Pathophysio Crf2 --revised

- Reduction in renal capillaries -Scarring of Glomeruli - Atrophy & Fibrosis of Renal tubules

Nitrogenous wastes impairs platelets

Malfunction of RAAS

> 90 % of kidney damage

Decreased Erythropoietin Production Continuous decline in renal function

Bleeding tendencies

Na & H2O retention

ANEMIA

Toxins irritate pericardial sac Pericarditis Cardiac Tamponade

-fatigue - weakness

Toxins impair immune system Decreased Immune system

Increased blood pressure

Edema

Pulmonary Edema, Peripheral Edema

Stage IV END-STAGE RENAL DISEASE (ESRD) GFR <10%

Oliguria Hypertension

Continuous Multisystem Affectation Multiple Organ Failure

Heart Failure

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Uremic frost

Risk for superinfection ┼

Decreased Urine Output

Urea deposits on the skin

DEATH

Sepsis

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Toxins affect CNS

Uremic Encephalopathy -changes in mentation/ psychiatric symptoms -irritability -fatigue -insomnia