Dushyant
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“NITRIC OXIDE AS THERAPEUTIC AGENT” A PROJECT REPORT FOR ELECTIVE SUBJECT SUBMITTED TO HEMCHANDRACHARYA NORTH GUJARAT UNIVERSITY, PATAN.
IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE DEGREE CERTIFICATE OF BACHELOR OF PHARMACY YEAR: 2006-2007
SUBMITTED BY
DUSHYANT B. PATEL SHREE S.K.PATEL COLLEGE OF PHARMACEUTICAL EDUCATION & RESEARCH, GANPAT VIDYANAGAR, KHERVA-382711 NORTH GUJARAT
CERTIFICATE This is to certify that the project report for the elective subject entitled “NITRIC
OXIDE
AS
THERAPEUTIC
AGENT” is the bonafide work of DUSHYANT B. PATEL satisfactorily carried under my guidance and supervision in the Department Of Pharmacology of Shree S.K.Patel College of Pharmaceutical Education and Research, Ganpat Vidyanagar, during the academic year 2006-2007 sincerely and methodically. This work is upto my satisfaction. Guide: Dr. N.J. PATEL (M.Pharm, Ph.D.) Head Of Department Department of pharmacology, Shree S.K. Patel College of Pharmaceutical Education & Research, Ganpat Vidyanagar, Kherva
Principal: Dr.MADHUBHAI M.PATEL M.Pharm, PhD, LLB, FIC. Department of Pharmaceutical Technology Shree S.K. Patel College of Pharmaceutical Education & Research, Ganpat Vidyanagar.
Date:
Place:
ACKNOWLEDGEMENT The successful completion of a project “NITRIC
OXIDE
AS
THERAPEUTIC AGENT ’’ is generally not an individual effort. It is an outcome of the cumulative effort of a number of persons, each having his own importance to the objective. This session is a vote of thanks and gratitude towards all those persons who have directly or indirectly contributed in their own special way towards the completion of this project. First of all I would like to thank my guide respected Dr.N.J.Patel for giving me guidance and also for supporting me in all the way to complete this project. I also like to thank our respected faculty members Mr. R.J.Patel, Mr. R.K.Patel for their valued guidance and encouragement towards the completion of our project. I am also very much thankful to our honorable principal Dr.M.M.Patel for providing infrastructure and research facilities at college. And I am really grateful to all those, whose ideas have been helpful in preparing this report. I am also thankful to our librarian Mr.P.I.Patel, Mahadevbhai, Mukeshbhai for providing me books & reference. I heartily thankful to Chaula madam for her great help to me in computer laboratory.
I am thankful to all my friends for always help me in my all difficulty. At last but not at least I express thanks to my dearest brother HASMUKH for his support and constant encouragement for successful completion of my project work. “May the candle be lightened forever, the joy is not of light alone, but of presence of those, who played the role behind the curtain.”
GANPAT
DUSHYANT B. PATEL 2006-07 FOURTH B.PHARM
VIDYANAGAR
Dedicated to God, My Family & Teachers
INDEX SR.
CONTENT
NO. 1. 2. 3.
3.
INTRODUCTION AND HISTORY OF NITRIC OXIDE CHEMISTRY AND PROPERTIES OF NITRIC OXIDE BIOSYNTHESIS OF NITRIC OXIDE
1 3.
DIFFERENT FORMS OF NITRIC OXIDE SYNTHASE
2 3.
DEGRADATION AND CARRIAGE OF NITRIC OXIDE
NO.
3 4.
PHYSIOLOGICAL AND PHARMACOLOGICAL EFFECT OF NITRIC OXIDE
5.
5.
PHARMACOKINETICS
1 5.
INDICATIONS
2 5.
CONTRAINDICATION OF NITRIC OXIDE
3 6. 7.
PAGE
DRUGS FOR MODULATING THE NO AND NOS ACTIVITY REFERENCES
IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE DEGREE CERTIFICATE OF BACHELOR OF PHARMACY YEAR: 2006-2007
SUBMITTED BY
DUSHYANT B. PATEL SHREE S.K.PATEL COLLEGE OF PHARMACEUTICAL EDUCATION & RESEARCH, GANPAT VIDYANAGAR, KHERVA-382711 NORTH GUJARAT
CERTIFICATE This is to certify that the project report for the elective subject entitled “NITRIC
OXIDE
AS
THERAPEUTIC
AGENT” is the bonafide work of DUSHYANT B. PATEL satisfactorily carried under my guidance and supervision in the Department Of Pharmacology of Shree S.K.Patel College of Pharmaceutical Education and Research, Ganpat Vidyanagar, during the academic year 2006-2007 sincerely and methodically. This work is upto my satisfaction. Guide: Dr. N.J. PATEL (M.Pharm, Ph.D.) Head Of Department Department of pharmacology, Shree S.K. Patel College of Pharmaceutical Education & Research, Ganpat Vidyanagar, Kherva
Principal: Dr.MADHUBHAI M.PATEL M.Pharm, PhD, LLB, FIC. Department of Pharmaceutical Technology Shree S.K. Patel College of Pharmaceutical Education & Research, Ganpat Vidyanagar.
Date:
Place:
ACKNOWLEDGEMENT The successful completion of a project “NITRIC
OXIDE
AS
THERAPEUTIC AGENT ’’ is generally not an individual effort. It is an outcome of the cumulative effort of a number of persons, each having his own importance to the objective. This session is a vote of thanks and gratitude towards all those persons who have directly or indirectly contributed in their own special way towards the completion of this project. First of all I would like to thank my guide respected Dr.N.J.Patel for giving me guidance and also for supporting me in all the way to complete this project. I also like to thank our respected faculty members Mr. R.J.Patel, Mr. R.K.Patel for their valued guidance and encouragement towards the completion of our project. I am also very much thankful to our honorable principal Dr.M.M.Patel for providing infrastructure and research facilities at college. And I am really grateful to all those, whose ideas have been helpful in preparing this report. I am also thankful to our librarian Mr.P.I.Patel, Mahadevbhai, Mukeshbhai for providing me books & reference. I heartily thankful to Chaula madam for her great help to me in computer laboratory.
I am thankful to all my friends for always help me in my all difficulty. At last but not at least I express thanks to my dearest brother HASMUKH for his support and constant encouragement for successful completion of my project work. “May the candle be lightened forever, the joy is not of light alone, but of presence of those, who played the role behind the curtain.”
GANPAT
DUSHYANT B. PATEL 2006-07 FOURTH B.PHARM
VIDYANAGAR
Dedicated to God, My Family & Teachers
INDEX SR.
CONTENT
NO. 1. 2. 3.
3.
INTRODUCTION AND HISTORY OF NITRIC OXIDE CHEMISTRY AND PROPERTIES OF NITRIC OXIDE BIOSYNTHESIS OF NITRIC OXIDE
1 3.
DIFFERENT FORMS OF NITRIC OXIDE SYNTHASE
2 3.
DEGRADATION AND CARRIAGE OF NITRIC OXIDE
NO.
3 4.
PHYSIOLOGICAL AND PHARMACOLOGICAL EFFECT OF NITRIC OXIDE
5.
5.
PHARMACOKINETICS
1 5.
INDICATIONS
2 5.
CONTRAINDICATION OF NITRIC OXIDE
3 6. 7.
PAGE
DRUGS FOR MODULATING THE NO AND NOS ACTIVITY REFERENCES
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