Organic Chem.docx

COLLEGE OF PHARMACY Carlatan, San Fernando City, La Union

PHILOSOPHY We believe in student centered approach to education and management. We believe in achieving a lot with limited resources by knowing what other institutions are doing, adopting or improving and using that can be applied to the College. We believe that a strong continuing faculty and staff development program in the college is a vital component of the total effort to attain the main goal of the College. We believe in the stability and strength as a base for achieving quality education, relevant to national means and development of the total person. We believe above all that giving honor and glory to God in everything we do, is most important in all official activities of the college.

VISION We envision Lorma Colleges as an educational institution with a global perspective emphasizing quality, Christian values, and leadership skills relevant to national development.

MISSION To empower students for service anywhere in the world through Christian-inspired, quality-driven, and service-oriented education and training.

INSTITUTIONAL GRADUATE ATTRIBUTES GOD FEARING DECISION MAKER, CRITICAL AND CREATIVE THINKER

IO1 IO2 IO3 IO4 IO5

EFFECTIVE COMMUNICATOR

IO6

SERVICE – DRIVEN CITIZEN REFLECTIVE LIFE LONG LEARNING COMPETENT PROFESSIONAL

IO7 IO8 IO9

INSTITUTIONAL OUTCOMES Internalize Christian values Model the Christian values in their personal and professional lives Generate ideas and insight utilizing appropriate decision making Utilize higher order thinking skills in decision making towards innovation and creating new technologies Apply innovative methods and new technologies to solve different problems and making decisions effectively Communicate effectively ideas and knowledge through listening, speaking, reading, writing using culturally appropriate language Imbibe the service- orientedness to oneself, to one’s profession and towards the community Commitment to continuously upgrade one’s education though readings, seminars and trainings Perform exceptional knowledge, skills and right attitude in accomplishing duties and responsibilities beyond acceptable standards

PHARMACY PROGRAM OUTCOMES After 4 – 5 years, the graduate will: Demonstrate Christian, ethical and moral values in the practice of the pharmacy profession in various settings Exemplify professional competence in all fields of pharmaceutical practice based on prevailing local and global standards Apply expertise in exhibiting morally and legally sound judgement in the delivery of pharmaceutical care and social service

INSTITUTIONAL OUTCOMES IO1, IO2, IO7

VISION

MISSION

PHILOSOPHY

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IO6, IO7, IO8, IO9

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IO3, IO4, IO5, IO6, IO7, IO9

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COURSE SYLLABUS 1. COURSE CODE 2. COURSE TITLE 3. PRE-REQUISITE 4. CO-REQUISITE 5. COURSE CREDIT 6. CONTACT HOURS/SEMESTER

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Chem 2 Organic Chemistry General and Inorganic Chemistry N/A 5 units (3units lecture/ 2units Laboratory) Lecture 3 hours/week Laboratory 3 hours/week

7. COURSE DESCRIPTION This is a five unit course intended for students majoring in Chemistry, Chemical Engineering, Food and Nutrition and Paramedic courses. It deals with the study of nomenclature, properties and mechanism reactions of organic compounds, its source and commercial uses. 8. LEVEL OUTCOMES AND RELATIONSHIP TO PROGRAM OUTCOMES LEVEL 2 OUTCOMES At the end of the third year, the students will be able to: 1 Communicate effectively in speaking, writing and presenting using appropriate language.

PHARMACY PROGRAM OUTCOMES 1

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Work effectively with a group or in collaboration with other member of the health care team.

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Analyze and solve accurately problems encountered in drug design and perform calculations related to pharmaceutical quantitative analysis and dosage regimen. Apply evidence-based practice in the clinical settings.

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Appraise the importance of plants and microorganisms in research study in relation to drug product discovery and development. Correlate the structure of the drug with its pharmacologic and pharmacokinetic property.

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Discuss the principles and technology involved in the design, formulation, manufacture and packaging of the various drug dosage forms and delivery systems. Discuss the rational use of drugs in the management of specific disease according to current therapeutic practice guidelines, recommendations and clinical trials. Manifest the values of accuracy, honesty, integrity and Christianity in the various fields of pharmacy as part of personal and professional growth.

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4 5 6 7 8 9 10

Manifest an appreciation of the pharmacist social and professional responsibilities in maintaining or restoring health through the delivery of quality patient care.

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Pharmacy Informatics

Pharrmaceuti -cal Calculations

Pharmaceuti cal Biochemistry

Drug Delivery System

Human Anatomy and Physiology with Pathophysiology Organic Chemistry

Health Ethics

Communicati on and Interpersonal Skills

SECOND (2nd LEVEL) 1. Ability to engage in lifelong learning and understanding of the need to keep abreast of the developments in the specific field of practice

PD

IPD

IP

IP

PD

IP

IPD

IPD

2. Ability to demonstrate effective communication and facilitation skills orally and in writing using both English and Filipino

PD

P

P

P

IP

IP

IP

IPD

3. Ability to work effectively and independently in multidisciplinary and multi-cultural teams

PD

IP

P

P

PD

PD

IP

PD

4. Ability to recognize professional, social and ethical responsibility

PD

P

P

IP

PD

PD

PD

PD

5. An appreciation of “Filipino historical and cultural heritage” (based on RA 7722)

PD

PD

PD

IP

PD

PD

IPD

PD

6. Ability to practice pharmacy in a professional and ethical manner

PD

PD

PD

P

IPD

IPD

IPD

IPD

7. Ability to provide pharmaceutical care

PD

PD

PD

P

IPD

IP

IP

IP

8. Ability to conduct relevant research and disseminate findings

PD

P

P

P

PD

PD

PD

D

9. Ability to apply management and entrepreneurial skills

PD

P

P

P

PD

PD

PD

PD

9. COURSE OUTCOMES AND RELATIONSHIP TO LEVEL OUTCOMES

COURSE OUTCOMES

Level 2 Outcomes

At the end of the course, the student will be able to: 1. Write the molecular, graphical, and structural formulas of organic compounds.

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IPD

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2. Name organic compounds in different ways

IPD

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IPD

IPD

IPD

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IPD

3. Present mechanic approach in treating the chemical properties of the organic compounds

IPD

IPD

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IPD

IPD

IPD

IPD

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4. Write chemical equations involving laboratory and commercial preparations of organic compounds

IPD

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5. Illustrate reaction mechanisms of the structure and reactivity of different organic systems

IPD

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6. State the advantages and disadvantages of using organic chemicals to our environment

IPD

IPD

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7. Apply structural concepts and organic reaction mechanisms in the study of organic natural products

IPD

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8. Recognize ways and means of transforming organic raw materials into finished products in the pursuit of the nation’s economic development

IPD

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IPD

INDICATORS: I- INTRODUCE; P-PARTICIPATE/PERFORM WITH SUPERVISION; D-DEMONSTRATE

10. COURSE COVERAGE

Week

1

Day

1-5

Classroom Topics

UNIT I. INTRODUCTION Introduction and Discussion of the Course content

Learning Resources

Assessment Tasks

Course Outcomes

Lecture

Laboratory

Principles of Organic Chemistry by Syliangco, Clara Page 1-13

Discussions Brainstorming Reading Assignment Online

Pre-laboratory discussion Perform Laboratory Activity

Recitation Pen and Paper Quiz

CO1, CO2, CO3, CO4

Principles of Organic Chemistry by Syliangco, Clara Page 14-16

Research Discussion Active Participation

Perform Laboratory Activity

Quiz Pen and paper Active participation Take home activity

CO1, CO2, CO3, CO4

Principles of Organic Chemistry by Syliangco, Clara Page 20-32

LectureDiscussion

Pre-laboratory discussion Perform Laboratory Activity

Pen and paper quiz Group Activities Pen and Paper Test/ Post test/ Multiple test

CO1, CO2, CO3, CO4

Laboratory: Creative Introduction and Discussion of the Course Content/ Laboratory Safety and Guidelines 1. History and Scope of Organic Chemistry 2. Definition of Organic Chemistry and organic compounds 3. Properties and classification of organic compounds

Teaching-Learning Activities

Exercise No. 1: Organic and Inorganic Compounds Laboratory: Exercise No. 2: Detection of Common Elements in Organic Compounds

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1-5

4. Types of bonding Laboratory: Exercise No.1: Organic and Inorganic

Class Activity

Compounds 5. Hybridization of Atomic orbitals

Principles of Organic Chemistry by Syliangco, Clara Page 50-62

Post Laboratory discussion LectureDiscussion Group Activity

CO1, CO2, CO3, CO4

6. Sigma and Pi Molecular orbitals UNIT 2: CHARACTER OF A COVALENT BOND 1. Electronegativity 2. Molecular Polarity 3. Bond polarity, Bond Energy and Bond Length Laboratory: Exercise No. 3 Purification of Liquids by Distillation

Principles of Organic Chemistry by Syliangco, Clara Page 65-73

LectureDiscussion Class Activity Online

Questions Take Home Activities

Perform Laboratory Activity Post Laboratory discussion

Quiz Pen and paper Active participation Take home activity CO1, CO2, CO3, CO4

Principles of Organic Chemistry by Syliangco, Clara Page 74-85

Laboratory: Exercise No. 4: Extraction 3

1-4

UNIT 3. ACQUAINTANCE WITH COVALENT SIGMA MOLECULES 1. Nomenclature and Isomerism 2. Hydrocarbons (HC) a. Aliphatic HC – alkanes, alkenes and alkynes b. Alicyclic HC c. Aromatic HC d. Heterocyclic HC e. Hydrocarbon derivatives f. Halogen Compounds Laboratory: Exercise No. 5: Purification by Extraction

Principles of Organic Chemistry by Syliangco, Clara Page 96-125

Principles of Organic Chemistry by Syliangco, Clara Page 96-125

Principles of Organic

Pretest/ Multiple Test LectureDiscussion Group Discussion

Perform Laboratory Activity Post laboratory discussion

Pen and paper quiz Group Activities Pen and Paper Test/ Post test/ Multiple test Questions Take Home Activities

LectureDiscussion Group Activity

Pre-laboratory discussion Perform Laboratory Activity

Quiz Pen and paper Active participation Take home activity

LectureDiscussion

Pre-laboratory discussion

Quiz Pen and paper

CO1, CO2, CO3, CO4

CO1, CO2, CO3, CO4

CO1, CO2, CO3,

(Isolation of Caffeine from Tea)

Chemistry by Syliangco, Clara Page 96-125

Group Activity Online

Principles of Organic Chemistry by Syliangco, Clara Page 126-142

LectureDiscussion

Perform Laboratory Activity

Active participation Take home activity

CO4

Perform Laboratory Activity Post laboratory discussion

Pen and paper quiz Group Activities Pen and Paper Test/ Post test/ Multiple test Questions Take Home Activities

CO1, CO2, CO3, CO4

Perform Laboratory Activity

Quiz Pen and paper Active participation Take home activity

CO1, CO2, CO3, CO4

Laboratory: Exercise No. 6: Thin Layer Chromatography Laboratory: Exercise No. 7: Purification by recrystallization 5 4

1-5

PRELIMINARY EXAMINATIONS 3. Oxygen-containing compounds a. alcohol b. phenols c. ethers d. thiols aldehydes and ketones e. Carboxylic acids f. Acid Derivatives – acid halides, acid amides, acid anhydrides and esters

Class Activity Online FLIP CLASSROOM

Laboratory: Exercise No. 8: Aromatic Hydrocarbons

5

1-5

Laboratory: Exercise No. 9: Properties and Reactions of Ethanol 4. Nitrogen-containing compounds 5. Sulfur containing compounds 6. Organometallic- containing compounds Laboratory: Exercise No.10

Principles of Organic Chemistry by Syliangco, Clara Page 143-156

Pretest/ Multiple Test LectureDiscussion Group Discussion Online

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1-4

Laboratory: Exercise No. 11: Properties of Formaldehyde UNIT 4. GEOMETRY COVALENT COMPOUNDS AND ISOMERISM 1. Hybridization, Geometry and Isomerism 2. Conformation of OpenChain compounds and ring chain compounds 3. Geometric Isomers

Principles of Organic Chemistry by Syliangco, Clara Page 143-156

Pretest/ Multiple Test LectureDiscussion Group Discussion Online

Perform Laboratory Activity Post Laboratory discussion

Quiz Pen and paper Active participation Take home activity

CO1, CO2, CO3, CO4

Principles of Organic Chemistry by Syliangco, Clara Page 183-197

LectureDiscussion Group Activity Online

Pre-laboratory discussion Perform Laboratory Activity

Quiz Pen and paper Active participation Take home activity Practicals – AMAZING RACE

CO1, CO2, CO3, CO4

Laboratory: Exercise No. 12: Acetone Laboratory: Exercise No. 13: Preparation of an Esters

5 7

1-5

Exercise No. 14: Properties and Reactions of Alcohol MIDTERM EXAMINATION UNIT 5: STRUCTURAL EFFECTS 1. Delocalization-Resonance and Hyperconjugation 2. Steric Effect 3. Inductive effect – Electron Attracting and Repelling 4. Intermolecular Forces of Attraction Exercise No. 15: Aldehydes Exercise No. 16: Carboxylic acid Exercise No. 17:

Properties of phenol 8

1-5

UNIT 6. ORGANIC REACTION MECHANISMS 1. Electrophiles, Nucleophiles and Reactive sites 2. Addition Reaction 3. Substitution reaction

Principles of Organic Chemistry by Syliangco, Clara Page 183-197

LectureDiscussion Group Activity Online

Perform Laboratory Activity Post laboratory discussion

Quiz Pen and paper Active participation Take home activity

CO1, CO2, CO3, CO4

Principles of Organic Chemistry by Syliangco, Clara Page 198-220

LectureDiscussion Group Activity Online

Perform Laboratory Activity Post laboratory discussion

Quiz Pen and paper Active participation Take home activity

CO1, CO2, CO3, CO4

Exercise No. 18: Amides/Amines

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1-4

Exercise No.19: Properties of Formaldehyde/aldehyde Exercise No.20: Esters Exercise No. 21: Ethers 4. Elimination reaction 5. Rearrangement Reaction 6. Free-radical Reaction Exercise No.22: Ketones Exercise No. 23: Properties of Aldehydes/ketones Exercise No. 24: Acetone Exercise No. 25: Preparation of Aspirin

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FINAL EXAMINATION

12. SUGGESTED READINGS AND REFERENCES 1. Principles of Organic Chemistry by Syliangco, Clara 2. Unified Organic Chemistry, Mackenzie, Charles 3. Organic Chemistry, Brewster Ray, William Mc Ewen 4. OrganiC Chemistry, Bernaldez A., Canizares N. 5. Ouelette, Robert J. Organic Chemistry. A Brief Introduction.

13. COURSE EVALUATION COURSE REQUIREMENT (Lecture Component)

Total Weight (%)

A. Term 1. Class Standing  

LECTURE Assignment/ Seatwork (As/SW) ------------------------------------------------------------------------------- 10% Note: Late submission of assignment is not accepted. Quizzes (Q) ---------------------------------------------------------------------------------------------------------- 90% Note: Special quizzes are given provided that the incurred absence is excused. Transmutation Formula for CS Grade Lecture: [ As/SW (0.10) + Q (0.90) ] X 60 + 40 Final Grade : As/SW (0.10) + Q/Amazing race (0.90) ] X 60 + 40

100%

LABORATORY • Attendance (At) -------------------------------------------------------------------------------------------5% Note: 3 accumulated late is equivalent to 1 day absence. • Behavior/Lab Participation (B/LP) --------------------------------------------------------------------- 5% • Laboratory reports/Assignments/Documentations (LR/As/D/LG/SW/P/Re) Laboratory gears (Lab cap, mask, gown), Seatwork/Projects/Reporting ---------------- 20% Note: Late submission of report due to absence is accepted provided that it is excused. 1 day is given to accomplish and pass the report. • Quizzes (Q) -------------------------------------------------------------------------------------------------- 70% Note: Special quizzes are given provided that the incurred absence is excused. Transmutation Formula CS Grade Laboratory: • [ At (0.05)+ B/CP (0.05) + LR/As/D/SW/P/Re (0.20) + Q (0.70) ] x 60 + 40 Final Grade : [ At (0.05) + B/CP (0.0.5) + LR/As/D/LG/SW/P/Re (0.20) + Q/Amazing race (0.70) ] X 60 + 40

TOTAL 2. Term Examination Formula Exam Grade: Total score x 60 + 40 Total # of items

100%

100% TOTAL

3. Term Grade Formula: ( CS Grade x 2 ) + Exam Grade 3

100%

100% TOTAL

4. Combined Grade  Lecture Grade  Laboratory Grade Formula: (Lecture grade x 0.60 ) + (Laboratory grade x 0.40)

100%

60% 40%

TOTAL

100%

B. Final – Final Grade 1. Preliminary Grade (Lecture grade + Laboratory Grade) 2. Midterm Grade (Lecture grade + Laboratory grade)

30% 30%

3. Final Grade (Lecture grade + Laboratory grade)

40%

Formula: (PG x 0.30) + (MG x 0.30) + (FG x 0.40) TOTAL

100%

14. CLASSROOM POLICIES A. Professional Decorum Student of Lorma Colleges’ College of Pharmacy are expected to behave properly at all times especially if in the school premises. The guidelines are as follows: 1. Courteously knock on every door before entering any room, wait for acknowledgment then introduce self. 2. Maintain a moderate tone voice anywhere especially along the corridors, classrooms and patient’s room. 3. Greet teachers, employees, classmates and peers as you meet them. 4. Friendliness is encouraged but always maintains professionalism since too much familiarity may compromise the respect for each other. 5. Practice and maintain good posture at all times. 6. Students are not allowed to go out of the classroom for their snacks/meals. 7. Students must observe humility, tactfulness and respect when dealing with others. Always observe the Code of Ethics for Pharmacy and practice the Golden Rule in everyday life. 8. Students must wear the prescribed uniform at all times with dignity and respect and should be worn only in the school premises. 9. Students are not allowed to entertain visitors while on class. Should an emergency occur where an immediate member of the family is involved, permission from the instructor must be sought first and accomplish. 10. Gambling, smoking and drinking of alcoholic beverages and drug use are strictly prohibited. 11. Cellphones are not allowed while having a quiz and during lecture hours. 12. Promptness at all times, in all occasions and in any setting must be observed. 13. Students must strictly adhere to the school’s rules and regulations. 14. Students should not loiter around while in school premises. These preceding guidelines professional decorum are not limited to as written. Other guidelines for social norms and general behavior are written in the Lorma Colleges’ Student Handbook and must strictly observe.

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2. 3. 4. 5. 6.

B. Classroom The students are required to wear the prescribed college uniform in the given day. Monday/Thursday – institutional uniform with blue slacks Tuesday – gala uniform with white shoes (skirt for the ladies) Wednesday- departmental t-shirt Friday- gala uniform with white shoes (pants) Attend the class regularly. Submit seat works, assignments, home works and other requirements as prescribed at specified deadlines. Pass projects/other related projects at specified deadlines. Pass the periodical exams (prelims, midterms and finals). Deliver an oral report and submit a written report as prescribed by instructor.

7. The students should strictly comply with the policies stated above, in terms of punctuality, attendance, compliance to the requirements, etc. 8. Any forms of misconduct like cheating, behaviors, etc. will be subjected to disciplinary action. NOTE: Students are advised to read the student handbook from pages 8 – 20. Any amendments to the student handbook and/or new issued policies, rules and regulations the administration and the college deemed necessary, shall be applied automatically to the student/s currently enrolled in the college.

15. CONSULTATION HOURS

NAME OF INSTRUCTOR

DAY

TIME

Vanessa Samarah O. Gao-ay, RPh

MTW

3-4

Ghinelli Anne P. Laygo, RPh

Course Title

Date Effective

Organic chemistry

1st SY 2017 – 2018 August December

Date Revised August 2017

Prepared by

Recommending Approval

Approved by

Vanessa Samarah G. Liwan, RPh

Ghinelli Anne P. Laygo, RPh

Marianne A. Menecio, RPh, MSPharm, CPS Dean, College of Pharmacy

Diadema La Madrid, Ph.D. Dean, Academic Affairs

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