Pa Sem 4. Respidocx.docx

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UJIAN PRAKTIKUM PATOLOGI ANATOMI (RESPI) 1. EDEMA PARU 

KLINIS : Memiliki riwayat penyakit : a.

Hemodynamic

 Tek. Hidrostatik ↗ : LHF ( >> ), Volume overload, Obstruksi V.pulmonalis  Tek.onkotik ↙: Hipoalbumin, Sindroma Nefrotik, Liver disease, Protein loosing enteropathies  Obstruksi sal.limfe ( jarang ) b. Microvascular injury ( alveolar injury )  Infeksi : pn, septicemi  Inhaled gases : oksigen, asap  Aspirasi cairan : gaster  Obat & bhn.kimia  Shock, trauma  Radiasi  Transfusi c.

Undeterminant origin

 High altitude  Neurogenic ( trauma CNS ) d. Left ventricular failure



e.

Mitral stenosis

f.

Mitral incompetence

MAKROSKOPIS :  Berat paru meningkat  Basah, terutama di bagian bawah  Supkrepitan  Akumulasi cairan pada basal lobus inferior (Stiff Lung)



MIKROSKOPIS :  Ada bendungan kapiler (pelebaran pembuluh darah)  Precliptant granular (endapan warna pink di intraalveoli)  Pelebaran alveoli  Microhaemorrage Alveoli (banyak eritrosit di dinding alveoli)  (+) Heart Failure Cell (Hemosiderin laden macrophage)

2. LYMPHADENITIS TUBERCULOSA  KLINIS :  Mengalami tuberculosis  Low fever dan night sweats  Biasanya di daerah leher  MAKROSKOPIS :  Ada reaksi inflamasi  Pembengkakan / pembesaran KGB  Konsistensi padat kenyal

 MIKROSKOPIS :  (+) Necrosis caseousa / Nekrosis pengejuan  (+) Sel datia langhans  (+) Infiltrasi sel MN dan fibroblast  (+) Sel Epithelioid (Hard Tubercle)

3.

Soft Tubercle

3. TUBERCULOSA PARU 

KLINIS : Seperti gejala TB (Trias TB)



MAKROSKOPIS :  Primary TB : Ghon Focus

 Secondary TB : Necrosis, Fibrosis, Cavitas 

MIKROSKOPIS :  Primary TB : Ghon Focus (+) Granuloma / Tubercle, Sel datia langhans, Infiltrasi Limfosit T  Secondary TB : Necrosis, Fibrosis (+) Granuloma / Tubercle dan infiltasi Limfosit T

4. ADENO CA PARU 

KLINIS :



MAKROSKOPIS :  Tumbuh lambat, metastase cepat  Jarang di central, sering di perifer  Abu-abu atau putih  Menembus dinding bronchus atau sekitarnya



MIKROSKOPIS :  Ada tubular papil  Atypical Adenomatous Hyperplasia  (+) sel Anaplasi : Pleomorfik, hiperkromatik, Inti menonjol  Invasive

5. LOBAR PNEUMONIA 

KLINIS : Konsolidasi fibrinosuppurative seluruh lobus paru, healthy young adults, Infeksi acquired ok Streptococcus pneumonia/pneumococcus(>>), Klebsiella, Legionella, demam.



MAKROSKOPIS :  Mengenai seluruh lobus / sebagian lobus  Heavy lung : 

Congestion : heavy, Boggy (berawa-rawa), Red



Red Hepatosation : Merah, padat, Airless, Liver like consistency





Grey Heapatisation : Grey, Brown, Dry surface



Resolution : Exudat berkumpul di alveolar space

MIKROSKOPIS :  Congestion : dilatasi pembuluh darah, cairan di intraalveoli, ada neutrofil  Red Hepatisation : Exudat fibrinopurulent di alveoli  Greay Hepatisation : Exudat neutrofil dan macrophage, diseintregasi red cell  Resolution : Konsolidasi exudat di alveolar space

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