Welcome To General Pathology

GENERAL PATHOLOGY: WELCOME TO TE COURSE & AN INTRODUCTION R. HUGO MARTÍNEZ LOZANO, M.D. August-25, 2006.

IDENTIFIED AS “GASTRIC BIOPSY”, WITHOUT ANY OTHER DAT THE FOLLOWING IMAGE:

-PROCESS: -ETIOLOGY -PATHOGENESIS -DIAGNOSIS -MOST IMPORTANT COMPLICATION

LEARNING OBJECTIVES: K & U INTRODUCTION TO PATHOLOGY - AS A MEDICAL DISCIPLINE - ITS ROLE IN THE STUDY OF MEDICINE - THE 4 ASPECTS OF DISEASE  CELLULAR RESPONSES TO STRESS  CELLULAR ADAPTATIONS OF G. & D. - MAJOR FORMS & RELATED CONDITIONS  CELL INJURY & DEATH (PART I) - INTRODUCTION: CONCEPTS - CAUSES - MECHANISMS Ref: (1) pp. 4-18 & lecture’s information 

PATHOLOGY AS A MEDICAL DISCIPLINE 

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DIAGNOSTIC: - CITOLOGY - FNB - SURGICAL PATHOLOGY - BIOPSIES - SURG. S. - SPECIAL TECHNIQUES TEACHING: - UNDERGRADUATE - POSGRADUATE RESEARCH:

RUDOLPH VIRCHOW “Omnis cellula e cellula”

LOUIS PASTEUR

ELIE METCHNIKOFF

DON SANTIAGO RAMÓN Y CAJAL

REYES’S SYNDROME

THE 4 ASPECTS OF DISEASE    

ETIOLOGY PATHOGENESIS MORPHOLOGY CLINICAL (OR PARACLINICAL) CONSEQUENCES

CELLULAR RESPONSE TO STRESS

CELLULAR ADAPTATIONS OF GROWTH & DIFFERENTIATION     

HYPERPLASIA HYPERTROPHY ATROPHY METAPLASIA DYSPLASIA

HYPERPLASIA  

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DEFINITION: PHYSIOLOGIC - HORMONAL - COMPENSATORY PATHOLOGIC

PREGNANT UTERUS

PROMETHEUS: POST-HEPATECTOMY COMPENSATORY HYPERPLASIA

TISSUE?

THYROID NODULAR HYPERPLASIA

HYPERTROPHY   

DEFINITION PHYSIOLOGIC PATHOLOGIC

Hypertrophy 

Non-dividing cells (remember: cell cycle)

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Synthesis of structural components Mechanisms: - TGF-b, IGF-1, FGF. - Epinephrin, angiotensin II, endothelin-1. - Other.

ATROPHY

BRAIN ATROPHY: ALZHEIMER DISEASE

ALZHEIMER DISEASE

METAPLASIA DEFINITION:

CONDILOMA ACUMINATUM

mal

DYSPLASIA Metaplasia Displasia in situ

Carcin

CELLULAR INJURY: CONCEPT

CELLULAR INJURY: CAUSES 

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OXIGEN DEPRIVATION (HYPOXIA/ISCHEMIA) PHYSICAL CHEMICAL INFECTIOUS IMMUNOLOGIC GENETIC NUTRITIONAL

MECHANISMS OF CELL INJURY     

DEPLATION OF ATP MITOCHONDRIAL DAMAGE INFLUX OF CA++ ACCUMULATION OF REACTIVE O SPECIES DEFECTS IN MEMBRANE PERMEABILITY

“EL VERDADERO CONOCIMIENTO NO PUEDE SER TRANSMITIDO… SÓLO PUEDE SER CONQUISTADO”. DR. IGNACIO CHÁVEZ.