Effects Of Nitrate And Ascorbic Acid On Carcinogenesis In The Operated Rat Stomach
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Select 3421810 1: Arch Geschwulstforsch. 1988;58(4):235-42.
[Effects of nitrate and ascorbic acid on carcinogenesis in the operated rat stomach]
Related Articles
[Article in German]
The cancer risk in the stomach subjected to nonresecting procedures. An experimental long-term[Scand study. J GastroenterolSuppl.1984]
Dittrich S, Seffner W, Seidel R.
Pathogenesis of carcinoma in operated stomach--an animal model. [Sb Ved PrLekFakKarlovyUniverzityHradci Kralove.1992]
Chirurgische Klinik des Bezirkskrankenhauses Plauen.
In the last few years, a great deal of attention has been paid to the hypothetical relationship between high nitrate intake, N-nitroso-compounds and gastric cancer. This long term study deals with the effect of nitrate and ascorbic acid contained in drinking water on the development of cancer in operated stomachs of rats without additional application of a carcinogen (tumor model). A total of 147 F1-Hybrids of WELS/Fohm X BD IX--rats were subjected to stomach operation (Gastroenterostomia antecolica anterior, truncular vagotomy and pyloroplasty). Carcinomas in stomach occurred within 33 weeks (post operationem). The surgical procedures altered the gastric flora, resulting in an increase and predominance of nitrate-reducing bacteria. The maximal tumor rate (10 of 13 rats) occurred in rats with gastroenterostomy and additional nitrate exposition. It may be possible, the nitrate is a precursor of gastric carcinogenesis. But we could not give any significant evidence of this fact. The addition of ascorbic acid to the drinking water lead to a suppression of the development of tumors. Our experience with the tumor model "operated stomach" underline the multifactorial genesis of stomach cancer in rats.
[Carcinoma in the operated stomach of the rat--a tumor model] [ArchGeschwulstforsch.1984] Review A possible role of iron deficiency in gastric cancer in Colombia. [Adv Exp Med Biol.1981] Review Are nitrates a significant risk factor in human cancer? [Cancer Surv.1989] » See Reviews...
|
» See All...
Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information
PMID: 3421810 [PubMed - indexed for MEDLINE]
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[Effects of nitrate and ascorbic acid on carcinogenesis in the operated rat stomach] Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant c... Uptake and cytotoxicity of ascorbic acid and dehydroascorbic acid in neuroblastoma (SK-N-S... Ascorbic acid-enhanced antiproliferative effect of flavonoids on squamous cell carcinoma i... The role of ascorbic acid in carcinogenesis.
Select 3421810 1: Arch Geschwulstforsch. 1988;58(4):235-42.
[Effects of nitrate and ascorbic acid on carcinogenesis in the operated rat stomach]
Related Articles
[Article in German]
The cancer risk in the stomach subjected to nonresecting procedures. An experimental long-term[Scand study. J GastroenterolSuppl.1984]
Dittrich S, Seffner W, Seidel R.
Pathogenesis of carcinoma in operated stomach--an animal model. [Sb Ved PrLekFakKarlovyUniverzityHradci Kralove.1992]
Chirurgische Klinik des Bezirkskrankenhauses Plauen.
In the last few years, a great deal of attention has been paid to the hypothetical relationship between high nitrate intake, N-nitroso-compounds and gastric cancer. This long term study deals with the effect of nitrate and ascorbic acid contained in drinking water on the development of cancer in operated stomachs of rats without additional application of a carcinogen (tumor model). A total of 147 F1-Hybrids of WELS/Fohm X BD IX--rats were subjected to stomach operation (Gastroenterostomia antecolica anterior, truncular vagotomy and pyloroplasty). Carcinomas in stomach occurred within 33 weeks (post operationem). The surgical procedures altered the gastric flora, resulting in an increase and predominance of nitrate-reducing bacteria. The maximal tumor rate (10 of 13 rats) occurred in rats with gastroenterostomy and additional nitrate exposition. It may be possible, the nitrate is a precursor of gastric carcinogenesis. But we could not give any significant evidence of this fact. The addition of ascorbic acid to the drinking water lead to a suppression of the development of tumors. Our experience with the tumor model "operated stomach" underline the multifactorial genesis of stomach cancer in rats.
[Carcinoma in the operated stomach of the rat--a tumor model] [ArchGeschwulstforsch.1984] Review A possible role of iron deficiency in gastric cancer in Colombia. [Adv Exp Med Biol.1981] Review Are nitrates a significant risk factor in human cancer? [Cancer Surv.1989] » See Reviews...
|
» See All...
Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information
PMID: 3421810 [PubMed - indexed for MEDLINE]
Recent Activity
Turn Off
Clear
[Effects of nitrate and ascorbic acid on carcinogenesis in the operated rat stomach] Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant c... Uptake and cytotoxicity of ascorbic acid and dehydroascorbic acid in neuroblastoma (SK-N-S... Ascorbic acid-enhanced antiproliferative effect of flavonoids on squamous cell carcinoma i... The role of ascorbic acid in carcinogenesis.
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