Immune System And Depression.docx

Immunology and the CNS  

Contemporary. Issues 06-10-17

Inflammation causes depression. People w schizophrenia & other disorders usually present high inflammation TSPO receptor ligand binds to microglia. Shows up inflammation at Pet-Scan

Reflex Control of Immunity Vagal nerve stimulation causes sphere to secrete more cytokines. Certain networks involved in emotion are also involved in detection peripheral stimulation after inflammation. Salience network: filter which is or is not important Cytokines Raised levels of cytokines seems to precede depression IL-6 levels measures (high) predicted depression in adults

BDNF: if decreased levels are found, you get less healthy neurogenesis Correlation between peripheral levels of cytokines and inflammation in CNS. Reduction of IL-6 seems to have a significant impact in “reducing” depression Serotonin transporter (SERT) Reduced inflammation in periphery, reduces activity of serotonin transporter

Recent data on effects of WBCs Microglia- dependent neurological deficits  

Mouse psoriasis model showed that a the brain (microglia) present high levels of chamomile’s which in turn recruit WBCs, in the event of peripheral inflammation . This process seems to be an ongoing problem Complicated but redundant immune system. Chemokines are key for how the brain develops, important for termo-regulation, HPA-axis, chemoattraction and neuro regulator

Dementia  

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Models of dementia usually develop al the symptoms of the disorders except the dementia. This disorder is the mor accurately know to present massive inflammation o Research is not looking for the start of the inflammatory process before pathology develops o C-reactive protein is used as an inflammatory marker to measure Childhood Grau a is associated with CNS and peripheral inflammation later at life Antidepressants are antagonist of anti inflammatory o Acute inflammation seems to help treat neurodegeneration but chronic inflammation seems detrimental

 Aleostesis: if there is a deficiency in certain process, the body upregulates itself. But it seems that when that process threshold is override, the organism has no way to down regulate.