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ABSTRACT HISTOPATHOLOGY DESCRIPTION OF WHITE RAT’S KIDNEY (Rattus norvegicus) WHITE STRAIN AFTER POKEA CLAM (Batissa violacea celebensis) FEEDING By : Sasqia Pratiwi Iqbal K1A1 15 040

Background. Batissa violacea celebensis known as pokea clam contained high level of nutritional value such as, protein, phosphor, calcium and iron. Pokea clam also acted as filter feeder, therefore it accumulated pollutants such as metals or other toxic chemicals in the clam’s environment and deposited in the clam’s body, thereafter will continue to accumulate. The purpose of this study was to find out the histopathology description of white rat’s kidney (Rattus norvegicus ) after pokea clam (Batissa violacea celebensis ) feeding. Method. This research applied the post test-only control group method. White rats (Rattus novergicus) was used as experimental animals. As much as 25 rats were divided into five groups. Group I (negative control), group II (5 mg/kg), group III (50 mg/kg), group IV (500 mg/kg) and group V (5000 mg/kg) which was given in 14 days. Results. Based on the result of histopathology examination on the kidneys of control group (negative), there was only one rat with normal appearance of kidney cells while four other kidneys experienced tubular kidney necrosis. On group II (P2) with 5 mg/kg treatment, the kidneys had tubular kidney necrosis. On group III (P3) with 50 mg/kg treatment, the kidneys had tubular kidney necrosis and calcification. On group IV (P4) with 500 mg/kg treatment, the kidneys had tubular necrosis and calcification, also glomerular atrophy. On group V (P5) with 5000 mg/kg treatment, the kidney’s had tubular calcificaton and glomerular atrophy. Conclusion. There was a change in microscopic description of white rat’s kidney, namely the higher the dose of pokea clam that was given, the more changes that was found in histopathology description of rat’s kidney. Keywords : Histopathology, Kidney, Rat, Pokea clam (Batissa violacea celebensis)