Pencampuran Acak Dan Interaktif,kuliah S1 Farmasi.pptx

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Formulasi & Teknologi Sediaan Padat PENCAMPURAN ???

Ilham Kuncahyo, M.Sc., Apt

PENCAMPURAN Homogenitas Mekanisme pencampuran interaktif

Acak   

Tidak terjadi interaktif (partikel-partikel



penyusunnya dipisah dan dicampur berulang-ulang)



Ideal : Jumlah tiap komponen dan ukuran partikel sama Dipengaruhi gaya gravitasi

 

 

Ilustrasi bentuk campuran

(Soebagyo,1986)

Terjadi interaktif Adhesivitas / kohesifitas tinggi jumlah tiap komponen dan ukuran partikel tidak perlu sama Komponen: Besar (pembawa, carier/host) Micronized (adherent) Ilustrasi bentuk campuran

MEKANISME PENCAMPURAN INTERAKTIF Adhesive forces

Detachment forces

(Unit interaktif) Syarat : Detachment forces kecil Adhesive forces :    

Detachment forces :

Gaya Van der Wall Gaya Coulomb Gaya Kapiler Gaya lain : interlocking

* Gaya gravitasi (m.g) * Gaya percepatan (m.a)

g dan a = konstanta Detachment forces kecil (Soebagyo,1986)

m = kecil mikronisasi

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