Ezetimibe (zetia)

INDEX Generic Name ezetimibe

Trade Name Zetia

Peak 4-12 hr

Onset UNK

NURS 2236 Clinical Form 3: Clinical Medications Worksheet (You will need to made additional copies of these forms) Classification Dose Route Time/Frequency Cholesterol Lowering agent Duration UNK

Why is your patient taking this medication?

PO

Normal Dosage range

qday

hs

10mg qday

PO

For IV meds, compatability with IV drips and/or solutions

Mechanism of action and indications Treatment of primary hypercholesterolemia alone or with an HMG-CoA reductace inhibitor (statin); treatment of homozygous sitosterolemia as an adjunct to diet Works at the lining of the small intestine inhibiting the absorption of cholesterol, but does not inhibit cholesterol synthesis in the liver or increases biles acid excretion. Thus it decreases the amount of intestinal cholesterol available to the liver. Lowers both total cholesterol and low-density lipd (LDL) cholesterol. Interactions with other patient drugs, OTC, or herbal medicines (ask patient specifically) cholestryramine; bile acid sequestrants; fibrates; cyclosporine; HMG CoA-reductase inhibitors

Nursing Process - Assessment (Pre-administration assessment Obtain diet history; Assess for unexplained muscle pain, tenderness and weakness.

10 mg

Nursing Implications (what to focus on) Contraindications/warnings/interactions Hypersensitivity; concurrent us with HMG-CoA reductase inhibitor in patients with active liver disease or elevated serum transaminases; moderate to severe hepatic disease; concurrent administration with fibrates; lactation; pregnancy; mild hepatic insufficiency. Common side effects Fatigue; arthralgia; back pain; myalgia; angiedema; myopathy; dizziness; headache; abdominal pain; diarrhea; pharyngitis; sinusitis; cough; thrombocytopenia; rash; hepatitis; pancreatitis; rhabdomyolysis. nausea; Lab value alterations caused by medicine Evaluate serum cholesterol and triglyceride levels before initiating, after 2-4 week of therapy, and periodically thereafter. May cause increased liver transaminases; Monitor liver enzymes. Be sure to teach the patient the following about this medication Medication should be used in conjunction with diet restrictions. Exercise and cessation of smoking. Does not assist in weight loss; Notify doctor of unexplained muscle pain, tenderness, or weakness occur. Follow-up appointments are important to determine effectiveness and to monitor for side effects

Assessment Why would you hold or not give this med? Rhabdomyolysis Angioedema Liver disease

Evaluation Check after giving Decrease in serum LDL and total cholesterol levels. Increase in HDL cholesterol levels