Bimm 110 Section 5 Slides

BIMM 100 Section 5 May 12, 2009 George Chen [email protected] www.pdfcoke.com/g_chen

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DAYS UNTIL

FINAL

Office Hours: Tu 12:30-1:30 Sierra Summit

Midterm announcements ●

Tests will be handed back in lecture tomorrow

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Regrade requests due in a week to Dr. Zhang

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Go over work with TAs in OH

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Preliminary Average = 70%

Mitochondria: Background ●

Main Function: Energy Production

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Has own genome ●

Almost entirely coding region

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Circular, like bacteria

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Codes for rRNA, tRNA, proteins

Mitochondria: Inheritance ●

Maternal

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Use mutations to track

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3 oldest lineages from Africa Data consistant with fossil findings 'Mitochondrial Eve'

Sidenote: Paternal Inheritance ●

'Y Chromosome Adam'

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Also 3 lineages from Africa

Mitochondria ●

Codons 'wobble'

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Endosymbiont Theory ●

Popularized by Lynn Margulis

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Explains bacterial characteristics

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Mitochondria can no longer survive outside cell

Genetic bottleneck Heteroplasmy Homoplasmy

MERRF ●

Rare

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Childhood onset

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Seizures

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Ataxia

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Myopathy

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Ragged Red Fibers

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90% mutation makes symptoms obvious

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Interferes with aminoacylation, codon-anticodon interaction

MELAS ●

Most common inherited mitochondrial disease

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Strokes

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Ataxia

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Myopathy

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Lactic acidosis

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Potential to combine with MERRF

LHON ●

Mitochondria disorder of eye ●

Loss of central vision

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Fading of colors

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5x more common in males than females

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18 possible missense mutations

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Homoplasmy is common

Kearns-Sayre ●

Sporatic somatic deletion

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Heteroplasmic

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Occurs before age 20

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Systemic, but commonly eye related

Treatments ●

NOTHING EFFECTIVE!