Drug Study: Ceftin - Cefuroxime Axetil

BRAND NAME

DOSAGE

Ceftin

500 mg TID

GENERIC NAME:

FORM:

Cefuroxime axetil CLASSIFICATIONS: Cephalosporins

tablet

MECHANISM OF ACTION Cefuroxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

INDICATIONS (1) Pharyngitis or tonsillitis due to S.pyogenes. (2). Acute bacterial otitis media due to S. Pneumoniae, H. Influenzae, M. catarrhalis. (3). Acute bacterial maxillary sinusitis due to S. pneumoniae, H. Influenzae. (4). Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis due to S. pneumoniae, influenzae.

ADVERSE REACTIONS

NURSING CONSIDERATIONS

Large doses can cause cerebral irritation and convulsions; nausea, vomiting, diarrhoea, GI disturbances; erythema multiforme, StevensJohnson syndrome, epidermal necrolysis.

>Note for the drugs, dosage, time, route, client. >Do not confuse cefuroxime with deferoxime. >Note the side effects of the drugs > Should be taken with the food.