Generic Name Trade Name Hydrochlorothiazide Dyazide / Triamterene

Generic name Trade name hydrochlorothiazide Dyazide / triamterene

Classification Route diuretic/anti-hypertensive/ PO antikaliuretic

Time/Frequency 1 daily

Normal Dosage - 1-2 capsules daily. Hydrochlorothiazide 25 mg and triamterene 37.5 mg

Indications-DYAZIDE is indicated for the treatment of Contraindications/warnings/interactions - Thiazides have been shown to hypertension or edema in patients who develop hypokalemia decrease on arterial responsiveness to norepinephrine. Thiazides have also been hydrochlorothiazide alone. DYAZIDE is also indicated for those shown to increase the paralyzing effect of nondepolarizing muscle relaxants such patients who require a thiazide diuretic in whom the development as tubocurarine; consequently caution should be observed in patients undergoing of hypokalemia cannot be risked. DYAZIDE may be used alone surgery. or Triamterene and quinidine have similar fluorescence spectra; s, thu as an adjunct to other anti-hypertensive drugs, such as beta- DYAZIDE will interfere with the fluorescent measurement of quinidine. Concurrent blockers. Since DYAZIDE may enhance the action of these use of hydrochlorothiazide with amphotericin B or corticosteroids or corticotropin agents, dosage adjustments may be necessary. (ACTH) may intensify electrolyte imbalance, particularly hypokalemia, although the presence of triamterene minimizes the hypokalemic effect. Antikaliuretic Therapy and Potassium Supplementation, Impaired Renal Function, Hypersensitivity, Hyperkalemia Mechanism of actionThe hydrochlorothiazide component blocks Common side effectsAnaphylaxis, rash, urticaria, subacute cutaneous lupus the reabsorption of sodium and chloride ions, and thereby erythematosus-like reactions, photosensitivity, Arrhythmia, postural hypotension, increases the quantity of sodium traversing the distal tubule and Jaundice, pancreatitis, nausea and vomiting, diarrhea, constipation, abdominal the volume of water excreted. The triamterene component of pain, Acute renal, interstitial nephritis, renal stones composed primarily of DYAZIDE exerts its diuretic effect on the distal renal tubule totriamterene, abnormal urinary sediment, Leukopenia, thrombocytopenia and inhibit the reabsorption of sodium in exchange for potassium purpura, and megaloblastic anemia, Muscle cramps, W eakness, fatigue, dizziness, hydrogen ions. headache, dry mouth, Impotence, sialadenitis, Paresthesias, vertigo, Xanthopsia, transient blurred vision, Allergic pneumonitis, pulmonary edema, respiratory distress, Necrotizing vasculitis, exacerbation of lupus, Aplastic anemia, agranulocytosis, hemolytic anemia. Lab value alterations-elevated BUN, and serum creatinine, hyperkalemia, hypokalemia, hyponatremia, acidosis, hypercalcemia, hyperglycemia, glycosuria, hyperuricemia, hypochloremia, liver enzyme abnormalities Nursing Considerationsmonitor fluid levels, BP, monitor calcium levels. Interactions with other patient drugs, OTC, or herbal medicines-Angiotensin-converting Enzyme Inhibitors W hy would you hold or not give thisEvaluation-I/O Oral Hypoglycemic Drugs, Nonsteroidal Anti-inflammatory Drugs, med? Hyperkalemia Lithium