MOA
RESPIRATORY TRACT drugs Indication
1. Decongestants local vasoconstriction decrease overproduction of secretions NasaL steroid
S/E
common cold, sinusitis, allergic rhinitis, relief of OM local burning/irritation dryness of mucosa, headache
a. Beclomethasone b. Budesonide Topical
a. topical ehphedrine b. phenylephrine
tachycardia, increase BP, anxiety cool & clammy skin, pallor
Oral
a. pseudoephedrine 2. Antihistamines block histamine --> decrease Inflammation
a. b. c. d.
allergic rhinitis, sinusitis
sedation, skin dryness, urinary retention
diphenhydramine cetirizine (Virlix, Zytec) hydroxyzine (Iterax) loratadine (Claritin)
3. Expectorants
increase productive cough to clear airways
bronchitis, pneumonia
GI upset headache & dizziness
a. guiafenesin b. terpin hydrate 4. Mucolytics
liquefy secretions to clear Airways
a. acetylcysteine b. dornase –alfa 5. Antitussives a. codeine central acting--> reduce excitability b. dextromethorphan of cough center c. benzonatate peripheral acting --> block signals d. demulcents fr vagus & glossopharyngeal nerves (honey, olive oil, glycerin)
GI upset, stomatitis, bronchospasm post-op clearing of secretions cystic fibrosis resp depression addiction, CNS depression constipation, dizziness, drowsiness