A service of the U.S. National Library of Medicine and the National Institutes of Health
All Databases
Search
PubMed
Nucleotide
PubMed
Limits Clear
Preview/Index
Protein
Genome
Structure
OMIM
My NCBI [Sign In] [Register] PMC
Journals
Books
History
Clipboard
Advanced Search
Go
for Details
Note: Performing your original search, Preventive Action of Vitamin C on Nitrosamine Formation, in PubMed will retrieve 3 records.
Display All: 1
AbstractPlus
Show
20
Sort By
Send to
Review: 1 Links
1: Int J Vitam Nutr Res Suppl. 1989;30:109-13.
Preventive action of vitamin C on nitrosamine formation.
Related Articles The inhibition of bacterially mediated N-nitrosation by vitamin C: relevance to the inhibition of endogenous N-nitrosation in the achlorhydric stomach. [Ca rcinog enesis. 1989]
Tannenbaum SR. N-Nitroso compounds are known to form endogenously in the human stomach from the precursors nitrite as well as secondary and tertiary amines. Ascorbic acid has been found to be an effective blocking agent for this process of formation of carcinogenic substances, both in vitro and in vivo. The mechanism by which ascorbic acid reacts is chemical in nature and results in the formation of NO and dehydroascorbic acid. Since NO can be recycled in the presence of O2 to form [NO]x, which is capable of additional nitrosation, greater than stoichrometric amounts of ascorbate are required for effective inhibition in vivo. The efficacy of ascorbic acid for inhibition of nitrosamine formation in humans has been demonstrated both clinically and epidemiologically through the use of "Nitrosoproline Test"--of Ohshima and Bartsch.
Review Inhibition of nitrosamine formation by ascorbic acid. [Am J ClinNutr. 1991] Effects of ascorbic acid and thiocyanate on nitrosation of proline in the dog stomach. [Ca rcinog enesis. 1988] Monitoring endogenous nitrosamine formation in man. [IARC SciPubl. 1984] Review Approaches to cancer prevention based on an understanding of N-nitrosamine carcinogenesis. [P rocSoc Exp Bi ol Med. 1997]
PMID: 2507690 [PubMed - indexed for MEDLINE] » See Reviews...
|
» See All...
Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information
Recent Activity Turn Off
Clear
Preventive action of vitamin C on nitrosamine formation. Prolongation of survival times of terminal cancer patients by administration of large dose... Vitamin C and cancer: an overview. The influence of ascorbic acid on the growth of solid tumors in mice and on tumor control ... Vitamin C lowers mutagenic and toxic effect of hexavalent chromium in guinea pigs.
Display
AbstractPlus
Show
20
Sort By
Send to
Write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Privacy Statement | Freedom of Information Act | Disclaimer