Addison's Disease Patho-physiology
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Hypothalamus Negativ e feedba
CR H Pituitary Gland A CTH Adrenal Cortex
High level of ACTH
MSH (melanocyte Stimulating Hormone) Melani n
Hyperpigmentat ion Producing insufficient cortisol
Causes of adrenal insufficiency: •Adrenal dysgenesis •Impaired steroidogenesis •Adrenal destruction
Insufficient amount of aldosterone being produced
Decrease in Na reabsorption fluid volume in the body
Blood pressure goes down
Addison’s disease
Orthostati c hypotensi on
CR H Pituitary Gland A CTH Adrenal Cortex
High level of ACTH
MSH (melanocyte Stimulating Hormone) Melani n
Hyperpigmentat ion Producing insufficient cortisol
Causes of adrenal insufficiency: •Adrenal dysgenesis •Impaired steroidogenesis •Adrenal destruction
Insufficient amount of aldosterone being produced
Decrease in Na reabsorption fluid volume in the body
Blood pressure goes down
Addison’s disease
Orthostati c hypotensi on
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