Zegen

Zegen® [cap] UAP [ UAP ]

MIMS Class : Cephalosporins

See related Zegen cap information Contents Indications

Cefuroxime (cap: axetil, vial: Na) Treatment of bone & joint infections, bronchitis (& other lower resp tract infections), gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections, surgical infections & UTI.

Dosage

Cap Adult & childn ≥10 yr 250-500 mg every 12 hr. Inj Adult 750 mg-1.5 g every 6-8 hr for 5-10 days. Childn >3 mth 50-100 mg/kg body wt/day in equally divided doses every 6-8 hr.

Administration Contraindications Warnings

Should be taken with food (Take immediately after food.). Known allergy to cephalosporins. For additional cautionary notes to warn of the potential risk of using the medicine... click to view

Special Precautions Adverse Drug Reactions

Hypersensitivity to penicillins. Possible superinfection in prolonged use. Nephrotoxicity & ototoxicity. Thrombophlebitis. Pruritus, urticaria, +ve Coombs' test, diarrhea, nausea, pseudomembranous colitis. Decrease in Hb & hematocrit, transient increase in liver enzymes, elevation in serum creatinine & BUN. Possibly seizure & angioedema. Click to view ADR Monitoring Website

Drug Interactions Diuretics eg furosemide or aminoglycosides. Probenecid. Click here for more Interaction Checks Pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). Caution For Usage

For caution against possible variation of physical aspect of

Storage

For special storage condition to ensure optimal shelf-life of

medicine... click to view

medicine... click to view Description

For details on the chemical structure, and the excipient or inactive compounds in the formulation... click to view

Mechanism of Action MIMS Class ATC Classification Poison Schedule

For Details of the mechanism of action, pharmacodynamics and pharmacokinetics ... click to view Cephalosporins

J01DC02 - Cefuroxime ;

Rx

Packing/Presentation Form

Packing/Price Zegen 250 mg x 100's (P4815)

Zegen capsule

Zegen 500 mg x 50's (P4100)

Zegen vial

Zegen 1.5 g x 1's (P467.5) Zegen 750 mg x 1's (P263.65)

Photo

MOA: Pharmacology: Cefuroxime, a semisynthetic, broad-spectrum 2nd generation

cephalosporin antibiotic, exerts its bactericidal activity by interfering with the synthesis of the bacterial cell wall. It binds to penicillin-binding protein 3, responsible for the synthesis of peptidoglycan, a heteropolymeric structure that gives the cell wall its mechanical stability. Microbiology: Spectrum of Activity: Cefuroxime is active in vitro against the following organisms: Gram-Positive Aerobes: Staphylococcus aureus (including β-lactamaseproducing strains), Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes (and other Streptococci). Gram-Negative Aerobes: Citrobacter sp, Enterobacter sp, Escherichia coli, Haemophilus influenzae (including β-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella sp (including Klebsiella pneumoniae), Moraxella catarrhalis (including β-lactamase-producing strains), Morganella morganii, Neisseria gonorrhea (including β-lactamase-producing strains), Neisseria meningitidis, Proteus mirabilis, Proteus inconstans, Providencia rettgeri, Salmonella sp, Shigella sp. Anaerobes: Gram-positive and gram-negative cocci (including Peptococcus and Peptostreptococcus sp), gram-positive bacilli (including Clostridium sp, gram-negative bacilli (including Bacteroides and Fusobacterium sp). Spirochetes: Borrelia burgdorferi. Pharmacokinetics: Following IM injection of a 750-mg dose of cefuroxime to normal volunteers, mean peak serum concentration was 27 mcg/mL at approximately 45 min. Following IV doses of 750 mg and 1.5 g, serum concentrations were approximately 50 and 100 mcg/mL, respectively, at 15 min, while the therapeutic serum concentrations of approximately 2 mcg/mL or more were maintained for 5.3 and 8 hrs or more, respectively. There was no evidence of cefuroxime accumulation in the serum following IV administration of 1.5-g doses every 8 hrs to normal volunteers. Serum half-life after either IM or IV injections is approximately 80 min.

Approximately 89% of a dose of cefuroxime is excreted by the kidneys over an 8-hr period, resulting in high urinary concentrations. Following IM administration of a 750-mg single dose, urinary concentrations averaged 1300 mcg/mL during the first 8 hrs. IV doses of 750 mg and 1.5 g produced urinary levels averaging 1150 and 2500 mcg/mL, respectively, during the first 8 hrs. Cefuroxime is detectable in therapeutic concentrations in pleural and joint fluids, bile, sputum, bone, aqueous humor, and in the cerebrospinal fluid (CSF) of adults and pediatric patients with meningitis. It does not pass the blood-brain barrier in patients without inflamed meninges. Cefuroxime is approximately 50% bound to serum protein. Natalac

Contents Indications

Moringa oleifera (Malunggay) leaves. Food supplement for breastfeeding mothers. Enhances milk letdown, lactation & increases milk vol.

Dosage Administration Description

1-2 cap/day. May be taken with or without food For details on the chemical structure, and the excipient or inactive compounds in the formulation... click to view

Mechanism of Action MIMS Class

For Details of the mechanism of action, pharmacodynamics and pharmacokinetics ... click to view Supplements & Adjuvant Therapy

ATC Classification

A13A - TONICS ; Used as tonics.

Poison Schedule

Non-Rx

Mechanism of action:

Enhances milk letdown and increases volume of milk production. It is an effective galactogogoue (lactation enhancer). Natalac’s active component, malunggay (Moringa oleifera), has gained acceptance as a health food supplement to help stimulate the secretion and flow of milk. The all natural and organic malunggay in Natalac, has been proven safe and does not contain toxic components. It has been used by generations of nursing mothers especially those with inadequate lactation. Although the galactogogue action of Natalac is not understood, literature and clinical studies have again and again mentioned and proved its definitive value for nursing mothers. Breast milk always gives the best nourishment for babies. Natalac is ideal for lactating mothers. It is rich in vitamins and minerals. It helps increase the secretion of milk which contains antibodies that protect the infant from infections. Breastmilk also imparts immunities that keep the baby away from allergies. Natalac increases lactation in nursing mothers which promotes breastfeeding. Breastfeeding provides the most natural way of caring for infants. It strengthens the emotional and physical bond between mother and child GENERIC NAME: MEFENAMIC ACID - ORAL (meff-en-AM-ick acid) BRAND NAME(S): Ponstel Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: This medication relieves pain and reduces inflammation. It is used to treat headaches, menstrual cramps, muscle aches, dental pain and athletic injuries. HOW TO USE: Take with food or milk to minimize stomach upset. This medication is most effective in relieving menstrual pain if taken at the earliest sign of pain. Take this medication with 6 to 8 ounces (180-240ml) of water. Do not lie down for at least 30 minutes after taking this drug. This medication should not be taken for more than 7 days at a time. SIDE EFFECTS: Stomach upset is the most common side effect. Others include nausea, loss of appetite, dizziness, drowsiness, diarrhea, and headache. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. Inform your doctor promptly if you develop: yellowing of the eyes, fever with or without chills, vision changes. If you notice any of the following unlikely but very serious side effects, stop taking this drug and consult your doctor or pharmacist immediately: black stools, persistent stomach/ abdominal pain, vomit that looks like coffee grounds. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. PRECAUTIONS: Tell your doctor your medical history, especially of: liver or kidney disease, blood disorders, ulcers, heart disease, alcohol use, high blood pressure, eye disease, allergies (especially drug allergies). Use caution when performing tasks requiring alertness. Limit alcohol intake as it may intensify the drowsiness effect of this medication. This medicine may cause stomach bleeding. Daily use of alcohol, especially when combined with this medicine, may increase your risk for stomach bleeding. Check with your doctor or pharmacist for more information. Do not take aspirin without consulting your doctor. Check the ingredients of any nonprescription medication you may be taking since many cough-and-cold formulas contain aspirin. Infrequently, this medication may increase the skin's sensitivity to sunlight. If this happens to you, avoid prolonged sun exposure, wear protective clothing and use a sunscreen. Avoid sunlamps. Caution is advised when this drug is used in the elderly. This medication should be used during

pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. Use of this drug in the last 6 months of pregnancy is not recommended. It is unknown if this drug is excreted into breast milk. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription drugs you may use, especially of: "blood thinners" such as warfarin, other arthritis medication, water pills, lithium. Do not start or stop any medicine without doctor or pharmacist approval. OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness. NOTES: Do not share this drug with others. MISSED DOSE: If you miss a dose, take it as soon as remembered; do not take if it is almost time for the next dose. Instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up. STORAGE: Store at room temperature away from moisture and sunlight. Do not store in the bathroom.