The Role Of Ascorbic Acid In Carcinogenesis

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Select 3591529 1: Adv Exp Med Biol. 1986;206:357-77.

The role of ascorbic acid in carcinogenesis. Glatthaar BE, Hornig DH, Moser U. Vitamin C is an essential nutrient whose protective role in carcinogenesis has been discussed for more than 50 years. Epidemiologic studies suggest that the consumption of vitamin C-rich foods is associated with a lower risk of cancers of the esophagus and stomach. The observation that cancer patients have low leukocyte vitamin C levels led to therapeutic trials the results of which are controversial; the hypothesis that vitamin C acts like a drug must be questioned. On the other hand, ascorbic acid interacts with various tumor-inducing compounds, such as the precursors of N-nitroso compounds, to prevent the formation of tumors. Experiments with animals and cell cultures indicate that ascorbic acid can interfere with the metabolism of tumor promoters. It has also been postulated that ascorbic acid helps to prevent cancer by enhancing cellular immunity. In general, evidence suggests that vitamin C can inhibit the formation of some carcinogens. PMID: 3591529 [PubMed - indexed for MEDLINE]

Related Articles Review Epidemiologic evidence regarding vitamin C and cancer. [Am JClin Nutr.1991] Review Vitamin C, vitamin E and cancer (review). [Anticancer Res .1988] Review Update on the effects of vitamins A, C, and E and selenium on carcinogenesis. [Proc Soc Exp Biol Med.1986] Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer. [Cancer.1986] Vitamin C and cancer. How convincing a connection? [Postgrad Med.1985] » See Reviews...

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Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information

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