Anaesthetic Doses

Table 3 - Intravenous Agents Drug

Typical Initial Clinical Clinical Onset Dose Duration

Thiopentone

4-5 mg/kg

20-30 sec

5-10 min

Propofol

1.5-2.5 mg/kg

1-2 min

5-10 min

Midazolam

0.01-0.1 mg/kg 2-4 min

1-2 hrs

Diazepam

0.02-0.2 mg/kg 3-6 min

4-8 hrs

Fentanyl

1-1.5 mcg/kg

1-4 min

2-3 hrs

Morphine

0.05-0.15 mg/kg

3-10 min

2-3 hrs

Pethidine

0.5-1.5 mg/kg

2-5 min

2-3 hrs

Ketamine

1-2 mg/kg

20-30 sec

5-10 min

Table 4 - Inhalation Agents Agent

MAC*

Concentration used

Blood/Gas partition coefficient

Oil/water solubility

Ether

1.92

2-15%

12

3

Halothane

0.76

0.5-3%

2.3

220

Enflurane

1.68

1-6%

1.9

120

Isoflurane

1.15

1-4%

1.4

120

Sevoflurane

2

1-6%

0.69

53

Nitrous Oxide

104

70%

0.47

2.2

Table 5 - Muscle Relaxants Initial Dose mg/kg

Approximate duration (min)

d-Tubocurarine

0.5

25-30

Alcuronium

0.3

20-25

Gallamine

1-2

20-30

Pancuronium

0.1

30-45

Vecuronium

0.1

15-20

Atracurium

0.5

20-25

Cisatracurium

0.15

20-25

Mivacurium

0.2

10-20

Rocuronium

0.6

20-30

1-1.5

3-5

Drug

Suxamethonium Table 6 - Resuscition Drugs

Drug Adrenaline Atropine Calcium Chloride Lignocaine

Recommended Dose

Average Adult Dose

0.01-0.05 mg/kg

0.5-1mg

0.02 mg/kg

0.6-1.2 mg

0.2 ml/kg (10%)

5-10 mL

1 mg/kg

10 mL 1%

● Local anaesthetics - lignocaine, bupivacaine, ropivacaine, cinchocaine.