburg, Germany. 1 Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology (IBMC), Porto; 2Mestrado Sa1.03 - Novel Immunotoxin: A Fusion Protein Consisting of de Imunologia Clinica, Universidade da Beira Interior; 3Instituto Gelonin and an Acetylcholine Receptor Fragment as a PotenSuperior de Saude do Alto Ave (ISAVE), Fontarcada, Portugal. tial Immunotherapeutic Agent for the TTreatment reatment of MyastheF2.58 - Quality Control of DNA with the Agilent 2100 nia gravis. 1 M. Hossann, Z. Li,2 Y. Shi,2 U. Kreilinger,1 J. Buettner,1 P. D. Bioanalyzer for Oligonucleotide Array CGH (aCGH). Vogel,1 Y. Jingming,2 J. G. Wise,1 W. E. Trommer.1 1Chemistry, Samar Lightfoot,1 Hans Brunnert,2 Carsten Buhlmann,2 Paige TU Kaiserslautern, Kaiserslautern, Germany; 2Biotechnology, Anderson.1 1Agilent Technologies, Palo Alto, USA; 2Agilent TechShanxi University, Taiyuan, China. nologies, Waldbronn, Germany. F2.59 - Improvement of Antimycobacterial Therapy Due to IL10 Activity Blockage is Strain Dependent S. Roque,1,2 C. Nóbrega, R. Appelberg,1 M. Correia-Neves.1,3 1 Laboratory of Microbiology and Immunology of Infection, Institute for Melecular and Cell Biology (IBMC), Porto; 2Mestrado de Imunologia Clínica, Universidade da, Beira Interior; 3Instituto Superior, de Saúde do Alto Ave, Fontarcada, Portugal.

Sa1.04 - Fumarate Therapy Ameloriates Chronic Experimental Autoimmune Encephalomyelitis (EAE). S. Schilling,1 S. Goelz,2 R. A. Linker,1 F. Luhder,1 R. Gold.1 1Institute for Multiple Sclerosis Research, University of Goettingen and Gemeinnuetzige Hertie-Stiftung, Goettingen, Germany; 2 Biogen Idec, Cambridge, USA.

Sa1.05 - Beneficial Autoimmunity Restrains Destructive Immuy Manner Regulatory Manner.. F2.60 - Somatostatins in Clinical Immunology: An Over view nity in a Regulator Overview 1 Nathan Karin, Yaniv Zohar,1 Uri Weinberg,1 Rachel Anunu,1 P.M. Van Hagen, V. Dalm, L.J. Hofland Dept. Internal Medicine 1 1 Gizi Wildbaum. Immunology, Rappaport Faculty of Mediand Immunology, Erasmus MC, Rotterdam, The Netherlands cine, Technion, Haifa, Israel.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.06 - CD4+CD25+FoxP3+ Regulator y T Cells Are a Highly Regulatory Apoptosis Sensitive T Cell Population with an Impaired Suppressive Function in Multiple Sclerosis. B. Fritzsching,1,2 N. Oberle,1 N. Eberhardt,1 J. Haas,2 M. Korporal,2 B. Wildemann,2 P. H. Krammer,1 E. Suri-Payer.1 1Department of Immunogenetics, German Cancer Research Center, Heidelberg, Germany; 2Section of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany.

™Sa1.12 - Antibodies Specific for Myelin Proteolipid Pro-

™Sa1.08 - The Pathology of Progressive Multiple Sclerosis.

Sa1.14 - The MHC Is the Major Determinant for the Requirement of B7.1/7.2-Costimulation in the Induction of Experimental Autoimmune Encephalomyelitis (EAE). B. Greve,1 C. Jabs Mansell,1 R. A. Sobel,2,3 A. H. Sharpe,4 V. K. Kuchroo.1 1Center for Neurologic Diseases, Harvard Institutes of Medicine, Brigham and Women’s Hospital, Boston, MA, USA; 2Laboratory Service, Veterans Affairs Medical Center, Palo Alto, CA, USA; 3Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; 4Department of Pathology, Harvard Medical School, Boston, MA, USA.

tein Are of Potential Pathogenic Relevance in Myelin Opsonization in Multiple Sclerosis. J. M. Greer,1 M. P. Pender.1 1School of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Sa1.13 - Autoantigen Specific T Cells Inhibit Glutamate Uptake in Astrocytes by Decreasing Expression of Astrocytic Glutamate TTranspor ranspor ter GLAST – A Mechanism Mediated by ransporter Tumor Necrosis Factor -a. Factor-a. ™Sa1.07 - Accumulation of CD4+CD25+ Regulator y T Cells Regulatory T. Korn,1 T. Magnus,2 S. Jung.1 1Department of Neurology, in the CNS during Recover y from EAE. Recovery Universitaet des Saarlandes, Homburg, Germany; 2Stem Cell M. J. McGeachy,1 L. A. Stephens,1 S. M. Anderton.1 1Institute Section, Laboratory of Neurosciences, National Institute on Agof Immunology and Infection Research, University of Edinburgh, ing, National Institutes of Health, Baltimore, MD, USA. Edinburgh, United Kingdom.

A. E. Kutzelnigg,1 C. Lucchinetti,2 W. Brueck,3 M. Schmidbauer,4 H. Lassmann.1 1Department of Neuroimmunology, Brain Research Center, Medical University Vienna, Vienna, Austria; 2Department of Neurology, Mayo Clinic, Rochester, MN, USA; 3Institute of Neuropathology, University of Goettingen, Goettingen, Germany; 4Department of Neurology, Municipal Hospital Lainz, Vienna, Austria.

Sa1.09 - Endoneural CD34+ Fibroblasts: Putative Regulators ve? Nerve? of Macrophage Activation in the Peripheral Ner scFv,, a Single-Chain Antibody Antibody,, AttenuSa1.15 - Anti-CTLA4 scFv A. Kroner,1 B. D. Kohl,1 I. Kobsar,1 R. Martini,1 M. Maeurer.1 ated Host Immune Responses during Repeated DNA Humoral 1 Experimental Developmental Neurobiology, Julius Maximilians Vaccination in Immune Competent Animals. University, Wuerzburg, Bavaria, Germany. An-Bang Liu,1 Steve R. Roffler.2 1Neuromuscular Research, Tzu Sa1.10 - Decreased TT-Cell -Cell Immunity to Epstein-Barr V irus in Chi Neuro-Medical Scientific Center, Tzu Chi Medical Center, Virus Hualien, Taiwan; 2Institute of Biomedical Science, Academia Multiple Sclerosis. Sinica, Taipei, Taiwan. M. P. Pender, A. Lenarczyk, J. M. Burrows, J. Harness, S. R. 1 Burrows. Medicine, The University of Queensland, Brisbane, y CD4+ T Cells and EAE. Memory QLD, Australia; 2Queensland Institute of Medical Research, Sa1.16 - Memor 1 1 W. Elyaman, T. Chitnis, J. Imitola,1 M. H. Sayegh,2 S. J. Khoury.1 Brisbane, QLD, Australia. 1 Center for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA, USA; 2Transplantation Center, Brigham and Sa1.11 - HLA-DR2 Is Associated with Chronic Inflammator y Inflammatory Women’s Hospital and Children’s Hospital, Boston, MA, USA. Demyelinating Polyradiculoneuropathy (CIDP) in Females, but Not Males. Sa1.17 - Therapeutic Effects of Glycosylated β Interferon P. A. McCombe,1 P. A. Csurhes,1 M. A. Alizart,1 J. M. Greer.1 (βIFN) on Childhood Adrenoleukodystrophy (ALDCCER) 1 School of Medicine, University of Queensland, Brisbane, G. A. Moviglia,1 A. E. Pereyra,1 G. S. Shuster,2 C. Ruggilo.2 Queensland, Australia. 1 Immunotherapy, Regina Mater Foundation, Buenos Aires, Argentina; 2MRI, Medical Image, Buenos Aires, Argentina. ™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

79

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.18 - Anti-Myelin Antibodies as an Immune-Modulator y Immune-Modulatory Marker for IVIG TTreatment reatment in Patients with Progressive Multiple Sclerosis. Sarah B. Kelley, Isaac Melamed, David Barr-Or. 1Immunology, 1st Immunology and Infusion Center, Englewood, CO, USA; 2Immunology, 1st Immunology and Infusion Center, Englewood, CO, USA; 3Trauma Research Department, Swedish Medical Center, Englewood, CO, USA.

™Sa1.19 - T Cell TTolerance olerance Induced by Cross-Reactive TCR Ligands Can Be Broken by Superagonist Ligand Resulting in Anti-Inflammator y Cytokine Production. Anti-Inflammatory Z. Illes,1,2 H. Waldner,1 J. Reddy,1 E. Bettelli,1 L. B. Nicholson,1,3 V. K. Kuchroo.1 1Center for Neurologic Diseases, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA; 2Department of Neurology, University of Pecs, Pecs, Hungary; 3School of Medical Sciences, Bristol, United Kingdom.

™Sa1.20 - Agonistic Anti-CTLA4 Antibody Inhibits T Cells

Sa1.23 - Individual Statins Differ in Immunomodulator y PoImmunomodulatory o TTreat reat Th1-Mediated CNS Autoimtential and Capability TTo mune Disease. M. J. Goldstein,1 M. S. Weber,2 S. E. Dunn,1 T. Prod’homme,2 L. Steinman,1 S. S. Zamvil,2 S. Youssef.1 1Neurology, Stanford University, Stanford, CA, USA; 2Neurology, University of California, San Francisco, CA, USA. Sa1.24 - FMRI Correlates of Strategic Planning in Multiple Sclerosis. J. J. Randolph,1 H. A. Wishart,1 R. M. Roth,1 B. C. McDonald,1 J. W. MacDonald,1 J. D. West,1 N. S. Koven,1 A. C. Mamourian,2 L. H. Kasper,3 A. J. Saykin.1 1Department of Psychiatry, Dartmouth Medical School, Lebanon, NH, USA; 2Department of Radiology, Dartmouth Medical School, Lebanon, NH, USA; 3Section of Neurology, Dartmouth Medical School, Lebanon, NH, USA. Sa1.25 - A New Clinically Relevant Approach TTo o Expand Myelin Specific T Cells. Nathalie Arbour,1 Rejean Lapointe,2 Philippe Saikali,1 Jack P. Antel.1 1Neuroimmunology Unit, Montreal Neurological Institute McGill University, Montreal, QC, Canada; 2Department of Medicine, Faculty of Medicine, University of Montreal (Hospital Centre Notre-Dame), Montreal, QC, Canada.

Expansion, Cytokine Production and Development of Autoimmunity munity.. K. Miyamoto,1,3 L. Vijayakrishnan,1 E. Greenfield,1 B. Carreno,1 A. Sharpe,2 V. Kuchroo.1 1Center for Neurolosic Diseases, BWH, Harvard Medical School, Boston, MA, USA; 2Pathology, BWH, Harvard Medical School, Boston, MA, USA; 3Neurology, Kinki Sa1.26 - IL-15 and IL-2 Fusion Proteins Attenuate ExperimenUniversity, Osaka-Sayama, Osaka, Japan. tal Autoimmune Encephalomyelitis. Sa1.21 - TTumor umor Necrosis Factor Factor-- α Gene Polymorphism in C. Gutierrez,1 T. Chitnis,1 M. H. Sayegh,2 X. X. Zheng,3 S. J. Khoury. 1Center for Neurologic Diseases, Brigham and Women’s Iranian Patients with Multiple Sclerosis. 2 M. Izad,1 A. A. Amirzargar,1 D. Fathi,2 M. H. Niknam,1 M. Hospital, Boston, MA, USA; Transplantation Center, Brigham Hospital and Children’s Hospital, Boston, MA, Vodjgani.1 1Dep.of Immunology, Faculty of Medicine, Tehran and Women’s 3 USA; Immunology, Beth Israel Deaconess Medical Center, BosUniversity of Medical Sciences, Tehran, Islamic Republic of Iran; ton, MA, USA. 2 Dep. of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. Sa1.22 - Corticotropin-Releasing Hormone Contributes to the Peripheral Inflammator y Response in Experimental AutoimInflammatory mune Encephalomyelitis. Y. Wang,1 C. Benou,1 J. Imitola,1 L. VanVlerken,2 C. Chandras,2 K. P. Karalis,2 S. J. Khoury.1 1Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; 2Division of Endocrinology, Children’s Hospital and Harvard Medical School, Boston, MA, USA.

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Sa1.27 - Dendritic Cells from the Mesenteric LLymph ymph Nodes of OV A Fed Animals Stimulate Naïve T Cells In V itro TTo o ExOVA Vitro press Latency-Associated Peptide. Kaiyong Yang,1 Ana Faria,2 Howard L. Weiner.1 1Center for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA, USA; 2Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Brazil.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.28 - Immature Dendritic Cells Can Reduce Experimental Autoimmune Encephalomyelitis in the Mouse. M. I. Iruretagoyena,1 S. E. Sepulveda,1 A. M. Kalergis.1 1 Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile.

Sa1.34 - Intrathymic Expression of TTorpedo orpedo Acetylcholine Receptor Alpha Subunit. D. Song,1 Y. Zheng,1 A. I. Levinson.1 1Allergy/Immunology Section, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Sa1.29 - CD4+CD25+ Regulator y T Cells Mediate Recover y Regulatory Recovery from Experimental Autoimmune Encephalomyelitis in Association with LAP+TGF β Secreting Cells. H. Ochi,1,2 X. Zhang,1,2 J. Reddy,1 D. Frenkel,1 V. K. Kuchroo,1 H. L. Weiner.1 1Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 2Contributed Equally.

Sa1.35 - The Cytokine Pattern of Glatiramer Acetate Reactive CD8+ T Cell Lines Derived from MS Patients and Healthy V olVolunteers. A. Dressel,1 A. Vogelgesang,1 S. Peters,1 F. Weber.2 1Department of Neurology, University Greifswald, Greifswald, Germany; 2 Section of Neurology, Max-Planck-Institute of Psychiatry, Munich, Germany.

Sa1.30 - Genetic Markers of Disease Risk, Prognosis and Treatment Response in Multiple Sclerosis. A. Foti,1 D. Lichter,1 J. Parekh,1 J. Bryce,3 G. Ginsburg,1 J. LekstromHimes,1 D. Hafler,2 P. DeJaeger,2 R. Roubenoff,1 S. Khoury,2 H. Weiner,2 A. Parker.1 1Department of Molecular Medicine, Millennium Pharmaceuticals, Inc., Cambridge, MA, USA; 2Department of Neurology, Harvard Medical School, Boston, MA, USA; 3 Department of Clinical Operations, Millennium Pharmaceuticals, Inc., Cambridge, MA, USA.

Sa1.36 - An Exploration of the Role of TLR2 and TLR4 in CD14+ Cells in Multiple Sclerosis. P. L. De Jager, C. S. Wolfish, V. Viglietta, J. Flores, H. L. Weiner, D. A. Hafler, S. J. Khoury. 1Neurology, Brigham and Women’s Hospital, Center for Neurologic Diseases, Harvard Medical School, Boston, MA, USA;

Sa1.31 - Investigating Anti Human MOG Antibodies in Multiple Sclerosis Using Stably MOG TTransduced ransduced Cell Lines. Rajneesh Srivastava,1 Dun Zhou,1 Stefan Nessler,1 Sabine Cepok,1 Hans-Peter Hartung,1 Bernhard Hemmer.1 1Department of Neurology, Heinrich-Heine-University Dusseldorf, Dusseldorf, NRW, Germany.

Sa1.37 - Regulation of Expression of Matrix Metalloproteinases in CNS Inflammation V ersus CNS Injur y. Versus Injury H. Toft-Hansen,1 A. A. Babcock,1 R. K. Nuttall,2 D. R. Edwards,2 T. Owens.1,3 1Neuroimmunology, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; 2School of Biological Sciences, University of East Anglia, Norwich, Norfolk, United Kingdom; 3Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark.

Sa1.38 - Searching for Biomarkers in Multiple Sclerosis: The Sa1.32 - Role of CD46 in Multiple Sclerosis. Need for Natural Histor y Studies. History A. L. Astier,1 D. A. Hafler.1 1Center for Neurologic Diseases, Vissia Viglietta,1 Bonnie Glanz,1 Guy Buckle,1 Howard L. Brigham and Women’s Hospital, Boston, MA, USA. Weiner,1 Samia J. Khoury.1 1Neurology, Brigham and Women’s Hospital, Boston, MA, USA. ™Sa1.33 - Myelin-Specific Cytokine Responses Show a Dramatic Gender Bias in Multiple Sclerosis (MS). Sa1.39 - Protection in a Rodent Model of Multiple Sclerosis I. M. Moldovan,1 A. C. Cotleur,1 N. Zamor,1 J.-C. Lee,3 R. A. by Carbon Monoxide Release. Rudick,2 C. M. Pelfrey.1 1Neurosciences, NC30, Cleveland Clinic M. V. George,1 S. Iyer,2 L. Gao,3 T. Fong,4 R. Buelow,5 D. J. Foundation, Cleveland, OH, USA; 2Mellen Center for MS Treat- Matthes.1 1Biological Sciences, San Jose State University, San ment and Research, Cleveland Clinic Foundation, Cleveland, Jose, CA, USA; 2Development Sciences, Genentech, South San OH, USA; 3Biostatistics, Cleveland Clinic Foundation, Cleveland, Francisco, CA, USA; 3Research, Genzyme Corporation, OH, USA. Framingham, MA, USA; 4Research, Cellerant Therapeutics, Palo Alto, CA, USA; 5Research, Therapeutic Human Polyclonals, Mountain View, CA, USA. ™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Sa1.40 - IFN γ− Dependent Regulation of the Neutrophil- ™Sa1.45 - Genetic Resistance to Autoimmunity Is Mediated IFNγ− γ−Dependent Activating Cytokines IL-17 and IL18 in EAE. R. D. Wheeler,1 L. M. Kelly,1 S. L. Carter,1 T. Owens.1,2 1 Neuroimmunology Unit, Montreal Neurological Institute, Montreal, QC, Canada; 2Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark.

by Autoantigen-Specific CD4+CD25+ Regulator y Cells. Regulatory J. Reddy, Z. Illes, X. Zhang, J. Encinas, J. Pyrdol, L. Nicholson, R. Sobel, K. Wucherpfennig, V. Kuchroo. 1Center for Neurologic Diseases, Brigham and Women’s Hosp/Harvard Medical School, Boston, MA, USA; 2Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, USA; 3Pathology, Sa1.41 - Differential Reactivity Against Solid-Phase and Liq- Stanford University School of Medicine, Stanford, CA, USA. uid-Phase Myelin/Oligodendrocyte Glycoprotein in Multiple Autoimmune Rheumatologic Diseases Sclerosis and Experimental Allergic Encephalomyelitis. 1 2 1 1 T. Menge, H.C. von Budingen, P. H. Lalive, S. L. Hauser, C. Sa1.46 - A 20 Y ear Old with Knee Ar thritis Develops Multiple Year Arthritis P. Genain.1 1Department of Neurology, University of California Organ Dysfunction: Think Zebras, Not Horses. San Francisco, San Francisco, CA, USA; 2Neurologische Klinik, P. B. Pinho,1 M. Rodriguez,1 D. Menasha,1 B. Suri,1 M. YouseffUniversitat Zurich, Zurich, Switzerland. Bessler,1 B. Suri,1 R. K. Messo,2 L. Bielory.1 1Internal Medicine, UMDNJ-NJMS, Newark, NJ, USA; 2Internal Medicine, Staten Sa1.42 - Characterization of B Cell Immunoglobulin V ariable Island University Hospital, Staten Island, NY, USA. Variable Region Genes Derived from Muscle Tissue of Subjects with Inclusion Body Myositis. Sa1.47 - Differential Expression of Co-Stimulator y Molecules Co-Stimulatory E. M. Bradshaw,1 L. Bregoli,1 A. A. Amato,2 D. A. Hafler,1 S. A. on PBMCs from Patients with Active Systemic Lupus Er ytheErytheGreenberg,2 K. C. O’Connor.1 1Department of Neurology, matosus and Rheumatoid Arthritis. Center for Neurologic Diseases, Brigham and Women’s HospiE. Rojas-Ramos,1 N. E. Martinez-Jimenez,1 Y. B. Garfias,2 E. G. tal, Boston, MA, USA; 2Department of Neurology, Division of Zenteno,2 R. L. Lascurain.2 1Clinical Immunology and Allergy, Neuromuscular Disease, Brigham and Women’s Hospital, BosISSSTE, Mexico, Mexico City, Mexico; 2Biochemistry, INER, SSA, ton, MA, USA. Mexico, Mexico City, Mexico. Sa1.43 - Analysis of Genomic DNA from Human Single Cells Using Multiple Displacement Amplification: Application to Band TT-Cell -Cell Receptor V ariable Region Genes. Variable L. Bregoli, K. O’Connor, D. A. Hafler. 1Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

Sa1.48 - Effects of TTaxus axus Y unnanensis for the Pain on Patients Yunnanensis with Rheumatoid Arthritis. Testuroh Okano, 1 Koya Kubo, 1 Yutaka Tajima, 2 Osamu Nakajima,3 Takahiro Nobukawa.4 1Immunology/AHS, Kitasato Univ, Sagamihara, Kanagawa, Japan; 2Infectiom Control Sciences, Juntendo Univ, Bunkyo, Tokyo, Japan; 3Rheumatology, Institute of Chem. Therapy, Chiba, Chiba, Japan; 4Med. Res. ariable Institute, Kanazawa Med. Univ., Kanazawa, Isikawa, Japan. Sa1.44 - Characterization of B Cell Immunoglobulin V Variable Region Genes Derived from Lesions of Patients with MS. K. C. O’Connor,1 N. H. Moore,1 L. Bregoli,1 E. Bradshaw,1 K. Sa1.49 - Protection from Collagen-Induced Arthritis by Wucherpfennig,2 D. A. Hafler.1 1Department of Neurology, Complement Receptor CR2/CR1 Deficiency Deficiency.. Harvard Medical School, Brigham and Women’s Hospital, Bos- K. A. Kuhn,1 V. M. Holers.1 1Immunology and Medicine, Uniton, MA, USA; 2Department of Cancer Immunology and AIDS, versity of Colorado Health Sciences Center, Denver, CO, USA. Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Sa1.50 - Leptin Modulates Autoimmune Reactivity in (NZB x NZW)F1 Lupus Mice. A. La Cava, F. M. Ebling, B. H. Hahn. 1Medicine/Rheumatology, University of California Los Angeles, Los Angeles, CA, USA.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.51 - Hyperhomocysteinemia in Hughes Syndrome. J. Carbone,1 A. Rodriguez-Huertas,2 E. Dulin,3 M. Rabadan,2 E. Sarmiento,1 D. Micheloud,1 R. Mora,1 E. Fernandez-Cruz.1 1 Clinical Immunology Unit, University Hospital Gregorio Maranon, Madrid, Spain; 2Hematology Department, University Hospital Gregorio Maranon, Madrid, Spain; 3Biochemistry Department, University Hospital Gregorio Maranon, Madrid, Spain.

Sa1.56 - Interferon-alpha Pathway Activation Identifies a Subgroup of Systemic Lupus Er ythematosus Patients with AntiErythematosus bodies against RNA-Binding Proteins, Renal Disease, and Low Complement. K. A. Kirou,1 C. Lee,1 S. George,1 K. Louca,1 M. G.E. Peterson,1 M. K. Crow.1 1Mary Kirkland Center for Lupus Research and Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY, USA.

Sa1.52 - Atherosclerosis in Murine SLE. Zhongjie Ma,1 Marc Monestier,2 Robert Eisenberg.1 1DepartSa1.57 - The Rheumatic Joint Contains Hyperreactive CD28null ment of Medicine, University of Pennsylvania, Philadelphia, PA; + 2 Department of Microbiology and Immunology, Temple Univer- CD4 T Cells. 1 A. E.R. Fasth, A.-K. Ulfgren,1 L. Klareskog,1 C. Trollmo,1 V. sity, Philadelphia, PA. Malmstrom.1 1Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. Sa1.53 - Association of a Single Nucleotide Polymorphism of PTPN22 (1858C/T) with Rheumatoid Factor Positivity in a Sa1.58 - Absence of B Cells Decreases Both Proliferation Healthy Population. and Cytokine Secretion. K. D. Deane,1 L. A. Parrish,1 D. S. Majka,1 J. H. Buckner,2 V. T. Wallerskog,1 L. Klareskog,1 V. Malmstrom,1 C. Trollmo.1 1RheuGersuk,2 P. Concannon,2 J. M. Norris,3 V. M. Holers.1 1Division matology Unit, Department of Medicine, Karolinska Institutet, of Rheumatology, University of Colorado Health Sciences CenStockholm, Sweden. ter, Denver, CO, USA; 2Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; 3Deparment of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Sa1.59 - Synovial Fluid NKT Cells Display Different Properties Compared to Peripheral Blood NKT Cells in Rheumatoid Denver, CO, USA. Arthritis. Sa1.54 - Anti C1q, Anti Histone Antibodies and C1q Depos- L. Linsen, V. Somers, M. Thewissen, P. Geusens, J. Raus, P. Stinissen. 1Biomedisch Onderzoeksinstituut (BIOMED), Limburgs its in Silent Lupus Nephritis. M. E. Zabaleta-Lanz,1 L. E. Munoz,1 R. E. Vargas-Arenas,1 F. J. Universitair Centrum (LUC)/Transnational University Limburg (tUL), Tapanes,1 N. E. Bianco.1 1Institute of Immunology, Central Uni- Diepenbeek, Belgium. versity School of Medicine, Caracas, DF, Venezuela.

Sa1.60 - Regulation of Myeloid Cell Function and MHC Class TNF.. Sa1.55 - Modulation of Inflammation in Refractor y II Expression by TNF 1 R. B. Mueller, A. Skapenko,1 M. Grunke,1 J. Wendler,1 B. Rheumathoid Arthritis by Granulocyte Apheresis: First Euro2 Stuhlmuller, J. R. Kalden,1 H. Schulze-Koops.1 1Department of pean Prospective Multicenter Open Pilot Study Study.. Internal Medicine III, University of Erlangen, Erlangen, Germany; R. Sanmarti,1 R. Lafuente,2 J. Gratacos,3 J. Valverde,4 S. Marsal,5 2 Department of Rheumatology, Charite University Hospital, Ber3 4 1 5 1 E. Casado, D. Reina, J. Rodriguez, A. Erra. Rheumatollin, Germany. 2 ogy, Hospital Clinic i Provincial, Barcelona, Spain; Intensive Care Unit, Hospital De L´Hospitalet, Barcelona, Spain; 3 Rheumathology, Hospital Parc Tauli, Sabadell, Barcelona, Spain; 4 Rheumathology, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain; 5Rheumathology, Hospital Vall d´Hebron, Barcelona, Spain.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

83

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.61 - Isolated TType ype 5 Antimitochondrial Autoantibodies Associated with Histor y of Thrombocytopaenia and Foetal History Loss. Alvarez Silvia, Sanchez-Ramon Silvia, Rodriguez-Mahou Margarita, Carbone Javier, Gil Juana, Micheloud Dariela, Fernandez-Cruz Eduardo. 1Immunology, University General Hospital Gregorio Maranon, Madrid, Spain.

™Sa1.66 - Modulation of Murine Lupus by an Inhibitor y Inhibitory

Sa1.62 - FOXP3+ Regulator y T Cells in the Rheumatic Joint: Regulatory Contribution of Both CD25+ and CD25- T Cells. D. Cao,1 A.-K. Ulfgren,1 C. Trollmo,1 V. Malmstrom.1 1Dept of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden.

Sa1.67 - The Phosphodiesterase Inhibitor Rolipram Facilitates the Suppression of Antigen-Induced Arthritis in Mice by Oral Administration of the Inducing Antigen. Shin Yoshino,1 Kouya Yamaki,1 Yoshiki Harada.1 1Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan.

Sa1.63 - Increased Systemic and Local Expression of TTollollLike Receptor 2 and 4 in Spondyloarthropathy Is umour Necrosis Factor alpha Blockade. Downmodulated by TTumour L. De Rycke,1 B. Vandooren,1 E. Kruithof,1 F. De Keyser,1 E. M. Veys,1 D. Baeten.1 1Rheumatology, Ghent University Hospital, Ghent, Belgium.

GpG Oligonucleotide. K. L. Graham,1 L. Y. Lee,2 P. Teo,1 L. Steinman,2 P. J. Utz,1 P. P. Ho.2 1Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA; 2Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.

Sa1.68 - Therapeutic Response of Rituximab in a Patient with Amyopathic Der matomyositis Refractor y to Methotrexate and Refractory Dermatomyositis Cyclosporin. S. M. Fung, R. Herzog, Y. Padeh, A. Rubenstein. 1Division of Allergy and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.

Sa1.64 - IgM Anti-dsDNA Antibodies Are the Main AntiNuclear Reactivity Induced by Infliximab but Not Etanercept Treatment: Biological and Clinical Implications. L. De Rycke,1 D. Baeten,1 E. Kruithof,1 E. M. Veys,1 F. De Keyser.1 1 Rheumatology, Ghent University Hospital, Ghent, Belgium.

Sa1.69 - Azathioprine Use but Not Hydroxycholorquine or Prednisone Use Is Associated with Lower Coronar y Ar ter y Arter tery Coronary Calcification Deter mined by Electron Beam Computed TTomogomogDetermined raphy (EBCT) in SLE Patients. E. R. Gehrie,1 A. J. Cucchiara,1 E. Nackos,1 J. M. Von Feldt.1 Sa1.65 - High Serum Levels of Chemokines but Low Expres- 1Department of Rheumatology, University of Pennsylvania, Philasion of Chemokine Receptors of Peripheral Blood Mono- delphia, PA, USA. nuclear Cells in Juvenile Systemic Lupus Er ythematosus. Erythematosus. J.-L. Huang,1 C.-J. Lin,2,3 C.-L. Liu,4 T.-C. Yao,1 H.-Y. Chang,2 G.- Sa1.70 - Proteomic Analysis of Secreted Proteins Defines SubW. Chen,2 C.-R. Shen.2 1Division of Rheumatology, Chang Gung types of Rheumatoid Arthritis. Children Hospital, Kweishan, Taoyuan, Taiwan; 2Graduate In- W. Hueber,1,2 B. H. Tomooka,1,2 W. J. van Venrooij,3 P. J. Utz,1 stitute of Medical Biotechnology, Chang Gung University, M. C. Genovese,1 W. H. Robinson.1,2 1Division of Immunology Kweishan, Taoyuan, Taiwan; 3Department of Loaboratory Medi- and Rheumatology, Stanford University School of Medicine, cine, Mackay Memorial Hospital, Taipei, Taipei, Taiwan; Stanford, CA, USA; 2GRECC, VA Palo Alto Heath Care System, 4 Graduate Institute of Engineering and Department of Biochemi- Palo Alto, CA, USA; 3Department of Biocehmistry, Radboud cal Engineering, Ming-Chi University of Technology, Taishan, University Nijmegen, Nijmegen, Netherlands. Taipei, Taiwan. Sa1.71 - Death Receptor 5 as a Therapeutic TTarget: arget: Increased Expression in B and T Cell Subsets in SLE. R. H. Carter,1 S. Pandey,1 T. Zhou.1 1Dept. of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.76 - Characteristics of Patients with Clinical Manifestations of APS with Anti-beta 2 -Glycoprotein-I but Not Anticardiolipin Antibodies or Any Other Autoimmune Condition. D. Micheloud,1 J. Carbone,1 S. Sanchez-Ramon,1 J. LopezLongo,2 A. Velastegui,1 J. Ruiz-Tiscar, 1 E. Sarmiento,1 E. Fernandez-Cruz,1 M. Rodriguez-Mahou.1 1Autoimmunity Section, Immunology Department, University Hospital Gregorio Maranon, Madrid, Spain; 2Rheumatology Department, Univerype I C2 Deficiency and Immunoglo- sity Hospital Gregorio Maranon, Madrid, Spain. Sa1.73 - Homozygous TType bulin Deficiencies in a HLA-B27 Positive Y oung Girl PresentYoung ranscriptional Regulation of Fli1 and Lupus. ing with an Antinuclear Antibody-Positive Juvenile Rheuma- Sa1.77 - TTranscriptional 1 J. D. Fulton, G. Gilkeson,1 T. Nowling.1 1Medicine, Rheumatoid Arthritis. G. Hauptmann,1 A. Meyer,2 B. Uring-Lambert,1 J. Goetz,2 I. tology Div., Medical University of South Carolina, Charleston, Jahn,2 S. Finck,3 B. Cribier,4 D. Lipsker.4 1Centre de Recherche SC, USA. Sa1.72 - Immune Response to a Citrullinated Peptide of Fibrinogen in DR4 tg Mice Following Intra-Articular Injection of Streptococcal Cell W all Antigen. Wall W. Brintnell,1 J. A. Hill,1 C. Nadasdy,1 D. A. Bell,1 E. Cairns.1 1 Department of Medicine, Division of Rheumatology and Department of Microbiology and Immunology, London Health Sciences Centre, University of Western Ontario, London, ON, Canada.

d’Immunologie, Faculte de Medecine, Strasbourg, France; 2 Laboratoire d’Immunologie, Hopitaux Universitaires, Strasbourg, France; 3Service de Pediatrie, Centre Hospitalier, Haguenau, France; 4Service de Dermatologie, Hopitaux Universitaires, Strasbourg, France.

Sa1.78 - Chronic GVH-Like Disease in a Man Exposed to Organic Solvents: Evidence for a Role of Microchimeric Cells of Maternal Origin. A. de Lavareille,1 O. Michel,2 P. Heimann,3 E. Cogan,4 M. Goldman,1 F. Roufosse.1,4 1Clinical Immunology Unit, Institute Sa1.74 - The Combination of Complement Deficiency and for Medical Immunology, Erasme Hospital, Brussels, Belgium; Cigarette Smoking as Risk Factor for Cutaneous Lupus Er ythe- 2Department of Internal Medicine, Saint Pierre Hospital, BrusErythe3 matosus (CLE) in Men; a Focus on Combined C2/C4 Defi- sels, Belgium; Department of Medical Genetics, Erasme Hospital, Brussels, Belgium; 4Department of Internal Medicine, Erasme ciency ciency.. Hospital, Brussels, Belgium. G. Hauptmann,1 P. Boeckler,2 M. Milea,2 A. Meyer,3 B. UringLambert,1 J. Goetz,3 B. Cribier,2 D. Lipsker.2 1Centre de Recherche d’Immunologie, Faculte de Medecine, Strasbourg, France; Sa1.79 - IgG Fc Receptor Polymorphisms Influence Suscepti2 Service de Dermatologie, Hopitaux Universitaires, Strasbourg, bility to Collagen-Induced Arthritis. 1 2 2 1 France; 3Laboratoire d’Immunologie, Hopitaux Universitaires, M. Andren, B. Johanneson, M. Alarcon-Riquelme, S. Kleinau. 1 Department of Cell and Molecular Biology, Uppsala UniverStrasbourg, France. sity, Uppsala, Sweden; 2Department of Genetics and PatholSa1.75 - Pregnancy Outcomes in TTen en Japanese W omen with ogy, Uppsala University, Uppsala, Sweden. Women Mixed Connective Tissue Disease. K. Abe, R. Matudaira, Y. Takasaki, H. Hashimoto. 1Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.80 - Outcome of a National Israeli Cohort of Pediatric Systemic Lupus Er ythematosus. Erythematosus. Natalia Gorodnitsky,1 Pinhas Hashkes,2 Masza Mukamel,3 Shai Padeh,4 Riva Brik,5 Judith Barash,6 Dror Mevorach,7 Yakov Berkun,7 Tzvia Tauber,8 Joseph Press,9 Liora Harel,3 Pnina Navon,10 Yakov Naparstek,7 Yosef Uziel.1 1Pediatric Medical Center, Meir Hospital, Kfar-Saba, Israel; 2Rheumatology, Cleveland Clinik, Cleveland, USA; 3Pediatric Medical Center, Schneider, Petach-Tikva, Israel; 4Pediatric Medical Center, TelHa Shomer Hospital, Ramat-Gan, Israel; 5Pediatric Medical Center, Rambam Hospital, Haifa, Israel; 6Pediatric, Kaplan Hospital, Rechovot, Israel; 7Rheumatology Center, Hadasa Hospital, Jerusalem, Israel; 8Pediatric Medical Center, Asaf-Ha-Rofe Hospital, Lood, Israel; 9Pediatric Medical Center, Soroca Hospital, Beer-Sheva, Israel; 10Pediatric, Hadasa, Mt Scopus, Jerusalem, Israel. Sa1.81 - Dyslipoproteinemia in the Active Course of SLE: A Contributor y Role for Anti-Double Stranded DNA AntibodContributory ies. Sara Kashef,1 Mohammad Mehdi Ghaedian,2 Akbar Rajaee,3 Abbas Ghaderi.4 1Allergy Research Center, Pediatric Immunology & Allergy, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Department of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran.

Sa1.84 - Synovial Fluid and Inflammator y Response in RheuInflammatory matoid Arthritis. Lj D. Petrovic-Rackov. 1Clinic for Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Belgrade, Serbia, Yugoslavia. Sa1.85 - Glycopeptides from TType ype II Collagen Incorporating o Study the Fine Galactosylated Hydroxylysine Mimetics TTo Specificity of Arthritogenic T Cells. J. Marin,1 M.-A. Blaton,2 J.-P. Briand,1 G. Chiocchia,2 C. Fournier,2 G. Guichard.1 1Immunologie et Chimie Therapeutiques (ICT), UPR 9021 CNRS, Institut de Biologie Moleculaire et Cellulaire (IBMC), Strasbourg, France; 2Departement d’Immunologie, Institut Cochin, INSERM U567, CNRS UMR8104, Universite Paris 5, Paris, France. α on Monocytes May Aggravate Immune-ComSa1.86 - CD8 CD8α plex Mediate Disease by Binding MHC Clacc I and Enhancing TNF Production. D. J. Gibbings,1 A. D. Befus.1 1Medicine, University of Alberta, Edmonton, AB, Canada.

Sa1.87 - Anti-Cyclic Citrullinated Peptide and Anti-Sa Antibodies for the Diagnosis of Rheumatoid Arthritis in an OutPatient Clinic of Chronic Inflammator y Connective TTissue issue Inflammatory Diseases (CICTD). J.L. Ruiz-Tiscar,1 S. Sanchez-Ramon,1 D. Micheloud,1 A. GarciaSegovia,1 B. Santamaria,1 R. Urrea,1 M. Escalona,2 A. Estecha,2 J.L. Lopez-Longo,2 E. Fernandez-Cruz,1 M. Rodriguez-Mahou.1 ranscripts of Systemic Lupus 1Immunology, Gregorio Maranon Hospital, Madrid, Madrid, Sa1.82 - Mutations in Gene TTranscripts Spain; 2Rheumatology, Gregorio Maranon Hospital, Madrid, Er ythematosus (SLE) T LLymphocytes. ymphocytes. Erythematosus Dama Laxminarayana.1 1Section on Rheumatology and Clini- Madrid, Spain. cal Immunology, Department of Internal Medicine, Wake Forest Sa1.88 - Evaluation of the Effect of Different Modified ExtraUniversity School of Medicine, Winston Salem, NC, USA. cellular Matrix Proteins in the Inflammation and Extracellular Sa1.83 - The Mechanism of Nasal TTolerance olerance in Lupus Prone Matrix TTur ur nover in Car tilage and Synovial TTissue issue Co-Cultures urnover Cartilage Mice Is T Cell Anergy Induced by Immature B Cells That Lack from Patients with Osteoarthritis (OA) and Rheumatoid ArB7 Expression. thritis (RA). Henry Yim Wu, Alon Monsonego, Howard L. Weiner. 1Center O. Munoz-Chable,1 J. Alcocer-Varela,1 E. Diaz-Borjon,2 J. Barfor Neurologic Diseases, Brigham and Women’s Hospital & rios, 3 R. Hernandez-Pando, 3 J. Furuzawa-Carballeda. 1 1 Harvard Medical School, Boston, MA, USA. Inmunologia y Reumatologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico; 2 Ortopedia; 3Patologia Experimental, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, DF, Mexico. 86

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.89 - Anti-alpha-Fodrin Antibodies of IgA Isotype in Patients with Sjögren’ Sjögren’ss Syndrome (SS). J.L. Ruiz-Tiscar, 1 S. Sanchez-Ramon, 1 D. Micheloud, 1 B. Santamaria,1 R. Urrea,1 M. Escalona,1 A. Estecha,2 F.J. LopezLongo,2 E. Fernandez-Cruz,1 M. Rodriguez-Mahou.1 1Immunology, Gregorio Maranon Hospital, Madrid, Madrid, Spain; 2 Rheumatology, Gregorio Maranon Hospital, Madrid, Madrid, Spain.

Sa1.94 - IL-1 Receptor Expression in Muscle Fibre Membrane and Muscle Cell Nuclei in Patients with Polymyositis or Dermatomyositis. I. E. Lundberg,1 C. Grundtman,1 C. Dorph,1 J. Burton,2 U. Andersson,3 S. Salomonsson.1,2 1Rheumatology Unit, Department of Medicine, Karolinska University Hosptial, Solna, Karolinska Institutet, Stockholm, Sweden; 2Department fo Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 3Department of Woman and Child Health, Karolinska Sa1.90 - TTumor umor Necrosis Factor Genetic Polymorphism as University Hosptial, Solna, Karolinska Institutet, Stockholm, Sweden. Part of Rheumatoid Arthritis Evolution. A. Cruzat,1 I. Schiattino,2 M. Cuchacovich,3 J. C. Aguillon.1 1 umor NeDisciplinary Program of Immunology, Faculty of Medicine. Uni- Sa1.95 - Increased Expression and Production of TTumor versity of Chile, Santiago, Región Metropolitana, Chile; 2Health crosis Factor-Related Apoptosis Inducing Ligand (TRAIL) by T Public School, Faculty of Medicine. University of Chile, Santiago, Cells from Lupus Patients Is a Feature of Active Disease. Región Metropolitana, Chile; 3Rheumatology Section, University V. Rus,1 V. Zernetkina,1 R. Puliaev,3 S. Mathai,1 C. Cudrici,2 C. of Chile Clinical Hospital. University of Chile, Santiago, Región S. Via.3 1Medicine, University of Maryland School of MediMetropolitana, Chile. cine, Baltimore, MD, USA; 2Neurology, University of Maryland School of Medicine, Baltimore, MD, USA; 3Pathology, Uniformed Sa1.91 - Mannan Binding Lectin and Complement C4A in Services of the University Health Sciences, Bethesda, MD, USA. Icelandic Multicase Families with Systemic Lupus Er ythemaErythematosus. Sa1.96 - Intramuscular Administration of Polymerized TType ype I S. Saevarsdottir,1 H. Kristjansdottir,2 G. Grondal,2 T. Vikingsdottir,1 Collagen for the TTreatment reatment of Patients with Rheumatoid Ar thriArthriK. Steinsson,2 H. Valdimarsson.1 1Department of Immunology, tis. A Double Blind Placebo-Controlled Clinical TTrial. rial. Landspitali University Hospital, Reykjavik, Iceland; 2Center for J. Furuzawa-Carballeda,1 J. Alcocer-Varela.1 1Immunology and Rheumatology Research, Landspitali University Hospital, Rheumatology, Instituto Nacional de Ciencias Medicas y Reykjavik, Iceland. Nutricion Salvador Zubiran, Mexico City, DF, Mexico. Sa1.92 - Abnormal Dendritic Cell Activation in SLE. H. Zhuang,1 D. C. Nacionales,1 S. Narain,1,2 E. Sobel,1,2 P. Y. Lee,1 Jason B. Weinstein,1 K. M. Kelly,1 H. B. Richard,1,2 M. Satoh,1,2 W. H. Reeves.1,2 1Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL, USA; 2Center for Autoimmune Disease, University of Florida, Gainesville, FL, USA.

Sa1.97 - Clinical Characteristics of 88 Patients with Juvenile or Adult Dermatomyositis. Tamas Constantin,1 Andrea Ponyi,1,2 Katalin Molnar,3 Judit Muller,1 Zsuzsanna Szalai,3 Gyorgy Fekete,1 Katalin Danko.2 1 2nd Department of Pediatrics Hungary, Semmelweis University, Budapest, Hungary; 23rd Department of Internal Medicine, Division of Clinical Immunology, University of Debrecen, Debrecen, Hungary; 3Department of Dermatology, Heim Pal ymphoma with Autoantibodies to Children’s Hospital, Budapest, Hungary. Sa1.93 - Marginal Zone LLymphoma RO52 in Sjogren’ Sjogren’ss Syndrome. R. Lyons,1 M. Rodriguez,1 E.K.L. Chan,1 L. Yang,1 C. Stewart,1 Sa1.98 - Pre-B Cell Colony Enhancing Factor Stimulates ProM. Satoh,1 W. H. Reeves.1 1Division of Rheumatology & Cliniduction of Proinflammator y Mediators by Human Monocytes Proinflammatory cal Immunology, University of Florida, Gainesville, FL, USA. and Is Overexpressed in Systemic Autoimmune Disease. S. Liu,1 C. Lee,1 K. A. Kirou,1 M. K. Crow.1 1Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

87

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.99 - Mannose-Binding Lectin Polymorphisms in Rheumatoid Arthritis and the Associations with Radiological Progression Rate and Serological Markers. L. De Rycke,1 I. Peene,1 E. Kruithof,1 T. Van De Casteele,2 L. Nuytinck,2 E. M. Veys,1 F. De Keyser.1 1Rheumatology, Ghent University Hospital, Ghent, Belgium; 2Innogenetics, Ghent, Belgium.

Sa1.105 - Efficacy of Apratastat, a Novel Dual Inhibitor of TNFa Converting Enzyme/Metalloproteinase, in Murine TNF-a Collagen-Induced Arthritis Models. M. Hegen,1 Y. Zhang,1 J. Levin,2 J. Xu,3 T. Cummons,3 K. Harding,4 B. J. Sheppard,5 M. W. Leach,5 L. L. Lin,1 J. Gibbons,3 J. Skotnicki,2 C. L. Nickerson-Nutter.1 1Inflammation, Wyeth Research, Cambridge, MA, USA; 2Medicinal Chemistry, Wyeth Research, Pearl River, NY, USA; 3Oncology, Wyeth Research, Sa1.100 - Interferon Inducible Proteins Are Novel Pearl River, NY, USA; 4Bioresources, Wyeth Research, Cambridge, MA, USA; 5Exploratory Drug Safety, Wyeth Research, Autoantigens in Systemic Lupus Er ythematosus. Erythematosus. D. L. Thibault,1 W. Hueber,1 T. Sylvester,1 D. Zeng,1 S. Strober,1 Andover, MA, USA. P. J. Utz.1 1Department of Medicine, Division of Rheumatology Sa1.106 - Marginal Zone (MZ) B Cells Are Most Susceptible and Immunology, Stanford University, Stanford, CA, USA. to Loss of TTolerance olerance in the Chronic GVH Model of SLE. Sa1.101 - Estrogen Receptor Effects on the Anti-Inflammator y A. Choudhury, P. L. Cohen, R. A. Eisenberg. 1Medicine, Div of Anti-Inflammatory Rheumatology, University of Pennsylvania, Philadelphia, PA, ARs in Lupus Mice. Action of PP PPARs 1 1 1 J. L. Svenson, G. S. Gilkeson. Rheumatology, Medical Univ. USA. of South Carolina, Charleston, SC, USA.

Sa1.107 - Elevated Levels of Anti-Oxidized Low Density LipoSa1.102 - Pathogenetic V alue of the Disbalance TTrace race Ele- protein Autoantibodies Is Correlated with Disease Activity of Value Systemic Lupus Er ythematosus. Erythematosus. ments under Systemic Sclerosis. 1 1 1 Ruihua Wu, Guoqiu Shen, Robert Morris, Galina Lummer, John Andriy I. Mazepa, Mariya A. Mazepa, Ivan V. Mazepa. 1 1 Sama, Allan Metzger. R & D, RDL Reference Laboratory, Los Biochemistry, Medical Academy, Ivano-Frankivsk, IvanoAngeles, CA, USA. Frankivsk, Ukraine. Sa1.108 - Pediatric Systemic Lupus Er ythematosus (SLE) - Loss Erythematosus olerance to Mater nal Microchimerism? of TTolerance Maternal A. M. Stevens,1 N. C. Lambert,2 H. M. Hermes,1 T. E. Erickson,2 J. L. Nelson.2,3 1Pediatrics, University of Washington, Seattle, WA, USA; 2Immunogenetics, Fred Hutchinson Cancer Research Institute, Seattle, WA, USA; 3Medicine, University of WashingSa1.104 - Rheumatoid Factor Seropositivity in a Normal ton, Seattle, WA, USA. Population Is Associated with the Use of Oral ContracepSa1.109 - Hypogammaglobulinemia in a Pediatric Patient tives and Cigarette Smoking. reated with 1 2 3 3 D. S. Majka, S. Pande, K. D. Deane, L. A. Parrish, W. P. with Idiopathic Retroperitoneal Fibrosis TTreated 3 3 2 1 Arend, V. M. Holers, J. M. Norris. Division of Rheumatol- Tamoxifen. 1 1 1 1 ogy, Northwestern University, Feinberg School of Medicine, R. Tachdjian, R. L. Roberts, D. K. McCurdy. Allergy, Immu2 Chicago, IL, USA; Department of Preventive Medicine and Bio- nology and Rheumatology, UCLA School of Medicine, Los Anmetrics, University of Colorado Health Sciences Center, Denver, geles, CA, USA. CO, USA; 3Division of Rheumatology, University of Colorado Health Sciences Center, Denver, CO, USA. Sa1.103 - Increased Granulopoiesis in Active SLE Blood: New Insights into SLE Pathogenesis. B. Vega, J. Borvak, A. Caldwell, V. Cantrell, J. Banchereau, V. Pascual. 1Baylor Institute for Immunology Research, Baylor Institute for Immunology Research, Dallas, TX, USA.

88

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.110 - Dendritic Cells Pulsed with TType ype II Bovine Collagen Modulate the Murine Collagen Induced Arthritis. L. E. Salazar,1 O. A. Aravena,1 P. Abello,2 A. Aguirre,1 D. Catalan,1 C. Llanos,3 F. Sabugo,3 F. Gonzalez,1 C. Gonzalez,2 M. Cuchacovich,3 J. C. Aguillon.1 1Disciplinary Program of Immunology, University of Chile; 2Program of Anatopatologic in Veterinaria, University of Chile; 3Department of Rheumatologic, Hospital Clinic of University of Chile, Santiago, Chile. Sa1.111 - IL-12 Regulates Collagen-Induced Arthritis in DQ8 Mice through ST AT4-Dependent Mechanisms. STA V. Taneja, M. Behrens, H. S. Luthra, M. M. Griffiths, C. S. David. 1 Immunology, Mayo Clinic, Rochester, MN, USA; 2Immunology, Mayo Clinic, Rochester, MN, USA; 3Rheumatology, Mayo Clinic, Rochester, MN, USA; 4Medicine, University of Utah, Salt Lake City, UT, USA; 5Immunology, Mayo Clinic, Rochester, MN, USA.

Sa1.115 - Four Systemic Lupus Er ythematosus Autoantigens Erythematosus Identified by HEp-2 Librar y Screening. Library A. D. Chang,1 L. Q. Tai,1 J. Nguyen,2 R. A. Gatti,2 D. K. McCurdy.1 1Pediatric Allergy, Immunology, Rheumatology, University of California,Los Angeles, Los Angeles, CA, USA; 2Pathology, University of California,Los Angeles, Los Angeles, CA, USA. Sa1.116 - Exploration of a Burn Medication for Potential AntiInflammator y Agent through Exter nal Application. External Inflammatory Yuching Wu,1 Rany Ly,1 Wenhsiou Wu,1 Abdulrahman Ibrahim.2 1 Immunology, MYC, Inc., Irvine, CA, USA; 2Center for Virus Research, The University of California at Irvine, Irvine, CA, USA.. ral usage to treat systemic inflammation.

Sa1.117 - Regulation of Autoimmune Arthritis by the Homologous Dominant Self and Cr yptic Mycobacterial Hsp65 Cryptic Sa1.112 - Identification of Genes Participating in Suppres- Epitopes. sion of Murine SLE by CD8+ Ti Cells. M. Durai,1 H. R. Kim,1 Y. Mia,1 E. Kim,1 K. D. Moudgil.1 1MiR. P. Singh, F. M. Ebling, D. Elashoff, D. V. Sven, C. Zamber, D. crobiology and Immunology, University of Maryland School of Patel, A. L. Cava, B. H. Hahn. 1Division of Rheumatology/ Medicine, Baltimore, MD, USA. Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Dept. of Biosatstics, Haematology/Onccology, Sa1.118 - Both Chlordecone and Estrogen Enhance the GerDavid Geffen School of Medicine at UCLA, Los Angeles, CA, minal Center B Cell Reaction and Reduce the Splenic B Cell USA; 3Research Department, Genome Explorations Inc., MemApoptosis in Ovariectomized (NZB x NZW) F1 Mice. phis, TN, USA. F. Wang,1,2 S. M. Roberts,1,3 E. S. Sobel.2 1Department of Pharmacology and Therapeutics, University of Florida College of Sa1.113 - Impact of Gender on Immune Nephritis. Medicine, Gainesville, FL, USA; 2Department of Medicine, UniT. Henry, Y. Fu, J. Zhou, C. Mohan. 1Internal Medicine-Rheuversity of Florida College of Medicine, Gainesville, FL, USA; matology, University of Texas Southwestern Medical Center, 3 Department of Physiological Sciences, University of Florida Dallas, TX, USA. College of Veterinary Medicine, Gainesville, FL, USA. Sa1.114 - Use of Gene-Expression Profiling in Labial Salivar y Glands Using cDNA Microarrays TTo o Identify New Pathovary genic Pathways in Primar y Sjögren’ Primary Sjögren’ss Syndrome. Jacques-Eric Gotttenberg,1 Carlo Lucchesi,2 Nicolas Cagnard,2 Franck Letourneur,2 Sylvie Mistou, 2 Jean Sibilia, 3 Gilles Chiocchia,2 Xavier Mariette.1 1Rheumatology, INSERM E 109, Bicetre Hospital, Le Kremlin Bicetre, France; 2Immunology, Institut Cochin, Paris, France; 3Rheumatology, Strasbourg Hospital, Strasbourg, France.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

Sa1.119 - IL10 Promoter Polymorphisms in Mexican Patients with Spondyloarthropathies. G. Vargas-Alarcon,1 J.M. Rodriguez-Perez,1 G. HernandezPacheco,1 J. Londono,2 C. Pacheco-Tena,3 J. Granados,2 R. Burgos-Vargas.3 1Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico; 2Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico; 3Rheumatology, Hospital General de Mexico, Mexico City, Mexico.

89

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.120 - Genetic Dissection of Congenital Heart Block in a Rat Model. L. S. Horvath,1 S. Salomonsson,1 M. Jagodic,2 K. Becanovic,2 S.-E. Sonesson,3 T. Olsson,2 M. Wahren-Herlenius.1 1Department of Medicine, Karolinska Institutet, Stockholm, Sweden; 2 Department of Neuroimmunology, Karolinska Institutet, Stockholm, Sweden; 3Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden.

Diabetes & Other Autoimmune Endocrine Diseases

Sa1.125 - A Fractal Analysis of Binding and Dissociation Kinetics of Connective Tissue Interstitial Glucose, Adipose Tissue Interstitial Glucose and Related Analytes on Biosensor Surfaces. A. M. Doke, A. Sadana. 1Chemical Enginnering, University of Mississippi, University, MS, USA; 2Chemical Enginnering, UniSa1.121 - Identification of Disease Profiles for Rheumatoid versity of Mississippi, University, MS, USA. Arthritis Using Antibody and Antigen Arrays. David L. Hirschberg,1 Anya Tsalenko,1 Mark Westall,1 Bill Fisher,1 Sa1.126 - Serum Levels of Interleukin-16 in Patients with Newly Bo Curry,1 Wolfgang Hueber, Orr Sharpe,2 Beren Toomoka,2 Diagnosed TType ype 1 Diabetes Mellitus. Dorothy Yang,1 Artie Schleifer,1 Willy McAllister,1 William H. V. V. Popova,1 S. V. Melnichenko,1 T. N. Malinovskaya,1 K. P. Robinson,2 Viorica Lopez-Avila.1 1Agilent Technologies Inc., Palo Zak,1 B. N. Mankovsky.1 1Diabetes, Institute of Endocrinology, Alto, USA; 2. Stanford University School of Medicine, Division of Kiev, Ukraine. Immunology and Rheunatology, Stanford, CA, USA. ™Sa1.127 - Antigen-Based Therapies Utilizing Ignored DeSa1.122 - Development and V alidation of the Simple Mea- terminants of ß-Cell Antigens Can More Effectively Slow LateValidation sures of Impact of Lupus Er ythematosus in Y oungsters Stage Autoimmune Disease in Diabetes-Prone Mice. Youngsters Erythematosus (c) (SMILEY ) Questionnaire. Angelica P. Olcott,1 Jide Tian,1 Valerie Walker,1 Hoa Dang,1 1 2 2 3 L. N. Moorthy, M. G. Peterson, M. J. Harrison, K. B. Onel, Blake Middleton,1 Luciano Adorini,2 Lorraine Washburn,1 Daniel M. J. Baratelli,1 D. R. Mohan,1 T. Lehman.2 1Robert Wood L. Kaufman.1 1Molecular and Medical Pharmacology, David Johnson University, New Brunswick, NJ; 2Hospital for Special Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Surgery, New York, NY; 3La Rabida Children’s Hospital, Chi- 2BioXell, Milano, Italy. cago, IL. Sa1.128 - NKT Cells May Contribute to the Sa1.123 - Relationship of School Attendance with Quality of Immunopathogenesis of Non-Alcoholic Steatohepatis. Life, Physical Function, Disease Activity and Damage in Pe- Kazuto Tajiri,1 Yukihiro Shimizu,1 Yoshiharu Tokimitsu,1 Yasuhiro ythematosus. diatric Systemic Lupus Er Erythematosus. Nakayama,1 Katsuharu Hirano,1 Masami Minemura,1 Kazumi 1 2 2 3 L N Moorthy, M G Peterson, M J Harrison, K B Onel, D R Ebata,1 Toshiro Sugiyama,1 Koichi Tsuneyama.2 1Third DepartMohan,1 Thomas Lehman.2 1Robert Wood Johnson University, ment of Internal Medicine, Toyama Medical and PharmaceutiNew Brunswick, NJ, USA; 2Hospital for Special Surgery, New cal University, Toyama, Japan; 2First Department of Pathology, York, NY, USA; 3La Rabida Children’s Hospital, Chicago, IL, Toyama Medical and Pharmaceutical University, Toyama, Japan. USA. accination as a Therapy Vaccination Sa1.124 - Development and V alidation of the Simple Mea- ™Sa1.129 - Pro-Apoptotic DNA V Validation ype 1 Diabetes. ythematosus in Y oungsters for TType sures of Impact of Lupus Er Erythematosus Youngsters A. Li, O. Ojogho, E. Franco, P. Baron, W. Concepcion, A. Escher. (SMILEY©) Questionnaire. 1 1 2 2 3 Transplantation Institute for Molecular and Translational MediL N Moorthy, M G Peterson, M J Harrison, K B Onel, M J 1 1 2 1 cine, Loma Linda University, Loma Linda, CA, USA. Baratelli, D R Mohan, T Lehman. Robert Wood Johnson 2 University, New Brunswick, NJ, USA; Hospital for Special Surgery, New York, NY, USA; 3La Rabida Children’s Hospital, Chicago, IL, USA. 90

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Sa1.130 - Increased β Cell Replication with Onset of Dia- ™Sa1.135 - The Role of Cytomegalovirus Infection in the betes and after Induction of Immune TTolerance olerance in the NOD Mouse. N. A. Sherry,1 M. Glandt,2 Y. Liu,1 A. M. Brillantes,2 K. Herold.2 1 Pediatrics, Columbia University, New York, NY, USA; 2Medicine, Columbia University, New York, NY, USA.

Development of TType ype 1 Diabetes-Associated Autoimmunity in HLA-Susceptible Children. J. Aarnisalo,1,2 O. Simell,1,3 M. Knip,1,4 J. Ilonen.1,2 1JDRF Center for Prevention of Type 1 Diabetes in Finland, Finland; 2Department of Virology, University of Turku, Turku, Finland; 3Department of Pediatrics, University of Turku, Turku, Finland; 4HosSa1.131 - A Subset of Insulin and Glucagon Positive Cells pital for Children and Adolescents, University of Helsinki, Helsinki, Finland. Sur vives Destruction in “Older” Female NOD Mice. Survives 1 1 1 1 1 M. Nakayama, N. Babaya, T. Still, E. Liu, R. Gianani. 1 -Cell Responses and TType ype 1 Barbara Davis Center for Childhood Diabetes, University of Sa1.136 - Rotavirus-Specific TT-Cell Diabetes (T1D): No Evidence for Interrelationship. Colorado Health Science Center, Denver, CO, USA. M. Makela,1,2 J. Marttila,1,2 M. Knip,1,3,4 O. Simell,1,5 J. Ilonen.1,2 1 ™Sa1.132 - PDL1 Regulates Autoimmunity by Limiting Ex- JDRF Center for Prevention of Type 1 Diabetes in Finland, Fin2 pansion of Autoreactive Th1 Cells and Mediates Resistance land; Department of Virology, University of Turku, Turku, Finland; 3Hospital for Children and Adolescents, University of to Diabetes in NOD Mice. Helsinki, Helsinki, Finland; 4Department of Pediatrics, Tampere I. Guleria,1 S. Eckenrode,2 M. J. Ansari,1 M. Azuma,3 M. University Hospital, Tampere, Finland; 5Department of PediatAtkinson,4 J. She,2 M. H. Sayegh.1 1Transplantation Research rics, University of Turku, Turku, Finland. Center, Brigham and Women’s Hospital and Children’s Hospi2 tal Boston, Harvard Medical School, Boston, MA, USA; Mediargets of Altered cal College of Georgia, Augusta, GA, USA; 3Tokyo Medical ™Sa1.137 - The Possible Biochemical TTargets 4 and Dental University, Tokyo, Japan; University of Florida, Col- Opioid Mediated Nocicpetion at Diabetes Conditions. Gayane S. Vardanyan,1 Aghadjanov I. Michael,1 Aghadjanova lege of Medicine, Gainesville, FL. M. Elena,1 Alla L. Shaljyan.1 1Biochemistry, Yerevan State Medi™Sa1.133 - Human HLA-A2 MHC Class 1 Molecule Is Per- cal University, Yerevan, Yerevan, Armenia. missive for the Development of Diabetes in Experimental Autoimmune Diabetes. A. Ide,1 E. Melanitou,1,2 E. Liu,1 H. Moriyama,1 D. Miao,1 G. S. Eisenbarth.1 1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA; 2 Institut Pasteur, Paris, France. Sa1.134 - Similarities and Differences in Autoimmune Responses between TType ype 1 and TType ype 1.5 Diabetes Patients. B. Brooks-Worrell,1,2 H. Chiu,1,2 A. Goel,1,2 J. P. Palmer.1,2 1Department of Medicine, University of Washington, Seattle, WA, USA; 2Metabolism and Endocrinology, Puget Sound Health Care System, Seattle, WA, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

™Sa1.138 - Combinatorial TTreatment reatment of Recent-Onset TType ype 1 Diabetes by Induction of Islet-Antigen Specific TTregs regs and Anti-CD3. Damien Bresson,1 Lisa Togher,1 Kevan Herold,2 Matthias von Herrath.1 1La Jolla Institute for Allergy and Immunology, San Diego, CA, USA; 2Columbia University, New York, NY, USA.

™ Sa1.139

- De Novo Generation of Antigen-Specific y T Cells from Human CD4+CD25Regulatory CD4+CD25+ Regulator Cells. M. R. Walker,1,3 B. D. Carson,2,3 S. F. Ziegler,2,3 G. T. Nepom,1,3 J. H. Buckner.1 1Diabetes, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; 2Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; 3Immunology, University of Washington, Seattle, WA, USA.

91

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa1.140 - TGFβ Enhances Autoimmune Diabetes by TGF-β Increasing Sur vival of Memor y Effector CD8 LLymphocytes. ymphocytes. Survival Memory Amy E. Juedes,1 Chrystelle Asseman,1 Lisa Togher,1 Yufeng Peng,2 Allison Green,2 Richard A. Flavell,2 Matthias G. von Herrath.1 1Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA; 2Immunobiology, Yale University, New Haven, CT, USA.

Sa1.144 - The (Relatively) Simple Genetics of a Polygenic Disease: TType ype 1 Diabetes (TID). Chester A. Alper,1,2 Charles E. Larsen,1,2 Edmond J. Yunis,2,3 Zaheed Husain,1,2 Zuheir L. Awdeh.1 1Immunogenetics Division, The CBR Institute for Biomedical Research, Boston, MA, USA; 2Departments of Pediatrics, Medicine and Pathology, Harvard Medical School, Boston, MA, USA; 3Department of Cancer Immunology and AIDS, The Dana-Farber Cancer InstiSa1.141 - Protection from TType ype 1 Diabetes by iNKT Cells tute, Boston, MA, USA. y T May Require Interactions with CD4+CD25+ Regulator Regulatory Sa1.145 - An Atypical Case of IPEX Syndrome with Multiple Cells. 1,2 3 1,2 1 FOXP3 Mutations. D. Ly, Q. S. Mi, T. L. Delovitch. Autoimmune/Diabetes 1 2 C. Azzari,1 M. Moriondo,1 L. Bianchi,1 A. M.G. E. Gambineri, Group, Robarts Research Institute, London, ON, Canada; De1 1 1 1 partment of Microbiology and Immunology, University of West- Gelli, A. Vierucci, M. de Martino. Department of Pediatrics, ern Ontario, London, ON, Canada; 3Center for Biotechnology “Anna Meyer” Childrens’ Hospital, University of Florence, Floand Genomic Medicine, Medical College of Georgia, Dept of rence, Italy. Pathology - Section of Dermatology, Augusta, GA, USA.

™Sa1.142 - Immunomodulation in TType ype 1 Diabetes by NBI6024, An Altered Peptide Ligand of the Insulin B(9-23) Epitope. D. G. Alleva,1 R. A. Maki,1 A. L. Putnam,2 M. S. Kipnes,3 P. Dandona,4 J. B. Marks,5 D. L. Simmons,6 C. J. Greenbaum,7 R. J. Jimenez,1 P. J. Conlon,1 P. A. Gottlieb.2 1Molecular Medicine, Neurocrine Biosciences, Inc., San Diego, CA, USA; 2Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA; 3Diabetes and Glandular Disease Clinic, San Antonia, TX, USA; 4Diabetes-Endocrinology Center of WNY Kaleida Health, Buffalo, NY, USA; 5Department of Diabetes, Endocrinology, and Metabolism, University of Miami, Miami, FL, USA; 6Division of Endocrinology and Metabolism, University of Arkansas for Med Sciences, Little Rock, AR, USA; 7Diabetes Clinical Research Unit,, Virginia Mason Research Center, Seattle, WA, USA. Sa1.143 - A Single Explanation for Three Puzzles in TType ype 1 Diabetes (T1D). Zuheir L. Awdeh,1 Edmond J. Yunis,1,2,3 Mark J. Audeh,4 Dolores A. Fici,1 Alberto Pugliese,5 Charles E. Larsen,1,3 Chester A. Alper.1,3 1Immunogenetics Division, The CBR Institute for Biomedical Research, Boston, MA, USA; 2Department of Cancer Immunology and AIDS, The Dana-Farber Cancer Institute, Boston, MA, USA; 3Departments of Pathology, Medicine and Pediatrics, Harvard Medical School, Boston, MA, USA; 4Boston College, Chestnut Hill, MA, USA; 5Diabetes Research Institute, University of Miami School of Medicine, Miami, FL, USA. 92

Immunology of the Eye

Sa1.146 - Increase of Serum KL-6 Levels In Sera of Uveitis Patients with Sarcoidosis. N. Kitaichi,1 S. Ohno.1 1Ophthalmology & Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. S a 1 . 1 4 7 - C y t o t o x i c C D 8 b r i g h tC D 5 6 + T C e l l s A r e Immunopathogenic Effectors in Patients with Active Behcet’ Behcet’ss Uveitis. Jae Kyoun Ahn,1 Hyeong Gon Yu,1 Hum Chung,1 Sung-pyo Park,1 Young Joo Kim.1 1Ophthalmology, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea. Sa1.148 - Flt3L-Elicited, In Vitro-Matured Splenic Dendritic Cells (DC) Induce Autoimmune Disease in the Retina. J. Tang,1 W. Zhu,1 P. B. Sliver,1 S.B. Shu,1 C.C. Chan,2 R. R. Caspi.1 1Section of Immunoregulation, Lab of Immunology, National Eye Institute, NIH, Bethesda, MD, USA; 2Section of Immunopathology, Lab of Immunology, National Eye Institute, NIH, Bethesda, MD, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Sa1.149 - Thrombospondin 1 Mediates a Contact Dependent Mechanism by Which Retinal Pigment Epithelial (RPE) Cells Regulate T Cell Function. J. L. Vega,1,2 S. Masli,2 A. W. Taylor,2 H. L. Weiner,1 J. W. Streilein.2 1Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 2Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA.

™Sa1.150 - Altered Peptide Ligands of a Retinal Antigen Protect from Anti-Retinal Autoimmunity by Eliciting Active Reguy Mechanisms. latory lator L. M. Cortes,1 D. Avichezer,1 P. B. Silver,1 C. C. Chan,1 R. R. Caspi.1 1Lab.of Immunology. National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Sa1.154 - Increased Ratio of Activating:Inhibitor y Killer ImActivating:Inhibitory munoglobulin-Like Receptor Genes in Uveitis. R. D. Levinson,1 Z. Du,2 G. N. Holland,1 E. F. Reed,2 R. Rajalingam.1 1Ophthalmology, David Geffen School of Medicine, UCLA, LA, CA, USA; 2Immunogenetics, UCLA, LA, CA, USA.

Poster Session 2 Saturday,, May 14, 2005 Saturday 3:30 pm - 7:30 pm Immunity and Infection

Sa2.01 - Quality Assurance Sur vey (QAS) in the Detection of Survey Infectious Diseases with Outbreak Potential. M. B. Dela Cruz. 1Office of the Secretary-Department of Health Philippines (on Leave), Department of Health, Manila, Manila, Sa1.151 - Modulation of Innate Immune Response with Philippines. Granulocyteapheresis in Behçet’ ear Experience. Year Behçet’ss Disease: 1 Y O. Garcia, R. Lafuente, J. Munoz, A. Vidaller, J. Arruga. 1Oph- Sa2.02 - Lack of Association between Interferon-Gamma Rethalmology, Hospital Universitari de Bellvitge, Hospitalet, ceptor -1 Polymorphism and Pulmonar y TTuberculosis uberculosis in Iraceptor-1 Pulmonary Barcelona, Spain; 2Intensive Care Unit, Hospital General, nian Population Sample. Hospitalet, Barcelona, Spain; 3Blood Bank, Hospital Universitari Mehdi Mirsaeidi,1 Masoud Houshmand,2 Payam Tabarsi,1 de Bellvitge, Hospitalet, Barcelona, Spain; 4Internal Medicine, Mohammad Mehdi Banoei,2 Sonia Zargari,1 Majid Amiri,1 Hospital Universitari de Bellvitge, Hospitalet, Barcelona, Spain; Davood Seyed Mansouri,1 Mohammad Sanati,2 Mohammad 5 Ophthalmology, Hospital Universitari de Bellvitge, Hospitalet, Reza Masjedi,1 Ali Akbar Velayati.1 1Tuberculosis & RespiraBarcelona, Spain. tory Infections, National Research Institute of Tuberculosis and Lung Disease, Tehran, Tehran, Islamic Republic of Iran; 2MoSa1.152 - Systemic Autoimmune Disease in Patients with Uvei- lecular Genetics, The National Research Center for Genetic tis. Engineering and Biotechnology, Tehran, Tehran, Islamic RepubJ. Carbone,1 E. Sarmiento,1 D. Micheloud,1 R. Mora,1 M. lic of Iran. Rodriguez-Mahou,1 R. Cobo,2 J.L. Vicario,3 J.J. RodriguezMolina,1 E. Fernandez-Cruz.1 1Clinical Immunology Unit, Im- Sa2.03 - The Functional Activity of Specific Antibodies in munology Department, University Hospital Gregorio Maranon, Progression of HIV -Infection. HIV-Infection. Madrid, Spain; 2Ophthalmology Department, University Hospi1 1 Irina I. Andreeva. Clinical of Immunology, Rostov State Medital Gregorio Maranon, Madrid, Spain; 3Transfusion Center, cal University, Rostov-on Don, Russian Federation. Community of Madrid. Sa2.04 - Impairment of Recent Thymic Emigrants in HCV InSa1.153 - In Silico Prediciton of Binding of Auto-Antigenic fection. ogt-Koyanagi-Harada Disease. Peptides to HLA-DRB1 in V Vogt-Koyanagi-Harada R. Cianci,1 M. Nasi,2 M. Pinti,2 S. Starnino,1 A. Florio,1 G. P. S. Prasad,1 R. D. Levinson.1 1Ophthalmology, David Geffen Cammarota,1 A. De Luca,3 R. Cauda,3 A. Grieco,1 G. Rapaccini,1 School of Medicine, UCLA, LA, CA, USA. G. Gasbarrini,1 A. Cossarizza,2 F. Pandolfi.1 1Internal Medicine, Catholic University, Rome, Italy; 2Biochemical Sciences, University of Modena, Italy; 3Infectious Diseases, Catholic University, Rome, Italy.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

93

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.05 - The Persistence of Allergen-Specific IgE and LongLived Plasma Cells. Elke O. Luger,1 Verena Fokuhl,1 Michael Wegmann,2 Harald Renz,2 Andreas Radbruch.1 1DRFZ, German Rheumatism Research Center, Berlin, Germany; 2Department of Clinical Chemistry and Molecular Diagnostics, Philipps-University Marburg, Marburg, Germany.

Sa2.10 - Discover y of Neutralizing CpG ODN from SeroDiscovery type 2 and 5 Adenoviruse Based on the Relationship between Free Energy and Bioactivity Bioactivity.. Zhou Hong,1 Wang Liangxi,1 Zheng Jiang,2 Ding Guofu,1 Liu Wei.1 1Department of Pharmacology, Department of Pharmacology, Chongqing, China; 2Medical Research Center, Southwestern Hospital, Chongqing, China.

ransmission Hepatic Electron Microscopic FindSa2.06 - TTransmission ings in Chronic Experimental Schistosomiasis Mansoni after Praziquantel and an Antifibrotic. A. M. Ahour,1 M. A. El khafif,2 S. I. Hassan,3 N. G. Nessim,3 N. M. Amer,3 I. M. Ali.3 1Biochemistry Department, Ein Shams Univeristy, Cairo, Egypt; 2Parasitology Department, Ein Shams University, Cairo, Egypt; 3Parasitology Department, Theodore Bilharz Research Institute, Guiza, Cairo, Egypt.

Sa2.11 - Evaluation of IL-10 Serum Level in Visceral Leishmaniasis. Abdolvahab Alborzi, Manoochehr Rasouli, Abolfazl Khoshdel, Simin Kiany. 1Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Clinical MicroSa2.07 - TTransmission ransmission Hepatic Electron Microscopic Find- biology Research Center, Shiraz University of Medical Sciences, ings in Acute Experimental Schistosomiasis Mansoni after Shiraz, Fars, Islamic Republic of Iran. Praziquantel and an Antifibrotic. S. I. Hassan,1 I. M. Ali,1 N. G. Nessim,1 N. M. Amer,1 M. A. El Sa2.12 - IL-10 Gene Polymorphisms and Susceptibility to BruKhafif,2 Amin M. Ahour,3 M. M. Mohandes.4 1Parasitology cellosis. Department, Theodore Bilharz Research Institute, Guiza, Cairo, Simin Kiany, Manoochehr Rasouli, Mohammad Ali Dehyadegari, 1 Egypt; 2Biochemistry Department, Ein Shams University, Cairo, Noredin Rafatpour, Abdolvahab Alborzi. Immunology of In3 Egypt; Parasitology Department, Ein Shams University, Cairo, fectious Diseases Department- Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, IsEgypt. lamic Republic of Iran; 2Immunology of Infectious Diseases DeSa2.08 - Serum TTransaminase ransaminase Levels in Murine Schistoso- partment- Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; miasis Mansoni after Giving Praziquantel and an Antifibrotic 3 Clinical Microbiology Research Center, Shiraz University of Agent. Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4CliniA. M. Ashour,1 M. A. El Khafif,2 Soad I. Hassan,3 N. G. Nessim,3 cal Microbiology Research Center, Shiraz University of Medical I. M. Ali,3 N. M. Amer.3 1Parasitology Department, Ein Shams Sciences, Shiraz, Fars, Islamic Republic of Iran; 5Clinical MicroUniversity, Cairo, Egypt; 2Biochemistry Departemnt, Ein Shams biology Research Center, Shiraz University of Medical Sciences, University, Cairo, Egypt; 3Parasitology Department, Theodore Shiraz, Fars, Islamic Republic of Iran. Bilharz Research Institute, Cairo, Egypt. Sa2.09 - Effect of a Novel Muramyl Dipeptide Derivative TToogether with Praziquantel in Experimental Schistosoma Mansoni Infection. S. S. Boutros,1 F. A. Ebeid,1 H. A. Ismail,2 N. G. Nessim.3 1 Parmacology Department, Theodore Bilharz Research Institute, Guiza, Cairo, Egypt; 2Immunology Department, Theodore Bilharz Research Institute, Guiza, Cairo, Egypt; 3Parasitology Department, Theodore Bilharz Research Institute, Guiza, Cairo, Egypt. 94

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.13 -Investigation of IFN- γ Gene Polymorphism in Visceral Leishmaniasis. Simin Kiany, Manoochehr Rasouli, Abolfazl Khoshdel, Abdolvahab Alborzi. 1Immunology of Infectious Diseases Department- Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2 Immunology of Infectious Diseases Department- Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Pediatric Infectious Diseases Department, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran.

Sa2.16 - Dendritic Cell Mediated Immune Response Is Impaired by the Mycobacterium tuberculosis MannosylatedLipoArabinoMannan. N. Dulphy,1 J.-L. Herrmann,2 J. Nigoux,3 G. Puzo,3 D. Charron,1 P. H. Lagrange, 2 A. Toubert. 1 1INSERM U662, Institut Universitaire d’Hematologie; Hopital Saint Louis, Paris, France; 2 Equipe d’Accueil EA3510, Faculte Lariboisiere-Saint Louis; Universite Paris VII, Paris, France; 3Departement “Mecanismes Moleculaires des Infections Mycobacteriennes”, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.

y Response and Apoptosis of Polymor Sa2.17 - Inflammator Inflammatory Polymor-phonuclear Neutrophils by Prevalent Strains of Mycobacterium tuberculosis. Sa2.14 - Polymorphisms of IL-10 Gene Promoter in Patients Pokkali Supriya,1 Rajavelu Priya,1 Das Sulochana.1 1Dept of with Kala-azar Kala-azar.. Immunology, Tuberculosis Research Centre, Chennai, Tamil Manoochehr Rasouli, Simin Kiany, Abdolvahab Alborzi, Nadu, India. Abolfazl Khoshdel. 1Immunology of Infectious Diseases Department-Clinical Microbiology Research Center, Shiraz University Sa2.18 - Comparison of Regional and Systemic Humoral Imof Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Imto a Parasitic Infection. munology of Infectious Diseases Department-Clinical Microbiol- mune Response 1 C. H. Wang, S. D. Wagner,1 H. Montalvo, Jr.,1 C. L. Hauschild,1 ogy Research Center, Shiraz University of Medical Sciences, 1 1 Shiraz, Fars, Islamic Republic of Iran; 3Clinical Microbiology A. M. Vanhoose. Biology, California State University Channel Research Center, Shiraz University of Medical Sciences, Shiraz, Islands, Camarillo, CA, USA. Fars, Islamic Republic of Iran; 4Pediatric Infectious Diseases, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Re- Sa2.19 - Co-Administration of Corticosteroids (CS) with AntiTuberculous Drugs (A TD) in TTuberculous uberculous Menangitis Had Not (ATD) public of Iran. Only Reduced the Intra- Cranial Pressure Symptoms, Also Had Sa2.15 - Role of Regulator y CD25+CD4+ Cells during Infec- Increased Patient’ Regulatory Patient’ss Compliance. tion with Tr ypanosoma cruzi. M. Ishaq, I. M. Sameera. 1Allergy/Pulmonology, Al-Junaid D. Golgher, R. Vasconcelos, R. Arantes, R. T. Gazzinelli. Hospital, Nowshera, Pakistan. 1 Departament of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Bra- Sa2.20 - Relationship Study between the Status of Innate Imzil; 2Departament of Biochemistry and Immunology, Universidade munology and the Infection of SARS. Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Bra- Wang Haibin.1 1Dept. of Clinic Immunology, 302 Hospital, zil; 3Departament of Pathology, Universidade Federal de Minas Beijing, Beijing, China. Gerais, Belo Horizonte, Minas Gerais, Brazil; 4Departament of Biochemistry and Immunology, Universidade Federal de Minas Sa2.21 - A Safe Nanoemulsion Adjuvant Produces a KilledGerais, Belo Horizonte, Minas Gerais, Brazil. Virus Nasal V accine for Smallpox. Vaccine A. U. Bielinska, K. W. Janczak, J. J. Landers, J. R. Baker, Jr.. 1 Internal Medicine and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

95

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Sa2.22 - Novel Pan-DR Binding TT-Cell -Cell Epitopes of Aden-

Sa2.28 - Circulating V δ1 and V δ2 T Cells in HIV -1-Infected Vδ Vδ HIV-1-Infected Patients: Response to CXCR3 and CXCR4 Ligands and to HIV HIV-1 TTat. at. A. Poggi,1 D. Fenoglio,2 G. Murdaca,2 M. Setti,2 F. Indiveri,2 M. R. Zocchi.3 1Oncogenesis, Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy; 2Department of Internal Medicine, Laboratory of Clinical Immunology, University of Genoa, Genoa, Italy; 3Department of Internal Medicine, Laboratory of Tumor Immunology, San Raffaele Scientific Sa2.23 - Naturally Occurring Breakdown Products of Inflam- Institute, Milan, Italy. mation, Generated in Inflammator y Sites, Functioned as DownInflammatory arget ProSa2.29 - Adenovirus Capsid Hexon Is the Main TTarget Regulator of Inflammation. + 1 2 1 3 -Cells That Display a Th1 Liora Cahalon, Zvi Landau, Raanan Margalit, Arie Admon, tein of Adenovirus-Specific CD4 TT-Cells Tamar Ziv,3 Alexandra Zanin-Zhorov,1 Ofer Lider.1 1Immunol- like Cytokine Profile in Healthy Adults. ogy, Weizmann, Rehovot, Israel; 2Internal Medicine “D”, Kaplan O. Arbach,1 M. Frentsch,1 B. Chmielewicz,2 M. Kaiser,3 H. Medical Center, Rehovot, Israel; 3Biology, the Smoler Proteomic Ellerbrok,2 R. Lauster,4 A. Radbruch,1 A. Scheffold,5 A. Thiel.1 1 Center, Technion, Haifa, Israel. Clinical Immunology Group, German Rheumatism Research Center, Berlin, Germany; 2Robert-Koch-Institute, Berlin, Germany; Sa2.24 - The Inflammator y & Immunological Complex Clini- 3GenExpress, Berlin, Germany; 4Molecular Biology, German Inflammatory cal Presentation of Mycoplasmal Infection in School Children. Rheumatism Research Center, Berlin, Germany; 5 M. Ishaq, I. M. Sameera. 1Allergy/Pulmonology, Al-Junaid Immunomodulation Group, German Rheumatism Research Center, Berlin, Germany. Hospital, Nowshera, Pakistan. ovirus Induce a Mixed Profile in Healthy Donors. L. M. Haveman,1,2 M. Bierings,1 M. R. Klein,1,2 S. Albani,2,3 B. J. Prakken.1,2 1Department of Pediatric Immunology, Wilhelmina Children’s Hospital / University Medical Center, Utrecht, Netherlands; 2IACOPO Institute, University of California, San Diego, USA; 3Department of Pediatrics, University of California, San Diego, USA.

Sa2.30 - Identification of SARS T Cell Epitopes Using the iT opia™Epitope Discover y System. Discovery iTopia™Epitope C. A. Johnson,1 J. Chang,1 C. M. Cameron,2 D. J. Kelvin,2 L. R. Lofaro,1 K. R. Bray.1 1Clinical Research and Development, Beckman Coulter, San Diego, CA, USA; 2Division of ExperimenSa2.26 - Phage Display Epitope Study of TTwo wo TToxins oxins Pro- tal Therapeutics, University Health Network, Toronto, Canada. duced by Enteroaggregative Esherichia coli That Cause Pewo TTwins, wins, Association to Sa2.31 - Leishmania Infection in TTwo diatric Diarrhea: Identification and Characterization of AntiPerforin Defect. genic and Immunogenic Mimotopes. M.E. Seoane,1 M.S. Lovillo,2 J.L. Jimenez,1 J.A. Leon,2 M.A. T. G. Gazarian,1 U. Hernandez,1 J. Villaseca,1 K. G. Gazarian,2 Munoz.1 1Division of Molecular Immuno-Biology, University C. Eslava. 1 1Department of Public Health, Faculty of General Hospital Gregorio Maranon, Madrid, Madrid, Spain; Medicine,UNAM, Mexico City, DF, Mexico; 2Department of 2 Department of Paediatrics, University General Hospital Virgen Molecular Biology and Biotechnology, Institute of Biomedical Redel Rocio, Sevilla, Sevilla, Spain. search, Mexican National University, Mexico City, DF, Mexico. Sa2.25 - Y east Cells Activation Method of Hemaimmune ReYeast action Road Map Experimental System. Guo Feng. 1Department of Blood Tansfusion, Changhai Hospital Second Military Medical University, Shanghai, China.

Sa2.27 - The Combined Modulation of Nicotine and Chlamydia Heat Shock Protein on Cell Proliferation and Apoptosis in HEp-2 Cells. A. I. Hakki, A. Radwan, H. Friedman, S. H. Pross. 1Medical Microbiology & Immunology, MDC-10, Collge of Medicine-University of South Florida, Tampa, FL, USA. 96

Sa2.32 - The Calcium-Promoted Ras Inactivator (CAPRI) Links Fcg Receptor to Cdc42 and Rac1 and Is Essential for Host Innate Defense. J. Zhang, I. Dzhagalov, J. Guo, W. Y. He. 1Immunology, Duke University, Durham, NC, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.33 - An 8 Y ear Old Girl with Recurrent Der matomal Her Year Dermatomal Her-pes Outbreaks. Cecilia P. Mikita,1 Steven M. Holland,2 Michael R. Nelson.1 1 Department of Allergy-Immunology, Walter Reed Army Medical Center, Washington, DC, USA; 2Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.

Sa2.38 - Evalution CD64 Marker in Neonatal Spesis for Rapid Diagnosis. Mino Adib, Farzad Oreizi, Fereshteh Sahebfosul, Vajiheh Ostadi. 1Immunology, Medical School of Science, Isfahan, Isfahan, Islamic Republic of Iran; 2Immunology, Medical School of Science, Isfahan, Isfahan, Islamic Republic of Iran; 3Immunology, Medical School of Science, Isfahan, Isfahan, Islamic Republic of Iran; 4Immunology, Medical School of Science, Isfahan, Sa2.34 - Reconstitution of Genetically Determined Deficiency Isfahan, Islamic Republic of Iran. of the Innate Immune Defence with Recombinant Mannan-BindSa2.39 - TT.. Whipplei Specific Immune Reactions Are Signifiing Lectin (MBL). 1 2 2 1 1 Whipple’ss Disease. J. C. Jensenius, M. Axelsen, L. Kongerslev, S. Thiel. Depart- cantly Reduced in Patients with Whipple’ 1 1 2 V. Moos, D. Kunkel, T. Marth, B. LaScola,3 M. Zeitz,1 T. ment of Medical Microbiology and Immunology, University of 1 1 Medical Clinic I, Charite, Campus Benjamin Aarhus, Aarhus, Denmark; 2NatImmune A/S, Copenhagen, Schneider. Franklin, Berlin, Germany; 2Internal Medicine, St Josef Hospital, Denmark. Zell/ Mosel, Germany; 3Unite de Rickettsies, Faculty of MediSa2.35 - An Active Role for Complement Regulator CD46 in cine, Marseille, France. Signal TTransduction ransduction upon Infection. ransfer of CFSE-Labeled Autologous PBMC P. S. Tsang, S. H. Sacks, N. S. Sheerin. 1Department of Neph- Sa2.40 - Adoptive TTransfer for the of T Cell Migration in a Non-Human Visualization rology and Transplantation, King’s College London, London, Primate Model. United Kingdom. D. Kunkel,1 V. Moos,1 C. Stahl-Hennig,2 F. J. Kaup,2 M. Zeitz,1 Sa2.36 - Access to the Entire Human Antigen-Specific CD4+ T. Schneider.1 1Medical Clinic I, Charite - Campus Benjamin 2 T-Cell Response According to Antigen-Reactive CD154 Ex- Franklin, Berlin, Germany; German Primate Center, Gottingen, Germany. pression. 1 1 2 Marco Frentsch, Olga Arbach, Dennis Kirchhoff, Thomas raumatic Stress Syndrome on the Post-Traumatic Schneider,3 Alexander Scheffold,2 Andreas Thiel.1 1Clinical Im- Sa2.41 - The Effect of Post-T accination. Vaccination. munology, German Arthritis Research Centre, Berlin, Berlin, Outcome of Influenza V 1 1 4 4 Germany; 2Immunmodulation, German Arthritis Research Cen- E. Kosor, A. Gagro, V. Folnegovic-Smalc, M. Vilibic, D. 5 5 2 1 3 tre, Berlin, Berlin, Germany; Gastroenterology and Infectious Kozaric-Kovacic, M. Grubisic-Ilic, V. Drazenovic, K. Gotovac, 1 3 3 Diseases, Charite - Campus Benjamin Franklin, Berlin, Berlin, A. Sabioncello, E. Cecuk, V. Kerhin-Brkljacic, I. GjeneroMargan,2 B. Kaic,2 S. Rabatic,1 G. Mlinaric-Galinovic,2 D. Germany. Dekaris.1 1Research and Development, Institute of Immunology, 2 Sa2.37 - Excessive Innate Immune Responses Could Prime Zagreb, Croatia; Virology, Croatian Institute of Public Health, Zagreb, Croatia; 3National Referal Organ Transplant and TisMassive Hepatocyte Apoptosis Induced by Lipopolysacchasue Centre, University Hospital Centre Zagreb, Zagreb, Croatia; ride. 4 University Department of Psychiatry, Psychiatric Hospital Vrapce, Katsuharu Hirano,1 Yukihiro Shimizu,1 Yasuhiro Nakayama,1 Zagreb, Croatia; 5Department of Psychiatry, National Center Masami Minemura,1 Yoshinari Atarashi,1 Satoshi Yasumura,1 for Psychotrauma Dubrava, Zagreb, Croatia. Toshiro Sugiyama.1 1The Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

97

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.42 - Cholesterol Loading of T Cells as a Model of T Cell Aging. A. Larbi,1,2 G. Dupuis,2 C. Fortin,1,2 H. Berrougui,1 A. Khalil,1 T. Fulop.1,2 1Laboratory of Immunology, Research Center on Aging, Sherbrooke, QC, Canada; 2Immunology Program, Faculty of Medicine, Clinical Research Center, Sherbrooke, QC, Canada.

Sa2.47 - Class I Restricted Epitopes Highly Represented in the Tr ypanosoma cruzi Genome Are Recognized by CD8+ T Cells from Individuals with Chronic T. cruzi Infection. S. A. Laucella,1 B. Weatherly,2 D. Martin,2 M. C. Albareda,1 M. G. Alvarez,3 G. Bertochi,3 A. H. Armenti,3 J. Sidney,4 A. Sette,4 M. Postan,1 R. L. Tarleton.2 1Research Department, Instituto Nacional de Parasitologia, Buenos Aires, Argentina; 2Center for Tropical and Emerging Global Diseases, UGA, Athens, GA, Sa2.43 - The Role of Programmed Death-1 Pathway in a Neu- USA; 3Hospital Interzonal Eva Peron, Buenos Aires, Argentina; 4 La Jolla Institute for Allergy and Immunology, San Diego, CA, trophil Mediated Shock Syndrome. 1 1 2 1 1 B. Zhu, K. Raddassi, M. H. Sayegh, S. J. Khoury. Center USA. for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA, USA; 2Transplantation Research Center, Brigham and Sa2.48 - Sustained Expansion, Activation and Maturation of Women’s Hospital and Children’s Hospital Boston, Boston, MA, Virus-Specific CD8+ T Cells after Acute Par vovirus B19 InParvovirus USA. fection. V. O. Kasprowicz,1 A. Isa,2 O. Norbeck,2 T. Tolfvenstam,2 P. Sa2.44 - Immune Response Balance on Human Cutaneous Klenerman,3 P. Bowness.1 1Human Immunology Unit, Weatherall Leishmaniasis. Institute of Molecular Medicine, University of Oxford, Oxford, L. Castellano,1 D. Correia Filho,1 L. Argiro,2 H. Dessein,2 A. Prata,1 United Kingdom; 2Department of Virology, Karolinska Institute, A. Dessein,2 V. Rodrigues.1 1Lab of Immunology, Faculdade de Stockholm, Sweden; 3Peter Medawar Building for Pathogen Medicina do Triangulo Mineiro, Uberaba, Minas Gerais, Bra- Research, University of Oxford, Oxford, United Kingdom. zil; 2Fac Medecine, INSERM U399, Marseille, France. Sa2.49 - Defining Putative T Cell Epitopes from PE and PPE Sa2.45 - Investigatin of IL-4 Gene Polymorphism in Patients Families of Proteins of Mycobacterium tuberculosis with V acVacwith Brucellosis. cine Potential. Manoochehr Rasouli, Amin Abbasian, Simin Kiany. 1Immunol- G. M. Chaitra,1 Sridhar Hariharaputran,2 Nagasuma R. ogy of Infectious Diseae Departrment, Clinical Microbiology Re- Chandra,2 S. M. Shaila,1 Rabindranath Nayak.1 1Department search Center- Shiraz University of Medical Sciences, Shiraz, of Microbiology & Cell Biology, Indian Institute of Science, BanFars, Islamic Republic of Iran; 2Immunology of Infectious Diseae galore, Karnataka, India; 2Bioinformatics Center, Indian InstiDepartrment, Clinical Microbiology Research Center- Shiraz tute of Science, Bangalore, Karnataka, India. University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Immunology of Infectious Diseae Departrment, Clinical Sa2.50 - The Study between the Changes of CD35 Expressed Microbiology Research Center- Shiraz University of Medical Scion Er ythrocyte in Patients with Hepatocirrhosis and the SeErythrocyte ences, Shiraz, Fars, Islamic Republic of Iran. verity of Liver Function Destroying. Ma Chi,1 Wang Haibin.2 1Dept. Immunology, Peking Union Sa2.46 - Immunophenotype Characterization of Peripheral Medical College, Beijing, China; 2Dept. Lab of Clinical ImmuBlood T LLymphocytes ymphocytes before and after TTreatment reatment in TTubercuubercu- nology, Beijing 302 Hospital, Beijing, China. losis Patients. Fereshteh Sahebfosul, Farzad Oreizi, Zohre Pessaran, Ahmad Sa2.51 - Deficient IgM to IgG Antibody Switch in Patients Ghavaminejad. 1Immunology, Medical School, Isfahan, Unresponsive TTo o Conjugate Pneumococcal Polysaccharides. Isfahan/Isfahn, Islamic Republic of Iran; 2Immunology, Medical L. E. Leiva, E. J. Saturno, H. Monjure, E. Barr, K. Mason, R. U. School, Isfahan, Isfahan/Isfahan, Islamic Republic of Iran; 3ImSorensen. 1Pediatrics, LSU Health Sciences Center and Children’s munology, Medical School, Isfahan, Isfahan/Isfahan, Islamic Hospital, New Orleans, LA, USA. Republic of Iran; 4Immunology, Medical School, Isfahan, Isfahan/Isfahan, Islamic Republic of Iran. 98

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2005 ANNUAL MEETING FINAL PROGRAM

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Sa2.52 - A Delayed Diagnosis of Cystic Fibrosis in a Patient with Asthma and Allergic Bronchopulmonar y Aspergillosis. Bronchopulmonary K. R. Lowe,1 C. P. Mikita.1 1Allergy/Immunology, Walter Reed Army Medical Center, Washington, DC, USA.

Sa2.57 - Human ‘Memor y’ CD4+ T Cells Are Distributed be‘Memory’ tween Five Phenotypically and Functionally Distinct Subsets. E. Amyes, A. J. McMichael, M. F.C. Callan. 1Division of Medicine, Chelsea and Westminster Hospital Campus, Imperial College, London, United Kingdom; 2MRC Human Immunology Unit, Sa2.53 - Determination of Borrelia burgdorferi Outer-Sur- Weatherall Institute of Molecular Medicine, Oxford, Oxfordshire, face Protein A161-175 Peptide Binding to HLA-DR Molecules United Kingdom. Associated with Antibiotic-Refractor y or Antibiotic-ResponAntibiotic-Refractory Sa2.58 - Characterization of the Th Cellular Immune Response sive LLyme yme Ar thritis. Arthritis. oxin Cr y1A Mutants in Spleen Cry1A 1 2 1 3 2 E. E. Drouin, B. Falk, L. J. Glickstein, W. Klitz, W. W. Kwok, Induced by the Diphtheria TToxin 2 4 1 1 G. T. Nepom, L.A. Baxter-Lowe, A. C. Steere. CIID/Rheu- Cells from Intranasally Primed BALB/c Mice. 1 1 1 matology Division, Massachusetts General Hospital / Harvard Fernando T. Hernandez, Gloria G. Guerrero. Escuela de 2 Medical School, Boston, MA; Benaroya Res Inst, Seattle, WA; Ciencias Biologicas. Unidad Torreon, Universidad Autonoma de 3 UC Berkeley, Oakland, CA; 4Immunogenetics and Transplan- Coahuila, Torreon, Coahuila, Mexico. tation Lab, UCSF, San Francisco, CA. accination with Chlamydial ProteaseSa2.59 - Intranasal V Vaccination Sa2.54 - Mycobacteria Directly Induces Cytoskeletal Rear- Like Activity Factor and Interleukin-12 Promotes the Clearance y C. trachomatis Infection. rangements for Macrophage Motility through TLR2-Dependent of Pulmonar Pulmonary 1 Ashlesh K. Murthy, Yu Cong,1 Guangming Zhong,2 Bernard P. PI3-K Signaling. 1 1 E. B. Lasunskaia,1 M. N. Campos,1 R. da Matta,2 T. L. Kipnis,1 Arulanandam. Biology, University of Texas at San Antonio, 2 W. D. da Silva.1 1Laboratory of Biology of Recognition, San Antonio, TX, USA; Microbiology and Immunology, UniverUniversidade Estadual do Norte Fluminense, Campos, Rio de sity of Texas Health Science Center, San Antonio, TX, USA. Janeiro, Brazil; 2Laboratory of Cell and Tissue Biology, Universidade Estadual do Norte Fluminense, Campos, Rio de Sa2.60 - Identification of ssRNA Sequences That Stimulate Janeiro, Brazil. Innate Immunity through TLRs. Alexandra Forsbach,1 Carmen Montino,1 Christian Muller,1 Jorg Sa2.55 - Chlamydia pneumoniae Infection of Human Immune Vollmer,1 Stefan Bauer,3 Grayson B. Lipford.2 1&ÿÿ2&ÿÿ3Inst. for Medical Microbiology & Immunology, Technical University of Cells Modulates Cytokine Production. 1 1 1 1,2 Y. Mamata, C. Newton, T. W. Klein, Y. Yamamoto, H. Fried- Munich, Munich, Germany. man.1 1Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL, USA; 2Basic Sa2.61 - Mechanism of In Vivo Cytotoxicity Mediated by Labolatory Science, Osaka University, Suita, Osaka, Japan. CFP10-Specific CD8+ T Cells. S. M. Behar,1 J. Woodworth,1 A. B. Kamath.1 1Division of RheuSa2.56 - Homeostatic Chemokines: Organizers of Cellular matology, Immunology, and Allergy, Brigham and Women’s Interactions Required for T Cell Priming in the Pulmonar y En- Hospital, Boston, MA, USA. Pulmonary vironment during the Influenza Infection. J. Rangel-Moreno,1 J. E. Moyron-Quiroz,1 K. Kusser, 1 S. Goodrich,1 L. Hartson,1 M. Tighe,1 T. D. Randall.1 1Immunology, Trudeau Institute, Saranac Lake, NY, USA.

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99

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Sa2.62 - Characterization of an Lck-Independent Pathway of T-Cell Activation Used by Bacterial Superantigens: Mechanistic and Therapeutic Implications on Autoimmunity Autoimmunity.. C. Bueno,1,2 G. Criado,1,2 M. L. Baroja,1,2 S. S. Ferguson,2,3 C. Tsoukas,5 J. Madrenas.1,2,4 1Immunology, FOCIS Centre for Clinical Immunology and Immunotherapeutics; 2Immunology, Robarts Research Institute; 3Department of Physiology and Pharmacology; 4Department of Microbiology and Immunology, The University of Western Ontario, London, ON, Canada; 5Department of Biology, San Diego State University, San Diego, CA, USA.

Sa2.67 - An Automated Methodology for Evaluation of Dendritic Cells in Whole Blood. C. Smith,1 E. Rabellino,1 J. Wilkinson,1 S. D’Costa.1 1Biomedical Research Division, Beckman Coulter Inc., Miami, FL, USA.

Sa2.68 - Ozonetherapy and Quality of Life in HIV Positive Patients. Osmel Gaspar Guerra Segura, Barbara Elias-Calles Fernadez. 1 Immunology Lab., Teach.and Gen Hosp. Dr.A. Neto, Guantanamo, Guantanamo, Cuba; 2Ozonetherapy Dept., Teach.and Gen Hosp. Dr.A. Neto, Guantanamo, Guantanamo, Sa2.63 - HLA Phenotype and the Production of IFNIFN-γγ and Cuba. Interleukin-10 in Patients with Chronic Urogenital Sa2.69 - Characteristics of Fas Ligand Expression by HuChlamydiosis. G. N. Drannik,1 V. E. Driyanskaya,1 S. N. Vashchenko,1 A. G. man Cytomegalovirus Infection. Drannik,2 L. M. DuBuske.3 1Institute of Urology, Academy of Eung-Soo Hwnag,1 Jung Heon Kim,1 Ye Jin Kwon,1 Hye Jin Jung,1 Medical Sciences, Kiev, Ukraine; 2McMaster University, Hamilton, Su-Yeon Kim,1 Chung-Gyu Park,1 Chang-Yong Cha.1 1DepartON, Canada; 3Immunology Research Institute of New England, ment of Microbiology and Immunology, Seoul National UniverGardner, MA, USA. sity College of Medicine, Seoul, Republic of Korea. Sa2.64 - Are Probiotics Essential Adjunctive Therapies for C difficile Enteritis? K. D. Karpa,1 N. Trenev,1 M. L. McCann.1 1College of Medicine, PSU, Hershey, PA, USA.

ype Immune Response Sa2.70 - Characterization of a Th1/T c1 TType Th1/Tc1 accine IC41 in Vaccine to the Novel Therapeutic Hepatitis C Peptide V Humans. S. Jelovcan,1 H. Wedemeyer,2 V. Buerger,1 E. Tauber,1 C. Klade.1 1 Intercell AG, Campus Vienna, Vienna, Austria; 2Medizinische Sa2.65 - Alterations in Th1 Subpopulations Correspond to Hochschule Hannover, Abt. Gastroenterologie, Hepatologie und Endokrinologie, Hannover, Germany. Clinical Pathology in Severe TTrauma rauma Patients. A. K. De,1 K. Laudanski,1 R. V. Maier,2 P. E. Bankey,1 J. P. Minei,3 irus X and C Protein Induce TTranscripranscripVirus C. Elson,4 D. Hayden,4 D. A. Schoenfeld,4 L. L. Moldawer,5 R. Sa2.71 - Hepatitis B V G. Tompkins,4 C. L. Miller-Graziano.1 1Surgery, University of tion of hfgl2 Prothrombinase Gene. Rochester Medical Center, Rochester, NY, USA; 2Surgery, Uni- Meifang Han,1 Dong Xi,1 Gary Levy,2 Xiaoping Luo,1 Qin Ning.1 versity of Washington, Seattle, WA, USA; 3Surgery, University 1Department of Infectious Disease, Tongji Hospital of Tongji of Texas Southwestern, Dallas, TX, USA; 4Surgery and Biostatis- Medical University, Huazhong University of Science and Techtics, Massachusetts General Hospital, Harvard, Boston, MA, nology, Wuhan, Hubei, China; 2Department of Medicine and USA; 5Surgery, University of Florida, Gainsville, FL, USA. Surgery and Multiorgan Transplant Program, The Toronto Hospital of the University of Toronto, Toronto, Canada. Sa2.66 - The Effect of Immunotherapies on In Vivo Antiviral accination of the Human Newbor n Induces Responses to HIV Sa2.72 - BCG V HIV.. Vaccination Newborn S. Andjelic,1 Z. Popmihajlov,1 L. Kelly-Rossini,1 P. Bellman,1 B. Specific Regulator y CD4+ T Cells. Regulatory Boyle,1 M. Lesser,1 J. Ruitenberg,2 C. Waters,2 R. El Habib,3 K. J. Riley,1 A. Keyser,1 A. Soares,1 H. Fletcher,3 W. Hanekom.1 A. Smith.1 1Medicine, Weill Medical College of Cornell Univer- 1Institute of Infectious Diseases, University of Cape Town, Cape sity, New York, NY, USA; 2Becton Dickinson, San Jose, CA, USA; Town, South Africa; 2University of Oxford, Oxford, United King3 Aventis Pasteur, Marcy l’Etoile, France. dom.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.73 - Effect of an Anti-Inflammator y Pentapeptide Produced Anti-Inflammatory by Entamoeba histolytica upon Gene Expression Related to Inflammation/W oundhealing. Inflammation/Woundhealing. R. Silva,1 G. Rico,1 I. Estrada,2 R. Ramos,2 D. Arenas,3 J. Gimenez,1 A. Torres,4 M. Morales,1 R. Kretschmer.1 1UIM Inmunologia, IMSS, Mexico, DF, Mexico; 2Inmunologia Molecular, IPN, Mexico, DF, Mexico; 3UIM en Genetica, IMSS, Mexico, DF, Mexico; 4Genetica de Poblaciones, IMSS, Mexico, DF, Mexico.

Sa2.79 - Clonal Organization of T Cell Memor y: Paradigm Memory: of “Focused Diversity” Contributes to Reper toire Flexibility Repertoire Flexibility.. Yuri N. Naumov,1 Shalyn C. Clute,1 Elena N. Naumova,2 Jack Gorski,3 Liisa K. Selin.1 1Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA; 2Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA, USA; 3Blood Research Institute, The Blood Center of S.-E. Wisconsin, Milwaukee, WI, USA.

y of Exogenous Lipid Sa2.80 - Capture and Specific Deliver Delivery Antigens by Apolipoprotein E. P. van den Elzen,1 S. Garg,2 M. Brigl,2 J. E. Gumperz,2 F. M. Sacks,3 G. S. Besra,4 D. B. Moody,2 M. B. Brenner.2 1Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United Kingdom; 2Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 3Nutrition, Harvard School of Public Health, Boston, MA, USA; 4School of Sa2.75 - Establishment of a Substitutive SARS Murine Model Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom. and Its Application in SARS Study Study.. Weiming Yan,1 Chuanglong Zhu,1 Xiaoping Luo,1 Qin Ning.1 1 Department of Infectious Disease, Tongji Hospital of Tongji Sa2.81 - Supertype Analysis: Definition of Overlapping Peptide-Binding Capacities for MHC Class I Molecules. Medical College, Wuhan, Hubei, China. R. Buchli,1 R. S. VanGundy,1 C. F. Giberson,1 W. H. Hildebrand.2 1 Sa2.76 - Direct Innate Immune Activation by Human Naive B Research Department, Pure Protein L.L.C., Oklahoma City, OK, USA; 2Department of Microbiology and Immunology, University Cells Via Combined TLR9 and RP105. of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Kazuko Yamazaki,1 Takashi Yamazaki,2 Takuma Hayashi,1 Kazuo Sugane,1 Kazunaga Agematsu.1 1Department of Infecalidation of Fluorescence Polar Validation Polar-tious Immunology, Graduate School of Medicine,Shinshu Uni- Sa2.82 - Development and V 2 ization-Based Competitive Peptide Binding Assays New versity, Matsumoto, Nagano, Japan; Department of Pediatrics, Screening TTools ools for Epitope Discover y. Discovery Shinshu University, Matumoto, Nagano, Japan. R. S. VanGundy,1 R. Buchli,1 C. F. Giberson,1 W. H. Hildebrand.2 Sa2.77 - Evaluacion del Numero de Linfocitos T Reguladores 1Research Department, Pure Protein L.L.C., Oklahoma City, OK, USA; 2Department of Microbiology and Immunology, University en Pacientes Con TTuberculosis. uberculosis. L. R. Gamez,1,2 M. Rocha,1 R. Gonzalez,2 S. Romano,1 D. P. of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Sa2.74 - Spectrum of CD1d-Restricted T Cells: Control of Anti-V iral and Anti-T umor Responses. Anti-Viral Anti-Tumor R. Wang,1 S. C. Yue,1 P. Ilyinskii,1 J. J. Van der Vliet,1 Kazuhiko Yanagisawa,1 A. Shaulov,1 Q. He,2 M. J. Koziel,2 S. P. Balk,1 M. A. Exley.1 1Cancer Biology, Hematology / Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 2Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Portales.1,2 1Inmunologia, Facultad de Ciencias Quimicas de la Universidad Autonoma de San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico; 2Inmunologia, Facultad de Medicina de la Universidad Autonoma de San Luis Potosi, San Luis Potosi, San Luis Potosi, Mexico.

Sa2.83 - Anthrax TToxins oxins Impair Pulmonar y Dendritic Cell FuncPulmonary tions: Implications in Pathogenesis. A. Cleret,1 A. Quesnel-Hellmann,1 J. Mathieu,1 D. Vidal,1 J.-N. Tournier.1 1Immunology Unit, CRSSA, La Tronche, France.

Sa2.78 - Direct Epitope Discover y for Y ellow Fever V irus Asibi-17D. Discovery Yellow Virus A. Collymore-Slovak,1 A. Gilb,1 C. Roberts,1 M. Jones,1 W. H. Hildebrand.1 1Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. ™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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Sa2.84 - Rheumatic Fever: Development of an Animal Model Using Streptococcal M1 Recombinant Protein. F. F. Alcantara,1,2,3 E. Postol,1,3 E.R. Alencar,1,3 V. R. Assis,1 L. Demarchi,1 J. Kalil,1,2,3 L. Guilherme.1,3 1Immunology Laboratory, Heart Institute (InCor), Sao Paulo, Sao Paulo, Brazil; 2Allergy and Clinical Immunology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil; 3Institute for Immunological Investigations, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.

Sa2.89 - Is There Any Relation between LLymphocyte ymphocyte Subsets, NK Activity and Infection in Beta Thalassemia Patients. Arezoo Jamali,1 Hossein Hadi nadoushan,2 Mina Izadyar,3 Farhad Vaezzadeh,1 Mahroo Mirahmadian,2 Bita Ansaripour.2 1 Medical Laboratory Scienses, Allied Medical School,Tehran University of Medical Scienses, Tehran, Tehran, Islamic Republic of Iran; 2Immunology, Tehran University of Medical Scienses, Tehran, Tehran, Islamic Republic of Iran; 3Medical Center of Peditrics, Tehran University of Medical Scienses, Tehran, Tehran, Sa2.85 - Effect of the Zinc in the Viability and Differentiation Islamic Republic of Iran. in Human and Murine Cells. Immuno-Oncology G. B. Vega,1 A. Polo,1 M. E. Morales,2 G. Rico.2 1Coordinacion de Educacion Medica Continua Facultad de Medicina, UNAM, Sa2.90 - Dysregulation of Histone Modification and DNA Mexico, DF, Mexico; 2UIM en Inmunologia. Hospital de Pediatria Methylation in Acute Myeloid Leukemia. CMN-SXXI, IMSS, Mexico, DF, Mexico. M. Ogawa, K. Sakashita, K. Koike. 1Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. Sa2.86 - IL-27/WSX-1 Signalling: An Important Role in the Pathogenesis of Experimental Septic Peritonitis. Sa2.91 - Immunological and Comparitive Study of Ras FamStefan Wirtz,1 Ingrid Tubbe,1 Mark Birkenbach,2 Richard S. ily Oncogene Product in V arious Human TTissues. issues. Various Blumberg,3 Neurath F. Neurath.1 1I. Medical Department, 1 V. Mehrotra, V. L. Lahiri. Biochemistry, Himalayan Institute of 2 Univesity of Mainz, Mainz, Germany; Department of Pathol2 Medical Sciences, Dehradun, Uttranchal, India; Pathology, S ogy and Anatomy, Eastern Virginia Medical School, Norfolk, N Medical College, Agra, Uttar Pradesh, India. 3 VA, USA; Gastroenterology Division, Brigham and Women’s Hospital, Harvard Medical, Boston, MA, USA. Sa2.92 - Defects in TCR Associated Proteins in Relation to Sa2.87 - Morphine Facilitates TTransendothelial ransendothelial Migration of Immune Impairment in Oral Cancer Patients. 1 2 1 1 1 HIV -1 Infected Monocytes across the Blood Brain Barrier by V. T. Cheriyan, S. C. Dutt, S. M. Krishna, P. Balaram. DiviHIV-1 sion of Cancer Research, Regional Cancer Centre, Trivandrum, Modulating P-Glycoprotein Expression in Brain MicrovascuKerala, India; 2Division of Radiotherapy, Regional Cacner Cenlar Endothelial Cells. tre, Trivandrum, Kerala, India. S. D. Mahajan, 1 S. A. Schwartz, 1 R. C. Chawda, 1 N. McCulloch, 1 M. P. Nair. 1 1 Medicine, Division of Sa2.93 - Is the Oncogenesis Epigenetic Induced Alternative Allergy,Immunology and Rheumatology, State University of New Way for Cell Sur vival? Survival? York at Buffalo, Buffalo, NY, USA. I. Bubanovic, S. Najman. 1Ob/Gyn, Medica Centre, Nis, Serbia, Yugoslavia; 2Department for Byology, Medical UniverSa2.88 - Intralesional T Cell Lines Obtained from Rheumatic sity School, Nis, Serbia, Yugoslavia. Hear ool for Searching Heartt Disease Lesions Can Be Used as a TTool for Non-Autoimmune M Protein Epitopes for Developing a Sa2.94 - Anti-Interleukin-10 Strategies in TTreatment reatment of MaligSafe V accine Against Group A Streptococci. Vaccine nant Diseases. L. Guilherme,1,3 S. E. Oshiro,1,3 C. Puschel,1,3 W. R. Silva,1,3 F. I. Bubanovic, S. Najman. 1Ob/Gyn, Medica Centre, Nis, Higa,1,3 L. Chaves,1,3 A. C. Tanaka,1 G. Spina,1 P. M.A. Serbia, Yugoslavia; 2Institute for Biology, Medical University Pomerantzeff,1 J. Kalil.1,2,3 1Heart Institute, University of Sao School, Nis, Serbia, Yugoslavia. Paulo, Sao Paulo, São Paulo, Brazil; 2Clinical Immunology and Allergy, School of Medicine, University of Sao Paulo, Sao Paulo, São Paulo, Brazil; 3Institute for Immunology Investigation, University of Sao Paulo, Sao Paulo, São Paulo, Brazil. 102

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.95 - Modulation of TNF alpha Effects on Apoptosis Induction in PC Cell Line. V. Jurisic,1 G. Bogdanovic,2 T. Srdic,2 V. Kojic,2 J. Dimitar,2 N. Kraguljac.3 1Pathophysiology, University of Kragujevac, School of Medicine, Kragujevac, Serbia, Yugoslavia; 2Experimental Oncology, Institute of Oncology, Novi Sad, Serbia, Yugoslavia; 3 Institute of Hematology, Belgrade, Serbia, Yugoslavia.

Sa2.99 - Innate Immune Adherence Activity to TTumor umor Cells Proper ties of Methotrexate-Loaded Adult and Cord Blood Er ythProperties Erythrocytes. Wang Xuan. 1Department of Transfusion, Changhai Hospital Second Military Medical University, Shanghai, China.

Sa2.100 - Er ythrocytes Promote the Expression of CXCR4 on Erythrocytes Leucocyte Membrane Actived by TTumor umor Cell. Sa2.96 - Priming of T Cells to Intracranial TTumor umor Antigens Cha Zhanshan. 1Department of Blood Transfusion, Changhai Does Not Confer a Sur vival Advantage. Survival Hospital Second Military Medical University, Shanghai, China. S. Velicu,1 Y. Han,1 I. Ulasov,1 T. Gajewski,1 M. S. Lesniak.1 1 Neurosurgery, The University of Chicago, Chicago, IL, USA. Sa2.101 - Cancer Cell Activation Study of Hemaimmune ReSa2.97 - An In V ivo Role for Tr ypanosoma cruzi Calreticulin Vivo in Antiangiogenesis. M. C. Molina,1 V. Ferreira,1 W. Schwaeble,2 D. Lemus,3 A. Ferreira.1 1Immunology Disciplinary Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Santiago, Chile; 2Morphology Disciplinary Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Santiago, Chile; 3Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom.

action Road Map Experimental System. Guo Feng. 1Department of Blood Tansfusion, Changhai Hospital Second Military Medical University, Shanghai, China. Sa2.102 - Apoptosis-Based Therapies for Hematological Malignancies. F. Q.B. Alenzi.1 1Department of Medical Laboratory Sciences, King Faisal University, Dammam, Saudi Arabia.

Sa2.103 - The Role of CD4+CD25+ T Cells in Leukemia ReBMT.. ™Sa2.98 - Post-T ranscriptional Control of MICA Expression lapse after BMT Post-Transcriptional F. Q.B. Alenzi.1 1Department of Medical Laboratory Sciences, by BCR/ABL Oncogene through PI3K/mTOR Pathway Pathway.. King Faisal University, Dammam, Saudi Arabia. N. Boissel,1 D. Rea,3 V. Tieng,1 N. Dulphy,1 M. Brun,1 J.M. 4 5 1 6 Cayuela, P. Rousselot, R. Tamouza, P. Le Bouteiller, F.X. Mahon,7 A. Steinle,8 D. Charron,1 H. Dombret,2 A. Toubert.1 Sa2.104 - The Immunoreactivity of Serum IgA with Gliadin in 1 Unite INSERM U396, Laboratoire d’Immunologie et Patients with Myeloma Multiplex. 1 2 1 d’Histocompatibilite, Institut Universitaire d’Hematologie, Paris, Zorica D. Juranic, Aleksandra I. Konic-Ristic, Svetislav Jelic, 1 1 1 2 France; Service d’Hematologie Adulte, Hopital Saint-Louis, Nenad Milanovic, Milica Marinkovic, Dusanka Milosevic, 1 1 1 3 Paris, France; Unite de Therapie Cellulaire et Clinique Jelena Radic, Nevenka Stanojevic-Bakic. Experimental OnTransfusionnelle, Hopital Saint-Louis, Paris, France; 4Laboratoire cology, Institute of Oncology and Radiology of Serbia, Belgrade, 2 Central d’Hematologie, Hopital Saint-Louis, Paris, France; 5Ser- Serbia, Yugoslavia; Institute of Bromatology, Faculty of Pharvice d’Onco-Hematologie, Centre Hospitalier de Versailles, Le macy, Belgrade, Serbia, Yugoslavia. Chesnay, France; 6Unite INSERM U563, Hopital Purpan, ranscription Factors Abnor malities Associated Abnormalities Toulouse, France; 7Laboratoire d’Hematologie, CHU de Bor- Sa2.105 - TTranscription deaux, Bordeaux, France; 8Institute for Cell Biology, Eberhard- with LLymphoid ymphoid Malignancies. Karls-University, Tuebingen, Germany. R. Beluzic,1 A. Tomljenovic,1 S. Dzebro,2 M. Dominis,2 M. Antica.1 1 Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia; 2 Merkur Clinical Hospital, Department of Pathology, Zagreb, Croatia.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Sa2.106 - Generation of Linear and Cyclic Peptides Revealed a Unique Fine Specificity of Rituximab and Its Possible Cross-Reactivity with an Acid Sphingomyelinase-Like Phosphodiesterase 3B Precursor Precursor.. Federico Perosa,1 Elvira Favoino,1 Maria Antonietta Caragnano,1 Marcella Prete,1 Franco Dammacco.1 1Department of Internal Medicine and Clinical Oncology (DIMO), University of Bari Medical School, Bari, Italy. Sa2.107 - Functional Analysis of Peripheral Blood LLymphoymphocytes Subsets in Patients with Cancer-Associated Dermatomyositis. A. Ponyi,1,2 M. Aleksza,1 L. Gergely,1 M. Garami,2 T. Constantin,2 K. Danko.1 1Division of Clinical Immunology, 3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary; 22nd Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Sa2.110 - The Application of an In Vitro Viability Assay Followed by Subtractive Hybridization for Identification of Prognostic Markers in Acute Myeloid Leukemia. A. Maha,1 H. F. Seow,1 S. K. Cheong,2 C. F. Leong.2 1Clinical Laboratory Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 2Clinical Haematology & Stem Cell Transplantation Services, Hospital University Kebangsaan Malaysia, Bandar Tun Razak, Kuala Lumpur, Malaysia. Sa2.111 - Expression of Granzyme B and CD86 Is Associated with Persistence of Cer vical Cancer Cancer.. Cervical Valeska B. Guzman,1 Andrey Morgun,1 Ismael D.C.G. Silva,2 Sylvia M.F. Brenna,2 Carmen R.N. Carvalho,2 Julisa C.L. Ribalta,2 Natalia Shulzhenko,1 Maria Gerbase-de-Lima.1 1Immunogenetics Division - Pediatrics Department, Federal University of Sao Paulo, Sao Paulo, SP, Brazil; 2Gynecology Department, Federal University of Sao Paulo, Sao Paulo, SP, Brazil. Sa2.112 - Potent TTumoricidal umoricidal Capacity of Macrophages Acativated by GcMAF and Therapeutic Use of GcMAF for a V Variety of Cancers. N. Yamamoto,1 M. Urade,2 Y. Koga,1 M. Ueda.1 1Molecular Immunology, Socrates Institute for Therapeutic Immunology, Philadelphia, PA, USA; 2Oral Surgery, Hyogo College of Medicine, Hyogo, Japan.

Sa2.108 - Bacteriophage HAP1: Molecular Basis of Its Antitumour Activity Activity.. K. Dabrowska,1 M. Zembala,2 J. Boratynski,1 M. Kujawa,3 K. Switala-Jelen,1 J. Wietrzyk,1 A. Opolski,1 A. Gorski.1,4 1Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland; 2Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Cracow, Poland; 3Center for Biostructure, Medical University of Warsaw, Warsaw, Sa2.113 - Clonal B Cells in Blood and Bone Marrow of PaPoland; 4Transplantation Institute, Medical University of War- tients with a Plasma Cell Dyscrasia- Light Chain Amyloidosis. saw, Warsaw, Poland. Michelle K. Manske,1 Stephanie Maiden,2 Roshini S. Abraham.1 1 Hematology / Internal Medicine, Mayo Clinic College of Medi+ Sa2.109 - Thy-1 Immature Natural Killer Cells Suppress Den- cine, Rochester, MN, USA; 2Department of Biochemistry, Univerdritic Cell Functions during the Development of Leukemia in a sity of Missouri at Rolla, Rolla, MO, USA. Mouse Model. Kazumi Ebata,1 Yukihiro Shimizu,1 Yasuhiro Nakayama,1 Sa2.114 - Immunomodulation by Different Forms of a Chiy Molecule That Selectively Binds to CD28. Costimulatory Masami Minemura,1 Jun Murakami,1 Tsutomu Kato,1 Toshiro meric Costimulator Sugiyama,1 Shigeru Saito.2 1Third Department of Internal Medi- M. Neighbors,1 J. C.-C. Chang,1 S. Leong,1 R. Ong,1 I. Sipos,1 cine, Toyama Medical and Pharmaceutical University, Toyama, D. Apt,1 J. Punnonen.1 1Human Therapeutics, Maxygen, RedToyama, Japan; 2Department of Obstetrics and Gynecology, wood City, CA, USA. Toyama Medical and Pharmaceutical University, Toyama, Toyama, Japan. Sa2.115 - Enhanced Melanoma TTumor umor Growth in CD28 Deficient Mice. F. Luhder,1 H. Voigt,2 D. Schrama,2 A. O. Eggert,2 J. C. Becker.2 1 Institute for Multiple Sclerosis Research, Georg-August University, Gottingen, Germany; 2Department of Dermatology, JuliusMaximilians-University, Wurzburg, Germany. 104

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.116 - ALL and CLL Cells Express Elevated TNF-alpha upon Stimulation When Compared with Normal B Cells. T. Selvaggi,1 S. Liau,1 M. Michelis,1 G. Mantile-Selvaggi.1 1Special Diagnostic Immunology Laboratory, Hackensack University Medical Center, Hackensack, NJ, USA.

Sa2.123 - Regulator y Cells and Human Malignant Gliomas. Regulatory A. Waziri,1 A. T. Ogden,1 R. C.E. Anderson,1 J. N. Bruce,1 D. E. Anderson.2 1Department of Neurological Surgery, Columbia University College of Physicians & Surgeons, the Gabriele Bartoli Brain Tumor Research Laboratory, the Neurological Institute, New York, NY, USA; 2Center for Neurologic Diseases, Harvard MediSa2.117 - Role of the MAP Kinase Signaling Pathway in the cal School, Boston, MA, USA. Regulation of Antigen Expression by Human Melanomas. ransfection of Breast and Lung Cancer Cell Lines M. Kono,1 I. S. Dunn,1,2 L. B. Rose,1,2 P. J. Durda,2 J. T. Kurnick.1,2 Sa2.124 - TTransfection 1 Pathology, Massachusetts General Hospital, Boston, MA, USA; with sHLA-A*0201 and sHLA-B*0702. 2 M. L. Gonzalez,1 C. M. Roberts,1 A. R. Gilb,1 W. H. Hildebrand.1 CytoCure, LLC, Beverly, MA, USA. 1 Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Sa2.118 - Optimization of a Manufacturing Process of Dendritic Cell V accine TTo o TTreat reat Colorectal Cancer Vaccine Cancer.. -Capture ELISA for GST-Capture O. Faure,1 R. Guillermo,1 M. Loudovaris,1 S. M. Lee,1 F. Aono,1 Sa2.125 - Serologic Study Using a GST 1 1 1 1 1 mination of Anti-HPV16 Antibodies in TTunisian unisian W omen. Women. Determination T. Vo, L. Ho, M. Schilling, J. Bender. Product Development Deter M. Achour, P. Sehr, D. Zeghal, L. Kochbati, F. Zouari, M. Pawlita, / Manufacturing Departments, IDM, Irvine, CA. R. Oueslati. 1Biology, Faculty of Sciences, Bizerte, Zarzouna, 2 3 Sa2.119 - Hfgl2 Prothrombinase/Fibroleukin Expression in Tunisia; DKFZ, Heidelberg, Germany; Hospital la Rabta, Tunis, 4 Tunisia; Institute Salah Azaiz, Tunis, Tunisia; 5Hospital la Rabta, Cancer and Its Potential Clinical Significance. Tunis, Tunisia; 6DKFZ, Heidelberg, Germany; 7Biology, Faculty Qin Ning,1 Fang Chen,1 Hanying Sun,1 Weiming Yan,1 Wenli of Sciences, Bizerte, Zarzouna, Tunisia. Liu.1 1Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Wuhan, Hubei, China.

Immunology of the Eye

Sa2.120 - Expression of Stromal Cell-Derived Factor-1 in Brain Biopsies from Patients with Primar y Central Ner vous System Primary Nervous Lymphoma. J. R. Smith,1 K. M. Falkenhagen,1 R. M. Braziel,2 S. E. Coupland,3 J. T. Rosenbaum.1 1Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA; 2Department of Surgical Pathology, Oregon Health & Science University, Portland, OR, USA; 3Department of Pathology, University Hospital Benjamin Franklin, Berlin, Germany. Sa2.121 - Phase 1-2 Evaluation of Different Immunotherapy Protocols for GBM. G. A. Moviglia,1 A. Carrizo,1 G. Varela,1 A. Kreutel,1 C. A. Gaeta,1 R. Moya,1 P. Farina,1 H. Costanzo,1 S. Merino,1 M. J. Veloso,1 A. Paes de Lima,1 H. Molina.1 1Immunotherapy, Regina Mater Foundation, Buenos Aires, Argentina.

Sa2.126 - The Involvement of Autoimmunity Against Retinal Antigens in Deter mining Disease Severity in TToxoplasmosis. oxoplasmosis. Determining 1 2 2 A. L. Vallochi, C. Silveira, R. Belfort, Jr., L. V. Rizzo.1 1Immunology, University of Sao Paulo, Sao Paulo, São Paulo, Brazil; 2 Ophthalmology, Federal University of Sao Paulo, Sao Paulo, São Paulo, Brazil. Sa2.127 - Ipsilateral LLymphadenectomy ymphadenectomy TTo o Inhibit Cor neal Corneal Allograft Rejection in Rats. Ling Shiqi, Hu Yanhua. 1Ocular Surface Center, Sun Yat-sen University, Guangzhou, Guangdong, China; 2Ophthalmology of Tongji Medical College, Huazhong University of Science and Technology.

Sa2.128 - Different Circulating Levels of Endothelin-1 in Plasma from Glaucoma Patients. Sa2.122 - Suppression of Lck Sensitizes Acute LLymphoblasymphoblas- Aida Jimenez-Martinez,1 MaCarmen Jimenez-Martinez,1 Vincent tic T Cells to the Antiproliferative Action of Interferon Alpha. Korder.1 1Research Unit, Institute of Opthalmology, Conde de S. M. Chan,1 P. J. Utz.1 1Medicine, Stanford University, Stanford, Valenciana, Mexico, D.F., Mexico, D.F., Mexico. CA, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Sa2.129 - LPS Stimulation Induce an up Regulation of TLR-4 on Limbal Epithelial Cells without Secretion of TNF-Alpha. Yonathan Garfias,1 Marisela Linares,1 Raul Suarez,1 Alejandra Sanchez-Navarro,1 MaCarmen Jimenez-Martinez.1 1Research Unit, Institute of Ophthalmology, Conde de Valenciana, Mexico, D.F., Mexico, D.F., Mexico.

Poster Session 1 Sunday,, May 15, 2005 Sunday 7:30 am - 1:30 pm Cytokines/Chemokines

Su1.01 - ST AT-1 Mediates the Stimulator y Effect of IL-10 on STA Stimulatory CD14 Expression in Human Monocytic Cells. Sa2.130 - CD80 and CD86 Expression on Corneal EpitheA. A. Rahim Rahimi,1 K. Gee,3 S. Mishra,1 W. Lim,1 A. Kumar.1,2,3 lial Cells Infected with Adenovirus. 1 1 1 1 Departments of Biochemistry, Microbiology and Immunology, MaCarmen Jimenez, Herlinda Mejia, Marisela Linares, 2 1 1 1 Alejandra Sanchez-Navarro, Raul Suarez, Yonathan Garfias. University of Ottawa; Pathology and Laboratory Medicine, 3 1 Research Unit, Institute of Ophthalmology, Fundacion Conde University of Ottawa; Division of Virology and Molecular Immunology, Research Institute, Children’s Hospital of Eastern Ontario, de Valenciana, Mexico, D.F., Mexico, D.F., Mexico. Ottawa, ON, Canada. Sa2.131 - Adamantiades-Behcet’ rend in TTime. ime. Adamantiades-Behcet’ss Disease: A TTrend L. I. Kump,1 K. L. Moeller,1 S. Kurup,1 G. F. Reed,1 R. B. Su1.02 - Altered Cytokine Production and Reduced Membrane Nussenblatt.1 1Laboratory of Immunology, National Eye Insti- Signaling through the Antigen Receptor in CD4+ T Cells tute, NIH, Bethesda, MD, USA. y-6A.2 Molecule. Overexpressing LLy-6A.2 Anil Bamezai, Jennifer Reed, Abraham Chacko. 1Biology DeSa2.132 - Visual Outcomes in Children with Juvenile Idio- partment, Villanova University, Villanova, PA, USA. pathic Arthritis-Associated Uveitis. ymphocytes Demonstrate Different Functioning L. I. Kump,1,2 R. A. Cervantes Castaneda,1 S. N. Androudi,1 G. Su1.03 - LLymphocytes 2 1 1 F. Reed, C. S. Foster. Ocular Immunology and Uveitis Ser- Changes Induced by Exogenous PDGF-AB and TGF-b In Vitro vice, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; at Cerebral and Coronar y Atherosclerosis: What Is EstabCoronary 2 Laboratory of Immunology, National Eye Institute, NIH, Bethesda, lished? MD, USA. Andrei I. Teplyakov.1 1Resrarch Institute for Ecopathology and Sa2.133 - Increased Expression of IIκ κB α Per mits TTolerance olerance Occupational Diseases, Mogilev, Belarus. Permits Induction by TGF β-T reated Antigen Presenting Cells. TGFβ -Treated A. P. Ghafoori,1 B. Turpie,2 J. W. Streilein,2 S. Masli.2 1HMS, Su1.04 - Live Measurement of Chemokine TTriggered riggered Integrin Harvard Medical School, Boston, MA, USA; 2Department of Activation on a Single-Molecule Level. Ophthalmology, Schepen Eye Research Institute,Harvard MediR. H. Eibl.1 1Institute of Pathology, Technical University of Munich, cal School, Boston, MA, USA. Munich, Germany. Sa2.134 - CD36 and Thrombospondin Interaction Is Essential for the TTolerance olerance Inducing Proper ties of TGF β-T reated Properties TGFβ -Treated Antigen Presenting Cells. S. Masli,1 B. Turpie,1 J. W. Streilein.1 1Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA.

Su1.05 - Sp1 Binding Site of TGF-beta1 Promoter Is the TTar ar ar-get for TTrans-Activation rans-Activation by HPV -16 E6 and E7 Oncoproteins. HPV-16 O. Peralta-Zaragoza,1 V. Bermudez-Morales,1 M. Bahena-Roman,1 J. Alcocer-Gonzalez,2 F. Recillas-Targa,3 V. Madrid-Marina.1 1Division of Pathogens Molecular Biology, National Institute of Public Health from Mexico, Cuernavaca, Morelos, Mexico; 2 School of Biological Sciences, Autonomous University of Nuevo Sa2.135 - α Blocking Therapy in Patients with Endogeneous Leon, Monterrey, Nuevo Leon, Mexico; 3Department of MolecuUveitis. lar Genetics, Institute of Cellular Physiology, National AutonoP.M. Van Hagen for the RESCU study group. Erasmus MC mous University of Mexico, Mexico, DF, Mexico. Rotterdam and, Eye Hospital Rotterdam, The Netherlands 106

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su1.06 - Orexin-A Has Delayed Reponse to Intestinal IschemiaReper fusion Injur y. Reperfusion Injury Ji Lin,1 Guang-Tao Yan,1 Xiu-Hua Hao,1 Lu-Huan Wang,1 Kai Zhang.1 1Research Laboratory of Biochemistry, Basic Medical Institute,General Hospital of P.L.A, Beijing, Beijing, China.

Su1.12 - Quantification of mRNA Expression of TNFα and TNF-α β− ime Quantitative R TGFβ− β−,, Fas, TNFR1 and 2 Using Real-T Real-Time RTTTGF PCR. F. Q.B. Alenzi. 1Department of Medical Laboratory Sciences, King Faisal University, Dammam, Saudi Arabia.

Su1.07 - Increased Interleukin-6 Serum Levels in Subjects with Metabolic Syndrome. I. N. Kondratska,1 B. N. Mankovsky.1 1Diabetes, Institute of Endocrinology, Kiev, Ukraine.

Su1.13 - Role of TWEAK, a Member of the TNFa Family of Cytokines, in Arthritis. S. Perper,1 B. Browning,2 C. Gao,1 K. Giza,1 L. Rajman,3 L. Runkel, 3 M. Scott, 3 L. C. Burkly, 2 T. Zheng, 2 H. Hess. 1 1 Immunopharmacology, Biogen Idec, Cambridge, MA, USA; 2 Su1.08 - LIGHT Regulates CD86 Expression on Dendritic Cells Exploratory Science, Biogen Idec, Inc, Cambridge, MA, USA; through NF-kB, but Neither p44/42 MAPK nor JNK/AP-1 Sig- 3Validation Genetics, Biogen Idec, Inc, Cambridge, MA, USA. ransduction Pathway nal TTransduction Pathway.. -Cells Is G. M. Zou,1 W. Y. Hu.2 1Bone Marrow Transplantation, Rush Su1.14 - The Anti-Proliferative Effect of Infliximab on TT-Cells 2 University Medical Center, Chicago, IL, USA; Physiology and Prevented by CD28 Induced Co-Stimulation. Biophysics, University of Illinois at Chicago, Chicago, IL, USA. B. Gunnlaugsdottir,1,2 S. M. Maggadottir,1,2,3 B. R. Ludviksson.1,2,3 1 Center for Rheumatology Research, Landspitali - University HosSu1.09 - An Impor tant Role of Inducible Histamine in PP.acnes.acnes- pital, Reykjavik, Iceland; 2Institute of Laboratory Medicine, DeImportant partment of Immunology, Landspitali - University Hospital, Primed and LPS-Induced Hepatitis in Mice. 3 1 1 1 1 M. Nishibori, H. K. Takahashi, M. Yokoyama, A. Yokoyama, Reykjavik, Iceland; Department of Medicine, University of IceT. Yoshino,2 T. Watanabe,3 T. Watanabe,4 H. Ohtsu,5 H. Wake,1 land, Reykjavik, Iceland.

S. Mori.1 1Department of Pharmacology, Okayama Univ Grad Schl of Med & Dent, Okayama, Okayama, Japan; 2Department of Pathology, Okayama Univ Grad Schl of Med & Dent, Okayama, Okayama, Japan; 3Department of Mol Immunology, Kyushu Univ, Fukuoka, Fukuoka, Japan; 4Department of Pharmacology, Tohoku Univ Gad Schl Med, Sendai, Miyagi, Japan; 5Department of Appl Quant Med Eng, Tohoku Univ Grad Schl Eng, Sendai, Miyagi, Japan. Su1.10 - Receptors for V ascular Endothelial Growth Factor Vascular (VEGF) on Murine LLymphocytes ymphocytes and Macrophages. Ekaterina P. Kisseleva,1 Andrei V. Krylov,1 Victoria I. Lioudyno.1 1 Immunology, Institute for Experimental Medicine, St.Petersburg, Russian Federation.

Su1.15 - Lack of Linkage between DNA Methylation and Interleukine-10 Gene Expression. Jun Dong,1 Claudia Ivascu,2 Florian Eckhardt,2 Hyun-Dong Chang,3 Carolina Haefliger,2 Lars Tykocinski,3 Martin Rudwaleit,4 Jochiem Sieper,4 Andreas Radbruch,3 Andreas Thiel.1 1Clinical Immunology, German Rheumatism Research Center, Berlin, Germany; 2Epigenomics, Berlin, Germany; 3Cell Biology, German Rheumatism Research Center, Berlin, Germany; 4Rheumatology, Charite Campus Benjamin Franklin, Berlin, Germany.

Su1.16 - Epigenetic Regulation of TNF alpha in Monocytes/ Macrophages. K. E. Sullivan,1 K. Dietzmann,1 A. R. Suriano,1 A. N. Sanford,1 Su1.11 - Modulation of Suppressor of Cytokine Signalling 3 M. A. Petri, M. Bhatia,2 B. Aramati.1 1Allergy Immunology, (SOCS3) Expression and Stability in Human Neutrophils and Children’s Hospital of Philadelphia, Philadelphia, PA, USA; 2 Stem Cell Biology, Robarts Research Institute, London, ON, in Differentiated PLB-985 Cells by G-CSF G-CSF,, GM-CSF and IL-4. Canada; 3Rheumatology, Johns Hopkins University School of 1 1 1 C. Ratthe, D. Girard. INRS, Institut Armand-Frappier, PointeMedicine, Baltimore, MD, USA. Claire, QC, Canada.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

107

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su1.17 - A Fast and Robust Multiplexed Immunoassay Panel for Simultaneously Quantifying 24 Cytokines/Chemokines in Rat Serum or Plasma Using Luminex xMAP TTechnology echnology echnology.. S. Ji,1 T. Whitehead,1 H. Hwang,1 R. Rick,1 J. Mistry.1 1. R&D, LINCO Research, St. Charles, MO, USA.

Su1.22 - Phosphodiesterase Regulation of TNFα Expression TNF-α after Spinal Cord Injur y. Injury S. M. Schaal, M. Perez, A. E. Marcillo, W. D. Dietrich, D. D. Pearse. 1Miami Project To Cure Paralysis, Departments of Neurological Surgery, Neurology, and Cell Biology and Anatomy, Miller School of Medicine, Miami, FL, USA.

Su1.18 - Markers of Inflammation, Vitamin E and Peripheral Ner vous System Function. The InCHIANTI Study Nervous Study.. R. Paganelli,1 A. Di Iorio,1 L. Ferrucci,2 E. Sparvieri,1 A. Michetti,1 C. Franceschi,4 A. Cherubini,3 U. Senin,3 G. Abate.1 1Department of Medicine and Sciences of Aging, University G. d’Annunzio, Chieti, Italy; 2Longitudinal Studies Section, Clinical Research Branch, NIH, Baltimore, MD, USA; 3Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy; 4Department of Biomedical Sciences, University of Bologna, Bologna, Italy.

Su1.23 - Analysis of IL-27 (EBI3/p28) Expression in EBV EBV-- and ymphomas: Heterogeneous Expression of HTL V-1-Associated LLymphomas: HTLV EBI3 Subunit by TTumoral umoral Cells. F. Larousserie,1,2 E. Bardel,1 S. Pflanz,3 B. Arnulf,4 C. LomeMaldonado,5 O. Hermine,1 L. Bregeaud,2 M. Perennec,2 N. Brousse,2 R. Kastelein,3 O. Devergne.1 1CNRS UMR 8147, Universite Paris V, IFR Necker, Paris, France; 2UPRES EA 219, Hopital Necker, Paris, France; 3DNAX Research Institute, Palo Alto, CA, USA; 4Service d’Immuno-Hematologie, Hopital SaintLouis, Paris, France; 5Department of Pathology, Instituto SalvaSu1.19 - Protective Effect of Galectins Against the General- dor Zubiran, Mexico City, Mexico. ized Shwartzman Reaction of Mice. Ryusuke Nakagawa,1 Hiroko Abe,1 Mitsuomi Hirashima,2 Akira Su1.24 - Pin1 Regulates Cytokine Expression in Human PeYamauchi.1 1Cell Regulation, Kagawa University, School of ripheral Blood Mononuclear Cells. Medicine, Kita-gun, Miki-cho, Kagawa, Japan; 2Immunology S. J. Esnault,1 Z. J. Shen,1 J. S. Malter.1 1Pathology and Laboraand Immunopathplogy, Kagawa University, School of Medicine, tory Medicine, Waisman Center, University of Wisconsin, MadiKita-gun, Miki-cho, Kita-gun, Miki-cho, Japan. son, WI, USA. Su1.20 - Analysis of Cytokine Network for Initiation of Immune Responses in the Hyperplastic Thymus Associated with Myasthenia Gravis. I. Kamo,1 A. Kikuchi,2 H. Tomoyasu,3 N. Sakuragawa.1 1Regenerative Medicine, School of Medicine, Toho University, Sagamihara, Kanagawa, Japan; 2Ultrastracuture, National Institute of Neuroscience, Kodaira, Tokyo, Japan; 3Respiratoy, Japan Red Cross, Ohmori, Tokyo, Japan. Su1.21 - Age-Related Changes in Cytokine Production in Cher nobyl Clean-up W orkers from Latvia. Chernobyl Workers Natalja Kurjane,1 Natalija Gabrusheva,2 Ruta Bruvere,2 Elvira Hagina,3 Tija Zvagule,1 Arija Volrate,4 Guna Feldmane.4 1Centre of Occupational and Radiological Medicine, P.Stradins University Hospital, Riga, Latvia; 2Biomedical Research and Study Centre, University of Latvia, Riga, Latvia; 3Institute of Immunology, Riga, Latvia; 4Institute of Virology and Microbiology, Riga, Latvia.

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racheobronchial Su1.25 - Cytokine and Enzyme Spectrum in TTracheobronchial Aspirate of Newbor ns with Pneumonia TTreated reated with RecomNewborns binant IL2. Dilbar Kajumova,1 Leonid Nikulin,1 Oleg Borovikov.2 1Pediatric Department, Kuban State Medical Academy, Krasnodar, Russian Federation; 2Clinical Immunology and Allergy, Kuban State Medical Academy, Krasnodar, Russian Federation. Su1.26 - Cytokines and Anticytokines Therapy in Severe Acute Pancreatitis. S. Chooklin,1 A. Perejaslov.1 1Department of Surgery, Medical University, Lviv, Ukraine.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su1.27 - Cytokine Production by Dendritic Cells Stimulated with Microbial Products Modulated by Epigallocatechin Gallate (EGCG). J. Rogers,1 I. Perkins,1 A. van Olphen,1 N. Burdash,1 T. W. Klein,1 H. Friedman.1 1Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL, USA.

Su1.33 - Regulation of Inducible Heparanase Gene Expression in Human TT-Cells -Cells by Soluble and Immobilize TNF α. TNFα. Ilya Sotnikov, Liora Cahalon, Oded Vainas, Rinat Eshel, BenZion Katz, Neta Ilan, Israel Vlodavsky, Irun Cohen, Ofer Lider. 1 Immunology, The Weizmann Institute of Science, Rehovot, Israel; 2Bone Marrow Transplantation, The Hematology Institute, Sourasky Medical Center, Tel-Aviv, Israel; 3Oncology, HadassahSu1.28 - TSG-6 Protein Up-Regulates Cyclooxygenase-2 Ex- Hebrew University Hospital, Jerusalem, Israel. pression and Prostaglandin Biosynthesis in Macrophage Cell Su1.34 - Serum Free PBMC Freezing and TTesting esting Conditions Line. Afford Enhanced Detection of Antigen-Specific T Cells and 1 1 1 1 1 C. Mindrescu, J. Le, H.-G. Wisniewski, J. Vilcek. Department of Microbiology, New York University, School of Medicine, Standardization of Immune Monitoring. W.J. Zhang,1 S. Gregory,2 M. Ewell,2 W. Lopaczynski,2 T. Watts,2 New York, NY, USA. C. Shive,1 N. Sigmund,1 S. Berry,1 O. Targoni,1 J. Lathey,2 P. V. 1 1 2 Su1.29 - The Experimental Study on the Antitumor Effect of 4- Lehmann. &1ÀŒ-õŒ-õ BBI Biotech Research Laboratories, A Division of SeraCare Life Sciences, Gaithersburg, MD, USA. 1BBL In Vivo. 1 Li Qiaoxia, Shan Baoen. Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; 2Re- Su1.35 - Serum High Mobility Group B1 [HMGB1] Is a Damsearch Center, The Fourth Hospital of Hebei Medical University, age Associated Molecular Pattern [DAMP] Cytokine Elevated in Chronic Hepatitis C Patients and Diminishing Following Shijiazhuang, Hebei, China. Or thotopic Liver TTransplantation. ransplantation. Orthotopic Su1.30 - Enhanced Immunol Efficacy of mIL-23 Gene Modi- M. T. Lotze,1 R. Day,2 M. E. DeVera,3 A. J. Demetris,3 R. A. DeMarco,1 O. Shakil.3 1Surgery, Bioengineering, and Molecufied TTumor umor V accine. Vaccine. 1 Shan Banen, H.A.O. Jingsheng. Research Center, The Fourth lar Genetics and Biochemistry, University of Pittsburgh Molecu2 Hospital of Hebei Medical University, Shijiazhuang, Hebei, lar Medicine Institute, Pittsburgh, PA, USA; Department of Bio3 2 China; Research Center, The Fourth Hospital of Hebei Medical statistics, University of Pittsburgh, Pittsburgh, PA, USA; Surgery, Medicine, and Pathology, Starzl Transplant Institute, Pittsburgh, University, Shijiazhuang, Hebei, China. PA, USA. Su1.31 - Expressions of mIL-23 Gene in Murine Colon Carcinoma Cells Induces Production of NO and TNFα in Murine TNF-α Macrophages. H.A.O. Jingsheng, Shan Baoen. 1Research Center, The Fourth Hospital of Hebei Medical University, China, Hebei, China; 2Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Su1.36 - Ex V ivo Pro-Inflammator y Cytokines Expression in Vivo Pro-Inflammatory Patients with Aggressive Periodontitis. F. E. Gonzalez,1,2 D. Catalan,1 J. C. Aguillon.1 1Disciplinary Program of Immunology, Faculty of Medicine, University of Chile, Santiago, Región Metropolitana, Chile; 2Dentomaxilofacial Service, University of Chile Clinical Hospital. University of Chile, Santiago, Región Metropolitana, Chile.

Su1.32 - Control of Apoptosis of Primar y Human Peripheral Primary CD4+ T Cells. M. Pajusto, J. Tarkkanen, P. S. Mattila. 1Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland; 2Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland; 3Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Su1.37 - IL-22 Increases the Innate Immunity of the Skin. K. Wolk, S. Kunz, E. Witte, M. Friedrich, K. Asadullah, R. Sabat. 1 Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charite, Berlin, Germany; 2Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charite, Berlin, Germany; 3Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charite, Berlin, Germany; 4Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charite, Berlin, Germany; 5CRBA Dermatology, Schering Inc., Berlin, Germany; 6Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charite, Berlin, Germany.

Su1.42 - Local TT-L -L ymphocytes from Subacute and Chronic -Lymphocytes Hypersensitivity Pneumonitis Show Phenotypic and Functional Differences. Felipe Mendoza,1 Lourdes Barrera,1 Emma Melendro,2 Annie Pardo,3 Moises Selman.1 1Inmunoquimica, National Institute of Respiratory Diseases, Mexico City, Mexico; 2Medicina Experimental, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico; 3Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.

Su1.43 - Phenotypic and Functional Analysis of Memor y CD4 Memory ymphocytes in Subacute and Chronic Hypersenand CD8 T LLymphocytes sitivity Pneumonitis. L. Barrera,1 F. Mendoza,2 M. Selman.1 1Immunochemistry, National Institute of Respiratory Diseases, Mexico City, Mexico Su1.38 - IL-7 in Human B Cell Development. 2 1 1 1 1 Y. K. Parrish, E. Sahakian, G. M. Crooks, E. Zielinska, L. W. City, Mexico; Sistemas Biologicos, Universidad Autonoma Barsky,1 K. J. Payne.1 1Research Immunolgy/BMT, Childrens Metropolitana, Mexico, D.F., Mexico. Hospital Los Angeles, Los Angeles, CA, USA. Su1.44 - Pro-Inflammator y and Anti-Inflammator y Cytokines Pro-Inflammatory Anti-Inflammatory T rack with KIR Haplotypes A and B in Octo/Nonagenarian Su1.39 - An Impor tant Role for CX3CR1 in V ascular Remodeling. Important Vascular P. Liu,1 S. Patil,2 M. Rojas,3 A. Fong,1 S.S. Smyth,3 D.D. Patel.1 Subjects. 1 Thurston Arthritis Research Center and Department of Medi- I. M. Rea,1 L. D. Maxwell,2 O. A. Ross,2 C. A. Rea-Lyon,1 H. D. cine, University of North Carolina at Chapel Hill, Chapel Hill, Alexander,3 D. Middleton.2 1Geriatric Medicine, Queens UniNC; 2School of Medicine, Duke University, Durham, NC; 3Divi- versity Belfast, Belfast, Northern Ireland, United Kingdom; 2NI sion of Cardiology and Carolina Cardiovascular Biology Cen- Regional Histocompatability and Immunogenetics Laboratory, ter, University of North Carolina at Chapel Hill, Chapel Hill, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom; 3 NC, USA. Haematology Laboratory, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom. Su1.40 - Chromatin Regulation of Interleukin 10 Gene ExSu1.45 - Evaluation of TH1/TH2 Cytokine Modulations in pression at the Allele Level. 1 2 1 1 -Infected Adults Who Received Therapeutic HIV-Infected D. Calado, D. Holmberg, H. Matthias. Cellular Differentia- Chronically HIV tion, Gulbenkian Institute for Science, Oeiras, Portugal; 2Umea Vaccination and Inter mittent HAAR T Intermittent HAARTT Following an Initial HAAR HAART Center for Genome Research, Umea University, Umea, Sweden. Intensification (CTN-140 Pilot TTrial). rial). Sardar Sindhu,1,2,3 Maude Loignon,1 Jose Menezes,2,3 Emil Su1.41 - Local Interleukin-1 Immunotherapy Effectiveness De- Toma.1,3 1Microbiology & Infectious Diseases, CHUM-Hotel Dieu pends on Cytokine Genetic Background. Hospital, Montreal, QC, Canada; 2Immunovirology Lab and 1 1 1 A. S. Simbirtsev, A. J. Gromova, L. E. Timchuk, E. A. Viral & Immune Diseases Program, CHUM-Ste Justine Hospital, Variouchina.1 1Immunopharmacology, Institute of Highly Pure Montreal, QC, Canada; 3Microbiology & Immunology, UniverBiopreparations, St.Petersburg, Russian Federation. sity of Montreal, Montreal, QC, Canada.

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May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su1.46 - Cytokine Expression in CD4+ Cells Exposed to the y Factor Produced by E. Inhibitory Monocyte Locomotion Inhibitor histolytica. S. Rojas,1 G. Rico,1 J. Perez,2 J. Velazquez,1 R. Kretschmer.1 1 UIM en Inmunologia, Hospital de Pediatria CMN S-XXI, IMSS, Mexico, DF, Mexico; 2Division de Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana, Mexico, DF, Mexico.

Su1.53 - TGFα in Foxp3 Expression and Development of TGF-α Peripheral CD4+CD25+ TTreg. reg. W.J. Chen, Y. Liu. 1Mucosal Immunology Unit, OIIB, NIDCR, NIH, Bethesda, MD, USA.

Su1.54 - Osteoprotegerin Synthesis by Circulating T Cells Is Related to Osteoporosis in HIV -Infected Patients. HIV-Infected A. Chakravarti,1 L. Flamand,1 R. Lalonde,2 P. E. Poubelle.1 1Department of Medicine, Centre de Recherche en Rhumatologie et Su1.47 - Interleukin 21 Modulates Cytokine Pathways That Immunologie,Universite Laval, Quebec, QC, Canada; 2Division of Infectious Diseases, Royal Victoria Hospital, McGill UniverContribute to the Pathology of Arthritis. 1 1 1 1 1 L. Lowe, M. Senices, M. Hegen, J. C. Keith, Jr., J. Lamothe, sity, Montreal, QC, Canada. P. Wu,1 M. Whitters,1 C. Nickerson-Nutter,1 D. Young,1 M. Collins.1 1Inflammation, Wyeth Research, Cambridge, MA, USA. Su1.55 - Detection of Cytokines in Patients with Hypersensitivity to Metals. Su1.48 - Critical Role of ST AT1 on Self-Renewal Capacity of Z. Venclikova,1 J. Bartova,1 L. Mrklas.1 1Clinical Department, STA The Institute of Dental Research, 1st Medical Faculty and GUH, CNS Stem Cells by an Inducible Interferon-g J. Imitola, R. Fryer, Y. Wang, S. Rasmussen, R. V. Jensen, S. J. Charles University, Prague 2, Prague, Czech Republic. Khoury. 1Neurology, Brigham and Women’s Hospital, Boston, Su1.56 - SCY A4L Polymorphism Genotyping by Fluorescent SCYA4L MA, USA. Resonance Emission (FRET) Probes in Real-Time PCR. Su1.49 - Role of CXCL1/CXCR2 in Promotion of Glial Sur- Roger Colobran,1 Rosa Faner,1 Carles Llop,1 Ricardo Pujol,1 Manel Juan.1 1LIRAD (Laboratori d’Immunobiologia per a la vival during Experimental Demyelination. L. T. Remington,1 S. P. Zehntner,1 C. A. Hollmann,1 T. Owens.1 Recerca i Aplicacions Diagnostiques) / IICSGTIP (Institut 1 Neuroimmunology, Montreal Neurological Institute, Montreal, d’Investigacio en Ciencies de la Salut Germans Trias i Pujol), CTBT (Centre de Transfusio i Banc de Teixits) / UAB (Universitat QC, Canada. Aut. Su1.50 - Standardizing Multiparameter Flow Cytometr y for Cytometry Evaluation of Cytokine-Secreting Activity in T Cells Via Automation of Sample Preparation and Analysis. J. Wilkinson,1 C. Smith,1 S. D’Costa,1 E. Rabellino.1 1Biomedical Research Division, Beckman Coulter Inc., Miami, FL, USA.

Su1.57 - Correlation of Interleukin-4 and Chronic Periodontitis. Mandana Sattari,1 Saeed Khalili,1 Leili Mehrdad.1 1Immunology, Shaheed Beheshti University Medical School, Tehran, Islamic Republic of Iran.

Su1.51 - LLT TβR Expressed, Functional, and Regulated on EnSu1.58 - Interleukin-21 Maintains T Cells in a Naive Phenodothelial Cells during Contact Sensitization. 1 1 1 S. Liao, N. H. Ruddle. Epidemiology and Public Health, type. S. Ferrari-Lacraz,1 D. C. Foster,2 R. Chicheportiche.1 1ImmunolYale University School of Medicine, New Haven, CT, USA. ogy and Allergy, University Hospital, Geneva, Geneva, Switzerland; 2Cytokine Biology, Zymogenetics, Seattle, WA, USA. Su1.52 - Interferon-að Inducing TLR9 Agonists. E. R. Kandimalla, D. Yu, T. Sullivan, S. Agrawal. 1Discovery, Hybridon, Inc., Cambridge, MA, USA.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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Su1.59 - Osteopontin, a Th1 Cytokine, Promotes Cell Survival and Inhibits Programmed Cell Death of Activated T Cells. E. M. Hur,1 L. Steinman.2 1Program in Immunology, Stanford University, School of Medicine, Stanford, CA, USA; 2Neurology and Neurological Sciences, Stanford University, Medical School, Stanford, CA, USA.

Su1.64 - Gene Identification of Single Chain Format Variable(scFv) Anti-ß2-Glycoprotein-I (aß2GP-I) and Anti-Prothrombin (aPt) Antibodies Obtained from a Primar y Anti-PhosPrimary pholipid Syndrome (P APS) Patient by Phage Display (PAPS) Display.. J. Cabiedes,1 M. Languren,1 B. Becerril,2 L. E. Fernandez-Altuna,2 D. F. Hernandez-Ramirez,1 V. Pascual,1 A. R. Cabral.1 1Immunology and Reumathology, Instituto Nacional de Ciencias Su1.60 - Comparison of RNA Preparation Methods and Their Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico; 2 Effect on Cytokine/Chemokine Gene Expression. Biotecnologia y Bioprocesos, Instituto de Biotecnologia. UNAM., 1 1 2 1 A. L. Asare, S. A. Kolchinsky, P. Wood, V. L. Seyfert-Margolis. Cuernavaca, Morelos, Mexico, Malta. 1 Immune Tolerance Network, University of California, San Francisco, San Francisco, CA, USA; 2Center for Human Genetics Su1.65 - A Novel Network of Human B Cell Effector Cytokines and Integrated Biology, University of Pittsburgh, Pittsburgh, PA, Is Implicated in Autoimmunity: Dysregulation in Patients with USA. arget. Multiple Sclerosis and Potential as Therapeutic TTarget. A. Bar-Or,1 M. Niino,1 M. Duddy,1 F. Adatia,1 S. Hebert,1 H.J. feron Gamma Expression by TTuu- Kim.1 1Neuroimmunology Unit, Montreal Neurological Institute, Su1.61 - Regulation of Inter Interferon mor Necrosis Factor Receptor TType ype 1 Signaling. McGill University, Montreal, QC, Canada. L. M. Kelly,1 R. D. Wheeler,1 T. Owens.1,2 1Neuroimmunology Unit, Montreal Neurological Institute, Montreal, QC, Canada; Su1.66 - Class Switch Recombination in B-L ymphopoiesis Is B-Lymphopoiesis 2 Medical Biotechnology Center, University of Southern Denmark, a Novel Pathway for Development of Autoimmune B Cells. Odense, Denmark. Doron Melamed.1 1Immunology, Technion, Faculty of Medicine, Haifa, Israel.

General Autoimmunity

Su1.62 - Bacterial HSP70 Immunization Inhibits ProteoglycanInduced Arthritis. S. E. Berlo,1 C. B. ten Brink,1 P. J. van Kooten,1 R. van der Zee,1 M. Singh,2 B. J. Prakken,3 T. T. Glant,4 W. van Eden,1 C. P. Broeren.1 1Department of Infectious Diseases and Immunology, University of Utrecht, Utrecht, Netherlands; 2German National Research Institute for Biotechnology, Braunscheig, Germany; 3 Department of Pediatric Immunology, UMCU, Utrecht, Netherlands; 4Department of Orthopedic Surgery, Rush University, Chicago, Netherlands.

Su1.67 - The Role of VCAM-1 in Self-Reactive T Cell Fate. Jonathan A. Abbas,1 Pandelakis A. Koni.1 1Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA.

Su1.68 - The Autoimmune Response to Modified Human LowDensity Lipoprotein. G. Virella,1 M. B. Derrick,1 C. Chassereau,1 S. R. Thorpe,3 M. F. Lopes-Virella.1,2 1Depts. of Microbiology & Immunology and Medicine, Medical University of South Carolina, Charleston, SC; 2 Ralph H. Johnson VAMC, Charleston, Charleston, SC; 3DepartSu1.63 - Characterization of Functionally Important Regions ment of Chemistry and Biochemistry, University of South Caroof CD200:CD200R for Immunoregulation Using Blocking Syn- lina, Columbia, SC. thetic Peptides and/or mAbs. ransduction Pathways Downstream R. M. Gorczynski, D. X. Chen. 1Transplant Research Division, Su1.69 - Studies on Signal TTransduction of CD28/IL-2 That Regulate the E3 Ligase, GRAIL. University Health Network (UHN), Toronto, ON, Canada. L. X. Wu,1 L. Soares,1 C. G. Fathman.1 1Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su1.70 - Immune Monitoring the Effects of hOKT3 hOKT3γγ1 Ala-Ala in a patient with New Onset TType ype 1 Diabetes Mellitus. W. H. Liu,1 G. Szot,1 K. E. Earle,1,2 K. C. Herold,3 U. Masharani,1,2 S. E. Gitelman,4 J. A. Bluestone.1,2 1Diabetes Center, University of California at San Francisco, San Francisco, CA; 2Department of Medicine, University of California at San Francisco, San Francisco, CA; 3Department of Medicine, Division of Endocrinology, and the Naomi Berrie Diabetes, Columbia University, New York, NY; 4Department of Pediatrics, University of California at San Francisco, San Francisco, CA.

Su1.75 - Premature Senescence of the Immune System in Rheumatoid Arthritis and Multiple Sclerosis Patients. M. M. Thewissen, L. Linsen, P. Geusens, J. Raus, P. Stinissen. 1 Biomedisch Onderzoeksinstituut (BIOMED), Limburgs Universitair Centrum (LUC)/Transnational University Limburg (tUL), Diepenbeek, Belgium. Su1.76 - Histamine Release and Autoantbodies in Chronic Idiopathic Urticaria and Cough. Francesca Gibellino,1 Stefania Stella,2 Michele Massimino,2 Manuela Di Stefano,3 Anna M. Longo,1 Costantino Sipione,4 Angelo Messina.1 1Respiratory Pathophisiology Service, Cannizzaro Hospital, Catania, Italy; 2Biomedical Sciences, University of Catania, Catania, Italy; 3Endoscopic Service, Cannizzaro Hospital, Catania, Italy; 4Endocrinology and Diabetes Unit, Cannizzaro Hospital, Catania, Italy.

Su1.71 - Essential Role of the Co-Receptor CD72 in B Cell Peripheral TTolerance. olerance. Daniel H. Li,1 Albert Chen,1 James Tung,2 Paulo Fontoura,3 Larry Steinman,3 Jane R. Parnes.1 1Department of Medicine, Stanford University, Stanford, CA, USA; 2Department of Genetics, Stanford University, Stanford, CA, USA; 3Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA. Su1.77 - A Polymorphism of the Inhibitor y Receptor Inhibitory Receptor,, Fc FcγγRIIb, Prevents It’ It’ss Access to Lipid Rafts and Alters Macrophage Su1.72 - Identification of the TTarget arget Self-Antigens in Ischemia/ Responses to Immune Complexes and Opsonized Bateria. Reper fusion Injur y. Reperfusion Injury R. A. Floto,1 M. R. Clatworthy,1 P. A. McAry,1 E. U. Walker,1 K. 1 5 1 2 1 M. Zhang, E. M. Alicot, I. Chiu, N. Verna, T. Vorup-Jensen, R. Heilbronn,1 A. Rankin,2 J. M. Allen,3 N. A. Watkins,2 K. G.C. B. Kessler,3 M. Shimaoka,1 R. Chan,2 D. Friend,2 L. H. Michael,4 Smith.1 1Cambridge Institute for Medical Research and DepartM. L. Entman,4 F. D. Moore,2 M. C. Carroll.1 1CBR Institute of ment of Medicine, University of Cambridge School of Clinical Biomedical Research, Harvard Medical School, Boston, MA, Medicine, Cambridge, Cambs, United Kingdom; 2Division of USA; 2Surgery-Brigham & Women’s Hospital, Harvard Medical Transfusion Medicine, University of Cambridge School of CliniSchool, Boston, MA, USA; 3Pathology, Harvard Medical School, cal Medicine, Cambridge, Cambs, United Kingdom; 3DiscovBoston, MA, USA; 4DeBakey Heart Center and Department of ery Biology, Inpharmatica, London, United Kingdom. Medicine, Baylor College of Medicine and the Methodist Hospital, Houston, MA, USA; 5DecImmune Therapeutics, Boston, Su1.78 - On the Role of Th1 Cytokines (gIFN, IL18) and Growth MA, USA. Factor TGFb1 in Autoimmune Thyroid Disease. Roman Khanferyan,1 Ljudmila Ravovaya.1 1Clinical ImmunolSu1.73 - Shared Epitopes among HLA Class II Molecules in ogy and Allergy, Kuban State Medical Academy, Krasnodar, Common Autoimmune Diseases. Russian Federation. Elissaveta J. Naumova,1 Milena I. Ivanova,1 Snejina M. Mihaylova, 1 Antoaneta P. Nedialkova, 1 Anastassia P. Su1.79 - Autoimmunity: Common Origin for Diverse Diseases. Mihaylova.1 1Central Laboratory for Clinical Immunology, Uni- G. J. Tobon,1,2 P. Vega,1,2 R. Pineda-Tamayo,1,2 J. M. Anaya.1,2 versity Hospital Alexandrovska, Sofia, Bulgaria. 1 Rheumatology, Clinica Universitaria Bolivariana, Medellin, Colombia; 2Cellular Biology and Immunogenetics Unit, Su1.74 - In Vivo Blockade of Human IL-2 Receptor (IL-2R) In- Corporacion para Investigaciones Biologicas, Medellin, Colomduces Expansion of CD56bright Regulator y NK Cells in Pa- bia. Regulatory tients with Active Uveitis. Zhuqing Li,1 Wee Kiak Lim,1,2 Sankaranarayana P. Mahesh,1 Robert B. Nussenblatt.1 1Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD, USA; 2Singapore National Eye Center, Singapore, Singapore. ™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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Su1.80 - Selective Unresponsiveness of TNFR1-/- Macrophages to IFN-g C. J. Calder,1 A. D. Dick,2 L. B. Nicholson.1,2 1Pathology & Microbiology, University of Bristol; 2Clinical Sciences, University of Bristol, Bristol, United Kingdom.

Su1.86 - Pinocytosis by Human Dendritic Cells TTargets argets Exogenous Material Selectively to Intracellular Cathepsin S. Michael Reich,1 Stella Erfurth,2 Marianne Kraus,1 Herman Overkleeft,3 Christoph Driessen.1 1Medicine II, University of Tubingen, Germany; 2Microbiology, University of Tubingen, Germany; 3Organic Chemistry, University of Leiden, Netherlands.

Su1.81 - Suppressor Potency among Regulator y T Cells Is Regulatory reg Suppressive Activity Su1.87 - Induction of CD4+CD25+ TTreg Discriminated by Functionally Active CD44. 1 1 1 1 M. Firan, P. Estess, M. Siegelman. Pathology, University of and IL-10 Production by IL-2. Texas Southwestern Medical Center, Dallas, TX, USA. Susan Brandenburg,1 Maurus De La Rosa,1 Gabriela Karsten,1 Heike Dorninger, 1 Sascha Rutz, 1 Alexander Scheffold. 1 Su1.82 - Characterization of Immune Response in β− β−TTubulin 1Immunomodulation, German Rheumatism Research Center, Berlin, Germany. Indiced Murine Autoimmune Hearing Loss. B. Zhou, J. Glickstein, J. Lee, M. H. Kermany, T. J. Yoo. 1Department of Medicine, University of Tennessee, Memphis, TN, USA. Su1.88 - Comparison of Anti- DNA Antibodies for Their Ability TTo o Restore Mesenteric Ischemia/Reper fusion-Induced InIschemia/Reperfusion-Induced y and Remote TTissue issue Damage in Rag 1 Deficient Mice. Su1.83 - Endogenous Expression of IRBP Is Dispensable for jur jury Generation of CD4+CD25+ Regulator y T Cells That Protect C. Moratz,1/4 S. Fleming,2 M. Monestier,3 G. Tsokos.1/4 1DeRegulatory partment of Medicine, Uniformed Services University of the Health Against IRBP-Induced Retinal Autoimmunity Autoimmunity.. 2 of Biology, Kansas R. S. Grajewski,1 P. B. Silver,1 R. K. Agarwal,1 S. B. Su,1 C. C. Sciences, Bethesda, MD, USA; Department 3 State Universtiy, Manhattan, KS, USA; Department of MicrobiChan,1 G. I. Liou,2 R. R. Caspi.1 1Laboratory of Immunology, ology and Immunology, School of Medicine, Temple Universtiy, NEI, NIH, Bethesda, MD, USA; 2Department of Ophthalmol4 Philladelphia, PA, USA; Department of Cellular Injury, Walter ogy, Medical College of Georgia, Augusta, GA, USA; Reed Army Institute of Research, Silver Spring, MD, USA. 3 Bethesda, MD, USA. Su1.84 - Prevention and TTreatment reatment of Experimental Autoimmune Myocarditis with Altered Peptide Ligand (APL). D. Cihakova,1 M. Kimura,1 M. Talor,1 J. Barin,1 E. Talor,2 D. Zimmerman,2 N. Rose.1 1Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 2Research and Development, CEL-SCI Corporation, Baltimore, MD, USA.

Su1.89 - The Functional Role of CD48-Related Pathways in Autoimmunity Autoimmunity.. A. Tamir,1 C. Arancibia,2 M. Ali,1 A. Sharpe,2 Y. Latchman.1 1 Department of Immunology, Puget Sound Blood Center and Program, Seattle, WA, USA; 2Department of Pathology, Harvard Medical School, Boston, MA, USA.

Su1.85 - T Cell Responses Induced by Myelin Oligodendrocyte Glycoprotein Are Suppressed by CD4+CD25+ FOXP3+ Regulator y T Cells from Thymus and Cord Blood. Regulatory K. Wing,1 P. Larsson,1 K. Sandstrom,2 S. Lundin,3 E. Suri-Payer,4 A. Rudin. 1 1Rheumatology and Inflammation Research, Gothenburg University, Gothenburg, Sweden; 2Paediatric Anaesthesia and Intensive Care at, The Queen Silvia Children’s Hospital, Gothenburg, Sweden; 3Medical Microbiology and Immunology, Gothenburg University, Gothenburg, Sweden; 4Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany.

Su1.90 - The Lifecycle of In Vitro Generated CD4+CD25+FoxP3+ Human TR: Generation, Expansion, and Persistence. M. R. Walker,1,3 B. D. Carson,2,3 S. F. Ziegler,2,3 J. H. Buckner.1 1 Diabetes, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; 2Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; 3Immunology, University of Washington, Seattle, WA, USA.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su1.91 - siRNA TTargeted argeted Reduction of IL-23 Production by Human Dendritic Cells Increases IL-10 Production and Decreases Antigen Presentation Capacity Capacity.. A. Vaknin-Dembinsky, H. L. Weiner. 1Neurology, Center for Neurological Diseases, Boston, MA, USA.

Su1.97 - Small Molecules TTrigger rigger Peptide Loading of HLA-DR by Allele-Specific Induction of a Peptide-Receptive State. Heiko Kramer,1 Katharina Dickhaut,1 Maria Hofstaatter,1 Sabine Hopner,1 Dominik Ruckerl,1 Arvid Soderhall,2 Viviana MarinEsteban,1 Ronald Kuhne,2 Christian Freund,2 Gunther Jung,3 Kirsten Falk,1 Olaf Rotzschke.1 1Celluar Immunology of AutoimSu1.92 - Opposite Effect of IL-4 and IL-13 in Experimental mune Reactions, Max-Delbruck-Center for Molecular Medicine (MDC), Berlin, Berlin, Germany; 2NMR Supported Structural BiAutoimmune Myocarditis (EAM). ology, Forschungsinstitut for Molecular Pharmacy (FMP), Berlin, Daniela Cihakova,1 Marina Afanasyeva,1,2 Miho Kimura,1 Berlin, Germany; 3Organic Chemistry, Eberhard Karls Universitat, Monica Talor,1 Jobert Barin,1 Noel R. Rose.1 1Department of Tubingen, Tubingen, Baden Wurtenberg, Germany. Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; 2Department of Medicine, University of Calgary, Calgary, Su1.98 - B Cell Receptor Editing Begins in the Bone Marrow Marrow.. AB, Canada. Elahna Paul,1 Thomas J. Schneider,2 Michael C. Carroll.2 1Pediatric Nephrology, Massachusetts General Hospital, Boston, Su1.93 - CTLA4-Ig Inhibts IL-2 Production and In-Vivo ExpanMA, USA; 2CBR Institute for Biomedical Research, Harvard sion of Antigen-Stimulated Memor y CD4 T Cells. Memory Medical School, Boston, MA, USA. M. P. Ndejembi, D. S. Patke, A. W. Bingaman, D. L. Farber. 1 Surgery, University of Maryland, Baltimore, MD. Su1.99 - The Macrophage C5a:C5aR-Gai2-FcgRIIB/FcgRIII-Axis Defines the Inflammator y Response in the Ar thus Reaction. Inflammatory Arthus Su1.94 - Both Fc FcγγR and C5a Are Indispensable in Antibody S. R. Ali,1 J. Skokowa,1 O. Felda,2 V. Kumar,1 S. Konrad,1 R. E. Dependent Autoimmune Disease. Schmidt, 1 R. P. Pierkorz, 2 B. Nunberg, 2 K. Spicher, 3 L. Varsha Kumar,1 Syed R. Ali,1 Olga Felda,1 Jorg Zwirner,2 Josef Birnbaumer,4 J. Zwirner,5 N. Rooijen,6 J. E. Gessner.1 1Clinical S. Verbeek,3 Reinhold E. Schmidt,1 Johannes E. Gessner.1 1De- Immunology, Hannover Medical School, Hannover, Germany; partment of Clinical Immunology, Hannover Medical School, 2Biochemistry and Molecular Biology, Heinrich-Heine-University, Hannover, Lower Saxony, Germany; 2Department of Immunol- Dusseldorf, Germany; 3Institute of Pharmacology, Berlin Free ogy, Georg-August-University Gottingen, Gottingen, Germany; University, Berlin, Germany; 4Laboratory of Signal Transduction, 3 Department of Human Genetics, Leiden University Medical NIEHS, NIH, USA; 5Department of Immunology, Georg August Center, Al Leiden, Netherlands. University, Gottingen, Germany; 6Department of Molecular Cell Biology, Vrije University, Amsterdam, Netherlands. Su1.95 - Regulator y T Cells: Differential Requirement for InRegulatory nate and Adaptive Immune Cells Inhibition In Vitro. Su1.100 - T Cells and Autoimmunity: Immunoregulation by S. Zelenay,1 I. Caramalho,1 J. Demengeot.1 1Lymphocyte Physi- CD40 Expressed on CD4+ T LLymphocytes. ymphocytes. ology Unit, Instituto Gulbenkian de Ciencia, Oeiras, Portugal. M. E. Munroe,1 G. A. Bishop.1,2 1Departments of Microbiology Su1.96 - CCR6 Expression Defines Regulator y Effector/ Regulatory Memor y-Like Cells within the CD25+CD4+ T Cell Subset. Memory-Like Markus Kleinewietfeld,1 Fabiola Puentes,1 Giovanna Borsellino,2 Luca Battistini,2 Olaf Rotzschke,1 Kirsten Falk.1 1Cellular Immunology of Autoimmune Reactions, Max-Delbruck-Center for Molecular Medicine (MDC), Berlin, Berlin, Germany; 2Laboratory of Neuroimmunology, IRCCS Santa Lucia, Rome, Rome, Italy.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

and Internal Medicine, University of Iowa, Iowa City, IA, USA; 2 VAMC. Su1.101 - Induction of TTolerance olerance by Gene Therapy with BCells Expressing Ig Fusion Proteins: Mechanisms and PreClinical Success in Naïve and Immune Hemophilia A Mice. D. W. Scott,1 T. C. Lei,1 Y. Su,1 N. Soukhareva.1 1Surgery, University of Maryland School of Medicine, Rockville, MD, USA.

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Su1.102 - Increase in Pancreatic NK Cells at Early Onset of Autoimmune Diabetes in IFN β Transgenic NOD Mice. IFNβ A. Alba,1 R. Planas,1 J. Carrillo,1 M. C. Puertas,1 R. Ampudia,1 X. Pastor,1 M. A. Fernandez,1 R. Pujol-Borrell,1 J. Verdaguer,1 M. Vives-Pi.1 1Immunobiology for Research and Diagnostic Applications, Transfusion Centre and Tissue Bank, Fundacio Institut d’Investigacio en Ciencies de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.

Su1.108 - Study of the Thymic Function in Patients with Autoimmune Thyroiditis. M. P. Armengol,1 M. A. Fernandez,2 L. Sabater,1 M. Juan,1 R. Pujol-Borrell.1 1Laboratory of Immunobiology for Research and Diagnosis (LIRAD). Centre for Transfusion and Tissue Bank (CTBT), Institut per a la Recerca Biomedica Germans Trias i Pujol., Badalona, Barcelona, Spain; 2Cytometry Unit, Institut per a la Recerca Biomedica Germans Trias i Pujol., Badalona, Barcelona, Spain.

o Generate TTolerogenic olerogenic Dendritic Su1.103 - Rapid Protocol TTo Cells Using Microbial Lipopeptide (BLP). O. A. Aravena,1 L. Salazar,1 C. Mass,1 A. Aguirre,1 D. Catalan,1 M. Hermoso,1 J. C. Aguillon.1 1Disciplinary Program of Immunology, ICBM, University of Chile, Santiago, Chile.

Su1.109 - A Novel Low-Calcemic Vitamin D Analog as a Potential Therapeutic TTreatment reatment for Autoimmune Diseases. N. Chouinard,1 A. H. Collop,1 K. A. Ryder,1 S. P. Tabash,1 G. H. Posner,2 B. Korczak,1 S. S. Chuang.1 1Research and Development, Cytochroma Inc., Markham, ON, Canada; 2DepartSu1.104 - Mucosal Administration of Anti-CD3 Antibody Sup- ment of Chemistry, The Johns Hopkins University, Baltimore, MD, presses EAE, Collagen Arthritis, Diabetes and Prolongs Car- USA. vival. diac Allograft Sur Survival. rigH. L. Weiner,1 H. Ochi,1 M. Abraham,1 H. Ishikawa,1 H. Wu,1 Su1.110 - SP-A May Be a Candidate of “Qi” Molecule TTrig1 1 1 1 1 gers Some Autoimmune Diseases. R. Maron, D. Frenkel, R. Gandi, M. L. Chen, A. Izawa, I. 1 2 1 Guleria,1 M. H. Sayegh.1 1Brigham and Women’s Hospital, J. Luo, Y. Wan. Orthopaedics, Rhode Island Hospital/Brown Medical School, Providence, RI, USA; 2Biology, Providence ColHarvard Medical School, Boston, MA, USA. lege, Providence, RI, USA. Su1.105 - The Role of Ultralarge Complexes (ULC) in Heparin Induced Thrombocytopenia (HIT). L. Rauova,1 D. B. Cines,2 B. B. Sachais,2 M. Poncz.1 1Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA; 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Su1.111 - The Inhibitions of Autoreactive TT-Cell -Cell Functions by a Peptide Based on the Complementarity Determining Region1 of an Anti-DNA Autoantibody Is Via TGF β Mediated SupTGFβ pression of LF A-1 and CD44 Expression and Function. LFA-1 Uri Sela,1 Nora Mauermann,1 Rami Hershkoviz,2 Edna Mozes,1 Liora Cahalon,1 Ofer Lider.1 1Immunology Department, The Su1.106 - Effect of Freezing/Thawing Conditions and Their Weizmann Institute of Science, Rehovot, Israel; 2Internal DepartOptimization for Quality Control of PBMC Viability and Func- ment D, Assaf-Harofeh Medical Center and the Sakler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel. tional Assays. Khadir Raddassi,1,2 Kasia Bourcier,2 Jose Estevam,1,2 David A. ransduced Monocyte-Derived (CD95L)-Transduced Hafler,1 Vicki Seyfert-Margolis.2 1Neurology, Harvard Medical Su1.112 - Fas Ligand (CD95L)-T School, Boston, MA, USA; 2Immune Tolerance Network, Univ. Killer-DC Are Protected from CTL-Induced Cytotoxicity and California San Francisco, San Francisco, CA, USA. Delete Antigen-Specific CD8+ T Cells. Ch. Schuetz,1 A. Mackensen,2 H. Herfarth,1 D. Halbritter,1 M. Su1.107 - MBLA/C Deficienct Mice Display Defective Fleck.1 1Department of Internal Medicine I, University of Regensburg, Regensburg, Bavaria, Germany; 2Division of HeApoptotic Cell Clearance but No Autoimmune Phenotype. 1,2 1 1 2 1 L. M. Stuart, K. Takahshi, L. Shi, J. Savill, R. A. Ezekowitz. matology, University of Regensburg, Regensburg, Bavaria, Ger1 Laboratory of Developmental Immunology, Massachusetts Gen- many. eral Hospital, Boston, MA, USA; 2MRC Center for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom. 116

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Inflammator y Bowel Diseases Inflammatory

Su1.117 - Cytokine and Chemokine TTranscript ranscript Profiles in Acute Pouchitis. Su1.113 - The Peripheral Cannabinoid Receptor CB2 Is ReA. Stallmach,1 T. Giese,2 C. Schmidt,3 B. Ludwig,3 S. Meuer.2 quired for the Normal Formation of B and T Cell Subsets. 1 Gastroenterology, Catholic Clinics Essen-Nord, Essen, Germany; D. A. Ziring,1 B. Wei,2 P. Velazquez,2 M. Schrage,2 N. Buckley,3 2Immunology, University of Heidelberg, Heidelberg, Germany; J. Braun.2 1Division of Pediatric Gastroenterology, UCLA David 3Internal Medicine II, Saarland University, Homburg, Germany. Geffen School of Medicine, Los Angeles, CA, USA; 2Department of Pathology and Laboratory Medicine, UCLA David Su1.118 - Inflammator y TTranscript ranscript Profiles Reflect Onset of Inflammatory Geffen School of Medicine, Los Angeles, CA, USA; 3DepartClinical Remission in Patients with Steroid Refractor y Crohn’ Refractory Crohn’ss ment of Biological Sciences, California State Polytechnic UniverDisease after TTreatment reatment with Cyclophosphamide or Infliximab. sity, Pomona, CA, USA. A. Stallmach,1 T. Giese,2 B. Ludwig,3 M. Zeitz,4 S. Zeuzem,3 S. 2 1 Su1.114 - The Effect of Bifidobacterium on Murine Experi- Meuer. Gastroenterology, Catholic Clinics Essen-Nord, Essen, Germany; 2Immunology, University of Heidelberg, Heidelberg; mental Colitis. 3 Internal Medicine II, Saarland University, Homburg, Germany; Aiping Bai, Qin Ouyang, Renwei Hu. 1Department of Gastro- 4 Internal Medicine I, Charite, Berlin, Germany. enterology, The First Affiliated Hospital, Sun Yat-sen University, 2 Guangzhou, Guangdong, China; Department of Gastroenterer m Follow-Up of Ulcerative Colitis (UC) erm ology, Westchina Hospital, Sichuan University, Chengdu, Su1.119 - Long TTer 3 Sichuan, China; Department of Gastroenterology, Westchina Treated with a Probiotic Containing the Pingel/BM Non-Pathogenic Strain of E coli. Hospital, Sichuan University, Chengdu, Sichuan, China. M. L. McCann, R. Buck.2; 2Microbiology, Kaiser Permanente, Su1.115 - Anti-Murine TNF-alpha Reverses TNBS Colitis in Cleveland, OH, USA. Mice but Not Oxazolone Colitis: Potential Role of Apoptosis Su1.120 - Blockade of Interleukin 21 with Soluble IL21RFc Induction. 1 1 2 y Cytokines and Correlates with SupInflammatory Chong Shen, Philippe Maerten, Gert VanAssche, Karel Reduces Inflammator 3 2 1 1 ransplanted with Geboes, Paul Rutgeerts, Jan L. Ceuppens. Laboratory of pression of Disease in Mice Adoptively TTransplanted Experimental Immunology, Campus Gasthuisberg, Catholic Uni- CD45RBhi CD4+ T Cells. versity Leuven, Leuven, Vlaams-Brabant, Belgium; 2Department M. Senices,1 L. Lowe,1 C. Groves,1 S. Benoit,1 X. Li,1 M. Leach,1 of Gastroenterology, Campus Gasthuisberg, Catholic University C. Nickerson-Nutter,1 M. Collins,1 D. Young.1 1Inflammation, Leuven, Leuven, Vlaams-Brabant, Belgium; 3Department of Pa- Wyeth Research, Cambridge, MA, USA. thology, Campus Gasthuisberg, Catholic University Leuven, Leuven, Vlaams-Brabant, Belgium. ™Su1.121 - Role of ICOS in Regulating Mucosal TTolerance. olerance. Su1.116 - Evaluation of 5 vs 10 Granulocyteapheresis TTreatreatments in Patients with Moderate Active Steroid Dependent Ulcerative Colitis: A Prospective Multicenter Randomized TTrial. rial. E. Ricart,1 D. Monfort,1 J. Panes,2 M. Esteve,3 R. Lafuente,4 M. Andreu,5 F. Casellas,6 M. Sans.2 1Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 2Gastroenterology, Hospital Clinic i Provincial, Barcelona, Spain; 3Gastroenterology, Hospital Mutua de Terrassa, Terrassa, Barcelona, Spain; 4 Intensive Care Unit, Hospital General de L´Hospitalet, Hospitalet de Llobregat, Barcelona, Spain; 5Gastroenterology, Hospital Vall d´Hebron, Barcelona, Spain.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

C. V. Arancibia, A. H. Sharpe. 1Department of Pathology, Harvard Medical School, Boston, MA, USA. Su1.122 - A Critical Regulator y Role of Th2-Like TTranscripranscripRegulatory tion Factor c-Maf in Th1-Mediated Experimental Colitis. B. Weigmann,1 A. Nemetz,1 C. Becker,1 H.-A. Lehr,2 D. Strand,1 P. R. Galle,1 I.-C. Ho,3 M. Neurath.1 1Laboratory of Immunology, I. Medical Clinic, Johannes Gutenberg University, Mainz, Germany; 2Institute of Pathology, Johannes Gutenberg University, Mainz, Germany; 3Harvard School of Public Health and Harvard Medical School, Boston, MA.

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Su1.123 - Dual Immune Suppressive Activity of 4AZA1378 Alleviates TNBS-Induced Colitis in Mice. Chong Shen,1 Yuan Lin,2 Gavin Clydesdale,2 Ilse Sienaert,2 Steven De Jonghe,2 Karel Geboes,3 Louis Boon,2 Paul Rutgeerts,4 Jan L. Ceuppens.1 1Laboratory of Experimental Immunology, Campus Gasthuiberg, Catholic University Leuven, Leuven, Vlaams-Brabant, Belgium; 24AZA Biosciences, Leuven, VlaamsBrabant, Belgium; 3Department of Pathology, Campus Gasthuiberg, Catholic University Leuven, Leuven, VlaamsBrabant, Belgium; 4Department of Gastroenterology, Campus Gasthuiberg, Catholic University Leuven, Leuven, VlaamsBrabant, Belgium.

Su1.127 - Immunohistochemical Localization of Copper/ Zinc-Containing Superoxide Dismutase in Normal Pancreas and in Pancreatitis. H. Milnerowicz,1 M. Jablonowska,1 J. Rabczynski,2 K. Grabowski.3 1Departament of Biomedical and Environmental Analyses, Wroclaw University of Medicine, Wroclaw, Poland; 2 Department of Pathological Anatomy, Wroclaw University of Medicine, Wroclaw, Poland; 3Department and Clinic of Gastointestinal and General Surgery, Wroclaw University of Medicine, Wroclaw, Poland. Su1.128 - The Response of Blood Monocytes of Coeliac Patients to Gliadin. L. Palova-Jelinkova,1 J. Cinova,1 B. Pecharova,1 M. Cerna,2 L. Tuckova,1 H. Tlaskalova-Hogenova.1 1Department of Immunology, Czech Academy of Sciences, Prague, Czech Republic; 23rd Medical Faculty, Charles University, Prague, Czech Republic.

Su1.124 - Immunohistochemical Localization of Interleukin-6 in Pancreatitis and Normal Pancreas. M. Jablonowska, 1 H. Milnerowicz, 1 J. Rabczynski, 2 S. Milnerowicz.3 1Departament of Biomedical and Environmental Analyses, Wroclaw University of Medicine, Wroclaw, Poland; 2 Department of Pathological Anatomy, Wroclaw University of Medicine, Wroclaw, Poland; 3Department and Clinic of Su1.129 - Eosinophilic Esophagitis (EE): Improved Clinical Gastointestinal and General Surgery, Wroclaw University of Responses without a Concomitant Reduction in Esophageal Medicine, Wroclaw, Poland. Eosinophilic Infiltration. F. M. Schaffer, R. B. Pillai, K. A. Hetherington, R. Shannon, T. ™Su1.125 - TTumor umor Derived TGF-beta Suppresses InflammaC. Hulsey, D. Lewin, S. N. Khubchandani, V. Tolia. 1Pediatric tion Dependent Colon Cancer Development by Inducing Pulmonary, Allergy, and Immunology, MUSC, Charleston, SC, FoxP3 in TTumor umor Infiltrating CD4+ T Cells. USA; 2Pediatric Gastroenterology, MUSC, Charleston, SC, 1 1 1 1 C. Becker, M. C. Fantini, C. Schramm, A. Nikolaev, P. R. USA; 3Pediatrics, MUSC, Charleston, SC, USA; 4Pediatric Galle,1 M. F. Neurath.1 1I. Dept. of Medicine, University of Gastroenterology, MUSC, Charleston, SC, USA; 5Pediatric Mainz, Mainz, Germany. Epidimiology, MUSC, Charleston, SC, USA; 6Pathology, MUSC, Charleston, SC, USA; 7Gastroenterology, Wayne State + ™Su1.126 - Cross-Linking of Lipid Rafts on CD4 T Cells School of Medicine, Detroit, MI, USA; 8Gastroenterology, Wayne State School of Medicine, Detroit, MI, USA. by an Epithelial Lectin, Galectin-4, Contributes to the Exacerbation of Intestinal Inflammation. K. Shirane,1 A. Hokama,1 Y. Shimomura,1 A. Ogawa,1 M. Yoshida,2 S. T. Rietdijk,3 S. B. Snapper,4 C. Terhorst,3 R. S. Blumberg,2 A. Mizoguchi.1 1Department of Pathology, Massachusetts General Hospital, Boston, MA, USA; 2Division of Gastroenterology, Brigham and Women’s Hospital, Boston, MA, USA; 3Department of Immunology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 4Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

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Poster Session 2 Sunday,, May 15, 2005 Sunday 3:30 pm - 7:30 pm Immunodeficiency: Primar y or Acquired Primary Su2.01 - Rheumatic Manifestations in a South Italy Population HIV Positive: Correlation with CD4 Count. A. Caliri,1 L. G. De Filippis,1 G. Scibilia,1 C. Romano,1 G. F. Bagnato.1 1Rheumatology Unit, Policlinico Universitario G Martino, Messina, ME, Italy. Su2.02 - Quality Control of siRNA, Optimizing It’ ransfecIt’ss TTransfection Efficiency and Monitoring CD4 Gene Silencing Effect with a Microfluidic Chip Device. T. Preckel,1 C. Buhlmann,1 M. Valer.1 1Liquid Phase Analysis, Agilent Technologies, Waldbronn, BW, Germany.

Su2.07 - The Prognostic Impor tance of V ariants of Allele Genes Importance Variants HLA DRB1 and IL-4 in HIV -Infection. HIV-Infection. Loudmila P. Sizyakina, Julia V. Sokolova. 1Center of Clinical Immunology, State Medical University, Rostov-on-Don, Russian Federation; 2Russian Federation. Su2.08 - Recurrent Infections and Cytokine Imbalance in Hyper -IgE Syndrome Are Not Due to a Defect in TToll-Like oll-Like ReHyper-IgE ceptor Pathways. E. D. Renner,1 F. Hoffmann,1 I. Pawlita,1 V. Hornung,2 D. Hartl,1 M. Albert,1 A. Jansson,1 S. Endres,2 G. Hartmann,2 B. H. Belohradsky,1 S. Rothenfusser.2 1University Children’s Hospital, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University, Munich, Germany; 2Department of Internal Medicine, Division of Clinical Pharmacology, Ludwig-Maximilians-University, Munich, Germany.

Su2.09 - Defective Functioning of Dendritic Cells in Common Su2.03 - Cardiac Thrombus in Omenn Syndrome. Variable Immuno Deficiency (CVID): A Common DenominaS. S. Kilic.1 1Pediatric Immunology, Uludag University School of tor for the Multiple Symptoms Displayed by CVID Patients. Medicine, Bursa, Turkey. Jagadeesh Bayry, Olivier Hermine, Eric Oksenhendler, Michel 1 Su2.04 - The Frequency and Effects of Vitamin A Deficiency D. Kazatchkine, Srini V. Kaveri. Memory Group, The Edward Jenner Institute for Vaccine Research; INSERM U681, Compton, in Common V ariable Immunodeficiency Patients. Variable Nr Newbury, Berkshire, United Kingdom; 2CNRS – UMR 8147, S. S. Kilic.1 1Pediatric Immunology, Uludag University School of Necker Hospital, Paris, France; 3Department of Clinical ImmuMedicine, Bursa, Turkey. nopathology, Saint Louis Hospital, Paris, France; 4INSERM U681, Institut des Cordeliers, Paris, France; 5INSERM U681, Institut des Su2.05 - Pulmonar y Abscess Due to Aspergillus spp. in Pa- Cordeliers, Paris, France. Pulmonary tients with Chronic Granulomatous Disease. S. S. Kilic.1 1Pediatric Immunology, Uludag University School of Su2.10 - Clinical Profile of Primar y Immunodeficiencies DisPrimary Medicine, Bursa, Turkey. eases Patientes Followed up at Hospital das Clínicas da Universidade Federal de Minas Gerais. Su2.06 - Hodgkin’ ymphoma Developing in a 4.5-Y ear -Old Hodgkin’ss LLymphoma 4.5-Year ear-Old L. A.O. Cunha,1 D. B. Greco,2 J. A. Pinto.1 1Paediatrics, Girl with Hyper-IgE Syndrome. Faculdade de Medicina da Universidade Federal de Minas Mohammad Amin Kashef,1 Sara Kashef,2 Farhad Hanjani,3 Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Infectious and Mehran Karimi.4 1Allergy Research Center, Shiraz University of Contagious Diseases, Faculdade de Medicina da Universidade Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Immu- Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Branology and Allergy, Shiraz University of Medical Sciences, Shiraz, zil. Fars, Islamic Republic of Iran; 3Dermatology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Pediatric Oncology, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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Su2.11 - New Single Nucleotide Polymorphisms in the Gene Encoding the Phagocyte Oxidase 67 kDa Protein. L. Gomez-Restrepo,1 M. T. Rugeles,2 P. J. Patino,2 A. CondinoNeto.1,3 1Pediatrics, State University of Campinas Medical School, Campinas, SP, Brazil; 2Immunology, University of Antioquia Medical School, Medellin, Colombia; 3Immunology Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

Su2.15 - The IgG 2F5-Like Antibody in Serum of Mexican Patients with AIDS Progression Prior to and after the Highly Active Anti-Retroviral Therapy Therapy.. Y. Palacios-Rodriguez,1 T. G. Gazarian,2 A. Majluf-Cruz,3 K. G. Gazarian.1 1Department of Molecular Biology and Biotechnology, Institute of Biomedical Research, Mexican National University(UNAM), Mexico-City, DF, Mexico; 2Department of Public Health, Faculty of Medicine, Mexican National University(UNAM), Mexico-City, DF, Mexico; 3AIDS Clinic, ReSu2.12 - Chronic Granulomatous Disease in Latin American gional Hoospital “Gabriel Mancera”, Mexico-City, DF, Mexico. Patients: Clinical Spectrum and Molecular Genetics. P. Agudelo-Florez,1 C. Prando-Andrade,1 J. A. Lopez,1 B. T. Costa- ™Su2.16 - Genetically Determined Deficiency of the Innate Carvalho,2 A. Quezada,3 F. J. Espinosa,4 M. A. Souza-Paiva,5 Immune Defence Protein, MBL-Associated Serine Protease-2 P. Roxo,6 M. M.S. Carneiro-Sampaio,7 P. E. Newburger,8 A. (MASP-2). Condino-Neto.1,7 1Pediatrics, State University of Campinas S. Thiel,1 J. C. Jensenius,1 L. Truedsson,2 M. Carlsson,2 W. K. Medical School, Campinas, SP, Brazil; 2Pediatrics - Allergy, Im- Ip,3 Y. C. Lau.3 1Medical Microbiology and Immunology, Unimunology & Rheumatology, Federal University of Sao Paulo versity of Aarhus, Aarhus, Denmark; 2Clinical Microbiology and Medical School, Sao Paulo, Brazil; 3Pediatrics, University of Chile Immunology, Lund University Hospital, Lund, Sweden; 3PaediatMedical School, Santiago, Chile; 4Immunology, National Insti- rics and Adolescent Medicine, The University of Hong Kong, tute of Pediatrics, Mexico, Mexico; 5Pediatrics, Rio de Janeiro Hong Kong, China. State Employees Hospital, Rio de Janeiro, Brazil; 6Pediatrics, Ribeirao Preto Medical School - University of Sao Paulo, Ribeirao Su2.17 - Phenotypic Analysis of Peripheral Blood and Tissue Preto, SP, Brazil; 7Immunology, Institute of Biomedical Sciences y B Cells in Common V ariable Immunodeficiency Memory Variable 8 University of Sao Paulo, Sao Paulo, Brazil; Pediatrics, Univer- Memor (CVID). sity of Massachusetts Medical School, Worcester, MA, USA. A. P. Williams,1 C. Stephens,1 L. Hedges,1 A. Mani,1 E. Hodges,1 1 1 Su2.13 - Hereditar y Angioedema in Childhood - A Practice J. Smith. Department of Clinical Immunology, Southampton Hereditary General Hospital, Southampton, United Kingdom. Guideline. 1 1 1 R. J. Boyle, M. L.K. Tang. Immunology, Royal Children’s HosSu2.18 - Plasma Interleukin-7 Levels before Highly Active pital, Parkville, Victoria, Australia. Antiretroviral Therapy May Predict CD4+ TT-Cells -Cells Recover y in Recovery HIV -Children. HIV-Children. ™Su2.14 - Abnor mal Neutrophil’ Abnormal Neutrophil’ss Chemotactic Activity in 1 1 1 2 Children with Congenital Insensitivity to Pain with Anhidrosis A. Perez, S. Resino, A.A. Meca, M.D. Gurbindo, M.A 1 1 Munoz-Fernandez. Laboratorio de Immunobiologia Molecu(CIP A): The Role of Ner ve Growth Factor in Chemotactic Ac(CIPA): Nerve lar, Hospital “Gregorio Maranon”, Madrid, Spain; 2Servicio de tivity tivity.. Inmuno-Pediatria, Hospital “Gregorio Maranon”, Madrid, Spain. A. Beigelman,1 J. Levy,1 N. Hadad,2 V. Pinsk,1 R. Levy.2 1Department of Pediatrics, Soroka Medical Center, Beer Sheva, IsSu2.19 - Different Profiles of Immune Reconstitution in Chilrael; 2Infectious Disease Laboratory, Soroka Medical Center, Beer dren and Adults with HIV -Infection after HAAR T. HIV-Infection HAART Sheva, Israel. S. Resino,1 E. Seoane,1 A. Perez,1 E. Ruiz-Mateos,2 M. Leal,2 M.A. Munoz-Fernadez.1 1Laboratorio de Inmuno-Biologia Molecular, Hospital General Universitario “Gregorio Maranon”, Madrid, Spain; 2Grupo de Estudio Hepatitis Virica y SIDA, Hospital Universitario “Virgen del Rocio”, Sevilla, Spain.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Su2.20 - Understanding HIV Infection through Dynamical

Su2.26 - Immunotherapy by Cytogenes in Patients with Acquired Neutropenia. Vardan Sergey Aprikyan, Nata Adolf Otieva. 1 Neuroimmunology, Inst. of Biochemistry, Yerevan, Armenia; 2 Su2.21 - Model for the Repopulating Capacity of TTransplanted ransplanted Pharmacology, State University, Yerevan, Armenia. T Cells. Sebastian Newrzela,1 Sanaz Taromi,1 Roland Zahn,1 Dorothee Su2.27 - Evaluation of Humoral Immune Responsein Children Von Laer.1 1Georg-Speyer-Haus (Chemotherapeutisches with Otitis Media and Control Group. Forschungszentrum), Georg-Speyer-Haus (Chemotherapeutisches Farzad Oreizi, Maryam Saleminik, Ahmad GhavamiNejad, Forschungszentrum), Frankfurt AM Main, Hessen, Germany. Fereshteh Sahebfosul. 1Immunology, Isfahan University of Medical Science, Isfahan, Isfahan, Islamic Republic of Iran; Su2.22 - Apoptosis and the Emergence of Clonal Dual Posi- 2Flowcytometry, BD Company, San Francisco, CA, USA; 3Immutive CD4CD8 Cells in a Y oung Boy with CD4 LLymphopenia. ymphopenia. nology, Isfahan University of Medical Sciences, Isfahan, Isfahan, Young 4 1 1 1 M. T. Krishna, E. Hodges, S. Harris, S. M. Morgan,1 J. O. Islamic Republic of Iran; Immunology, Isfahan University of Warner,2 J. Hourihane,2 J. L. Smith.1 1Wessex Immunology Ser- Medical Sciences, Isfahan, Isfahn, Islamic Republic of Iran. vice, Southampton University Hospitals NHS Trust, Southampton, reatment of Hampshire, United Kingdom; 2Division of Infection, Inflamma- Su2.28 - New Composition Immunotherapy in TTreatment y Immunodeficiency Accompanied by V iral InfecViral Secondary tion and Repair, School of Medicine, Southampton University Secondar Hospitals NHS Trust, Southampton, Hampshire, United Kingdom. tious Syndrome. Nesterova V. Irina. 1Department of Family Medicine, Educa™Su2.23-Hypogammaglobulinemia and tional-Scientific Centre of Medical Centre of MD of Russian President, Moscow, Russian Federation. Lymphoproliferation in TTwo wo Patients with Heterozygous Modeling: V accines W on’ ork, What W ill? Vaccines Won’ on’tt W Work, Will? I. Kramer.1 1Physics, Univ. of MD, Catonsville, MD.

Deleterious Mutation of the Caspase-9 Gene. A. Chiocchetti,1 R. Mesturini,1 T. Bensi,1 A. Biava,1 M. Ferretti,1 C. Santoro,1 C. Pignata,2 F. Rieux-Laucat,3 I. Dianzani,1 U. Ramenghi,4 L. D. Notarangelo,5 U. Dianzani.1 1IRCAD and Department of Medical Sciences, University of Eastern Piedmont, Novara, Italy; 2Department of Pediatrics, University of Naples, Naples, Italy; 3INSERM Unite 429, Hopital Necker-Enfants Malades, Paris, France; 4Department of Pediatrics, University of Turin, Turin, Italy; 5Department of Pediatrics, University of Brescia, Brescia, Italy. Su2.24 - Haplotypes, Mutations and Phenotype Genotype Correlation in TTurkish urkish A-T Patients. O. Sanal,1 B. Behjatnia,2 M. Mitsui,2 F. Ersoy,1 I. Tezcan,1 A. I. Berkel,1 R. A. Gatti.2 1Pediatric Immunology, Hacettepe University Scool of Medicine, Ankara, Turkey; 2Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA, USA. Su2.25 - Mechanisms of Immunotoxicity of Mycotoxins. Elena Dorofeeva,1 Roman Khanferyan.1 1Immunoregulation, Institute of Allergy and Asthma, Krasnodar, Russian Federation.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

Su2.29 - Therapeutic Efficacy of Gc Protein-Derived Macrophage Activating Factor for HIV -Infected/AIDS Patients. HIV-Infected/AIDS N. Yamamoto,1 M. Ueda.1 1Molecular Immunology, Socrates Institute for Therapeutic Immunology, Philadelphia, PA, USA. Su2.30 - Pathogenic Significance of α-N-Acetylgalactosaminidase Activity Found in the Fusion irus TType ype 1. Protein gp160 of Human Immunodeficiency V Virus N. Yamamoto. 1Molecular Immunology, Socrates Institute for Therapeutic Immunology, Philadelphia, PA, USA. Su2.31 - Clinical and Laborator Laboratory y Findings in TTwenty wenty Eight y Immunoglobulin Deficiency AssociPrimary Patients with a Primar ated with LLymphadenopathy ymphadenopathy ymphadenopathy,, Hepatosplenomegaly and Pulmonar y Infiltrates. monary W. Ding,1 C. R. Weiler.1 1Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.

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May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.32 - Thir teen Y ears of M. bovis-BCG Culture-Positive InThirteen Years β1 Deficient Patient: TTreatment reatment and OutIL-12Rβ fection in an IL-12R come. Sergio D. Rosenzweig,1 Judith Yancoski,1 Andrea Bernasconi,1 Silvia Krasovec,1 Beatriz E. Marciano,1 Lidia Casimir,1 Norberto Simboli,2 Griselda Berberian,1 Marcela Russeau,1 Graciela Calle.1 1Hospital Nacional de Pediatria, “J. P. Garrahan”, Buenos Aires, Argentina; 2Servicio de Micobacterias, INEI ANLIS “Dr. C. G. Malbran”, Buenos Aires, Argentina.

Su2.37 - Immunological Characterization of Children with Transient Hypogammaglobulinemia of Infancy (THI): In V itro Vitro Immunoglobulin Production Is a Candidate Predictive Marker Marker.. V. Moschese,1 S. Graziani,1 M.A. Avanzini,2 R. Carsetti,3 I. Quinti,4 A. Plebani,5 A. Soresina,5 S. Di Cesare,1 L. Chini,1 M. Marconi,2 G. Bossi,6 M. La Rocca,1 R. Maccario,2 P. Rossi,1,3 A.G. Ugazio.3 1Pediatrics, Policlinico Tor Vergata, University of Tor Vergata, Rome, Italy; 2Laboratorio Area Trapianti, IRCCS, Policlinico San Matteo, Pavia, Italy; 3Ospedale Pediatrico Bambino Gesu, Rome, Holy See (Vatican City State); 4University Su2.33 - Equivalent Per for mance of V ACUT AINER® CPT™to La Sapienza, Rome, Italy; 5Pediatrics, University of Brescia, Perfor formance VACUT ACUTAINER® 6 Ficoll-Hypaque Gradient Separation in Maintaining the Qual- Brescia, Italy; Scienze Pediatriche, Policlinico San Matteo, Pavia, Italy. ity and Function of PBMC from HIV Seropositive Blood Samples. Su2.38 - Health-Related Quality of Life in Patients with PriJ. J. Ruitenberg,1 C. B. Mulder,2 V. C. Maino,1 A. L. Landay,2 S. y Immunodeficiencies in Nor th America Receiving HomeNorth mary A. Ghanekar.1 1&1pGL2Immunology and Microbiology, RUSH mar Based Subcutaneous Immunologlobulin Replacement Therapy Therapy.. University Medical Center, Chicago, IL, USA. Uwe Nicolay,1 Peter Kiessling,2 Ann Gardulf,1 Hans D. Ochs.3 1 S u 2 . 3 4 - B i n d i n g o f t h e G r e e n TTe e a P o l y p h e n o l , Department of Laboratory Medicine, Section of Clinical Immunology, Karolinska Institutet at Karolinska University Hospital, Epigallocatechin Gallate, to the CD4 Receptor on Human Stockholm, Sweden; 2Clinical Research & Development, ZLB -1-gp120 Binding. Behring GmbH, Marburg, Germany; 3Department of PediatCD4+T Cells Resulting in Inhibition of HIV HIV-1-gp120 C. L. Nance,1 M. P. Williamson,2 T. G. McCormick,1 W. T. rics, University of Washington, Seattle, WA, USA. Shearer.1 1Pediatrics/Allergy and Immunology, Baylor College of Medicine, Houston, TX, USA; 2Biochemistry, University of Su2.39 - Host MHC Influences Susceptibility to HypersensiSheffield, Sheffield, England, United Kingdom. tivity Reactions to TTwo wo Drugs Commonly Used in HIV Therapy Therapy.. F. T. Christiansen,1 A. M. Martin,1 D. A. Nolan,1 S. Gaudieri,1 Su2.35 - Defect in CRAC Ca2+ Channel Function Associated C. A. Almeida,1 E. Phillips,1 P. U. Cameron,1 C. B. Moore,1 I. with Altered K+ Channel Gating Properties in T Cells from James,1 S. A. Mallal.1 1Department of Clinical Immunology & Immunodeficient Patients. Biochemical Genetics & Centre for Clinical Immunology & BioS. Feske,1 M. Prakriya,2 R. S. Lewis,2 A. Rao.1 1CBR Institute for medical Statistics, Royal Perth Hospital, Perth, Western AustraBiomedical Research, Harvard Medical School, Boston, MA, lia, Australia. USA; 2Dept Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA. Su2.40 - Multisystem Disease in CAEBV Infection.

Su2.36 - Proposal for Diagnostic Criteria for Immunodeficiency Associated with DiGeorge Syndrome. A. Sediva,1 A. Janda.1 1Institute of Immunology, University Hospital Motol, Prague, Czech Republic.

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A. P. Williams,1 J. O’B Hourihane,2 E. Hodges,1 H. B. Gaspar,3 J. Smith.1 1Department of Clinical Immunology, Southampton General Hospital, Southampton, United Kingdom; 2Department of Child Health, Southampton General Hospital, Southampton, United Kingdom; 3Molecular Immunology Unit, Institute of Child Health, London, United Kingdom.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.41 - Infants with Recurrent Infections and Low Immunoglobulins: Analysis of Immunoglobluin Normalization. M. A. Whelan,1 S. J. Kung,1 S. J. McGeady.2 1Allergy/Immunology, Thomas Jefferson University Hospital, Philadelphia, PA, USA; 2Allergy/Immunology, AI duPont Hospital for Children, Wilmington, DE, USA.

Su2.47 - Efficacy and Safety of Subcutaneous Immunologlobulin Replacement Therapy at Home in Patients with Primar y Immunodeficiency Diseases: Combined AnalyPrimary sis of TTwo wo Clinical Studies, One in Nor th America and One North in Europe. Hans D. Ochs & Clinical Investigators,1 Ann Gardulf,2 Michaela Praus,3 Peter Kiessling.4 1Department of Pediatrics, University of Washington, Seattle, WA, USA; 2Department of Laboratory Medicine, Section of Clinical Immunology, Karolinska Intitutet at Karolinska University Hospital, Stockholm, Sweden; 3Biostatistics, Accovion GmbH, Marburg, Germany; 4ZLB Behring GmbH, Marburg, Germany.

Su2.42 - The Role of Wiskott Aldrich Syndrome Protein in T Helper Cell Function. J. Aoki,1 A. Konno,2 D. Jankovic,3 J. Cannons,1 F. Candotti,2 P. Schwartzberg.1 1Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD, USA; 2Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD, USA; 3Laboratory of Parasitic Su2.48 – Abstract Withdrawn Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. Su2.49 - Association of IgA Deficiency and Ciliar y DyskineCiliary ymphopenia and Absence Interleukin- sia: Report of a Familiar Case. Su2.43 - Cyclic CD4 LLymphopenia D. Strozzi,1,3 M. Toledo-Barros,1,3 L. V. Rizzo,1,3 P. H.N. Saldiva,2 2: A Novel Immunodeficiency Presentation. E. G. Caldini,2 J. Kalil,1,3 C. M. Kokron.1,3 1Division of Clinical Ronit Herzog, Joan Berman, Shirley Fung, Arye Rubinstein. 1AlImmunology and Allergy, Department of Medicine, University of lergy and Immunology, Albert Einstein College of Medicine, Sao Paulo Medical School, Sao Paulo, São Paulo, Brazil; 2DeBronx, NY, USA. partment of Pathology, University of Sao Paulo Medical School, Sao Paulo, São Paulo, Brazil; 3Institute for Investigation in ImmuSu2.44 - Novel Severe TT-Cell -Cell Immunodeficiency Syndrome nology (iii), Sao Paulo, São Paulo, Brazil. Involving Absent Thymus, Coloboma, Bullous Dermatitis, Eosinophilia, and Elevated IgE. Su2.50 - Atypical Mycobacterial Infection and Chronic K. P. Shanks,1 L. M. Noroski,1 C. Langston,2 E. M. McKay,2 M. Granulomatous Disease: Experience of One Center Center.. L. Levy,3 S. L. Abramson.1 1Department of Pediatrics, Baylor G. Uzel,1 H. L. Malech,2 S. M. Holland.1 1NIAID, Laboratory College of Medicine, Houston, TX, USA; 2Department of Pathol- of Clinical Infectious Diseases, NIH, Bethesda, MD, USA; ogy, USA; 3Department of Dermatology, USA. 2 NIAID, Laboratory of Host Defenses, NIH, Bethesda, MD. Su2.45 - Isolated PCP Infection in Children – A Systemic or Specific Immunodeficiency? A. P. Williams,1 J. O’B Hourihane,2 E. Hodges,1 G. Davies,3 J. Smith.1 1Department of Clinical Immunology, Southampton General Hospital, Southampton, United Kingdom; 2Department of Child Health, Southampton General Hospital, Southampton, United Kingdom; 3Molecular Immunology Unit, Institute of Child Health, London, United Kingdom.

Su2.51 - Use of Subcutaneous Immunoglobulin for TTreatment reatment of Chronic W ar ts in Patient with Common V ariable ImmunoWar arts Variable deficiency deficiency.. J. H. Lin,1 R. L. Roberts.1 1Department of Pediatric Allergy, Immunology, Rheumatology, University of California Los Angeles, Los Angeles, CA, USA.

Su2.46 - Combined Immunodeficiency with Defective Expression in MHC Class II Genes. Anastassia P. Mihaylova,1 Kalina L. Penkova,1 Danilela N. Baltadzhieva,1 Milena I. Ivanova,1 Elissaveta J. Naumova.1 1 Central Laboratory for Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria. ™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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Su2.52 - Distribution and Clinical Aspects of Pediactir Primar y Immunodeficiencies in TTaiwan. aiwan. mary Wen-I. Lee,1 Jing-Long Huang,1 Ming-Ling Kuo,2 Syh-Jae Lin,1 Cheng-Jang Wu.2 1Department of Pediatric Allergy, Immunology and Rheumatology, Chang Gung University and Children’s Hospital, Kwei-Shan, Taoyuan, Taiwan; 2Department of Microbiology and Immunology, Graduate Institute of Basic Medical Sciences, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan.

Su2.56 - The Higher pH Level Present in the Skin of Patients with Atopic Eczema Stimulates the Release of Malassezia sympodialis Allergens. Annika Scheynius,1 Christine Selander,1 Omid Rasool,1 Reto Crameri,2 Arezou Zargari.1 1Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden; 2Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Su2.53 - Experimental Study of the Complex Bi-Directional Interactions between Human Immunodeficiency V irus TType ype 1 Virus (HIV -1) and the Protozoan Parasite Leishmania. (HIV-1) Chenqi Zhao,1 Michel J. Tremblay.2 1Microbiology-Immunology, Centre de Recherche en Infectiologie, Ste-Foy, QC, Canada; 2 Microbiology-Immunology, Centre de Recherche en Infectiologie, Ste-Foy, QC, Canada.

Su2.57 - TTuberculin uberculin Skin TTesting esting W idely Used as a Dianostic Widely Aid for TTuberculosis, uberculosis, False Negative Outcome Has Questioned Its Specificity & Sensitivity Inspite of TTuberculous uberculous Infection. M. Ishaq, I. M. Sameera, K. M. Miraj. 1Allergy/Pulmonology, Al-Junaid Hospital, Nowshera, NWFP, Pakistan.

Su2.54 - Hereditar y Angioedema: A New Mutation and a Hereditary Search of Gravity Factor? Kamel Djenouhat, Veronique Fremeaux-Bacchi, Jacques Blouin, Marie Therese Guinnepin, Jerome Laurent, Mario Tosi, Mohamed Cherif Abbadi. 1Immunology, Institut Pasteur d’Alger, ElHamma, Alger, Algeria; 2Immunology, Hopital Europeen Georges Pompidou, Paris, Paris, France; 3Immunology, Hopital Europeen Georges Pompidou, Paris, Paris, France; 4Allergy, Institut Pasteur de Paris, Paris, Paris, France; 5Allergy, Institut Pasteur de Paris, Paris, Paris, France; 6Immunogenetic, Faculte de Medecine et de Pharmacie, Rouen, Rouen, France; 7Immynology, I.P.ALGER, Alger, Alger, France.

Immuno-dermatology Su2.55 - Bexarotene Gel 1% vs. V ehicle Gel in Combination Vehicle with Narrow-Band Ultraviolet B Phototherapy for Moderate to Severe Psoriasis V ulgaris. Vulgaris. M. A. Magliocco,1 K. Pandya,1 V. Dombrovskiy,1 Y. Wong,1 L. Christiansen,1 A. B. Gottlieb.1 1Clinical Research Center, UMDNJRobert Wood Johnson Medical School, New Brunswick, NJ, USA.

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™Su2.58 - Absence of Draining LLymph ymph Nodes Results in Th2 Immune Deviation and Loss of Resistance to Leishmania major Infection. T. W. Spahn,1,2 W. Domschke,1 J. Roth,3 C. Sorg,3 T. Kucharzik,1 J. M. Ehrchen.3 1Department of Medicine B, Muenster University Hospital, Muenster, NRW, Germany; 2Department of Internal Medicine and Gastroenterology, Marienhospital Osnabrueck, Osnabrueck, Niedersachsen, Germany; 3Department of Experimental Dermatology, Muenster University Hospital, Muenster, NRW, Germany. Su2.59 - Dissociation of TTransactivation ransactivation from TTransrepression ransrepression Activity by a Selective Glucocorticoid Receptor Agonist (SEGRA) Leads to Separation of Therapeutic Effects from Side Effects. H. Schaecke,1 A. Schottelius,1 W.D. Doecke,1 P. Strehlke,2 S. Jaroch,2 N. Schmees, 2 H. Rehwinkel,2 H. Hennekes,3 K. Asadullah.1 1RBA Dermatology, Schering AG, Berlin, Germany; 2 Medicinal Chemistry, Schering AG, Berlin, Germany; 3Corporate Project Management SBU Specialized Therapeutics, Schering AG, Berlin, Germany.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.60 - The Effect of Bur n TTrauma rauma in Rats on Neutrophil ReBurn cruitment and Antioxidant Enzymes Activity in Epidermis. E. V. Mikhal’chik,1 S. M. Titkova,2 M. V. Anurov,2 A. P. Oettinger,2 L. G. Korkina.1 1Department of Molecular Biology, Russian State Medical University, Moscow, Russia, Russian Federation; 2Department of Physiology, Russian State Medical University, Moscow, Russia, Russian Federation; 3Deparment of Physiology, Russian State Medical University, Moscow, Russia, Russian Federation; 4Department of Physiology, Russian State Medical University, Moscow, Russia, Russian Federation; 5Department of Molecular Biology, Russian State Medical University, Moscow, Russia, Russian Federation.

Su2.66 - Expression of the Costimulator y Molecules on AntiCostimulatory gen-Presenting Cells in Atopic Dermatitis. G. N. Drannik,1 A. I. Kurchenko,1 L. M. DuBuske.2 1Dept. Clinical Immunology and Allergology, National Medical University, Kiev, Ukraine; 2Immunology Research Institute of New England, Gardner, MA, USA. Su2.67 - Differential Distribution of LLymphocyte ymphocyte Subpopulations in Peripheral Blood and Muscle Biopsies in Untreated Juvenile Dermatomyositis (JDM). C. Chuu,1 M. O’Gorman,1 L. M. Pachman.1 1Pediatrics, Feinberg College of Medicine, Northwestern University, Chicago, IL, USA.

opiSu2.61 - Quantitative Changes of Mast Cells Following TTopical Application of Honey on Third Degree Burns in Rats. Mohammad Bayat,1 Mojtaba Karimipour,1 Mohammadali Almasieh.1 1Anatomy, Shaheed Beheshti University of Medical Siences, Tehran, Tehran, Islamic Republic of Iran.

Su2.68 - Thalidomide, an Anti-Inflammator y Medication. InAnti-Inflammatory umor Necrosis Factor α) in hibits the Induction of TTumor (TNFα Factor-- α (TNF Ultraviolet B (UVB)-Irradiated Human Keratinocytes by Destabilizing the TNF α mRNA. TNFα J. H. Lin,1 M. M. Bashir,1 W. Zhang,1 V. P. Werth.1,2 1Dermatol2 ™Su2.62 - Anti-IFN-gamma as a Universal TTreatment reatment for Th1 ogy, U. of Penn., Phila., PA, USA; Dermatology, Phila. VA Medical Center, Phila., PA, USA. Mediated Skin Diseases. 1 2 3 3 S. Skurkovich, B. Skurkovich, N. Korotky, N. Sharova, G. ranscripts as Potential Diagnostic Markers Lukina,4 Y. Sigidin.4 1R&D, Adv Biotherapy, Inc., Rockville, MD, Su2.69 - Gene TTranscripts 2 3 USA; Brown Med School, Providence, RI, USA; Dept of Skin for Allergic Contact Dermatitis. 1 1 1 2 1 Dis, Russian St Med U, Moscow, Russian Federation; 4Clinic, M. B. Hansen, L. Skov, T. Menne, J. Olsen. Department of Dermatology, Gentofte Hospital, Hellerup, Denmark; 2DepartRheumatol Inst, Moscow, Russian Federation. ment of Medical Biochemistry and Genetics, University of Su2.63 - Buschke’ Buschke’ss Scleredema: Atypical Onset and Evolu- Copenhagen, Copenhagen, Denmark. tion. Case Report. Victor Cristea,1 Monica Crisan,1 Claudia Magurici,1 Ramona Bologa,1 Nicolae Miron.1 1Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Cluj, Romania. Su2.64 - The Characteristics of Mucosal Immunity in Chronic Adult Periodontitis Patients. I. Kaidashev,1 V. Shinkevich,1 L. M. DuBuske.2 1Ukrainian Medical Stomatological Academy, Poltava, Ukraine; 2Immunology Research Institute of New England, Gardner, MA, USA.

y Effect of TTopical opical Nuclear Su2.70 - Potent Anti-Inflammator Anti-Inflammatory Factor kappa B Decoy in Skin Inflammation. B. Schryver,1 T. Muchamuel,1 A. Oo,1 J. Alleman,1 M. Dajee,1 L. M. McEvoy,1 R. Ehrhardt.1 1Research, Corgentech.Inc, South San Francisco, CA, USA. Su2.71 - Dual Diagnosis of Pemphigus V ulgaris and ConnecVulgaris tive Tissue Disease. Mohsin Malik,1 A. Razzaque Ahmed.1 1Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.

Su2.65 - Acquired Angioedema and Coagulopathy Several Years after Syphilis. Soheil F. Chegini, Michael J. Davies, Timothy J. Craig. 1Medicine, Division of Pulmonary, Allergy & Critical Care, Penn State College of Medicine, Hershey, PA, USA. ™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

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May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

™Su2.72 - Production and Characterization of Human Mono-

Laborator y Immunology Laboratory

clonal Antibody Against Desmoglein 3 from Pemphigus V ulVulgaris Patient. Shih Wei Yeh,1 Kailash C. Bhol,1 Mukesh Kumar,2 Lisa A. Cavacini,2 Marshall Posner,2 A. Razzaque Ahmed.1 1Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA; 2Beth Israel Deaconess Medical Center, Boston, MA, USA.

Su2.77 - Influence of Atopic Histor y on Cord Blood IgE. History Mohammad Amin Kashef,1 Sara Kashef,2 Narjes Pishva,3 Mozhgan Afshari, Zahra Amirgofran,4 Hamed Jalaeian.1 1Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Neonatalogy, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Immunology, Shiraz Su2.73 - Identification of Epitope for Autoantibody and Its University of Medical Sciences, Shiraz, Fars, Islamic Republic of Role in Basement Membrane Separation in Oral Pemphig- Iran. oid. ymphocyte Adenosine Deaminase Activity in ChilKhwaja Aftab Rashid,1 Adnan Q. Usman,1 Shih Wei Yeh,1 Joel Su2.78 - LLymphocyte N.H. Stern,1 Kailash C. Bhol,1 A. Razzaque Ahmed.1 1Oral dren with Idiopathic Nephrotic Syndrome. Medicine, Infection and Immunity, Harvard School of Dental Om P. Mishra, Jayant K. Ghosh, Ziledar Ali, Malay R. Sen, Medicine, Boston, MA, USA. Rajniti Prasad. 1Dept of Pediatrics, Institute of Medical Sciences, Varanasi, Uttar Pradesh, India; 2Dept of Pediatrics, Institute of ™Su2.74 - Effects of Electrical Microcurrent on Open Skin Medical Sciences, Varanasi, Uttar Pradesh, India; 3Dept of Biochemistry, Institute of Medical Sciences, Varanasi, Uttar Pradesh, Wound Healing in Rabbit. 4 Mohammad Bayat,1 Zahra Asgari-Moghadam,1 Mohammad India; Dept of Microbiology, Institute of Medical Sciences, 5 1 1 1 Rakhshan, Fateme-sadat Rezai, Mohammadali Almasieh. Varanasi, Uttar Pradesh, India; Dept of Pediatrics, Institute of 1 Anatomy, Shaheed Beheshti University of Medical Sciences, Medical Sciences, Varanasi, Uttar Pradesh, India. Tehran, Tehran, Islamic Republic of Iran. Su2.79 - ESN: A Potent Natural Inhibitor of Proliferationg Su2.75 - Morphometric Assessment of Nitrofurazone Oint- and Inducer of Apoptosis on K562 Cells. Yang Ping Niu. 1School of Pharmacology, Zhejiang Univerisity ment on Healing of Infectous Second Degree Burns of Rat. 1 1 Mohammad Bayat, Hasan Bagheri-Yazdi, Mohammadali of Technology, Hangzhou, Zhejiang, China. Almasieh.1 1Anatomy, Shaheed Beheshti University of Medical Su2.80 - An Automatic System for the Image Analysis and Sciences, Tehran, Tehran, Islamic Republic of Iran. Interpretation of HEp-2 Image Pattern. Su2.76 - Effect of Low-Power Gallium Aluminum Arsenide Laser Petra Perner,1 Horst Perner.1 1Research Dept., ImageInterpret Radiation on Mast Cells of Open Skin W ound Bed of Rats. GmbH, Leipzig, Germany. Wound Mohammad Bayat,1 Mohammadghasem Golmohammadi,1 Mohammadali Almasieh.1 1Anatomy, Shaheed Beheshti Uni- Su2.81 - Determination of ANA Autoantibodies with Multiversity of Medical Sciences, Tehran, Tehran, Islamic Republic of plexed Immunoassays. Iran. J. L. Hadley,1 D. O. Onley,1 G. J. Harradence,1 N. F. Cahir,1 C. Garey,1 P. A. Swarbrick.1 1R&D, SmartBead Technologies, Cambridge, United Kingdom. Su2.82 - Distribution of Killer Cell Immunoglogulin-Like Receptors Genes in Chinese Han Population. K. Jiang, F. M. Zhu, Q. F. Lv, L. X. Yan. 1HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.

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™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.83 - Problems of Immunodiagnostics of Hepatitis C in Senior Patients. A. A. Potapova, P. G. Bogush, E. B. Redchenko. 1Laboratory of HIV-Detection, Urban Sexually Transmitted Diseases Clinic N 1 of Moscow Health Care Department, Moscow, Russian Federation. Su2.84 - The Novel Docosatriene, Protectin D1, Produced by TH2-Polarization Promotes Human T Cell Apoptosis Via LipidRaft Clustering. Amiram Ariel,1 Pin-Lan Li,1,2 Wei Wang,1 Wang-Xian Tang,1,2 Song Hong,1 Katherine H. Gotlinger,1 Charles N. Serhan.1 1 Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; 2Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA. Su2.85 - FFACS-Based ACS-Based Method TTo o Evaluate Inhibitor y AntibodInhibitory ies in Patients Receiving Enzyme Replacement Therapy Therapy.. K. Seiger,1 L. Cherry,1 V. Theobald,1 S. Richards.1 1Clinical Laboratory Science, Genzyme Corporation, Framingham, MA, USA. Su2.86 - Experimental (war) TType ype System of Hemaimmune Reaction Road Map. Guo Feng. 1Department of Blood Transfusion, Chang Hai Hospital Second Military Medical University, Shanghai, China. Su2.87 - Activation of Red Blood Cell Innate Immune Reaction Main Road by Antigen. Guo Feng. 1Department of Blood Tansfusion, Changhai Hospital Second Military Medical University, Shanghai, China. Su2.88 - Evaluation of the Effects of Different Freezing Procedures on the Function and Composition of LLymphocyte ymphocyte Subpopulations from Blood and Synovial Fluid. Mona Widhe,1 Nimrod Kiss,1 Therese Wallerskog,1 Andreas Fasth,1 Vivianne Malmstrom,1 Christina Trollmo.1 1Rheumatology Research Unit, Dep of Medicine at Solna, Karolinska Institutet, Stockholm, Sweden.

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

Su2.89 - Does the CD203c Basophil Marker Improve the FlowCytometr y Diagnosis of Immediate Allergy? Cytometry A. Ocmant,1 A. Michils,2 Y. Peignois,1 L. Schandene.1 1Department of Immunology, Erasme Hospital, Brussels, Belgium; 2Department of Chest Medecine, Erasme Hospital, Brussels, Belgium. Su2.90 - Prospective Comparison of ELISA and Immunodiffusion for Detection of Antibodies to Extractable Nuclear Antigens. J. L. Schmitz,1 K. Freeman,1 S. Orton,1 J. D. Folds.1 1McLendon Clinical Laboratories, UNC Hospitals, Chapel Hill, NC, USA. Su2.91 - A Novel Proteomics Assay Employing Amplification of Oligonucleotide TTags ags from Monoclonal Antibodies. M. G. Kattah,1 J. Coller,2 P. J. Utz.1 1Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA; 2 Stanford Functional Genomics Facility (SFGF), Stanford University, Stanford, CA, USA. Su2.92 - Identification of Major Histocompatibility Complex (MHC) Class I-Realted Genes in Cattle. C. De Juan Sanjuan,1 S. A. Ellis.1 1Immunopathology, Institute for Animal Health, Compton, Berkshire, United Kingdom. Su2.93 - an of Influenza Virus. N. Yamamoto,1 M. Urade,2 M. Ueda.1 1Molecular Immunology, Socrates Institute for Therapeutic Immunology, Philadelphia, PA, USA; 2Oral Surgery, Hyogo College of Medicine, Hyogo, Japan. Su2.94 - Role of L-Arginine TTranspor ranspor ter ransporter ter,, Solute Carrier 7A2 (SLC7A2), in the Immune System. R. M. Sanchez-Munoz,1 J. Kleeman,1 C. L. MacLeod,1 L. G. Ellies.1 1Cancer Center, University of California San Diego, San Diego, CA, USA. Su2.95 - Improved Immunological Methods Using Peptides: Wester n Blots, Peptide Arrays, Kinase Assays and ELISAs. estern I. Ghosh,1 L. Sun,1 M.-Q. Xu.1 1Research and Development, New England Biolabs, Beverly, MA, USA.

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Su2.96 - Characterization of Assay V ariability in Real-T ime Variability Real-Time and Batch Assays of Sequential Samples from the Same Donors. J. L. Lathey,1 K. Martinez,1 S. Gregory,1 P. D’Souza,2 W. Lopaczynski.1 1Virology/Immunology, BBI Biotech, a Division of SeraCare Life Sciences, Gaithersburg, MD, USA; 2Vaccine, NIAID, Bethesda, MD, USA.

Su2.102 - A Multi-Level Approach to Analyzing Immune Responses in TTargeted argeted Cells by Combining Cytomic and Proteomic TTechniques echniques of Cell Sor ting and Protein FractionSorting ation. S. D’Costa,1 E. Betgovargez,1 C. Snow,1 M. Simonian.1 1Biomedical Research Division, Beckman Coulter Inc., Miami, FL, USA.

Su2.97 - HLA-T yped PBMC Samples with Established AntiHLA-Typed gen/Peptide Reactivity for Accelerating and Standardizing Human Immunological Research. P. V. Lehmann,1 S. Gregory,2 M. Ewell,2 W. Lopaczynski,2 T. Watts,2 C. Shive,1 N. Sigmund,1 O. Targoni,1 J. Lathey,2 W.J. Zhang.1 1&2BBI Biotech Research Laboratories, A Division of SeraCare Life Sciences, Gaithersburg, MD, USA.

Su2.103 - Notch Modulation of Peripheral Immunity: A Novel Approach to Antigen-Specific Immunotherapy Immunotherapy.. B. R. Champion,1 S. Ballantyne,1 A. Rust,1 L. Perry,1 H. BeacockSharp,1 C. Howard,1 L. Green,1 A. Watkins,1 R. Bartram,1 G. Martin,1 E. Briend,1 H. Harper,1 T. Tugal,1 S. Ragno,1 L. L. Young.1 1 Discovery Research, Lorantis Ltd, Cambridge, United Kingdom.

Su2.98 - Cell Proliferation Index. A Reliable and V alidated Validated Method That Quantifies Cell Proliferation According to CFSE Dilution. J. C. Crispin,1 M. I. Vargas-Rojas,1 J. Alcocer-Varela.1 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.

Su2.104 - Serum Heat-Inactivation and Granulocyte Presence Exerts a Differential Effect on the Antigen-Induced Proliferation of LLymphoid ymphoid Subsets. N. J. Andersen,1 D. A. Lawrence.1 1Wadsworth Center, New York State Dept of Health, Albany, NY, USA.

Su2.105 - Provision and Integration of HLA Alleles into Scientific Research. S. J. Cate,1 R. Tian,1 M. Jones,1 S. Chandrasekaran,1 W. H. Su2.99 - Evaluation of CellPrep, an Automated Cell W ashing Hildebrand.1 1Microbiology, University of Oklahoma, Oklahoma Washing Instrument for Analysis of Surface Markers on Leukocyte Sub- City, OK, USA. populations V ia Flow Cytometr y. Via Cytometry J. G. Wilkinson,1 C. Aparicio,1 C. Smith,1 E. Rabellino,1 S. Su2.106 - Potassium Channels IR, Kv1.5, and Kv1.3 Are ExD’Costa.1 1Biomedical Research Division, Beckman Coulter Inc., pressed on Human Dendritic Cells and Have a Functional Miami, FL, USA. Role in Maturation. K. M. Mullen,1 M. Rozycka,2 L. Hu,1 H. Rus,2 J. Graber,1 M. W. Su2.100 - Optimization of the Aspiration Dose of IL-1ra Prepa- Pennington,3 D. C. Johns,4 S. I. Judge,2 P. A. Calabresi.1 1Neuration TTo o Stop an Inflammation in the Mouse Respirator y TTract. ract. rology, Johns Hopkins University, Baltimore, MD, USA; 2NeurolRespiratory 1 2 2 A. M. Ischenko, B. P. Nikolaev, E. V. Vorobeychikov, L. Yu ogy, University of Maryland, Baltimore, MD, USA; 3Bachem BioYakovleva,2 T. V. Kotova,2 L. Ya Soloviova,1 V. G. Konusova.3 science, Inc, King of Prussia, PA, USA; 4Neurosurgery, Johns 1 Protein Biochemistry, Institute of Highly Pure Biopreparations, Hopkins Hospital, Baltimore, MD, USA. Saint-Petersburg, Russian Federation; 2New Drug Formulations, Institute of Highly Pure Biopreparations, Saint-Petersburg, Rus- Su2.107 - Monitoring the Effects of Immuno-Modulating Therasian Federation; 3Immunopharmacology, Institute of Highly Pure pies. Biopreparations, Saint-Petersburg, Russian Federation. J. B. Woodcock, J. A. Britz, D. R. Post, R. J. Kowalski.1 1Product Development, Cylex Incorporated, Columbia, MD, USA. Su2.101 - The Use of Arginine-Rich Peptide Conjugated Antisense Oligomers TTo o Alter Immune Function. N. B. Marshall,1 D. V. Mourich,1 H. M. Moulton,1 P. L. Iversen.1 1 Biology, AVI BioPharma Inc., Corvallis, OR, USA. 128

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.108 - Development of a V ersatile Murine T Cell Expander Versatile Bead: Combining Quality with Practicality Practicality.. E. Leung,1 A. Aas-Eng,2 G. Okern,2 A. M. Rasmussen,2 O. Amellem, 2 A. Simonsen, 2 O. A. Garden. 1 1Molecular Immunoregulation Team, Dep. of Immunology, Imperial College London, London, United Kingdom; 2Immunosystems, Dynal Biotech ASA, Oslo, Norway.

Su2.114 - Phenotypically and Functionally Distinct CD8+ LLymymphocyte Populations in Long-T er m Drug-Free TTolerance olerance in HuLong-Ter erm man Kidney Graft Recipients. D. Baeten,1 S. Louis,1 C. Braud,1 C. Braudeau,1 A. Pallier,1 M. Giral,1 S. Brouard,1 J.P. Soulillou.1 1INSERM U643, ITERT, Nantes, France.

Su2.109 - Characterization of Endogenously Loaded Rhesus Macaque MHC Class I Peptides. A. R. Gilb,1 H. D. Hickman-Miller,1 W. Bardet,1 A. D. Luis,1 D. I. Watkins,2 K. Jackson,1 W. H. Hildebrand.1 1Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Wisconsin Regional Primate Center, University of Wisconsin, Madison, WI, USA.

Su2.115 - Could Early Posttransplant Allosensitivity Predict Patients at High Risk for Rejection and Graft Loss in Kidney Transplantation. Petia P. Boneva, 1 Anastassia P. Mihaylova,1 Daniela N. Baltadzhieva,1 Kalina L. Penkova,1 Daniela L. Jordanova,1 Pepi K. Angelova,1 Elissaveta J. Naumova.1 1Central Laboratory for Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria.

Su2.110 - NUSE and RLE: Quality Assessment of Oligonucleotide Microarray Data TTo o Quantify Systemic V ariation. Variation. F. Collin,1 A. L. Asare,1 S. A. Kolchinsky,1 T. P. Speed,2 V. L. Seyfert-Margolis.1 1Immune Tolerance Network, University of California, San Francisco, Bethesda, MD, USA; 2Department of Statistics, University of California, Berkeley, CA, USA.

Su2.116 - Humoral and Cellular Response to Influenza V acVacolerant to a Kidney cination in Human Recipients Naturally TTolerant Allograft. G. Roussey-Kesler,1 C. Ballet,1 J. T. Aubin,2 S. Brouard,1 J. P. Soulillou.1 1ITERT, INSERM U643, Nantes, France; 2Centre National de Reference du Virus Influenza, Institut Pasteur, Paris, France.

Su2.111 - High Resolution HLA TTyping yping for V accine and AuVaccine toimmune Studies. Su2.117 - Pharmacodynamic Monitoring of Calcineurin InR.Y. Tian,1 S. J. Cate,1 M. M. Jones,1 W. H. Hildebrand.1 1Mihibitors by Quantitative Analysis of NF AT-Regulated Gene ExNFA crobiology and Immunology, University of Oklahoma Health pression. Science Center, Oklahoma City, OK, USA. T. Giese,1 M. Schoels,1 T. Dengler,2 M. Zeier,3 S. Meuer.1 1Immunology, University of Heidelberg, Heidelberg, Germany; 2CarOrgan TTransplantation ransplantation diology, University of Heidelberg, Heidelberg, Germany; 3NephSu2.112 - On the Possibility of Oral TTolerance olerance TTo o Be Used in rology, University of Heidelberg, Heidelberg, Germany. Graft TTransplantation. ransplantation. olerant” Kidney ReXiao-Bin Zheng. 1Research and Development, Beijing Su2.118 - Profiling of “Operationally TTolerant” Spectroscopy.. Zhongbangyumin Sci-trade Company Co.Ltd., Beijing, China. cipients Using SELDI-TOF Mass Spectroscopy Christophe Braud,1 Alexandre DuPont,1 Magali Giral,1 JeanSu2.113 - Evidence for Naturally Occurring and Induced Paul Soulillou,1 Sophie Brouard.1 1INSERM U643, ITERT-CHU Hotel Dieu Nantes, Nantes, France. Regulator y TT-Cells -Cells in Non-Human Primates. Regulatory 1 1 1 1 K. G. Haanstra, J. A.M. Wubben, M. Jonker. Immunobiology, Biomedical Primate Research Centre, Rijswijk, ZH, Netherlands.

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May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.119 - Mega Dose Allogeneic Hematopoietic Stem Cell Transplantation, Natural Suppressor Cell Chimerism and TTololerance in Clinic- Ahmedabad Experience. H. L. Trivedi, A. V. Vanikar, P. R. Modi, V. R. Shah, J. M. Vakil, S. I. Khemchandani, V. B. Trivedi. 1Department of Transplantation Medicine, Institute of Transplantaion Sciences and Institute of Kidney Diseases & Research Centre, Ahmedabad, Gujarat, India; 2Department of Pathology, Lab Medicine and Transfusion Services and Dept. of Immunohematology, Institute of Transplantaion Sciences and Institute of Kidney Diseases & Research Centre, Ahmedabad, Gujarat, India; 3Department of Urology, Institute of Transplantaion Sciences and Institute of Kidney Diseases & Research Centre, Ahmedabad, Gujarat, India; 4 Department of Anesthesia, Institute of Transplantaion Sciences and Institute of Kidney Diseases & Research Centre, Ahmedabad, Gujarat, India; 5Department of Transplantation Medicine, Institute of Transplantaion Sciences and Institute of Kidney Diseases & Research Centre, Ahmedabad, Gujarat, India; 6Department of Urology, Institute of Transplantaion Sciences and Institute of Kidney Diseases & Research Centre, Ahmedabad, Gujarat, India; 7Department of Pathology, Lab Medicine and Transfusion Services and Dept. of Immunohematology, Institute of Transplantaion Sciences and Institute of Kidney Diseases & Research Centre, Ahmedabad, Gujarat, India.

Su2.122 - New Insights in Mechanisms of Action of Different Immunosuppressive Drug Therapies by Assessing the Pharmacodynamics in Hear ransplant Recipients. Heartt TTransplant M. J. Barten,1 A. Rahmel,1 M. Richter,1 J. Garbade,1 H. B. Bittner,1 S. Dhein,1 F. W. Mohr,1 J. F. Gummert.1 1Cardiac Surgery, University Leipzig, Heart Center Leipzig, Leipzig, Germany. Su2.123 - Assessment of Peripheral Blood Dendritic Cell Subsets and Their Functions TTo o Monitor Immunosuppression after Hear ransplantation. Heartt TTransplantation. M. J. Barten,1 A. Rahmel,1 M. Richter,1 J. Garbade,1 H. B. Bittner,1 S. Dhein,1 F. W. Mohr,1 J. F. Gummert.1 1Cardiac Surgery, University Leipzig, Heart Center Leipzig, Leipzig, Germany. Su2.124 - T Helper Cells Produced Increased IL-6 and TNFα TNF-α Levels in Human Hear ransplant Recipients. Heartt TTransplant M. J. Barten,1 A. Rahmel,1 M. Richter,1 J. Garbade,1 H. B. Bittner,1 S. Dhein,1 F. W. Mohr,1 J. F. Gummert.1 1Cardiac Surgery, University Leipzig, Heart Center Leipzig, Leipzig, Germany.

Su2.125 - The Expression of Sur vivin in T Cells and Its PosSurvivin sible Significance. Ning Zeng, Bicheng Chen, Zhonghua Klause Chen, Li Tang, Shang Chang, Dunfeng Du. 1Key Laboratory of Organ TransSu2.120 - Analysis of HLA Class One Alloantibodies in the plantation Ministry of Education, Key Laboratory of Organ Transplantation Ministry of Health, Institute of Organ Transplantation Sera of Sensitized Patients on Hemodialisis. 1 2 1 Minoo K. Adib, Edna Abkarshahnazar. Immunology, Medi- Tongji Hospital, Wuhan, Hu Bei, China. cal School, Isfahan, Isfahan, Islamic Republic of Iran; 2Immunology, Medical School., Isfahan, Isfahan, Islamic Republic of Iran. Su2.126 - Anti-CD132 Monoclonal Antibodies Inducing Activated T Cells Apoptosis after Alloantigen Stimulation. Su2.121 - IgG Monitoring Can Predict the Development of Fu-li Xiang,1 Chang Sheng,1 Bicheng Chen,1 Dunfeng Du,1 Zhonghua Clause Chen.1 1Organ Transplantation, Tongji HosInfection in Hear ransplantation. Heartt TTransplantation. E. Sarmiento,1 J.J. Rodriguez-Molina,1 J. Fernandez-Yanez,2 J. pital, Tongji Medical College, HUST, Wuhan, Hubei, China. Palomo,2 P. Munoz,3 E. Fernandez-Cruz,4 E. Bouza,1 J. Carbone.1 1 -Cell Immunity Is Immunology Department, University Hospital Gregorio Su2.127 - Cytomegalovirus-Specific CD4 TT-Cell Maranon, Madrid, Spain; 2Cardiology Department, University Associated with Protection from Human Cardiac Allograft Hospital Gregorio Maranon, Madrid, Spain; 3Microbiology Rejection and Negative Coronar y-Ar ter y Remodeling. Coronary-Ar y-Arter tery Department, University Hospital Gregorio Maranon, Madrid, W. Tu,1 L. Potena,2 P. Stepick-Biek,1 L. Liu,1 K. Y. Dionis,1 L. Spain. Bashyam,3 W. Fearon,2 H. A. Valantine,2 E. S. Mocarski,3 D. B. Lewis.1 1Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA; 2Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; 3Deaprtment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. 130

™=Poster of Distinction. Scored in TTop op 10% of Poster Submissions.

2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.132 - The Role of Indoleamine 2,3-Dioxygenase (IDO) in a Murine CTLA4Ig-Based Mixed Chimerism Model. I. Pree,1 S. Bigenzahn,1 P. Nierlich,1 Z. Koporc,1 P. Blaha,1 F. Langer,1 E. Selzer,2 D. Fuchs,3 C. Winkler,3 G. Brandacher,4 M. Sykes,5 F. Muehlbacher,1 T. Wekerle.1 1Dept. of Surgery, Div. of Transplantation, Medical University of Vienna; 2Dept. of Radiotherapy and Radiobiology, Vienna Gernal Hospital; 3Inst. of Medical Chemistry and Biochemistry; 4Dept. of General and 5 Su2.129 - Baohuoside-1, a Novel Immunosuppressive Mol- Transplant Surgery, University of Innsbruck, Austria; Transplantation Biology Research Center, MGH/Harvard Medical School, itro and In V ivo. ecule, Inhibits LLymphocyte ymphocyte Activation In V Vitro Vivo Boston, USA. MA/Anlun,1 Qi/Shijie,1 Xu/Dasheng,1 Daloze/Pierre,1 Chen/ Huifang.1 1CHUM, Notre-Dame Hospital, University of Montreal, Su2.133 - Evaluation of Immuknow-Immune Cell Function AsMontreal, QC, Canada. say as a New Parameter of Net State of Immunosuppresion ransplant Recipients. Su2.130 - Cellular Reactivity to Human Hsp60 in Murine Skin in Monitoring Renal TTransplant 1 2 Moshe Israeli, Eytan Mor,1 Dan Krest,2 Tirza Klein.2 Alex Yussim, and Hear ransplantation. Heartt TTransplantation. 1 Veronica Coelho,1,2,3 Ernesto Luna,1,2 Luiz A. Benvenuti,1 Luiz R. Department of Transplantation, Research Unit, Rabin Medical Mundel,1 Valquiria Bueno,4 Leo K. Iwai,1 Cristina Caldas,1 Jorge Centre, Affil. 2to Tel Aviv University School of Medicine, Petach Kalil.1,2,3 1Heart Institute (Incor), University of Sao Paulo, Sao Tikva, Israel; Tissue Typing Laboratory. Su2.128 - Immunological Evaluation of LLymphocyte ymphocyte Activation, Cytokines and Apoptosis on TTacrolimus-Sirolimus-Inacrolimus-Sirolimus-Induced Long-T er m Allograft Sur vival in Nonhuman Primates. Long-Ter erm Survival MA/Anlun,1 Qi/Shijie,1 Xu/Dasheng,1 Daloze/Pierre,1 Chen/ Huifang.1 1Laboratory of Experimental Surgery, Research Centre Hospitilier de l’University de Montreal (CHUM), Hopital NotreDame, Universite de Montreal, Montreal, QC, Canada.

Paulo, Sao Paulo, Brazil; 2Division of Allergy and Clinical Immunology, Internal Medicine Department, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil; 3Institute for Investigation in Immunology-Millenium Institute, CNPq, Brazil; 4Nephrology Division, Department of Medicine, Paulista School of Medicine, Paulista School of Medicine UNIFESP, Sao Paulo, Sao Paulo, Brazil.

Su2.134 - CD80 but Not CD86 Costimulator y Molecules SupCostimulatory presses Xenogeneic Humoral Rejection by Regulation of Complement C3dg Generation. K. A. Hosiawa,1,2 H. Wang,3 B. Garcia,3 R. Zhong,2,3 D. J. Kelvin.1,2,4 1Division of Experimental Therapeutics, University Health Network-Toronto General Research Institute, Toronto, ON, vival Using the Encap- Canada; 2Microbiology and Immunology, University of Western Su2.131 - Evaluation of Skin Graft Sur Survival sulated Hsp60 Peptide (p277) in a Murine Model of Minor Ontario, London, ON, Canada; 3Surgery, University of Western Ontario, London, ON, Canada; 4Immunology, University of Antigen Disparities. Ernesto Luna,1,2 Edilberto Postol,1 Luiz A. Benvenuti,1 Jose M. Toronto, Toronto, ON, Canada. Rodrigues,4 Karla M. Lima,4 Cristina Caldas,1 Jorge Kalil,1,2,3 Veronica Coelho.1,2,3 1Heart Institute (Incor), University of Sao Su2.135 - Lack of Correlation between the Presence of AntiPaulo, Sao Paulo, Sao Paulo, Brazil; 2Division of Allergy and Human Panel Reactive Antibodies (PRA) and Anti-Swine NonClinical Immunology, Dep.Internal Medicine, University of Sao Galactoseα1,3-Galactose (NonGal) Cytotoxic Antibodies in Galactose-α Paulo, Sao Paulo, Sao Paulo, Brazil; 3Institute for Investigation Patients A waiting Life-Saving Organ TTransplantation. ransplantation. Awaiting in Immunology, Millenium-Institute, Brazil; 4Center for Tuberculo- B. S. Wong,1 P. E. O’Malley,1 Y.-L. Tseng,1 F. J.M.F. Dor,1 S. L. sis Research, School of Medicine of Ribeirao Preto, Ribeirao Saidman,2 K. Yamada,1 D. H. Sachs.1 1Transplantation BiolPreto, Sao Paulo, Brazil. ogy Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; 2Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

Su2.136 - TIRC7 Is Expressed upon Immune Activation Early in Peripheral Blood LLymphocytes ymphocytes and Remains Induced in Inflammator y Cells during Rejection after Kidney TTransplantaransplantaflammatory tion as W ell as in Joints from Patients with Established RheuWell matoid Arthritis. S. G. Tullius,1 H. D. Volk,2 A. Tamura,2,3 M. Winter,2 P. Fraser,5 R. S. Blumberg,5 N. Utku.2,4 1Department of General and Transplantation Surgery, Charite-Campus Virchow Clinic, HumboldtUniversity, Berlin, Germany; 2Institute of Medical Immunology, Humboldt-University of Berlin, Berlin, Germany; 3School of Medicine, Keio University, Tokyo, Japan; 4GenPat77 Pharmacogenetics AG, Berlin, Germany; 5Department of Medicine, Rheumatology and Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. Su2.137 - Peripheral and Graft Infiltrating T Cell Responses to Self Heat Shock Protein 60 in Renal TTransplant ransplant Patients. C. Caldas,1 M. Spadafora-Ferreira,1 S. E. Oshiro,1 J. A. Fonseca,2 E. Luna,1,5 P. L. Ho,3 J. Kalil,1,4,5 V. Coelho.1,4,5 1Heart Institute (InCor), University of Sao Paulo Medical School; 2Renal Transplantation Unit, University of Sao Paulo Medical School; 3 Butantan Institute; 4Institute for Investigation in ImmunologyMillenium Institute; 5Clinical Immunology and Allergy, Departament of Clinical Medicine, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil.

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2005 ANNUAL MEETING FINAL PROGRAM

May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts

CME Self-Reporter SELF-REPORTING SYSTEM: The 5th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS) will offer Continuing Medical Education (CME) credits for physicians jointly sponsored by the Clinical Immunology Society (CIS) and FOCIS. Please note that not all FOCIS sessions and activities offer CME credit. The amount of credit offered for each session is included on the back of this form. Please circle the corresponding CME credits (other side) and total at the bottom of the CME form.

Base credit will not be offered at the FOCIS meeting. Each delegate will be required to complete this Self-Reporter Form in order to receive a certificate of credit. This form lists all sessions offered for credit, as well as the amount of credit available per session from the Clinical Immunology Society (CIS) and FOCIS. PLEASE FOLLOW THESE INSTRUCTIONS TO RECEIVE YOUR CER TIFICA TE OF CREDIT CERTIFICA TIFICATE CREDIT:: 1. Complete this Self-Report Form, tear it out of the final meeting program and return it to the FOCIS Information Booth, 3rd floor of the Westin Copley Place. Certificates will be issued only upon completion of this form. OR 2. Mail your completed Self-Report Form to the FOCIS office (555 East Wells Street, Suite 1100, Milwaukee, WI 53202) 3. Please print your name and address in the box below:

PLEASE NOTE: that this information will be used to issue CME certificates. Your name will be printed on your certificate the way it appears in this box.

4. Please transfer the TOTAL NUMBER OF CME CREDITS from the bottom of the other side to the space below. ________________________ TOT AL CME CREDITS TOTAL 5. Signature: ____________________________________________

Date: ________________

*PLEASE NOTE: Delegates must complete this Self-Report Form in order to receive their certificate of credit for the 5th Annual Meeting of the Federation of Clinical Immunology Societies. Delegates not completing this form will not be issued a certificate. 133

2005 ANNUAL MEETING FINAL PROGRAM

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THURSDA Y, MA Y 11, 2005 THURSDAY MAY

CREDITS

SUNDA Y, MA Y 15, 2005 SUNDAY MAY

CREDITS

Society Satellite Sessions 8:30am-12:30 pm CIS: Emerging Lab Technologies ......................................... 4 ‰

Plenary Session 8:30-10:00am Tracking Pathogenic & Therapeutic Immune Responses ....... 1.5 ‰

8:00am-5:00 pm CIS: Primary Immune Deficiency Disease Conference ............ 8 ‰

Thematic Symposia 10:30 am-12:30 pm In Vivo Imaging ................................................................ Costimulation and Tolerance .............................................. Mast Cell, Eosinophils, Allergic Reactions ........................... Living with the Bugs: Good or Bad .....................................

8:00am-5:00 pm FOCIS: Basic Immunology for Clinicians: Update 2005 ........ 8 ‰

FRIDA Y, MA Y 13, 2005 FRIDAY MAY Plenary Session 8:30-10:00 am Regulation of T Cell and Differentiation ............................. 1.5 ‰ Thematic Symposia 10:30 am-12:30 pm ................................................................ Regulatory T Cells in Transplant and Autoimmunity ............... 2 ‰ FCR and Complement ........................................................ 2 ‰ Dendritic Cells .................................................................. 2 ‰ Antibodies in Disease Pathogensis and Therapy .................... 2 ‰ Industry Symposium 1:30-3:00 pm Biogen IDEC Symposium: ................................................ 1.5 ‰ Concurrent Oral Abstract Sessions 3:30-5:30 pm Antibodies and B Cells ...................................................... Innate Immune System Regulating Disease ............................ T Regs and Regulations of Immunes Responses ..................... New Pathways of Immune Regulation .................................. NK and NKT Cells ............................................................

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SA TURDA Y, MA Y 14, 2005 SATURDA TURDAY MAY

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Industry Symposium 1:30-3:00 pm Genentech Symposium .................................................... 1.5 ‰ Oral Abstract Sessions 3:30-5:30 pm New Animal Models: Defining Antigens Recognition by Animal Models .............. Costimulation .................................................................... Immunotherapy .................................................................. Trafficking and Adhesion .................................................... Cytokine Mediated Immunoregulation ..................................

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MONDA Y, MA Y 16, 2005 MONDAY MAY Plenary Session 8:30-10:00am Genetics and Genomics .................................................. 1.5 ‰ Thematic Symposia 10:30am-12:30 pm Therapeutic Vaccines ......................................................... Development of Immune-Based Therapeutics ......................... Roles of Interferons in Defense and Disease .......................... Immunodiagnostic Disease Predictors ..................................

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Plenary Session 8:30-10:00 am Genetics and Gene Therapy ............................................ 1.5 ‰ Thematic Symposia 10:30 am-12:30 pm Genetics of Immune Mediated Diseases & Transplantation ..... TLR, NK, Innate Immunity ................................................... Immunodysregulation and Immunoreconstitution .................... Disease Regulation: Role of Antigens, Cytokines, Chemokines

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Industry Symposium 1:30-3:00 pm Centocor Symposium: ..................................................... 1.5 ‰ Oral Abstract Sessions 3:30-5:30 pm Genetics and Genomics ..................................................... Immunodiagnosis ............................................................... Tolerance ......................................................................... Dendritic Cells and Regulation of Disease ............................ Immunodeficiency ..............................................................

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TOT AL CREDITS (T ransfer Credits to For m on Page): _________ TOTAL (Transfer Form

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