Dr.sabar.docx
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Hemoglobinopathies Primary hemochromatosis
Thalasemia
Ineffective erthropoesis
Repetitive transfusions
Increased iron absorption
Iron overload
Transferrin Saturation
Proinflammatory
Non-transferrin-bound ion
IL-1, IL-6 Cardiomiocyte iron overload
Fe2+ Fe3+ (Feniton) OH+
NO
Oxidative stress
ENOS↓
↓ROS↑ Cinnamal -dehide
Decreased NADPH oxidase
Endothelial dysfunction
MAD
GSH, CAT
Thalasemia
Ineffective erthropoesis
Repetitive transfusions
Increased iron absorption
Iron overload
Transferrin Saturation
Proinflammatory
Non-transferrin-bound ion
IL-1, IL-6 Cardiomiocyte iron overload
Fe2+ Fe3+ (Feniton) OH+
NO
Oxidative stress
ENOS↓
↓ROS↑ Cinnamal -dehide
Decreased NADPH oxidase
Endothelial dysfunction
MAD
GSH, CAT
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