Chronic Inflammation & Inflammation Outcomes

CHRONIC INFLAMMATION, SYSTEMIC EFFECTS & CONSEQUENCES R. HUGO MARTÍNEZ LOZANO, M.D. September 1st., 2006

LEARNING OBJECTIVES: KNOW & UNDERSTAND: THE GENERAL FEATURES CAUSES MORPHOLOGY CELLS GRANULOMATOUS INFLAMMATION -TYPES OF GRANULOMAS SYSTEMIC EFFECTS DEFECTS OR EXCESS (Consequences) ¡¡¡ CLINICAL SIGNIFICANCE !!! Ref: pp. 78-85.

GENERAL FEATURES 

DEFINITION: -TIME. -CHARACTERISTICS – ACTIVE - T. DESTRUCTION - REPAIR -CLINICAL SIGNIFICANCE…

CAUSES   

PERSISTENT INFECTION PROLONGED EXPOSURE AUTOIMMUNITY

Chlamydiae intracellular inclusions. (Pap stained smear).

CAUSES   

PERSISTENT INFECTION PROLONGED EXPOSURE AUTOIMMUNITY

CAUSES   

PERSISTENT INFECTION PROLONGED EXPOSURE AUTOIMMUNITY

LES

IDEM

CELLS

OTHER CELLS

GRANULOMATOUS INFLAMMATION

IDEM

TYPES OF GRANULOMA FOREIGN BODY

IMMUNE

TALC

SYSTEMIC EFFECTS OF INFLAMMATION 

FEVER: PYROGENS - EXOGENOUS

SYSTEMIC EFFECTS OF INFLAMMATION 

FEVER: PYROGENS - ENDOGENOUS

SYSTEMIC EFFECTS OF INFLAMMATION 

ACUTE-PHASE PROTEINS: - CRP - SAA - FIBRINOGEN (ESR)

SYSTEMIC EFFECTS OF INFLAMMATION

DEFECTIVE INFLAMMATION 

DIABETIC ULCER

EXCESSIVE INFLAMMATION BRONCHIAL ASTHMA

STATUS ASMATHICUS

QUESTIONS?