Effect Of Ascorbic Acid On The Intragastric Enviro...[iarc Sci Publ. 1991] - Pubmed Result

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1: IARC Sci Publ. 1991;(105):139-42.

Effect of ascorbic acid on the intragastric environment in patients at increased risk of developing gastric cancer. Reed PI, Johnston BJ, Walters CL, Hill MJ.

Related Articles Levels of nitrite, nitrate, N-nitroso compounds, ascorbic acid and total bile acids in gastric juice of patients with and without precancerous conditions [Ca rcinog of enesis. the 1991] Evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions.

Lady Sobell Gastrointestinal Unit, Wexham Park Hospital, Slough, Berks, UK.

Ascorbic acid has been shown to decrease nitrosation in vivo, and epidemiological data suggest that the consumption of foods rich in this vitamin is associated with a reduced risk for gastric cancer. In order to study this suggestion further, fasting gastric juice samples were obtained from 62 high-risk patients (seven with atrophic gastritis, ten with pernicious anaemia, ten with partial gastrectomy, 21 with vagotomy and drainage and 14 with highly selective vagotomy), before, during four weeks' treatment with 1 g ascorbic acid four times daily, and four weeks after treatment. Samples were analysed for pH, total and nitrate-reducing bacterial counts, nitrite and N-nitroso compounds. Treatment with ascorbic acid lowered the median pH only in the vagotomized patients (p less than 0.001) but resulted in a reduction in median nitrate-reducing bacterial counts and in nitrite and N-nitroso compound concentrations in all groups, except for an increase in the nitrate-reducing bacterial count in atrophic gastritis patients and in nitrite in those with pernicious anaemia. These data suggest that treatment with a high dose of ascorbic acid reduces the intragastric formation of nitrite and N-nitroso compounds. PMID: 1855837 [PubMed - indexed for MEDLINE]

[ Gut. 1986]

Mutagens, N-nitroso compounds and their precursors in gastric juice from patients with and without precancerous lesions of the stomach.[Eur J Cancer. 1993] Review N-nitroso compound formation in human gastric juice. [Cance rSurv. 1989] Review Alterations in intragastric nitrite and vitamin C levels during acid inhibitory therapy. [Best Pr act Res ClinG astroe nte rol. 2001] » See Reviews...

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Cited by PubMed Central article Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid. [ Gut. 1994]

Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information

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