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1: J Surg Oncol. 1980;15(1):85-90. Related Articles
Indomethacin and ascorbate inhibit desmoid tumors.
Noncytotoxic drug therapy for intra-abdominal desmoid tumor in patients with familial adenomatous polyposis. [D is Col on Rectum. 1992]
Waddell WR, Gerner RE. Administration of indomethacin caused complete resolution of a desmoid tumor after a partial response to radiation. In another patient, this drug caused an immediate response, then became ineffective. When large doses of ascorbic acid were given with indomethacin, slow resolution of the tumor began and has continued for 14 months. Treatment of a third case with indomethacin and ascorbic acid from the beginning produced shrinkage of the tumor which has continued to date. PMID: 7421272 [PubMed - indexed for MEDLINE]
Testolactone, sulindac, warfarin, and vitamin K1 for unresectable desmoid tumors. [Am JSurg. 1991] The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis. [Cancer. 1987] Review Successful treatment of a desmoid tumor with doxorubicin. [Cancer. 1993] Review Combined administration of ethodolac, ascorbic acid and radiotherapy as adjuvant therapies in an extrathoracic desmoid tumor with gross [JBUON. 2006] » See Reviews...
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Cited by PubMed Central articles Therapeutic utility of aspirin in the ApcMin/+ murine model of colon carcinogenesis. [BMC Cancer. 2002] Effects of sulindac on sporadic colorectal adenomatous polyps. [ Gut. 1997] Mesenteric mass in a 28-year-old woman. [Postg rad Me dJ. 1997] » See all (8)...
Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Indomethacin (Indocin® ) Indomethacin is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused ... Source: AHFS Consumer Medication Information
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Indomethacin and ascorbate inhibit desmoid tumors. Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C. Preventive action of vitamin C on nitrosamine formation. Prolongation of survival times of terminal cancer patients by administration of large dose... Vitamin C and cancer: an overview.
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