Pathophysiology Of Chronic Renal Failure (condensed) Part 1

PATHOPHYSIOLOGY (Chronic Renal Failure) Predisposing Factors:

Precipitating Factors:

■ Ages 55 and above

■ Lifestyle - smoking - alcohol drinking

■ Family History (Diabetes Mellitus, Hypertension)

■ Certain Diseases (Hypertension, Diabetes Mellitus, Recurrent infections

Thickening and/or an in the amount of collagen in the basement membranes of the small vessels

Impaired/sluggish blood flow

Glomerulosclerosis

GFR (Glomerular Filtration Rate) proteinuria

Renal blood

Stage I DIMINISHED RENAL RESERVE GFR 50%

Normal BUN, creatinine More than 75% damage Stage II RENAL INSUFFICIENCY GFR 20-50% BUN, creatinine levels begin to rise Remaining nephrons undergo changes to compensate for those damaged nephrons

Filtration of more concentrated blood by the remaining nephrons

Hypertrophy of nephrons Intolerance and exhaustion of the remaining nephrons

Further damage of the nephrons 80-90% damage

Stage III RENAL FAILURE GFR 10-20%

Impaired kidney function and Uremia