1324

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Etapele majore ale hemostazei primare

ADP = adenozin difosfat FCP = factorul de creştere plachetar FvW = factorul von Willebrand

Bazele moleculare ale adezivităţii şi agregării plachetare Aderare plachete la stratul subendotelial - fvW formează o punte între fibrilele de colagen din peretele vascular şi receptorul plachetar, glicoproteina Ib-IX

Agregare plachete - este mediată de fibrinogen, care leagă plachetele adiacente prin intermediul receptorului plachetar Gp IIb-IIIa

Generarea TxA2 de către plachete şi a prostaciclinei (PGI2) de către celulele endoteliale Acid arahidonic Ciclooxigenaza

Endoperoxizi (PGG2, PGH2) Tromboxan sintetaza

Tromboxan A2

Tromboxan B2 (plachete)

Prostaciclin sintetaza

Prostaciclină (PGI2)

6-Ceto-PGF1α (Celule endoteliale)

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