Zegen

Brand Name: Zegen Generic Name: Cefuroxime Indications: Treatment of bone and joint infections, bronchitis (and other lower respiratory tract infections), gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections, surgical infections and UTI. Drug Classification: Antibiotics Mechanism of Action: Bind to bacterial cell wall membrane which causes cell death. Dosage: Cap Adult and children > 10 y/o 250-500mg q8h, Inj Adult 750mg-1.5g every 68 hrs for 5-10 days. Children > 3 months 50-100 mg/kg body wt/day in equally divided doses every 6-8 hrs. Special Precaution: Hypersensitivity to penicillins. Possible superinfection in prolonged use. Nephrotoxicity and ototxicity. Pregnancy Risk: B Adverse Reaction: Thrombophlebitis, Pruritus, urticaria, +ve Coombs’s test, diarrhea, nausea, pseudomembrenous colitis,. Decrease in Hb and hematocrit transient increase in liver enzymes, elevation in serum creatinine and BUN. Possible seizure and angiodema. Contraindications: Known allergy to cephalosporins.

Form: Capsule and inj. Nursing Responsibilities:  Assess patient fro infection at the beginning and during the therapy.  Before initiating thepary, obtain a history to determine previous use of and reaction to penicillin or cephalosporins. Person with a negative history of penicillin sensitivity may still have an allergic response.  Obtain specimens for culture and sensitivity before initiating the therapy.  Observe patient for sings and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing)  Assess patient for renal dysfunction and adjust accordingly.