Q2 Product Update

......Inspire Biodiscovery 2009 New Product Announcement 5-10% Promotional Discount

RT2 miRNA PCR Array

RT2 ProfilerTM PCR Array

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Focus on your pathway: Quantitative Profiling of 84 genes in a biological pathway

PCR Arrays

miRNA Profiling with PCR Array Technology

Over 100 pathways available. The real-time qPCR expert. cancer

inflammation

stem cell cell cycle apoptosis neuroscience

See complete list of pathways: http://www.sabiosciences.com/ArrayList.php?pline=PCRArray SABiosciences is now Podcasting! Download a pre-recorded seminar. Watch and listen on your iPod or on your computer on your own time - on the train or the bus, at home, during lunch, or while working in the lab. Listen to the overview of PCR array technology here: http://www.sabiosciences.com/seminarlist.php

Agilent Whole Genome Microarray

WOULD YOU PREFER US TO RUN THE EXPERIMENT FOR YOU?

Catalogue 60-mer oligo: with SurePrint Technology

Agilent Microarray Services

Agilent’s microarrays are in situ synthesized using industrial inkjet printers. During the printing process the oligonucleotide probes are synthesized base-by-base onto the glass slides. Agilent’s 60-mer probe design ensures excellent specificity as well as sensitivity, even for genes with low expression levels. Available organisms: ● Arabidopsis (V4) ● Bovine ● C. elegans (V2) ● Chicken ● Dog (V2) ● Drosophila ● E. coli ● Frog ● Horse

● Human Genome ● M. grisea 2 ● Maize ● Mosquito ● Mouse Genome ● Porcine ● Rabbit ● Rat Genome ● Rhesus Monkey

● Rice ● Salmon ● Sheep ● Tobacco ● Yeast (V2) ● Zebrafish (V2)

We offers services with Agilent Whole Genome 4×44K Microarrays for flexible, dual-mode gene expression analysis. Send your samples to us and we will handle them for you. Contact us for your project at [email protected]

Explore different aspects of Genomics using Agilent Microarray Platform

aCGH

CH3

Copy number

Methylation

Renilla Luciferase CMV

Monster GFP

Tandem TRE

Components

● DUAL-LUCIFERASE FORMAT: Exceptional sensitivity, reproducibility, specificity, and signal to noise ratio ● GFP FORMAT: Single cell resolution; Real-time live cell quantification Transcription factor-specific reporter, negative control, positive control. Supplied material provides sufficient reporter for 500 assays.

See how it works here : http://www.sabiosciences.com/reporterassays.php

Popular Cignal Reporter Assays

Tandem TRE

- Ideal for analysis of: • siRNA/shRNA/miRNA phenotypes • biological responses to chemical compounds • mechanisms of action of proteins, peptides and ligands - Transfection-ready format with your favourite cell lines

RNA

DNA

CignalTM Reporter Assays New 11 Luciferase Reporter Assays Added

Firefly Luciferase

- One-shot analysis of 88 or 376 pathway-focused miRNA sequences - Single nucleotide mismatch discrimination - Distinction between mature miRNA and their precursors ● Sensitivity: As little as 0.5 µg total RNA needed ● Multi-Sequence Flexibility: Analyze up to 376 sequences simultaneously ● Simplicity: As easy as a real-time PCR experiment - Available miRNA PCR Arrays: Cancer Cell Differentiation & Development Whole Genome miFinder http://www.sabiosciences.com/dna_methylation.php

ChIP

GX

Transcription Factors

mRNA

Splice Variants mRNA isoforms

miRNA RNA interference

PATHWAY

TRANSCRIPTION FACTOR

LUCIFERASE

Androgen Antioxidant Response C/EBP cAMP/PKA Cell Cycle p53/DNA Damage Early Growth Response Estrogen Receptor GC Box Binding TF Glucocorticoid Receptor Heat Shock Hypoxia Type I Interferon Interferon Gamma MADS Box MAPK/ERK MAPK/JNK c-myc NFκB Notch PI3K/Akt Pathway PKC/Ca++ PPAR Retinoic Acid Receptor STAT3 Stem Cell Marker TGFβ VDRE Wnt

Androgen Receptor Nrf2 & Nrf1 C/EBP CREB E2F/DP1 p53 Early Growth Response 1 Estrogen Receptor (ER) SP1 Glucocorticoid Receptor (GR) HSF Hypoxia-inducible Factor-1 (HIF-1) STAT1/STAT2 STAT1/STAT1 MEF2 Elk-1/SRF AP-1 Myc/Max NFκB RBP-Jk FOXO NFAT PPAR Retinoic Acid Receptor (RAR) STAT3 Oct4 SMAD2/SMAD3/SMAD4 Vit D Receptor TCF/LEF

CCS-1019L CCS-5020L CCS-001L CCS-002L CCS-003L CCS-004L CCS-8021L CCS-005L CCS-6027L CCS-006L CCS-4023L CCS-007L CCS-008L CCS-009L CCS-7024L CCS-010L CCS-011L CCS-012L CCS-013L CCS-014L CCS-1022L CCS-015L CCS-3026L CCS-016L CCS-9028L CCS-0025L CCS-017L CCS-2029L CCS-018L

GFP

CCS-013G CCS-002G CCS-018G CCS-002G CCS-010G CCS-017G CCS-018G CCS-002G CCS-010G CCS-010G CCS-011G CCS-002G CCS-013G CCS-017G CCS-018G CCS-002G CCS-017G CCS-018G

ChampionChIP™ PCR System

Methyl-ProfilerTM PCR Array NEW! Fast and Accurate Detection of CpG Island - Replaces the low-throughput bisulfite-based methods with a simple restriction digest and qPCR. - Available as individual CpG assays. - Features: ● Simpler Protocol: Restriction-enzyme based ● Faster: Higher Gene & Sample Throughput; 4 to 6 h digestion, up to 96 genes ● No Loss + Amplification = Less Material Needed

- Complete platform for the analysis of in vivo protein-DNA interactions using ChIP and qPCR detection. - Simple and robust one-day preparation kit with a genome-wide qPCR primer design to quickly deliver reliable and biologically relevant results

Methly-Profiler PCR Arrays Panels

ChampionChIP PCR Array System includes: ● ChampionChIPTM Antibody Kits- Validated ChIP-grade antibodies with positive/negative control primers ● ChampionChIPTM One-Day Kit- Simple and Robust ChIP kit ● ChampionChIPTM Real-Time PCR Primers- Analyze any transcription factor and histone binding to chromatin via qPCR

Cat #

Catalog # MeAH-011 Human Breast Cancer Human Gastric Cancer MeAH-021 Human Liver Cancer MeAH-031 MeAH-041 Human Lung Cancer Human Prostate Cancer MeAH-051 http://www.sabiosciences.com/dna_methylation.php

ChampionChIP™ qPCR Primer

http://www.sabiosciences.com/chipqpcr.php

RayBio® Adipokines Array NEW!

RayBio® Apoptosis Array NEW!

Profile 182 Human adipokines in 43 factors in a single assay! one sample

DECODE: ChIP-qPCR Assay Search Portal Supported by SABiosciences' proprietary database known as DECODE (DECipherment Of DNA Elements), this search portal reports binding sites for over 200 different transcription factors in any human promoter. Use this search portal to find PCR primers for your favorite transcription factors' binding sites especially if you DO NOT know their location relative to the Transcription Starting Site (TSS) of your human genes of interest.

- Sandwich-based method where each of the capture antibodies is printed on membranes or glass slide, and, treated or untreated cell lysate is added onto the array. - Features: ● High Sensitivity: detects most proteins at pg levels ● Affordable enough for routine use ● High specificity ● May be used with diverse biological samples ● Customizable ● Requires as little as 100 ul (membranes) or 30 ul (glass chip)

- Sandwich-based method to ensure high specificity. - Features: ● Reliable results with wide range of cell lines ● Internal control included ● High specificity, sensitivity and reproducibility ● No special equipment required ● 2 choices: chemiluminescence (membrane-based) or fluorescence (glass-slide) detection systems Fig 1. Apoptotic protein profiling in HeLa cell lines 400 mg of cell lysate from human HeLa cell line was incubated overnight with RayBio Human Apoptosis Antibody Array membrane.

DECODE TSS Search Portal

Please visit : http://www.sabiosciences.com/chipqpcrsearch.php

See full Adipokine-related products here: http://www.raybiotech.com/Adipokine.asp

See the list of targets here: http://www.raybiotech.com/apoptosis_array.asp

Agilent 3100 OFFGEL Fractionator NEW! Protein fractionation based on isoelectric point, in-solution recovery

Pathway CentralTM

Research shows that prefractionation of proteins and peptides prior to LC/MS analysis can dramatically increase the number of proteins ultimately identified. The new Agilent 3100 OFFGEL Fractionator uses a novel isoelectric focusing technique to achieve excellent pI-based fractionation. -Features ● Separates proteins or peptides according to pI ● Based on the resolving power of immobilized pH-gradient (IPG) gels ● Performs traditional in-gel IEF and OFFGEL ● OFFGEL mode provides analytes in solution compatible with LC-MS and upfront sample preparation techniques ● When combined with high-sensitivity on-chip protein detection- enabling alternative to 2D gel electrophoresis

Genomax Technologies Pte Ltd

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Read more about our system here: http://www.agilent.com/chem/capillary

FREE Editable Pathway Map in Powerpoint Format - A pathway study resource for you to find pathway reviews and presentation-ready pathway maps. NEW FEATURES: • Download free pathway maps in PowerPoint. Ready-to-use for your lab meeting! - Three easy ways to navigate in the pathway central • Browse based on your research areas. • Search with key words. • View the complete pathways Youlist willoflove it!

http://www.sabiosciences.com/pathwaycentral.php

(65) 6777 1886

[email protected]

To benefit from these offers, please make sure you quote Geno09 on your order. Prices are valid until 30/4/2009 and are not compatible with other offers, special prices or discounts.