Artritis Reumatoide Juvenil (arj)

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Infecciones: Parvovirus B19, Epstein Barr, Rubeola. Auto antigenos de colageno tipo II: LT con recptores especificos para antigenos de la mebrna basal Activacion de LB y autoantigenos: Variaciones del HLA: HLADRB1: asciado con enfermedad poliarticular. HLA DR8 B1*0801 y DR5 B1*1104 Patologia: Hipertrofia e hiperlasia vellosa. Hiperplasia de endotelio vascular. Congestion y edema de tejidos subsinoviales. Infiltrado de Mo y Cel. Plasmaticas

Lesiones inflamatorias iniciales

Patologia: Panus Erosión progresiva del cartilago y hueso.

Lesiones inflamatorias crónicas

American College of Reumatology

Corticoesteroides

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