Influence Of Ascorbic Acid On Mca-induced Carcinogenesis In The Uterine Cervix Of Mice

A service of the U.S. National Library of Medicine and the National Institues of Health

Select 8402567 1: Cancer Lett. 1993 Aug 16;72(1-2):121-5.

Influence of ascorbic acid on MCA-induced carcinogenesis in the uterine cervix of mice. Das P, Rao AR, Srivastava PN. Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

The present study evaluates the possible modulatory influence of ascorbic acid (AA) on (methylcholanthrene) MCA-induced cervical carcinogenesis in mice. Ascorbic acid was given daily for different durations in drinking water at the dose level of 2 mg/ml. In animals that received no modulator, placement of cotton threads impregnated with beeswax containing -600 micrograms of MCA for 16 weeks yielded 76.1% carcinomas in the uterine cervix. Administration of AA for the entire period of 16 weeks resulted in the reduction of MCA-induced cervical carcinomas to 33.3%. AA was capable of reducing cervical cancer incidence to 33.3% even when it was given for only 6 weeks following MCA-thread insertion into the uterine cervix. However, when it was given for a period of 10 weeks after 6 weeks of MCA-thread insertion the carcinoma incidence was as high as 66.6%. Results of the present study demonstrate that AA, especially when given during the initiational phase, significantly inhibits MCA-induced cervical carcinogenesis in mice. PMID: 8402567 [PubMed - indexed for MEDLINE]

Related Articles Chemopreventive action of selenium on methylcholanthrene-induced carcinogenesis in the uterine [Oncology. cervix 1992] Modulation of methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse by indomethacin. [Cancer Lett.1988] Modulatory influences of exogenous estrogen on MCA-induced carcinogenesis in the uterine cervix of mouse. [Cancer Lett.1988] Review Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium [Int J Toxicol.2005] Review Strategies for phase II cancer chemoprevention trials: cervix, endometrium, and ovary. [JCellBiochemSuppl.1995] » See Reviews...

|

» See All...

Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information

Recent Activity

Turn Off

Clear

Influence of ascorbic acid on MCA-induced carcinogenesis in the uterine cervix of mice. Antagonism between catalase and ascorbic acid in control of normal and neoplastic cell mul... Characterization of a silencer element in the first exon of the human osteocalcin gene. Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro. [Effects of nitrate and ascorbic acid on carcinogenesis in the operated rat stomach]