Generic Name T Rade Name Classification Route Warfarin Coumadin Anticoagulants

Generic name T rade name Classification Route warfarin Coumadin anticoagulants

T ime/Frequency Normal Dosage- based on INR and PT

Indications-Prophylaxis and treatment of Venous Contraindications/warnings/interactions wounds, active ulcer thrombosis, pulmonary embolism, atrial fibrilation with disease, recent brain, eye, or spinal cord injury, or surgery, severe embolization, Management of MI's (decreases risk of liver or kidney disease, uncontrolled hypertension, preganancy Use death, decreases risk of subsequent MI, and decreases cautiously in: malignancy, patients with history of ulcer or liver disease, risk of future thromboembolic events.) Prevention of history of poor compliance, and women with childbearing potential. thrombus formation and embolization after prosthetic valve placement. M echanism of action-acts by inhibiting vitamin K-dependent Common side effects- Cramps, nausea, dermal necrosis, bleeding coagulation factors and fever Lab value alterations- PT, INR Nursing Considerations-Signs of bleeding and hemorrhage (bleeding gums; nosebleed; unusual bruising; tarry, black stool; hematuria; fall in hematocrit or blood pressure; guaiac-positive stools, urine, or nasogastric aspirate. vital signs Interactions with other patient drugs, OT C, or herbal medicines-Abciximab, androgens, capecitabine, cefoperazone, cefotetan, chloral hydrate, chloramphenicol, clopidogrel, disulfiram, fluconazole, Why would you hold or not giveEvaluation- Prolonged PT (1.3fluoroquinolones, itraconazole, metronidazole, this med?PT is excessively 2.0 times the control; may vary thrombolytics, eptifibatid, tirofiban, ticlopidine, prolonged or if minor bleeding with indication) or INR of 2-4.5 sulfonamides, quinidine, quinine, NSAID's, valproates, occurs. without signs of hemorrhage. aspirin, acetaminophen, alcohol, barbiturates, hormonal contraceptives,