Kerkon 28e.docx
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Tn. X, 51 th, Suspek Pneumonia
Infeksi Bakteri
Pelepasan endotoksin / eksotoksin di sirkulasi
Aktivasi makrofag dan monosit
Pelepasan sitokin proinflamasi
IL 1, TNF α, IFN
Fagitosis, pelepasan lisis sel
Sintesis NO
Perubahan set point termostat di hipothalamus
Kerusakan sel endotel
Hiperthermia
CRT Memanjang
Vasodilatasi Kapiler
Permebilitas kapiler ↑
Hipovolemia relatif
Cairan intravaskular ke interstitial
Hipotensi
Penurunan perfusi jaringan
Hipoksia jaringan
Supply O2 Otak ↓
Metabolisme anaerob
Penurunan Kesadaran
Hiperlaktatemia
GCS : 11 Respon to verbal
Asidosis laktat
Hiperventilasi : takipneu
Quick SOFA : 3 (Sepsis)
Kompensasi : Takikardi
Infeksi Bakteri
Pelepasan endotoksin / eksotoksin di sirkulasi
Aktivasi makrofag dan monosit
Pelepasan sitokin proinflamasi
IL 1, TNF α, IFN
Fagitosis, pelepasan lisis sel
Sintesis NO
Perubahan set point termostat di hipothalamus
Kerusakan sel endotel
Hiperthermia
CRT Memanjang
Vasodilatasi Kapiler
Permebilitas kapiler ↑
Hipovolemia relatif
Cairan intravaskular ke interstitial
Hipotensi
Penurunan perfusi jaringan
Hipoksia jaringan
Supply O2 Otak ↓
Metabolisme anaerob
Penurunan Kesadaran
Hiperlaktatemia
GCS : 11 Respon to verbal
Asidosis laktat
Hiperventilasi : takipneu
Quick SOFA : 3 (Sepsis)
Kompensasi : Takikardi
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