Bab 3.docx

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Bab 3. Kerangka Konseptual Penelitian 3.1 Kerangka Konseptual Penelitian Diabetes Melitus tipe 2

Hiperglikemia

Metabolisme karbohidrat ↑

ROS ↑ Kerusakan sel β pankreas

Insulin dalam sirkulasi ↑

Resitensi insulin

Disfungsi berbagai organ ↓Fungsi Osteoblas

↓ Osteocalcin

Adiposit: ↓sekresi adiponektin ↑adipogenesis ↑lipolisis

↑Risiko osteoporosis dan aterosklerosis

Gambar 3.1. Kerangka Konsep Penelitian 15

3.2 Hipotesis Penelitian Ha : -

Terdapat perbedaan yang bermakna kadar osteokalsin pada pasien DM tipe 2 dengan kontrol sehat

16

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