Flagyl
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Brand Name: Flagyl Generic Name: Metronidazole Indications: mild pain, fever Drug Classification: Anti-infectives, anti-protozoals, antiulcer agents Mechanism of Action: Disrupts DNA and protein synthesis in susceptible organisms. Most notable for activity against anaerobic bacteria, including: Bacteroides, Chlostridium. In addition, is active against Trichomonas vaginalis, Entamoeba hystolystica, Gardia lamblia, H. Pylori, and Chlostridium difficile. Dosage: Adult: Anaeroboc infections – 7.5 mg/kg q 6 hr. Trichomoniasis – 250 mg q 8 hr for 7 days or single 2-g dose or 1 g bid for 1 day. Amebiasis – 500-750 mg q 8 hr for 5-10 days. H. pylori – 250 mg qid or 500 mg bid for 1-2 wks. Bacterial vaginoses – 750 mg od as ER tablets for 7 days. Children: Trichomoniasis – 5 mg/kg q 8 hr for 7-10days. Amebiasis – 11.6-16.7 mg/kg q 8 hr for 5-10 days. Special Precautions: History of blood dyscrasias, history of seizures or neurologic problems, severe hepatic impairement, pregnancy, lactation, children. Pregnancy Risk Category: B Adverse Reactions: CNS: Seizures, dizziness, headache EENT: tearing (topical only)
Derm: Rash, urticaria; topical only – burning, mild dryness, skin irritation, transient redness GI: Abdominal pain, anorexia, nausea, diarrhea, dry mouth, furry tongue, glossitis, unpleasant taste, vomiting Hemat: Leucopenia Local: Phlebitis at IV site Neuro: Peripheral neuropathy Misc: superinfection. Contraindications: Hypersensitivity, hypersensitivity to parabens (topical only), first trimester of pregnancy. Forms: Tablets – 250 mg, 500 mg; ER tablets – 750 mg; Capsules – 375 mg; Powder for injection – 500 mg vials; Topical gel – 0.75% in 28.4-g tubes; Topical cream – 0.75% in 28.4-g tubes; Topical lotion – 0.75% in 59-ml bottle; Vaginal gel – 0.75% in 70-g tubes. Nursing Responsibilities: Assess patient for infection at the beginning of and throughout therapy. Obtain specimens for culture and sensitivity before initiating therapy. Monitor neurologic status during and after IV infusions. Monitor intake and output and daily weight Administer with food or milk to minimize GI irritation. Tablets may be crushed for patients with difficulty in swallowing.
Derm: Rash, urticaria; topical only – burning, mild dryness, skin irritation, transient redness GI: Abdominal pain, anorexia, nausea, diarrhea, dry mouth, furry tongue, glossitis, unpleasant taste, vomiting Hemat: Leucopenia Local: Phlebitis at IV site Neuro: Peripheral neuropathy Misc: superinfection. Contraindications: Hypersensitivity, hypersensitivity to parabens (topical only), first trimester of pregnancy. Forms: Tablets – 250 mg, 500 mg; ER tablets – 750 mg; Capsules – 375 mg; Powder for injection – 500 mg vials; Topical gel – 0.75% in 28.4-g tubes; Topical cream – 0.75% in 28.4-g tubes; Topical lotion – 0.75% in 59-ml bottle; Vaginal gel – 0.75% in 70-g tubes. Nursing Responsibilities: Assess patient for infection at the beginning of and throughout therapy. Obtain specimens for culture and sensitivity before initiating therapy. Monitor neurologic status during and after IV infusions. Monitor intake and output and daily weight Administer with food or milk to minimize GI irritation. Tablets may be crushed for patients with difficulty in swallowing.
