Course Outline Of Sbt 2130-genetics

INTERNATIONAL ISLAMIC UNIVERSITY MALAYSIA

COURSE OUTLINE Kulliyyah

Science

Department

Biotechnology

Programme

Bachelor of Biotechnology (BBT)

Course Title

Genetics

Course Code

SBT 2130

Status

Core Course

Level

2

Credit Hours

3

Contact Hours

5 (2 lecture hours and laboratory hours per week)

Pre-requisites (if any)

Nil

Co-requisites (if any)

Nil

Instructional Strategies

The instructional strategies are:1. The lecture is conducted in active participation basis (dual-way) to prepare the students with sufficient theoretical knowledge. 2. Comprehensive laboratory experiments are given to the students to prepare themselves with appropriate foundation technical skills to execute research or to be applied in relevant career. 3. Industrial application related topics are given as assignments to expose the students with real-world application of the subject. 4. Presentation of cutting-edge issues and technologies relevant to the course are assigned to the student to update their knowledge and enhance their communication skills. LO Method % All Quizzes 10 2,4 Laboratory reports 20 All Mid-term examination 25 All Final Examination 45 TOTAL 100

Course Assessment State weightage of each type of assessment.

1

Instructor(s)

Assoc. Prof. Dr. Arokiaraj Pappusamy Telephone No: 09 - 5716400 - Ext: 2826 Email: [email protected]

Semester Offered Course Synopsis

Semester I

Course Objectives

The objectives of the course are to: 1. Introduce genetics as the science of heredity. 2. Provide students with the basic concepts of modern genetics. 3. Help students be familiar with genetic terminologies. 4. Realize how genetics can affect individual and population as well as help the ummah, in particular, to understand the science of genetics.

Learning Outcomes

At the end of the course the student will be able to: 1. Discuss up-to-date basic concepts of genetics. 2. Illustrate the application of technology related to genetics in biotechnology field. 3. Demonstrate knowledge of the basic science behind the science of genetics and understand the potential economic, social, ethical and political impacts of the burgeoning field on society. 4. Show critical and creative thinking to solve genetics related problems through problem solving based assessments given in the course.

This course investigates how genotypes become phenotypes: the nature of life at the level of molecules, genes and how they function. Inheritance of simple traits, recombination and linkage. Chromosomes, non-mendelian inheritance, mechanisms of genetic changes and modern genetic analysis.

Content Outlines Weeks

Topics

Task/Reading

1

An Introduction to Genetics Brief history and the basic concepts of genetics. Dr. Arokiaraj Cell Division and Chromosomes Mitosis, meiosis and sexual reproduction. The significance of meiosis. (Part time lecturer)

Chapter 1

2

3

Mendelian Genetics Gregor Mendel experimental approach. The monohybrid and dihybrid Cross. (Part time lecturer)

2

Chapter 2

Chapter 3

4

5

6

7

8

9

10

11

12 13

Mendelian Genetics Trihybrid cross. The Punnet Square and Test Cross. Chapter 3 Independent assortment and variation. Probability and genetic event. Chi-Square analysis. Human pedigree. (Part time lecturer) Extension of Mendelian Genetics Potential function of allele. Incomplete, partial dominance Chapter 4 and co-dominance. Multiple (ABO blood grouping) and lethal alleles. Discontinuous variation. (Part time lecturer) Quantitative Genetics Quantitative inheritance, analysis of polygenes traits and Chapter 5 mapping traits loci. (Part time lecturer) Linkage and Mapping in Eukaryotes Linkage versus independent assortment. Incomplete linkage. Chapte Single and multiple crossover. r6 (Part time lecturer) Linkage and Mapping in Eukaryotes Three point mapping. Determining gene sequences. A Chapter 6 mapping problem in maize. Multiple strand exchanges and accuracy of mapping. Interference of the coefficient of coincidence. Somatic cell hybridization and human gene mapping. (Part time lecturer) Sex Chromosomes and Sex Determination Diploid chromosomes number. Sex differentiation and sex Chapter 7 determination. The X chromosomes, Barr bodies, the Lyon hypothesis. Aneuploidy and polyploidy: Gene deletion, duplication, inversions and translocation. (Part time lecturer) The Molecular Basis of Genetics Chapters 9, 10 DNA structure, replication, recombination, chromosomes and 11 organization. Dr. Arokiaraj Genetic Expression Chapters 12, The genetic code, transcription, translation. Gene mutation 13 and 14 and DNA repair. Dr. Arokiaraj Gene Regulation in Prokaryotes Chapter 16 Beta galatosidase gene of the lac operon. Dr. Arokiaraj DNA Biotechnology Application and ethics. Mapping the human genome, the Chapters 18, restriction length fragment polymorphisms or RLFPs. 19 and 20 Diagnosing genetics disorder, gene therapy, DNA fingerprinting and genome projects. Dr. Arokiaraj 3

14 References

Genetics and the Ummah Discussions Discussion on various genetics issues in Islamic society. Dr. Ibrahim Shogar and Dr. Arokiaraj Required 1. Klug, W.S., & Cummings, M.R., (2002), Concepts of Genetics, 7th ed., Prentice Hall. Recommended 1. Tamarin, R.H., (1999), Principles of Genetics, 6th ed., McGraw Hill. 2. Weaver, R.F., & Hedrick, P.W., (1997), Genetics, 3rd ed., McGraw Hill. 3. Mertens, T.R., & Hammersmith, R.L., (1995), Genetics Laboratory Investigation. 10th ed., Prentice Hall. 4. Mohsin, A. F., (1993), Biomedical Issues: Islamic Perspective. 1st ed. A.S. Norrdeen Pub.

Proposed Start Date (Semester) Batch of Students to be Affected

Semester I, 2003/2004 Batch 2002

Prepared by:

Checked by:

Approved by:

______________ Assoc. Prof. Dr. Arokiaraj Pappusamy Lecturer

_____________________ Kamarul Rahim Kamarudin Head, Department of Biotechnology

_____________________ Prof. Dr. Ridzwan Hashim Dean, Kulliyyah of Science

NOTE: 1. The course outlines should reflect the course description/synopsis and Islamic mission of the university as well as to provide the room for Islamic critique. 2. Latest editions of textbooks and references should be used unless otherwise necessary or if the course is classical in nature. Please check with the library to ensure that the books are up-to-date and incorporating the latest edition. 3. The reference lists shall be presented in accordance with APA bibliographic practices and in alphabetical order. 4. The reference title shall be italicised or underlined or bold. If in doubt, please consult the Librarian. 5. Proposed new course outlines should be presented to the Senate Standing Committee for approval at least four months prior to the course offering. 6. Any changes to the course outlines must be reported back to the Standing Senate Committee two months prior to the course offering.

4