W6 Chronic Inflammation

CHRONIC INFLAMMATION

LP 6

CHRONIC INFLAMMATION Definition : The chronic inflammation represents a long lasting inflammatory process (weeks, months, years) associated with: -Important tissue destruction -Inflammatory infiltrate form by lymphocytes, plasma cells, macrophages -Conective tissue repair

Nonspecific: presents a diffuse or focal inflammatory infiltrate with mononucleate cells. Specific (granulomatous):  Immune • Caseous • Non caseous  Nonimmune • Forein body gtranuloma

TUBERCULOUS INFLAMMATION

The characteristic microscopic lesion (irrespective of where it is located) is: TUBERCULOUS GRANULOMA :

giant multinucleate

cells (Langhans);  epithelioid cells;  lymphocyte; Caracteristic aspects :

- Tendancy to fusion; - Tendency to caseous necrosis.

Colorația HE

Tuberculous lymphadenitis Tendancy to fusion

Coloraţia HE

Tuberculou s inflammati on

Caseous necrosis

HE

Pulmonary tuberculous inflammation

 Tendency to fusion Caseous necrosis

HE

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ACTINOMYCOSIS It is produced by Actinomyces israeli

Microscopic: (histologic section through pus):

Bacterial colony – intense basophile; - filamentous.

Around - purulent exudate.

Colorația HE