Ascorbic Acid-enhanced Antiproliferative Effect Of Flavonoids On Squamous Cell Carcinoma In Vitro.

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Select 8457720 1: Anticancer Drugs. 1993 Feb;4(1):91-6.

Ascorbic acid-enhanced antiproliferative effect of flavonoids on squamous cell carcinoma in vitro. Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E Jr. Department of Medicine, State University of New York, School of Medicine and Biomedical Sciences, Buffalo 14203.

We examined the effects of flavone and two polyhydroxylated plant flavonoids (quercetin and fisetin), either singly or in combination with ascorbic acid, on the growth of a human squamous cell carcinoma cell line (HTB 43) in vitro. Fisetin and quercetin significantly impaired cell growth in the presence of ascorbic acid. Exposure of cells to ascorbic acid (2 micrograms/ml) and 2 micrograms/ml of either fisetin or quercetin resulted in 61 and 45% inhibition of cell growth, respectively, in 72 h, while treatment with ascorbic acid alone had no effect on cellular proliferation. Flavone and ascorbic acid, either as single agents or in combination, exhibited no significant inhibition at any of the concentrations tested. The enhancement of the antiproliferative effect of the above flavonoids by ascorbic acid may be due to its ability to protect these compounds against oxidative degradation. PMID: 8457720 [PubMed - indexed for MEDLINE]

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Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information

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