Patofisiologi Bph.docx

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Teori dihidrotestosteron

Ketidakseimbangan estrogen testosteron

Interaksi sel stroma dan sel epitel prostat

Berkurangnya apoptosis

Peningkatan 5αreduktase, dan reseptor androgen

Penurunan kadar testosteron, estrogen tetap

sintesis growth factor oleh sel stroma

Ketidakseimbangan proliferasi dan apoptosis

Ketidaktepatan aktivitas sel stem

Peningkatan proliferasi sel prostat

Estrogen meningkatkan proliferasi prostat

Stimulasi proliferasi sel stroma dan sel epitel

Peningkatan jumlah sel prostat

Produksi sel prostat berlebihan

Hyperplasia prostat

Penyempitan lumen uretra posterior

Peningkatan tekanan intravesical

Buli-buli

Ginjal dan ureter

Hipertrofi otot detrusor Trabekulasi Selula Divertikel buli-buli

Refluks vesicu-ureter Hidroureter Hidronefrosis Pionefrosis Gagal ginjal

Teori sel stem

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