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1: Int J Vitam Nutr Res Suppl. 1982;23:257-63.
The influence of ascorbic acid on the growth of solid tumors in mice and on tumor control by X-irradiation. Tewfik FA, Tewfik HH, Riley EF. Swiss mice drank either distilled water or 0.1% ascorbic acid in distilled water for one week prior to and during the experiments. Solid tumors were induced by injecting Ehrlich ascites tumor cells i.m. into the hind limb of Swiss male and female mice. It was found that the tumor growth was significantly faster in the mice that were drinking distilled water. Beginning two days after tumor cell injection, the tumor bearing limbs were irradiated every 24 h as follows: a) 6 exposures of 400 R, 500 R, 600 R, or 700 R each, b) 10 exposures of 400 R each, and c) 11 exposures of 400 R each. Our results indicated that when 6 exposures of 700 R each were given every 24 h to mice drinking distilled water, about 80-85% tumor control was achieved; the percent tumor cure was even better in mice drinking ascorbic acid in water than in mice drinking water.
Related Articles The influence of ascorbic acid on survival of mice following whole body X-irradiation. [ Int J Vitam Nutr Res Suppl. 1982] [Antitumor effect of combined treatment with ionizing radiation and vitamin B12-C complex] [Ra di ats Bi ol Rad ioecol. 2002] [Animal experiments on ozone therapy of non-irradiated and irradiated tumors. II. Ehrlich ascites carcinoma in vivo] [Strahle nth era pie. 1976] Review [Induction of glutathione and activation of immune functions by low-dose, whole-body irradiation with gamma-rays] [Yak uga ku Zasshi. 2006] Review Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium [I nt JT oxicol. 2005] » See Reviews...
PMID: 6811485 [PubMed - indexed for MEDLINE]
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Cited by PubMed Central article Effect of dietary ascorbic acid on the incidence of spontaneous mammary tumors in RIII mice. [P roc Natl Acad Sci U SA. 1985]
Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information
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The influence of ascorbic acid on the growth of solid tumors in mice and on tumor control ... Vitamin C lowers mutagenic and toxic effect of hexavalent chromium in guinea pigs. A case-control study of nutrient status and invasive cervical cancer. I. Dietary indicator... Antimetabolic activity of L-ascorbic acid in human and animal tumors. In vivo antineoplastic activity of ascorbic acid for human mammary tumor.
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