Seroquel

INDEX Generic Name quetiapine

Trade Name seroquel

Peak unknown

Onset unknown

NURS 2236 Clinical Form 3: Clinical Medications Worksheet (You will need to made additional copies of these forms) Classification Dose Route Time/Frequency antipsychotic

100 mg

Duration 8-12 hours

Normal Dosage range Max- 800 mg per day

Why is your patient taking this medication? psychotic disorder

PO

Q HS

For IV meds, compatability with IV drips and/or solutions

Mechanism of action and indications Functions as an antagonist at multiple neurotransmitter receptors in the brain including 5HT, dopamine and adrenergic alpha 1&2 receptors

Nursing Implications (what to focus on) use cautously in: Cardiovascular Contraindications/warnings/interactions disease, cerebrovascular disease dehydration or hypovolemia, History of seizures, Alzheimer's dementia, Hepatic impairment, Hypothyroidism, history of suicide attempt

Decrease manifestation of psychoses or acute mania

Contra- Hypersensitivity Common side effects EPS, pseudoparkinsonism, akathisia, dystonia, tardive dyskinesia, drowsiness, insomnia, agitation, anxiety, headache, seizures, neuroleptic malignant syndrome, dizziness orthostatic hypotension, tachycardia nausea, anorexia, constipation, abdominal pain, dry mouth, rash, asthenia back pain, fever, ear pain, rhinitis, Lab value alterations caused by medicine cause increase in AST and ALT, may also cause anemia, thrombocytopenia, leukocytosis, leukopenia, may cause increase total cholesterol and triglycerides

Interactions with other patient drugs, OTC, or herbal medicines (ask patient specifically) antihistamines, opoid analgesics, sedative/hypnotics Antihypertensives, phenytoin, thioridaxine, carbamazepine, barbiturates, rifampin, corticosteriods, ketoconazole, intraconazole, flluconazole, erthromycin

Be sure to teach the patient the following about this medication instruct patient to take meds as directed, inform patient of EPS, advise patient to change positions slowly, may cause drowsiness- caution patient to avoid driving advise patient to avoid extremes in temperature- impairs body temperature regulation, caution patient to avoid concurrent us of alcohol and other CNS depressants, notify health care providor of sore throat, fever, or unusual bleeding Assessment Evaluation Why would you hold or not give Check after giving this med? Evalution the patient for decrease In excited, seizures manic, paranoic or withdrawn behavior, make sure patient has swallowed medication and is not cheeking or hording meds.

Nursing Process - Assessment (Pre-administration assessment Monitor mental status, Monitor mood changes, Assess for suicidal tendencies, Monitor Blood pressure and pulse before administraion, Observe patient carefully when administering to ensure medication is swallowed, Monitor for onset of EPSMonitor for development of neuroleptic malignant syndrome