Ascorbic Acid Is Cytotoxic For Pediatric Tumor Cells Cultured In Vitro.

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Select 7703904 1: Biochem Mol Biol Int. 1994 Nov;34(5):871-4.

Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro. Medina MA, García de Veas R, Schweigerer L. Sektion Onkologie/Immunologie, Universitäts Kinderklinik, Ruprecht-Karls-Universität, Heidelberg, Germany.

2 mM Ascorbic acid has a potent cytotoxic effect on neuroblastoma, osteosarcoma, retinoblastoma, and rhabdomyosarcoma cells cultured in vitro. At a lower concentration (0.2 mM), ascorbic acid remains highly cytotoxic for neuroblastoma, osteosarcoma and retinoblastoma cells, but it has a stimulatory effect on the growth of rhabdomyosarcoma cells.

Related Articles MGI 114: augmentation of antitumor activity when combined with topotecan. [JPediatrHematolOncol.2000] Growth inhibition of neuroblastoma cells by lovastatin and L-ascorbic acid is based on different mechanisms. [Cancer Lett.1999] In vitro antitumor activity of rebeccamycin analog (NSC# 655649) against pediatric solid tumors. [JPediatrHematolOncol.1998] Review Ascorbic acid and cancer. [Subcell Biochem.1996]

PMID: 7703904 [PubMed - indexed for MEDLINE]

Review In vitro assays for chemotherapy sensitivity. [Crit RevOncol Hematol.1993] » See Reviews...

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Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information

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