Worksheet Iv Infus.docx

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WORKSHEET FARMAKOKINETIKA KLINIK IV INFUS A. Kelompok Mahasiswa Terdiri Dari 4-5 Orang B. Worksheet Di Uploud Pada Google Form Dengan Link Sebagai Berikut : https://goo.gl/forms/lSs0XzMSN8QyOM8b2

1. Suatu antibiotik Vd= 10L, K=0,2/jam, Css yang diharapkan= 10 mcg/ml. berapa kecepatan infusi yang harus diberikan? R= Css.K.Vd 2. Jika px mengalami uremia dan K menjadi 0,1/jam. Berapa R yang harus diberikan jika tetap menghendaki Css 10 mcg/ml ? R= Css.K.Vd 3. Suatu obat diberikan dg infus intravena dengan kec. Tetap (50mg/jam) kepada subyek selama 4 jam. Dari pustaka dik bahwa T ½ eliminasi 8 jam dan Vd 5L. Berapa kadar obat dalam darah 4 jam sejak pemberian infus? Cp 

R (1  e  kt  Vd.k

4. Seseorang akan mendapat anestesi pada kec. Infus 2 mg/jam secara IV. Tetapan kec. Eliminasi = 0,1/jam dan Vd=10L. Berapa dosis muatan yang harus diberikan jika kadar 2mcg/ml segera dicapai?

DM 

R K

Css 

DM Vd

5. What is the main reason for giving a drug by slow IV infusion? 6. Why do we use a loading dose to rapidly achieve therapeutic concentration for a drug with a long elimination half-life, instead of increasing the rate of drug infusion or increasing the size of the infusion dose? 7. What are some of the complications involved with IV infusion?

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