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Kondisi yang memperburuk atau memfrofokasi angina : 1. Vasodilatasi 2. Penggantian tiroid yangberlebihan 3. Vasokontriksi Masalah medis lainnya 1. Anemia berat, hipertensi yang tidak terkontrol 2. Hipertiroid 3. Hipoksemia Masalah jantung 1. Takiaritmia 2. Badiaritmia 3. Penyakit katup jantung 4. Kardiomiopati hipertrofik