Cardiotonic Not Cardiac Glycosides Flavonoids EX: Crategus Cardio Active Cardiac Glycosides EX: Digitalis Iatropic – Affects Force of contraction of heart +ve Iatropics: increase force (cardiace glycosides) -ve Iatropics: decrease force (beta blockers) +ve action of ATPase Pump Chromotropic affects freq of heart (heart rate) -ve Chromotropics: decrease frequency Cardiac Glycosides on ANS -ve Chromotropics: increase frequency Ephredrine Dromotropic Affects Flow Rate of blood from heart -ve dromotropics: decrease cardiac glycosides due to increase effectiveness of heart mostly digitalis change in refractory period acts on AV node Cardiac Glycosides Increase profiency of heart beats Decrease congestion of heart Overall diuretic effect Clear fluid All decrease congestive heart failure (based on all 3 effects) Cardenolides Main in gigitalis Apocynum STRONG Vs (different in structure) Bufenoides IE: helleborous, convallaria (also cardenoides) in other herbs Categories of plants to treat common heart problems Hypotensive Rauwolfia Veratrium
Crategus Allium Viscum Apocynum Cardiants (for CHF) Convularia Crategus Digitalis Selenumserous Palpitations (arrthymias) Lionarius Selenumserous Crategus Raufolfia Lipids/decrease cholesterol Alliums X2 Cynara Commu Mukula